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The Clinical Use of Stem Cell Research in Chronic Obstructive Pulmonary Disease: A Critical Analysis of Current Policies.

Chronic obstructive pulmonary disease (COPD) is a disorder affecting more than 200 million people around the world, resulting in three million deaths per year. COPD is characterized by the loss of lung tissue and airway remodelling, with chronic inflammation of the airways and progressive destruction of lung parenchyma. The use of stem cells may lead to regenerative processes that address biological damage. However, this approach raises ethical issues that need to be considered in clinical trials using stem cell therapy, such as informed consent, patient recruitment and harm minimization, as w

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… In non-smokers and particularly children, bronchiolitis usually results from bacterial or viral infection [ 12 ]. Living in low socio-economic conditions seems to be a contributing factor to COPD development. … Lavage fluids analyzed in COPD patients demonstrate that smokers exhibit a different protein expression profile to non-smokers. This may suggest that genetic alterations affect protein expression levels. …

Long Term Therapeutic Plan for Patients with Non-Small Cell Lung Cancer Harboring EGFR Mutation.

Non-small cell lung cancer harboring epidermal growth factor receptor (EGFR) sensitizing mutations has a distinct disease entity. Patients with this cancer have better prognosis, and frequently achieve long-term survival. EGFR-tyrosine kinase inhibitor (TKI) is the drug of choice for this cancer; but the disease inevitably progresses, after durable response. The tumor is a mixture of EGFR-TKI sensitive clones and resistant clones, regardless of their molecular mechanisms. EGFR-TKI sensitive clones are very susceptible to this drug, but rarely eradicated; so, withdrawal of the drug permits rapi

NAPCON 2025 – Best Original Research Abstracts

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… However, many patients are non-smokers. In India, biomass fuel, second-hand smoke, tuberculosis, and low socioeconomic status are important contributors. The etiology and clinical profile of COPD in non-smokers remain less explored. … Objective: To study the etiology, clinical profile, and severity of COPD in non-smokers. Methods: A cross-sectional study was conducted in 100 nonsmoker COPD patients at the Institute of Chest Diseases, Government Medical College, Kozhikode, over 18 months. …

Accuracy of self-reported tobacco use status among hematopoietic SCT patients.

Tobacco use is a risk factor for adverse outcomes among hematopoietic SCT (HSCT) patients. Accurate identification of tobacco use offers a vital opportunity to treat this risk factor. The current study compared self-reported tobacco use status with serum cotinine levels among HSCT patients at the time of pre-transplant evaluation. A total of 444 participants completed both assessments; 44 participants (9.9%) were classified as tobacco users with serum cotinine concentrations >2 ng/mL vs 29 with self-reporting. Sensitivity and specificity of self-reporting were 65.9% and 100%, respectively. Pos

Impact of Oncology Patients’ Knowledge and Awareness on Emergency Visits and Hospital Admissions: A Cross-Sectional Study

INTRODUCTION: Chemotherapy remains a cornerstone of cancer treatment, but is frequently accompanied by adverse effects that can affects patients' quality of life. In Saudi Arabia, patients' understanding of chemotherapy regimens and related toxicities is not well characterized. This study aimed to evaluate chemotherapy awareness among cancer patients and examine its association with hospital admissions and emergency department (ED) visits. METHODS: This cross-sectional descriptive study was conducted at a tertiary hospital in Saudi Arabia, between year of 2022 to 2023. Adult cancer patients r

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… The smoking status of the participants indicated that 220 (81.5%) were non-smokers, 30 (11.1%) were ex-smokers, and 20 (7.4%) were current smokers. The majority of participants were Saudi nationals (95.6%), while only 12 (4.4%) were residents of other nationalities. … Widowed/Divorced | 25 (30.5) | 58 (30.8) | 83 (30.7) Prefer not to say | 4 (4.9) | 5 (2.7) | 9 (3.3) Education High School Diploma | 29 (35.4) | 65 (34.6) | 94 (34.8) Bachelor’s Degree and Higher | 17 (20.7) | 60 (32.0) | 77 (28.5) Prefer not to say | 36 (43.9) | 63 (33.5) | 99 (36.7) Smoking Status Non-smoker …

Chemokines in COPD: From Implication to Therapeutic Use.

: Chronic Obstructive Pulmonary Disease (COPD) represents the 3rd leading cause of death in the world. The underlying pathophysiological mechanisms have been the focus of extensive research in the past. The lung has a complex architecture, where structural cells interact continuously with immune cells that infiltrate into the pulmonary tissue. Both types of cells express chemokines and chemokine receptors, making them sensitive to modifications of concentration gradients. Cigarette smoke exposure and recurrent exacerbations, directly and indirectly, impact the expression of chemokines and chem

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… Prevalence and incidence of COPD in smokers and non-smokers: The Rotterdam Study Eur. J. Epidemiol. 2016 31 785 792 10.1007/s10654-016-0132-z 26946425 PMC5005388 4. Stoller J.K. Aboussouan L.S. Alpha1-antitrypsin deficiency Lancet Lond. …

Факторы, влияющие на развитие усталости у многочисленных склерозовых пациентов.

Усталость является одним из наиболее распространенных и недействующих симптомов у пациентов с MS, однако в настоящее время проводятся ограниченные исследования по изучению продольных детерминант развития усталости. Цель этого исследования состоит в том, чтобы выявить социально-демографические, поведенческие и клинические характеристики и терапевтические режимы, которые со временем соотносятся с усиливающейся усталостью у пациентов, у которых диагностированы синдромы MS. Это ретроспективная диаграмма 483 пациентов. Главным результатом этого стало изменение результатов по шкале 5 (MFIS-5) с перв

Физическая активность в период отдыха, воздействие солнца и риск множественных склерозов: тематическое исследование по вопросам контроля за населением.

Физическая активность способствует возникновению симптомов и функций у людей с множественным склерозом (MS), однако ее актуальность для MS-чувствительности остается неопределенной и может быть трудно отделить от корреляционного образа жизни и экологических факторов, включая воздействие на солнце. МЕТОДЫ: В рамках данного исследования по вопросам контроля за положением населения в Швеции было проведено, в частности, следующее: 3,008 случаи ДБ и 5773 Совпадающие с контрольными. Анализы проводились только для участников, у которых в рамках системы контроля был установлен соответствующий базисный

Prediagnostic self-rated health and survival in women diagnosed with cancer in the Norwegian Women and Health Study: a prospective cohort study.

ObjectivesSelf-rated health (SRH) is a well-established predictor of all-cause mortality. However, its predictive value in patients with cancer remains unclear. We aimed to elucidate the relationship between prediagnostic SRH and mortality among patients with cancer using data from the Norwegian Women and Health (NOWAC) Study.DesignA prospective cohort study.Settings and participantsThis study included 26 405 women from the NOWAC cohort who were diagnosed with cancer between 1992 and 2020. Subgroup analyses focused on the most common cancer types among Norwegian women: breast (n=8299), colorec

Oral squamous cell carcinoma vs. medication-related osteonecrosis of the jaw in patients assuming bone-modifying agents: a diagnostic challenge in a multi-hospital case series.

BACKGROUND: Despite advances in the diagnosis of oral squamous cell carcinoma (OSCC), most cases are diagnosed in advanced stages, influencing negatively the patient's prognosis. The absence of specific signs and symptoms contributes to the diagnostic delay of OSCC, often leading to confusion with various oral conditions, including, in patients with a history of bone modifying agents (BMA) and/or anti-angiogenic (AA) molecules, the Medication-Related Osteonecrosis of the Jaw (MRONJ). This study aims to investigate the characteristics of OSCC and MRONJ, focusing on clinical and radiological fea

Survival Outcomes and Factors Associated with Revision Surgery for Metastatic Disease of the Spine.

STUDY DESIGN: Retrospective review of a prospective database. OBJECTIVE: Certain subset of patients undergoing surgical treatment for spinal metastasis will require a revision surgery in their disease course; however, factors predictive of revision surgery and survival outcomes are largely unknown. The goal of this study is to report on survival outcomes as well as factors predictive of revision surgery in this unique patient population. METHODS: A total of 55 patients who met the inclusion criteria were included from January 2010 to December 2015. Twelve (22%) of these patients underwent a

Factors associated with palliative care symptoms in cancer patients in Palestine.

Palliative care is critical to redundancy in cancer patients seeking to improve their quality of life. Evaluation should be incorporated into clinical practice routines at all stages of cancer. The Edmonton Symptom Assessment System (ESAS) was used to rate the intensity of ten symptom evaluations designed and validated for cancer patients in various languages and cultures. Therefore, the study aims to assess the symptoms reported using ESAS scores to identify patients who would benefit from palliative care that can improve the integration of palliative care into standard cancer care at An-Naja

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… Shortness of breath dimension In Additional file 1: In Table S6 of the SOB domain, smoking was reported to be highly associated with this symptom ( p = 0.021) and was the only predictor of SOB, as shown in Table 4 , where the SOB score was 2.5 [0.0–5.0] for smokers and 1.0 [0.0–3.0] for non-smokers. … Furthermore, the SOB score was significantly higher in smokers than in non-smokers, consistent with previous findings that identified increased dyspnea in cancer patients who smoke 37 . …

Comparison of clinical and prognostic characteristics of patients with classic and AIDS-related Kaposi sarcoma: A single-center experience.

Kaposi sarcoma (KS) is a rare disease caused by human herpesvirus-8 (HHV-8) infection, that occurs in the elderly and more often in men. We aimed to compare the clinical and prognostic features of patients with classic and AIDS-related KS who have been followed in our clinic over the last 10 years and to present real-life data in first-line treatment. We retrospectively reviewed the medical records of 73 patients with KS, 57 with classic KS and 16 with acquired immunodeficiency syndrome (AIDS)-related KS, who were followed up at our clinic between January 2014 and December 2023. Information an

Презентация и результаты оптического неврита: опыт одного центра из Северной Саудовской Аравии.

Цель этого исследования заключалась в анализе демографических характеристик, клинического представления и результатов лечения пациентов с оптическим неуритом (ОН) в больнице им. короля Халида, Хейла, Саудовская Аравия. Было проведено ретроспективное когортное исследование, в ходе которого были рассмотрены медицинские записи 40 пациенты, диагностированные в период с января 2021 и декабрь 2024. Собранные данные включали демографические данные, клинические представления, неврологические выводы, результаты съемки и результаты лечения. По данным исследования, в основном женщины (n = 32, 80%), гражд

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… Regarding smoking habits, 5.0% were smokers, and 95.0% were non-smokers. Finally, concerning chronic health problems, 80.0% of participants reported no such issues, while 20.0% indicated having chronic health problems (hypertension, diabetes mellitus, and autoimmune disorders). … Smoking did not significantly affect outcomes, with 100% of smokers and 78.9% of non-smokers showing improvement (χ² = 0.526, p = 0.468). …

SUBJECT INDEX Volume 125 (JANUARY–JUNE, 2004)

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Metagenomic Profiling of Oral Microbiome Dynamics During Chemoradiotherapy in Head and Neck Squamous Cell Carcinoma Patients.

BACKGROUND: We explored the interaction between the oral microbiome and the development of radiation-induced mucositis in patients with head and neck squamous cell cancer (HNSCC) undergoing chemoradiotherapy (CRT). We prospectively studied the oral microbiome and compared it to healthy controls. Additionally, we compared patients with low-grade (LGM) vs. high-grade mucositis (HGM). METHODS: Ten HNSCC patients scheduled for CRT were included. Saliva samples were characterized prior to, during, and nine months after CRT using metagenomic sequencing. We similarly characterized samples from seven

Which cancer survivors are at risk for a physically inactive and sedentary lifestyle? Results from pooled accelerometer data of 1447 cancer survivors.

BackgroundPhysical activity has beneficial effects on the health of cancer survivors. We aimed to investigate accelerometer-assessed physical activity and sedentary time in cancer survivors, and describe activity profiles. Additionally, we identify demographic and clinical correlates of physical activity, sedentary time and activity profiles.MethodsAccelerometer, questionnaire and clinical data from eight studies conducted in four countries (n = 1447) were pooled. We calculated sedentary time and time spent in physical activity at various intensities using Freedson cut-points. We used latent p

Patterns and Outcomes of Permanent Vascular Access in End-Stage Kidney Disease: A Multicenter Experience.

Background End-stage kidney disease (ESKD) is a growing health problem worldwide, with hemodialysis serving as the main treatment when transplantation is not feasible. Permanent vascular access is essential for effective dialysis, yet its patterns and outcomes remain variable across patient populations. Aim This multicenter study aimed to describe the patterns of vascular access use and evaluate the outcomes of permanent vascular access in patients with ESKD undergoing hemodialysis. Methods A retrospective multicenter cross-sectional study (January-June 2024) was conducted at two tertiary hosp

Pancreatitis: TIGAR-O Version 2 Risk/Etiology Checklist With Topic Reviews, Updates, and Use Primers.

The Toxic-metabolic, Idiopathic, Genetic, Autoimmune, Recurrent and severe acute pancreatitis and Obstructive (TIGAR-O) Pancreatitis Risk/Etiology Checklist (TIGAR-O_V1) is a broad classification system that lists the major risk factors and etiologies of recurrent acute pancreatitis, chronic pancreatitis, and overlapping pancreatic disorders with or without genetic, immunologic, metabolic, nutritional, neurologic, metaplastic, or other features. New discoveries and progressive concepts since the 2001 TIGAR-O list relevant to understanding and managing complex pancreatic disorders require an up

Evaluating Vaporized Cannabinoid Therapy in Multiple Sclerosis: Findings from a Prospective Single-Center Clinical Study.

Introduction: Multiple Sclerosis (MS) is associated with a wide range of debilitating symptoms, and conventional therapies often fail to adequately address the disease's multifaceted challenges. Cannabidiol (CBD) 13.0% + Delta9-tetrahydrocannabinol (THC) 9.0% (CBD13/THC9), a vaporized cannabis-based medicinal product, presents a novel therapeutic option for managing MS symptoms. Methods: This single-center longitudinal study followed 69 MS patients over a six-month period. Participants were assessed at treatment initiation and at three- and six-month intervals. Key measures included muscle spa

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… Smoking status was recorded as a binary variable, with participants categorized as either smokers or non-smokers based on self-reported tobacco use. … Smoking status was treated as a binary variable (smoker/non-smoker) based on self-reported tobacco use. Daily frequency of CBD13/THC9 use was recorded as the self-reported number of times per day participants used the vaporized formulation. …