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Oxidative stress biomarkers and chondrocyte apoptosis as predictors of postoperative outcomes in osteonecrosis of the femoral head.

BACKGROUND: Osteonecrosis of the femoral head (ONFH) is a progressive disease where oxidative stress and chondrocyte apoptosis contribute to cartilage degeneration and postoperative complications. Identifying reliable biochemical markers is essential for prognosis after hip resurfacing arthroplasty (HRA). METHODS: A retrospective analysis was conducted in 134 ONFH patients (ARCO stage II-III) treated with HRA. Serum oxidative stress markers-reactive oxygen species (ROS), superoxide dismutase (SOD), and malondialdehyde (MDA)-were measured preoperatively and at serial postoperative timepoints.

Predictors of Fear of Childbirth in Nulliparous Women: Childhood Traumas and Attachment Patterns.

This study aimed to investigate the predictors of fear of childbirth (FoC) in nulliparous women by focusing on the effects of childhood trauma and attachment styles. Identifying psychological factors contributing to FoC is important for improving early intervention strategies and maternal well-being. The study included 496 nulliparous women who had never experienced pregnancy or childbirth. Participants completed the Women's Childbirth Fear-Prior to Pregnancy Scale (WCF-PPS), the Childhood Trauma Questionnaire-Short Form (CTQ-SF), and the Experiences in Close Relationships-Relationship Structu

Effect of bariatric surgery on headache frequency, duration and severity.

OBJECTIVES: This retrospective cross-sectional study aimed to investigate the differences and influencing factors between the headache patients who achieved complete remission or significant reduction in headache frequency postoperatively and those whose frequency remained unchanged. METHODS: The study was conducted on 386 patients who underwent bariatric surgery at the four university hospitals between January 2018 and June 2024. Patients were divided two groups as with or without headache and then patients with headache were divided into migraine and tension-type headache groups. RESULTS:

Child Amputee Prosthetics Project-Prosthesis Satisfaction Inventory (CAPP-PSI): Validation of Italian Version in Children with Upper Limb Amputation.

Background: The Child Amputee Prosthetics Project-Prosthesis Satisfaction Inventory (CAPP-PSI) is a comprehensive instrument designed to measure satisfaction across functionality, aesthetic, and service domains. This study aimed to translate, culturally adapt, and evaluate the psychometric properties of the CAPP-PSI in an Italian pediatric population. Methods: Following international guidelines, the CAPP-PSI was translated and culturally adapted. Internal consistency was evaluated using Cronbach's alpha, while test-retest reliability was assessed with intraclass correlation coefficients (ICCs)

Effect of serum magnesium level on carotid intima media thickness in hemodialysis patients.

BACKGROUND: We aimed to examine whether serum magnesium level is related to cardiovascular events in hemodialysis patients by investigating the relationship between serum magnesium (Mg) level and carotid intima media thickness (CIMT). METHODS: In this cross-sectional study, we evaluated 88 hemodialysis patients. The mean CIMT of these patients was measured and recorded by doppler ultrasonography. Patients were divided into two groups according to their serum magnesium level. Correlation analysis and linear regression analysis were used to define the relationship between study parameters. We d

Plasma glial fibrillary acidic protein as a biomarker of blood-brain barrier integrity in patients with occult cerebral small vessel disease.

OBJECTIVE: To investigate the association between plasma glial fibrillary acidic protein (GFAP) levels and blood-brain barrier (BBB) integrity in patients with occult cerebral small vessel disease (CSVD). METHODS: This retrospective study included patients with occult CSVD (CSVD group, n = 68) and age-matched individuals without CSVD (control group, n = 61). Demographic and clinical characteristics were compared between groups. Cognitive function was assessed using the Montreal Cognitive Assessment-B (MoCA-B). Plasma GFAP levels were measured, and all participants underwent sequential magneti

Peripheral Microvascular and Cerebral White Matter Dysfunction in Schizophrenia: Implications of a Body-Brain Endothelial Pathophysiology.

BACKGROUND AND HYPOTHESIS: Schizophrenia spectrum disorder (SSD) is a chronic neuropsychiatric illness accompanied by significant brain structural and functional abnormalities and higher rate of cardio- and cerebrovascular comorbidities. We hypothesized that genetic and environmental risk factors that led to SSD act throughout the body and demonstrated the association between lower integrity of peripheral vascular endothelium and white matter (WM) microstructure. STUDY DESIGN: Microvascular endothelial function was evaluated using brachial artery post-occlusive reactive hyperemia (PORH), in w

Illness perceptions predict subjective cognitive complaints independently of sex and psychological distress in post-acute mTBI.

Cognitive symptoms are common after mild traumatic brain injury (mTBI) and can interfere with return to work. Factors underlying these symptoms are poorly understood. This prospective observational study explored relationships between illness perceptions, coping style, and cognitive symptom reporting in mTBI, including when controlling for sex and psychological distress. Individuals with mTBI (n = 70) and trauma controls (n = 42) were assessed 6-10 weeks post-injury. Measures included the Brief-COPE, the Illness Perceptions Questionnaire-Revised (IPQ-R), and subjective cognitive and post-concu

The association of ınsomnia with fatigue and mood in postmenopausal osteoporosis.

OBJECTIVE: The aim of the study was to investigate the prevalence of insomnia in postmenopausal osteoporotic women. It also evaluated the relationship between insomnia, fatigue, and mood disorders. METHODS: This cross-sectional study was conducted with 200 postmenopausal osteoporotic women aged 50-75 years. Insomnia severity was assessed using the Insomnia Severity Index, while fatigue and mood disorders were measured using the Fatigue Severity Scale and the Hospital Anxiety and Depression Scale, respectively. The participants were divided into two groups based on the Insomnia Severity Index

Design, synthesis and biological evaluation of N-salicyloyl tryptamine derivatives as multifunctional neuroprotectants for the treatment of ischemic stroke.

Ischemic stroke (IS) is a disease of high death and disability worldwide with few medications in clinical treatment. Neuroinflammation and oxidative stress are considered as crucial factors in the progression of IS. In our previous studies, N-salicyloyl tryptamine derivative (NST) L7 exhibited promising anti-inflammatory properties and is considered a potential clinical therapy for IS but had limited antioxidant capacity. Here, we have designed, synthesized, and biologically evaluated 30 novel NSTs for their neuroprotective effects against cerebral ischemia-reperfusion (CI/R) injury. To identi

Трабковая кость как дополнительный инструмент для оценки плотности костных минералов у пациентов с асимптоматической моноклонной гаммопатией.

Фон/цели: Моноклональные гаммопатии, такие, как Моноклональная Гаммопатия Неопределенной Значимости (MGUS) и Смолдинг Мильома (SMM), являются условиями, характеризующимися перепроизводством конкретных моноклонных белков. Известно, что больные, страдающие этими заболеваниями, подвержены более высокому риску переломов по сравнению с населением в целом, однако не существует каких-либо руководящих принципов оценки или регулирования состояния их здоровья. Скорость кости (TBS), которая может быть рассчитана на основе изображений поясничного позвоночника DXA, позволяет получить дополнительную информа

Совпадение в аннотации оригинала
Background/Objectives: Monoclonal gammopathies, such as Monoclonal Gammopathy of Undetermined Significance (MGUS) and Smoldering Multiple My … indicated a weak positive correlation (R = 0.405) between DXA and TBS T-scores, suggesting that other factors may influence the measurements. When analyzed separately, the correlations remained weak for both MGUS (R = 0.250) and SMM (R = 0.485). Interestingly, discrepancies were noted in T-score classifications; for instance, a patient classified as normal …

Atypical functional hierarchy contributed to the tinnitus symptoms in patients with vestibular schwannoma.

OBJECTIVE: Tinnitus is frequently found in patients with vestibular schwannoma (VS), but its underlying mechanisms are currently unclear. METHODS: Both preoperative (VS pre ) and postoperative (VS post ) functional MR images were collected from 32 patients with unilateral VS and matched healthy controls (HCs). Connectome gradients were generated for the identification of altered regions and perturbed gradient distances. Tinnitus measurements were conducted for predictive analysis with neuroimaging-genetic integration analysis. RESULTS: There were 56.25% of preoperative patients and 65.63% of

Risk of cytomegalovirus infection and subsequent allograft failure after pancreas transplantation.

Cytomegalovirus (CMV) is a common cause of infection after transplantation, but few studies have evaluated its epidemiology, risk factors, and outcomes among pancreas transplant recipients. We performed a retrospective cohort study of adults who underwent pancreas transplantation from January 1, 2010, through December 31, 2020, at 3 sites in Arizona, Florida, and Minnesota. The primary outcome was clinically significant CMV infection (csCMVi), defined as CMV disease or infection requiring antiviral therapy. The secondary outcome was pancreas allograft failure. Among 471 pancreas transplant rec

Ten-year experience with penile prosthetic surgery for the treatment of erectile dysfunction: outcomes of a tertiary referral center and predictors of early prosthetic infection.

We aimed to evaluate ten-year outcomes of penile prosthesis (PP) implantation for the treatment of erectile dysfunction and to assess predictors of early prosthetic infection (EPI). We identified 549 men who underwent 576 PP placements between 2008 and 2018. Univariate and multivariate analyses were used to identify potential predictors of EPI. An EPI predictive nomogram was developed. Thirty-five (6.1%) cases of EPI were recorded with an explant rate of 3.1%. In terms of satisfaction, 82.0% of the patients defined themselves as "satisfied," while partner's satisfaction was 88.3%. Diabetes (P

Effect of Baicalin on Wound Healing in a Mouse Model of Pressure Ulcers.

One of the most frequent comorbidities that develop in chronically ill or immobilized patients is pressure ulcers, also known as bed sores. Despite ischemia-reperfusion (I/R)-induced skin lesion having been identified as a primary cause of pressure ulcers, wound management efforts have so far failed to significantly improve outcomes. Baicalin, or 5,6,7-trihydroxyflavone, is a type of flavonoid which has been shown to possess a variety of biological characteristics, including antioxidative and anti-inflammatory effects and protection of I/R injury. In vitro wound scratch assay was first used to

Effects of Familial Relationships on School Adjustment of Adolescents and Young Adults With Congenital Heart Disease.

BACKGROUND: As more than 85% of patients with congenital heart disease (CHD) have grown to adulthood through improvement in treatment and surgery, the difficulties they experience are expanding into areas related to daily life. Accordingly, adjustment to school in adolescents and young adults (AYAs) with CHD is of increasing interest and is influenced by familial factors. OBJECTIVE: This was a cross-sectional descriptive study to examine the effects of parental positive emotional expressiveness and sibling relationships on school adjustment of AYAs with CHD. METHODS: In this study, a self-re

Fatigue in Brazilian patients with Parkinson's disease.

UNLABELLED: Fatigue is a non-motor symptom of high prevalence in Parkinson's disease (PD); however, it is still unknown and neglected by health professionals. OBJECTIVE: This study aimed to demonstrate the prevalence of fatigue in patients with PD after excluding confounding factors, as well as its correlation with clinical and demographic data, and to find its negative impact on the quality of life of these patients. METHODS: A cross-sectional study was carried out with 237 randomly selected patients. According to inclusion and exclusion criteria, we selected 53 patients, who were then subm

Surgical treatment of liver metastases from non-colorectal non-neuroendocrine carcinomas.

INTRODUCTION: In the literature, results after surgical treatment of non-colorectal non-neuroendocrine liver metastases (NCNNLM) are reported that are often inferior to those from colorectal liver metastases. The selection of patients with favorable tumor biology is currently still a matter of discussion. MATERIALS/METHODS: The retrospective data analysis was based on data that were collected for the multicenter study "Role of surgical treatment for non-colorectal liver metastases" in county Thuringia. RESULTS: For the study, 637 patients were included from 1995 to 2018. 5 and 10-year surviv

Determining the sexual quality of life and related factors in patients referred to the department of cardiac rehabilitation: A cross-sectional study.

BACKGROUND: One of the neglected issues among cardiovascular participants is sexual activity, which can affect their general quality of life. OBJECTIVE: To evaluate the sexual quality of life and its related factors. MATERIALS AND METHODS: This cross-sectional study was conducted on 200 cardiovascular participants, referred to the department of rehabilitation of the Shahid Beheshti Hospital of Kashan, Iran in May 2017. Individuals who met the inclusion criteria filled the demographic characteristics questionnaires, including sexual quality of life questionnaire (SQOL)-female and SQOL-male, s

Relationship Between Halitosis and Periodontitis: a Pilot Study.

OBJECTIVE: Halitosis, or oral malodour, is an unpleasant smell emanating from the oral cavity. It is a common complaint among patients with periodontitis, however, their relationship is not fully elucidated. This study aimed to evaluate the association between halitosis measures, clinical indicators of periodontitis and tongue coating, as well as a novel measure, periodontal inflamed surface area (PISA). MATERIAL AND METHODS: Data of 10 patients with periodontitis and halitosis were included in this study. Halitosis was assessed by the organoleptic method and the portable sulphide monitor, me