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Oxidative Assault: How Pyrogallol's Pro-Oxidant Chemistry Drives Cell Cycle Arrest and Apoptosis in Cancer.

Cancer is characterized by uncontrolled cell proliferation and the evasion of programmed cell death. The dysregulation of the cell cycle is a fundamental hallmark of nearly all human cancers, making its core machinery an attractive target for therapeutic intervention. Concurrently, the ability of cancer cells to resist apoptotic signals is a primary mechanism of tumorigenesis and therapy resistance. This has spurred the search for agents that can simultaneously reinstate cell cycle control and trigger robust cell death pathways. Natural products, particularly polyphenols, have emerged as a pro…

Biocontrol potential of aqueous and methanolic extracts of Russian knapweed, Acroptilon repens, L. (Asteraceae) against Trialeurodes vaporariorum (Hemiptera: Aleyrodidae).

Plant based natural products could be used as new alternative of chemical insecticides due to their co-friendly, safety to non-target organi … . Moreover, the results illustrated that some secondary metabolites (e.g. flavonoids, alkaloids and polyphenols) were rich in methanolic extract compared to the control. The leaf dipping method was used for the bioassay tests against whiteflies. According our findings, the aqueous extract (LC50: 1802.59 ppm) was more toxic than the methnolic treatment (LC50: …

Metal-phenolic networks assisted construction of multi-layered endothelium-mimetic polyelectrolyte coating with nitric oxide generation and glycocalyx functionalization.

During cardiovascular-stent endothelialization, application of an endothelium-mimetic coating is desirable to establish a conducive microenv … alities similar to that of natural endothelial cells. The presence of cation-anion electrolytes and polyphenols enhances the loading, stability, and uniformity of the coating through various interactions such as electrostatic adsorption, hydrogen bonding, π-π stacking, and covalent crosslinking of phenol-aldehyde-amine. Systematic in-vitro and in-vivo studies …

Activity-based chemical proteomics reveals caffeic acid ameliorates pentylenetetrazol-induced seizures by covalently targeting aconitate decarboxylase 1.

BACKGROUND: Epilepsy is a neurological disorder characterized by recurrent seizures, tightly associated with neuroinflammation. Activation of inflammatory cells and molecules in damaged nervous tissues plays a pivotal role in epilepsy. Caffeic acid, one of the most abundant polyphenols in coffee, has shown potent protective effects as a phytomedicine in various neurological disorders. However, the direct protein targets and exact molecular mechanisms of caffeic acid in epilepsy, remain largely elusive. PURPOSE: This study aimed to explore the protective effects of caffeic acid in epilepsy and…

Climate-Driven Changes in the Nutritional Value and Food Safety of Legume Seeds.

Background/Objectives: Leguminous plants (Fabaceae) are essential for global food and nutritional security due to their high protein content … ex carbohydrates, fibers, and essential fatty acids, and contain valuable phytochemicals, including polyphenols, carotenoids, saponins, and bioactive peptides, with antioxidant, anti-inflammatory, and cardioprotective effects. Nevertheless, elevated CO2 levels and temperature stress can reduce protein, iron, and zinc contents, while altering phenolic and isof …

Anti-Inflammatory Activity of the Shaggy Ink Cap Medicinal Mushroom Coprinus comatus (Agaricomycetes) Nanogel in Complete Freund's Adjuvant-Induced Rheumatoid Arthritis: In Silico and In Vivo Approach.

The Coprinus comatus (O.F. Mull.) Pers. (saggy ink cap) medicinal mushroom is widely found in Indonesia, the utilization and cultivation of this mushroom is still very rare, so further exploration is needed. The potential of bioactive compounds of C. comatus as a nutraceutical therapeutic is starting to be developed both as antidiabetic, anticancer, antioxidant, and anti-inflammatory. Compounds such as polyphenols, flavonoids, triterpenoids, quercetin and rutin in C. comatus are known to have biological and pharmacological activities. Many applications of C. comatus are carried out in the form…

Risk factors for gastric cancer: an umbrella review of systematic reviews and meta-analyses.

BACKGROUND: This umbrella review aims to critically appraise and synthesize epidemiological evidence from meta-analyses to identify and clas … intake, total cholesterol (TC), HDL cholesterol (HDL-C), NSAIDs, β-carotene, vitamins, and dietary polyphenols. Risk factors included depression, Helicobacter pylori (Hp) infection, dermatomyositis, and Graves' disease. Class III evidence confirmed that aspirin, non-aspirin NSAIDs, soy food intake, non-fermented soy food intake, physical activity, vitamin A, …

Корреляция физико-химических свойств с антиоксидантной активностью в фенолах и тиофенолах.

Окисляющий стресс, связанный с чрезмерным производством реактивных видов кислорода и азота (ROS, RNS), способствует развитию и развитию многих заболеваний, таких, как старение, сердечно-сосудистые заболевания, болезнь Альцгеймера, болезнь Паркинсона, диабет, рак, предэклампсия или множественный склероз. В то время как фенолы и полифенолы являются наиболее изученными структурно схожими соединениями антиоксидантов, такими, как анилины или тиофенолины, периодически анализируются, несмотря на их радикальный потенциал сбора. В ходе этой работы проводится оценка воздействия структурных особенностей

Совпадение в аннотации оригинала
Oxidative stress, associated with excessive production of reactive oxygen and nitrogen species (ROS, RNS), contributes to the development and progression of many ailments, such as aging, cardiovascular diseases, Alzheimer's disease, Parkinson's disease, diabetes, cancer, preeclampsia or multiple sclerosis. While phenols and polyphenols are the most studied a…

Natural compounds mitigate mycotoxins-induced neurotoxicity by modulating oxidative tonus: in vitro and in vivo insights - a review.

This review explores the repercussions of mycotoxin contamination in food and feed, emphasising potential threats to agriculture, animal hus … ontamination of many food products. Specifically, the protective role of natural compounds, such as polyphenols, is highlighted, showcasing their efficacy in mitigating mycotoxicosis in the central nervous system (CNS), as evidenced by findings in various animal models. In summary, countering mycotoxin-induced neurotoxicity requires a multifaceted approach. T …

Unraveling the hepatoprotective and anti-pancreatic cancer potential of Caralluma europaea: a comprehensive in vivo, in vitro and in silico evidence.

Caralluma europaea Guss. (C. europaea) is a medicinal plant used for cancer treatment. However, these treatments may be associated with complications that need to be investigated. This work aims to evaluate not only the chemical composition but also the hepatoprotective and anticancer properties of C. europaea extracts. The chemical constitution of the hydroethanolic extract was explored using gas chromatography-mass spectrometry (GC-MS) and high-performance liquid chromatography (HPLC). The hydroethanolic extract, flavonoids, and polyphenols-rich extract at 100, 15, and 50 mg/kg, respectively…

Biogenic silver nanoparticle synthesis using orange peel extract and its multifaceted biomedical application.

The aim of this study was to employ an agro-industrial byproduct, specifically Citrus sinensis peels, as a reservoir of polyphenols. The natural chemicals present in C. sinensis peels serve as reducing agents in an environmentally benign method for synthesizing silver nanoparticles (AgNPs). This methodology not only provides a more environmentally friendly method for synthesizing nanoparticles but also enhances the value of agricultural waste, emphasizing the sustainable utilization of resources. In our study, AgNPs were successfully synthesized using peel aqueous exact of C. sinensis and then…

Exploring role of citrus fruits in comorbid neurodegenerative disorders associated with psoriasis.

A neurodegenerative illness is a disorder in which the brain and/or spinal cord's neurons, or nerve cells, gradually deteriorate and disappe … erythroid 2-related factor 2 (Nrf2). Due to their immunomodulatory and anti-inflammatory qualities, polyphenols may be able to control the immune response in psoriasis. We performed a thorough review in order to investigate for the first time to understand the role of citrus fruits in comorbid neurodegenerative disorders associated with psoriasis. For better …

White Tea Consumption Alleviates Anthropometric and Metabolic Parameters in Obese Patients.

Background and Objectives: Obesity and related disorders are an increasing global health problem. Achieving and maintaining long-term weight loss through lifestyle changes and/or pharmacological interventions have not met expectations. Dietary supplements and alternative treatments have also shown limited effectiveness in this regard. The consumption of green tea in general has been shown to benefit obese patients, with effects attributed to caffeine, catechins, polyphenols and other components. However, the potential of white tea to prevent and treat the negative effects of obesity has not be…

Identification and determination of usnic acid and fatty acid from various lichen species in arequipa, Peru, as well as antibacterial and antioxidant capacity.

Seven species of lichens such us Umbilicaria aff. calvescens, Hypotrachyna enderythraea, Punctelia graminicola, Cladonia chlorophaea, Xantho … a potential antimicrobial metabolites source whereas P. distincta (ts) and Puntelia graminicole for polyphenols with antioxidant compound.

Unveiling the apoptotic potential of antioxidant-rich Bangladeshi medicinal plant extractives and computational modeling to identify antitumor compounds.

Nowadays, there has been a significant surge in the exploration of anticancer compounds derived from medicinal plants due to their perceived … xyl (IC50: 3.9 ± 0.1 μg/mL) free radicals. Furthermore, the total antioxidants, reducing power, and polyphenols of B. ceiba bark were higher than those of other extracts. B. ceiba bark also showed significant antiproliferative capacity against MCF-7 cells (86.67 %) in the MTT assay, followed by Cocos nucifera roots (83.92 %), Bixa orellana leaves (44.09 %), a …

Therapeutic strategies to modulate gut microbial health: Approaches for sarcopenia management.

Sarcopenia is a progressive and generalized loss of skeletal muscle and functions associated with ageing with currently no definitive treatm … tabolites like short-chain fatty acids (SCFAs), which aid in improving muscle health. Foods rich in polyphenols are anti-inflammatory and have an antioxidant effect, contributing to a healthier gut. Pharmacological interventions like faecal microbiota transplantation (FMT), non-steroidal anti-inflammatory drugs (NSAIDs), ghrelin mimetics, angiotensin-converti …

Investigating the effects of Thymus vulgaris essential oil, Allium cepa extract, and their active compounds (thymol and quercetin) on expression profile of genes related to Alzheimer's disease in PC12 model cell.

Thymus vulgaris and Allium cepa are plants with great medicinal importance. Thymol monoterpene and quercetin, which are present in these pla … aris can be proposed as candidates to be included in the diet of Alzheimer's patients. In addition, polyphenols thymol and quercetin as derivates from the studied plants can be used in new drugs development for Alzheimer's disease, with greater safety than currently used drugs. These results are significant because most of the drug for Alzheimer's treatments …

The Potential Impact of Probiotics on Human Health: An Update on Their Health-Promoting Properties.

Probiotics, known to be live microorganisms, have been shown to improve or restore the gut microbiota, which in turn has been linked to impr … nsortia, live biotherapeutic products, and genetically modified organisms, with renewed interest in polyphenols, fibers, and fermented foods to ensure human health. This manuscript aims to analyze recent, emerging, and anticipated trends in probiotics (sources, doses, mechanism of action, diseases for which probiotics are administered, side effects, and risks …

Factors affecting iron absorption and the role of fortification in enhancing iron levels.

Iron is an important micronutrient required for a number of biological processes including oxygen transport, cellular respiration, the synth … onents such as meat proteins and organic acids increase iron absorption, while phytate, calcium and polyphenols reduce iron absorption. Iron levels in the body are tightly regulated since both iron overload and iron deficiency can exert harmful effects on human health. Iron is stored mainly as haemoglobin and as iron bound to proteins such as ferritin and hem …

Dietary and Nutraceutical Interventions as an Adjunct to Non-Surgical Periodontal Therapy-A Systematic Review.

The aim of this study was to conduct a systematic literature review on the influence of dietary and nutraceutical interventions as an adjunc … odontal therapy, an adjunctive intake of micronutrients, omega-3 fatty acids, green/oolong tea, and polyphenols and flavonoids could be beneficial. Long-term clinical studies with full data reports (especially within-group differences) are needed for conducting a meta-analysis.