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ECC-4 Abstracts

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ISEV2021 Abstract Book

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… ISEV2021 International Organizing Committee IOC Chairs: Lorraine O'Driscoll (Ireland), Sophie Rome (France) IOC Members: Antonella Bongiovanni (Italy), Dave Carter (United Kingdom), Vincent Hyenne (France), Soazig Le Lay (France), Andreas Möller (New Zealand), Eva Rohde (Austria), Tang‐Long Shen (Taiwan …

Impact of anti-T-lymphocyte globulin dosing on graft versus host disease in matched sibling peripheral blood stem cell transplantation.

Anti-T-lymphocyte globulin (ATLG) is commonly administered to reduce graft-versus-host disease (GVHD) in allogeneic stem cell transplantation (allo-SCT). However, the optimal ATLG dose in matched-sibling-donor (MSD) peripheral blood stem-cell transplantation (PBSCT) remains uncertain. We compared two ATLG doses (15 mg/kg vs. 30 mg/kg) in the MSD-PBSCT setting to assess allo-SCT outcomes. In this single-center retrospective study, we included 165 consecutive patients with hematologic malignancies who underwent MSD-PBSCT. Of these, 71 received 15 mg/kg ATLG (ATLG-15), and 94 received 30 mg/kg AT

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… All statistical analyses were conducted using R (version 3.0, R Development Core Team, Vienna, Austria; https://www.r-project.org/ ). The following R packages were used: survival, cmprsk, ggplot2, dplyr, survminer, mstate, tableone, matchit, cobalt, and forestplot. …

Early timepoint 99mTc-DPD whole body scintigraphy and quantitative SPECT/CT imaging for diagnosis of cardiac ATTR amyloidosis.

BACKGROUND: Cardiac transthyretin amyloidosis (ATTR-CM) is a progressive myocardial disease ultimately leading to heart failure. Standard diagnostic workup includes 99mTc-DPD scintigraphy performed after 2.5-3 h. The purpose of this study is to compare early (1 h after injection) to late imaging of 99mTc-DPD scintigraphy and SPECT for the detection of ATTR-CM. Early imaging could improve patient comfort and examination efficiency. RESULTS: 50 patients undergoing 99mTc-DPD scintigraphy and SPECT for suspected ATTR-CM were included. Imaging was performed at both 1 h and 2.5-3 h post-injection.

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… Statistical analysis was performed using R statistical software in version 4.5.1 (R Foundation for Statistical Computing, Vienna, Austria). Results Patient characteristics A total of 50 patients were included. Of these, 14 (28.0%) presented with ATTR-CM. …

Impact of germline predisposition genes to hematologic malignancies on transplant outcomes and donor selection.

INTRODUCTION: Germline predisposition gene mutations may influence outcomes in patients undergoing hematopoietic stem cell transplantation (HSCT). METHODS: This retrospective study of 558 patients undergoing HSCT (allo-HSCT in 557 cases, auto-HSCT in 1 case) evaluated the impact of germline predisposition gene mutations on outcomes. RESULTS: Enrichment of HAVCR2 mutations in B-NHL and UNC13D mutations in MDS was associated with poorer prognosis. While homozygous mutation carriers (7.5%) overall did not have reduced survival, their outcomes were significantly better with unrelated versus rela

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… Footnotes Edited by: Avichai Shimoni , Sheba Medical Center, Israel Reviewed by: Patrycja Zielińska , Medical University of Silesia, Poland Bernhard Strasser , Clinic Wels-Grieskirchen, Austria Data availability statement The raw data supporting the conclusions of this article have been uploaded …

Early dFLC response by C1D7 predicts complete hematologic response in systemic AL amyloidosis.

Daratumumab and bortezomib, the first-line drugs for AL amyloidosis, typically yield a complete hematologic response (CHR) rate of nearly 60% when used in combinations. An early achievement of CHR is crucial in amyloidosis. We retrospectively evaluated the relationship between dFLC (the difference between free light chain) reduction by Day 7 in Cycle 1 (C1D7) and CHR, organ response, and survival in 48 newly diagnosed AL amyloidosis patients receiving daratumumab, bortezomib, and dexamethasone. The CHR rate within six months was 66.7%. Using Receiver Operating Characteristic Curve curve analys

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… Statistical analyses were performed with R version 4.0.2 (R Core Team, Vienna, Austria), SPSS 22.0 (SPSS Inc., Chicago, IL, USA), and GraphPad Prism 9 software (GraphPad Software Inc., La Jolla, CA, USA). …

Patient-reported outcomes in patients with hematologic malignancies treated with CAR T-cell therapy in Europe.

AbstractPatient-reported outcomes (PROs) give direct insights into the treatment's impact on patient's life and complement clinical outcomes. However, since the advent of chimeric antigen receptor T-cell therapy (CAR-T), PROs have been underreported. Particularly, little is known about long-term health-related quality of life (HRQoL) and dimensions such as mental- and social well-being, working life, and financial burden. Therefore, we evaluated multidimensional PROs in a cross-sectional study among European patients who received CAR-T for hematologic malignancies. Patients completed validated

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… Characteristics | European CAR-T recipients (N = 389) Age, median (mean; range), y | 61 (59; 18-85) >70 y, n (%) | 68 (17) Female, n (%) | 142 (37) Country, n (%) | Austria | 9 (2) Belgium | 27 (7) France | 129 (33) Germany | 57 (15) Ireland | 6 (2) Italy | 12 (3) The Netherlands | 95 (24) Portugal …

Impact of myosteatosis on prognosis in multiple myeloma patients: A subgroup analysis of 182 cases and development of a nomogram.

BACKGROUND: This study aims to explore the prognostic value of myosteatosis in multiple myeloma (MM) and to analyze the factors influencing myosteatosis. METHODS: A retrospective analysis was conducted on 182 patients treated for MM at our institution from 2009 to 2020 who underwent MRI examinations. The fatty infiltration rate (FIR) of the erector spinae and multifidus muscles at the L3 level was measured to assess the degree of myosteatosis. Patients were grouped based on fracture presence and median FIR, and group differences were compared, with P < 0.05 considered statistically significan

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… The FIR cut-off value was calculated using the “survminer” package in R Studio 4.2.1 (R Development Core Team, Vienna, Austria). The cut-off value was used to group patients, and survival curves were plotted using the “ggsurvplot” package with log-rank tests performed. …

Clinical impact of airflow obstruction after allogeneic hematopoietic stem cell transplantation.

Criteria for airflow obstruction (AFO) at one year after allogeneic hematopoietic stem cell transplantation (allo-HSCT) in pulmonary function tests (PFTs) are more stringent than the bronchiolitis obliterans syndrome (BOS) criteria of the National Institutes of Health. This single-center, retrospective cohort study evaluated the clinical impact of the AFO criteria at any time after transplantation. In 132 patients who underwent allo-HSCT from 2006 to 2016, the 2-year cumulative incidence of AFO was 35.0%, and the median time to diagnosis of AFO was 101 days after transplantation (range 35-716

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… All statistical analyses were performed with EZR (Saitama Medical Center, Jichi Medical University, Saitama, Japan) [ 22 ], which is a graphical user interface for R (The R Foundation for Statistical Computing, Vienna, Austria). …

Какие факторы связаны с неблагоприятным прогнозом у нескольких пациентов с миеломой после операции?

Для изучения прогнозов пациентов с множественной миеломой (ММ) после операции, анализа факторов риска, ведущих к неблагоприятным результатам послеоперационного лечения, и создания номограммы. МЕТОДЫ: Клинические данные 154 пациентов с MM, которые прошли операцию в нашем учреждении между 2007 и 2019 был ретроспективно проанализирован. Оценка и сопоставление уровней боли, качества жизни и функционального состояния пациентов до и после операции (Р) < 0.05) были признаны статистически значимыми. Кривая выживания Каплана-Мейера использовалась для оценки средней продолжительности выживаемости. Отриц

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… Establishment and validation of nomogram The nomogram based on the results of multivariable logistic regression analysis was developed using RStudio (version 4.2.1; RStudio Development Core Team, Vienna, Austria) and the “rms” package. …

The clinical features, treatment and prognosis of neutropenic fever and Coronavirus disease 2019 results of the multicentre teos study.

This multicentre (22 centres in Turkey) retrospective cohort study aimed to assess the clinical outcomes of patients with neutropenic fever and SARS-CoV-2 positivity. Study period was 15 March 2020-15 August 2021. A total of 170 cases (58 female, aged 59 ± 15.5 years) that fulfilled the inclusion criteria were included in the study. One-month mortality rate (OMM) was 44.8%. The logistic regression analysis showed the following significant variables for the mentioned dependent variables: (i) achieving PCR negativity: receiving a maximum of 5 days of favipiravir (p = 0.005, OR 5.166, 95% CI 1.63

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… According to a meta-analysis, the 30-day mortality rate for patients with septic shock was found to be 33.7% in the USA, 32.5% in Europe, and 26.4% in Austria 22 . In a multicentre study conducted in Turkey, the in-hospital mortality rate was reported as 72.6% 23 . …

Prevalence and Prognostic Significance of Malnutrition in Older Japanese Adults at High Surgical Risk Undergoing Transcatheter Aortic Valve Implantation.

Background The usefulness of preprocedural nutritional status to stratify prognosis after transcatheter aortic valve implantation has been evaluated; however, the studies conducted so far have been relatively small and/or focused on a single nutritional index. This study sought to assess the prevalence and prognostic impact of malnutrition in patients with severe aortic stenosis undergoing transcatheter aortic valve implantation. Methods and Results We applied the Controlling Nutritional Status score, Geriatric Nutritional Risk Index, and Prognostic Nutritional Index to 1040 consecutive older

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… Moreover, the areas under the curve between the indexes were compared using the method of DeLong et al. 22 All statistical analyses were performed using JMP 14.2.0 (SAS Institute Inc., Cary, NC) and R version 4.0.2 (R Foundation for Statistical Computing, Vienna, Austria). …

A novel dual HDAC and HSP90 inhibitor, MPT0G449, downregulates oncogenic pathways in human acute leukemia in vitro and in vivo.

Acute leukemia is a highly heterogeneous disease; therefore, combination therapy is commonly used for patient treatment. Drug-drug interaction is a major concern of combined therapy; hence, dual/multi-target inhibitors have become a dominant approach for cancer drug development. HDACs and HSP90 are involved in the activation of various oncogenic signaling pathways, including PI3K/AKT/mTOR, JAK/STAT, and RAF/MEK/ERK, which are also highly enriched in acute leukemia gene expression profiles. Therefore, we suggest that dual HDAC and HSP90 inhibitors could represent a novel therapeutic approach fo

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… Histopathological evaluation was assessed by TissueFAXS (TissueGnostics, Vienna, Austria). …

Centromere protein E as a novel biomarker and potential therapeutic target for retinoblastoma.

Retinoblastoma is the most common intraocular malignancy during childhood. Currently, there is no effective treatment for metastatic retinoblastoma. We investigated potential biomarkers of retinoblastoma by utilizing three datasets from a public database. Functional enrichment analysis, including gene ontology, Kyoto encyclopedia of genes and genomes, gene set enrichment analysis and variation analysis, suggested that differentially expressed genes in retinoblastoma were enriched in accelerated cell cycle events. Protein-protein interaction analysis constructed a network consisting of six hub

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… Identification of differentially expressed genes The Affy package in R software 4.0.3 (R Foundation for Statistical Computing, Vienna, Austria) was used to preprocess the raw data of these three datasets[ 18 ], and the corresponding gene expression profiles were obtained. …

Compatibility of Biosimilar Filgrastim with Cytotoxic Chemotherapy during the Treatment of Malignant Diseases (VENICE): A Prospective, Multicenter, Non-Interventional, Longitudinal Study.

IntroductionFebrile neutropenia (FN) is a serious and frequent complication of cytotoxic chemotherapy. Biosimilar filgrastim (Nivestim™, Hospira Inc, A Pfizer Company, Lake Forest, IL, USA) is a granulocyte-colony stimulating factor licensed for the treatment of neutropenia and FN induced by myelosuppressive chemotherapy. The primary goal of this VENICE study (ClinicalTrials.gov identifier, NCT01627990) was to observe the tolerability, safety and efficacy of biosimilar filgrastim in patients receiving cancer chemotherapy.MethodsThis was a prospective, multicenter, non-interventional, longitudi

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… Presented as an Abstract at ECC-ESMO 2015 in Vienna, Austria. Available at: http://www.ejcancer.com/article/S0959-8049(15)30023-X/abstract. Disclosures S. Fruehauf reports receiving lecture honoraria from Hospira (Prague, SIOG Meeting, 2015). B. …

Preclinical evaluation of the novel, orally bioavailable Selective Inhibitor of Nuclear Export (SINE) KPT-335 in spontaneous canine cancer: results of a phase I study.

BackgroundThe purpose of this study was to evaluate the activity of Selective Inhibitors of Nuclear Export (SINE) compounds that inhibit the function of the nuclear export protein Exportin 1 (XPO1/CRM1) against canine tumor cell lines and perform a Phase I clinical trial of KPT-335 in dogs with spontaneous cancer to provide a preliminary assessment of biologic activity and tolerability.Methods and findingsCanine tumor cell lines derived from non-Hodgkin lymphoma (NHL), mast cell tumor, melanoma and osteosarcoma exhibited growth inhibition and apoptosis in response to nanomolar concentrations o

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… Barbara Rütgen (University of Vienna, Austria) [28] , [29] and human DLBCL cell lines OCI-Ly3 [30] , [31] and OCI-Ly10 [32] obtained from Dr. …

Artificial Intelligence Resources for the Screening of Titles and Abstracts in Systematic Reviews: A Scoping Review.

IntroductionArtificial intelligence (AI) is a branch of technology enabling machines to emulate complex human skills; it can also entail problem-solving using bioinspired methods. It is used for automating systematic literature reviews (SLR), that is, defining a clinical question, locating relevant literature, preliminary screening, study evaluation, data extraction and analysis. Title and abstract screening is one of the most time-consuming and error-prone phases involved in developing a systematic review. While AI promises to expedite this process, adopting it faces challenges due to concern

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… for cardiovascular disease [ 151 ] | Simon | Denmark | 2019 | BioReader (Biomedical Research Article Distiller), Medline ranker | Tumor suppressor gene p53 [ 121 ] | Guo | Canada | 2024 | GPT‐4 | COVID‐19 treatment and antimalarials, Nonopioid analgesia, Raynaud's syndrome [ 152 ] | Gartlehner | USA/Austria … Commentary [ 191 ] | Westgate | Australia | 2019 | Commentary [ 192 ] | van Dijk | Netherlands | 2023 | Communication paper [ 163 ] | Khraisha | Ireland | 2024 | Design, development, and implementation study [ 160 ] | Pilz | Germany | 2024 | Design, development, and implementation study [ 193 ] | Sandner | Austria …

Burden of non-communicable diseases among adolescents aged 10-24 years in the EU, 1990-2019: a systematic analysis of the Global Burden of Diseases Study 2019.

BackgroundDisability and mortality burden of non-communicable diseases (NCDs) have risen worldwide; however, the NCD burden among adolescents remains poorly described in the EU.MethodsEstimates were retrieved from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019. Causes of NCDs were analysed at three different levels of the GBD 2019 hierarchy, for which mortality, years of life lost (YLLs), years lived with disability (YLDs), and disability-adjusted life-years (DALYs) were extracted. Estimates, with the 95% uncertainty intervals (UI), were retrieved for EU Member Stat

Combinatorial Approaches for Cancer Treatment Using Oncolytic Viruses: Projecting the Perspectives through Clinical Trials Outcomes.

Recent cancer immunotherapy breakthroughs have fundamentally changed oncology and revived the fading hope for a cancer cure. The immune checkpoint inhibitors (ICI) became an indispensable tool for the treatment of many malignant tumors. Alongside ICI, the application of oncolytic viruses in clinical trials is demonstrating encouraging outcomes. Dozens of combinations of oncolytic viruses with conventional radiotherapy and chemotherapy are widely used or studied, but it seems quite complicated to highlight the most effective combinations. Our review summarizes the results of clinical trials eva

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… The most recent retrospective analysis of 88 patients with melanoma treated with T-VEC in Austria, Switzerland and Germany has demonstrated a high ORR (63.7%) and substantial complete remission (CR) rate (43.2%) [ 70 ]. … Real-life use of talimogene laherparepvec (T-VEC) in melanoma patients in centers in Austria, Switzerland and Germany. J. Immunother. Cancer. 2021;9:e001701. doi: 10.1136/jitc-2020-001701. 71. …

Clinical value and cost-effectiveness analysis of conditionally approved anticancer drugs in China from 2015 to 2023.

BackgroundThe conditional approval (CA) process in China was established in 2015 to expedite access to urgently-needed drugs, however, the clinical benefits of CA drugs and potential gaps between pre-approval and confirmatory trials remain uncertain. Herein, we aim to compare the clinical values between CA and non-CA anticancer drugs from 2015 to 2023, and to explore the relationship between clinical benefit and average daily cost of treatment of drugs.MethodsThis retrospective study analyzed anticancer drugs first approved in China [2015-2023] using data from National Medical Products Adminis

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… Figures were conducted using R (R Core Team, Vienna, Austria), version 4.1.1 (R package forestplot, version 3.1.3 and R package ggplot2, version 3.4.4). P<0.05 was considered to be statistically significant. …