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Psychiatric comorbidity among first-time and repeat DUI offenders.

Driving under the influence of alcohol or other substances is a serious public health concern. Previous research has shown that psychiatric comorbidity is more prevalent for repeat offenders than the general population, and that first-time offenders exhibit elevated rates of psychiatric comorbidity, but few studies have directly compared first-time and repeat DUI offenders. The current study compares psychiatric comorbidity among repeat and first-time DUI offenders. First-time and repeat DUI offenders completed the screener module of the Computerized Assessment and Referral System (CARS), adap

Patient preferences for the treatment of type 2 diabetes: a scoping review.

BACKGROUND: As more studies report on patient preferences, techniques are needed to identify, assess and, eventually, synthesize results from a diverse set of methodologies. Data on patient preferences are valuable to decision makers in a variety of ways. Preferences for outcomes can be used to inform decision and cost-effectiveness models, while preferences for treatments can inform patient-centered outcomes research (PCOR) and patient-centered care. OBJECTIVES: This project sought to identify and assess the literature reporting on the treatment preferences of adult patients with type 2 diab

Differences between physician and patient preferences for cancer treatments: a systematic review.

BackgroundShared decision-making is useful to facilitate cancer treatment decisions. However, it is difficult to make treatment decisions when physician and patient preferences are different. This review aimed to summarize and compare the preferences for cancer treatments between physicians and patients.MethodsA systematic literature search was conducted on PubMed, Embase, PsycINFO, CINAHL and Scopus. Studies elicited and compared preferences for cancer treatments between physicians and patients were included. Information about the study design and preference measuring attributes or questions

Характеристики самоидентифицированных сексуальных азартных игроков в клинике азартных заболеваний.

Фон и цели Исследования сексуального зависимости процветали в последний десятилетний период, стимулированные развитием большого количества онлайн-сексуальных активностей. Несмотря на накопление исследований, однако, доказательства, собранные в клинических образцах людей, ищущих лечение, остаются редкими. Целью этого исследования было описать характеристики (социodemографические, сексуальные привычки и сопутствующие заболевания) самоназначенных «сексуальных зависимых». Методы Образец составлял 72 пациента, обратившихся в поликлинический центр лечения по поводу своих сексуальных поведений. Данны

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… Indeed, excessive sexual behaviors are increasingly described as a behavioral (i.e., non-chemical) addiction and aligned with psychiatric conditions such as gambling disorder or Internet gaming disorder ( Billieux, Schimmenti, Khazaal, Maurage, & Heeren, 2015 ). … Post-traumatic stress disorder 5.6 100  Psychotic syndrome 2.8 50  Anorexia 1.4 100  Bulimia 0 Addictive comorbidities 72  Nicotine dependence 38.9 77.8  Alcohol abuse 27.8 70  Alcohol dependence 16.7 50  Substance abuse 11.1 75  Substance dependence 15.3 63.6  Compulsive video gaming 8.3 66.7  Problem gambling …

Глобальное состояние исследований и тенденции навязчивого сексуального поведения: всеобъемлющий библиометрический анализ.

СТРОИТЕЛЬНОЕ ПОЛОЖЕНИЕ В СВЯЗИ С СТРАТЕГИЧЕСКИМ ПОЛОЖЕНИЕМ В СВЯЗИ С СТРАТЕГИЧЕСКИМ ПОЛОЖЕНИЕМ (CSBD) - это состояние психического здоровья, которое привлекло к себе значительное внимание в ходе научных исследований, особенно после его включения в одиннадцатый пересмотренный вариант Международной классификации болезней (International Classification of Beasons) (International Classification of Bisons (CSBDD).ICD-11) Всемирной организацией здравоохранения. Несмотря на это признание, эта область по-прежнему является фрагментарной в связи с продолжающимся обсуждением вопроса о ее классификации и о

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… Although further research is warranted, preliminary neurochemical evidence suggests that treatments such as naltrexone—traditionally used for substance and gambling addictions—may also reduce CSBD symptoms ( Raymond, Grant, & Coleman, 2010 ). … Additionally, Rumpf and Montag (2022) compared diagnostic criteria for CSBD, gaming disorder, and gambling disorder, identifying shared features such as loss of control, prioritization of behavior, and persistence despite negative outcomes. …

Supping with the Devil: Belief and the Imaginary World of Multiple Myeloma Therapies Invented by the Institute for Clinical and Economic Review.

Previous commentaries in Innovations in Pharmacy and other peer reviewed journals have made the case that the analytical framework, if that is not too strong a term, to support pricing and access recommendations endorsed by the Institute for Clinical and Economic Review (ICER) fails to meet the standards of normal science. By any criteria the ICER analysis is best described as pseudoscience; it fails the demarcation test between biological evolution and intelligent design. Like intelligent design it has its believers; a meme for all seasons. ICER is fully aware of the fact that it fails these

Навязчивое сексуальное поведение у депрессивных женщин

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… There was no history suggestive of decreased self-care, any attempt to harm her, repetitive thought of checking/cleaning/doubt, strong urge for fire setting/hair pulling/gambling/stealing, and any unusual sexual preferences. There was no significant medical/surgical or family history. …

Acupuncture Synergized With Bortezomib Improves Survival of Multiple Myeloma Mice via Decreasing Metabolic Ornithine.

Multiple myeloma (MM) is a hematological malignancy worldwide in urgent need for novel therapeutic strategies. Since Velcade (bortezomib) was approved for the treatment of relapsed/refractory MM in 2003, we have seen considerable improvement in extending MM patient survival. However, most patients are fraught with high recurrence rate and incurability. Acupuncture is known for alleviating patient symptoms and improving the quality of life, but it is not well investigated in MM, especially in combination with bortezomib. In this study, we employed LC-MS and UHPLC-MS together with bioinformatics

Intravenous zoledronic acid for the treatment of osteoporosis: The evidence of its therapeutic effect.

INTRODUCTION: Osteoporosis is a disease characterized by low bone mineral density and poor bone quality resulting in reduced bone strength and increased risk of fracture. Oral bisphosphonates, first-line therapy for most patients with osteoporosis, are associated with suboptimal adherence to therapy due to factors that include a complex dosing regimen and gastrointestinal intolerance in some patients. Intravenous bisphosphonates address these limitations through infrequent injectable dosing that assures 100% bioavailability. Intravenous zoledronic acid is the newest bisphosphonate to be approv

Clinical utility of ustekinumab in Crohn's disease.

The introduction of anti-tumor necrosis factor (TNF) therapy marked an important milestone in the management of moderate-to-severe Crohn's disease (CD). However, there remains a pressing demand for alternative therapeutic options for patients with primary nonresponse, secondary loss of response, or intolerable side effects to conventional treatment and TNF antagonists. Ustekinumab (UST) is a fully human IgG1κ monoclonal antibody that inhibits the p40 subunit shared by the proinflammatory cytokines, the interleukin (IL)-12 and -23. This blockade leads to dampening of the inflammatory cascade an

Extraskeletal benefits and risks of calcium, vitamin D and anti-osteoporosis medications.

UnlabelledDrugs used for the prevention and the treatment of osteoporosis exert various favourable and unfavourable extra-skeletal effects whose importance is increasingly recognized notably for treatment selection.IntroductionThe therapeutic armamentarium for the prevention and the treatment of osteoporosis is increasingly large, and possible extra-skeletal effects of available drugs could influence the choice of a particular compound.MethodsThe present document is the result of a national consensus, based on a systematic and critical review of the literature.ResultsObservational research has

Metabolic effects of pamidronate in patients with metastatic bone disease.

We have evaluated the value of specific bone resorption markers in monitoring metastatic bone disease to define the duration of action of a single high-dose pamidronate infusion. Twenty patients received a single infusion of pamidronate 120 mg for painful bone metastases. Ten out of these 20 patients also received a second infusion. They were evaluated at baseline, 2, 4 and 8 weeks after each infusion. A composite pain questionnaire, serum and urine tests were carried out at these time points. Bone resorption markers measured included urinary calcium, hydroxyproline and two new markers: pyridi

Разногласия по признаку пола в агрессивном сексуальном поведении.

Навязчивое сексуальное поведение — это неспособность контролировать сильные, повторяющиеся сексуальные порывы или желания, приводящие к сексуальному поведению, вызывающему серьезные страдания или расстройство. По данным исследований, связанных с навязчивым сексуальным поведением, среди мужчин больше мужчин. Существуют различия по признаку пола в симптомах и поведении, связанных с CSB, например, сексуальное возбуждение и мотивация. МЕТОДЫ: Систематический поиск в базах данных PubMed/Medline и Scopus в период с января 2000 года по январь 2026 года с использованием терминов поиска, связанных с се

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… Fattore et al. (2014) argued that men and women differ in their propensity to addiction involving rewarding stimuli such as sex and food, as well as behaviors like gambling and exercise. … Five types of color images were presented in a block design: (1) dopaminergic drugs cues; (2) appetizing food cues; (3) money and gambling cues; (4) sexual cues; and (5) neutral cues in fMRI. …

Bisphosphonates in oncology: evidence for the prevention of skeletal events in patients with bone metastases.

Bone metastases frequently occur in patients with advanced solid tumors, particularly breast and prostate cancers, and nearly all patients with multiple myeloma have some degree of skeletal involvement. The strides made in treating these primary tumors have extended median survival times and thereby increased patient risk for skeletal-related events (SREs), including pathologic fractures, spinal cord compression, need for palliative radiation therapy or surgery to bone, and hypercalcemia. Bisphosphonates, inhibitors of osteoclastic bone resorption that were first established as treatment of os

Instagram v. Reality: The Case for Regulating Adolescent Social Media Use.

In the span of just two decades, social media has transformed from a novel communication platform into an omnipresent force in modern life, … ming patterns have emerged that mirror addictive behaviors typically associated with substances and gambling. Medical research reveals that social media use can cause neurological changes with striking similarities to those seen in substance use disorder and behavioral addictions. Some levels of social media use would be more accurately described as social …

The state of the science of interprofessional collaborative practice: A scoping review of the patient health-related outcomes based literature published between 2010 and 2018.

IntroductionIf interprofessional collaborative practice is to be an important component of healthcare reform, then an evidentiary base connecting interprofessional education to interprofessional practice with significantly improved health and healthcare outcomes is an unconditional necessity. This study is a scoping review of the current peer reviewed literature linking interprofessional collaborative care and interprofessional collaborative practice to clearly identified healthcare and/or patient health-related outcomes. The research question for this review was: What does the evidence from t

Feasibility of Deriving Health State Utilities in Mycosis Fungoides Cutaneous T-Cell Lymphoma Using Mapping Algorithms.

BACKGROUND: A prospective, observational, US-based study (PROVe) used three questionnaires (Pruritus-VAS, Skindex-29, MF/SS-CTCL QoL) to assess quality of life in patients diagnosed with mycosis fungoides cutaneous T-cell lymphoma (MF-CTCL); however, none of these studies was provided with a preference-based algorithm yielding health state utility values (HSUVs). OBJECTIVE: This study aimed to assess the feasibility of deriving HSUVs from published mapping algorithms by comparing mapped utilities with the HSUVs reported in the MF-CTCL literature. METHODS: We searched PubMed, the School of He

Patient-reported utilities in advanced or metastatic melanoma, including analysis of utilities by time to death.

BackgroundHealth-related quality of life is often collected in clinical studies, and forms a cornerstone of economic evaluation. This study had two objectives, firstly to report and compare pre- and post-progression health state utilities in advanced melanoma when valued by different methods and secondly to explore the validity of progression-based health state utility modelling compared to modelling based upon time to death.MethodsUtilities were generated from the ipilimumab MDX010-20 trial (Clinicaltrials.gov Identifier: NCT00094653) using the condition-specific EORTC QLQ-C30 (via the EORTC-

Development of fever following first administration of zoledronate as a prognostic factor in advanced non-small cell lung cancer patients with bone metastases.

Nitrogen-containing bisphosphonates (N-BPs), which are usually used for the treatment of advanced cancer with bone metastasis, occasionally cause fever following the first administration. However, it is unclear as to how the development of fever following the first administration of N-BP is associated with clinical outcome. The aim of the present study was to determine the prognostic value of the development of fever following the first administration of N-BP in advanced non-small cell lung cancer patients with bone metastases. The present study reviewed the data of 46 patients with advanced n

Психотипные рецепты у пациентов с биполярным расстройством до установленного диагностирования биполярного расстройства.

Объективное биполярное расстройство I (БП-I) часто неправильно диагностируется как серьезное депрессивное расстройство (ДДД), что затягивает соответствующее лечение. Цель этого исследования заключалась в изучении методов лечения пациентов BP-I, неправильно диагностированных с помощью MDD, и в оценке воздействия этих режимов на период до диагностики BP-I. 21,771 Пациенты BP-I первоначально неправильно диагностировали MDD и 50,667 Правильно диагностировали пациентов с BP-I. Модели лечения и их влияние на время диагностирования BP-I оценивались с использованием мультиномиальной логистической регр

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… F50.8, F98.21, F50.01, F50.02, F50.2, F50.9 Disruptive, impulse‐control, and conduct disorders F91.3, F63.81, F91.1, F91.2, F63.3, F91.9, F91.8, F60.2, F63.1, F91.9 Gender dysphoria F64.2, F64.8, F64.9, F64.1 Paraphilic disorders F65.3, F65.2, F65.81, F65.89, F65.51, F65.52, F65.4, F65.0, F65.1, F65.9 Gambling … F98.21, F50.01, F50.02, F50.2, F50.9 Disruptive, impulse‐control, and conduct disorders | F91.3, F63.81, F91.1, F91.2, F63.3, F91.9, F91.8, F60.2, F63.1, F91.9 Gender dysphoria | F64.2, F64.8, F64.9, F64.1 Paraphilic disorders | F65.3, F65.2, F65.81, F65.89, F65.51, F65.52, F65.4, F65.0, F65.1, F65.9 Gambling …