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Urethroplasty with a bilayered poly-D,L-lactide-co-ε-caprolactone scaffold seeded with allogenic mesenchymal stem cells.

Reconstructive surgery for urethral defects employing tissue-engineered scaffolds represents an alternative treatment for urethroplasty. The aim of this study was to compare the therapeutic efficacy of the bilayer poly-D,L-lactide/poly-ε-caprolactone (PL-PC) scaffold seeded with allogenic mesenchymal stem cells (MSCs) for urethra reconstruction in a rabbit model with conventional urethroplasty employing an autologous buccal mucosa graft (BG). The inner layer of the scaffold based on poly-D,L-lactic acid (PL) was seeded with MSCs, while the outer layer, prepared from poly-ε-caprolactone, protec

[Evaluation of the results of sodium fumarate, furosemide, and mannitol on the initiation and outcome of renal warm ischemia in an experimental study].

UNLABELLED: While performing surgical treatment of the localized form of renal cell cancer by means of open or laparoscopic partial nephrect … . MATERIALS AND METHODS: The experiments were carried out on 360 conventional male-rabbits of the "Chinchilla" breed weighed 2,6+/-0,3 kg which were allocated into 10 groups. The control group No1 included intact animals, the control group No2 included the rabbits in which renal artery was not clamped. For the animals from the trial groups (No3-No10) the ex …

Increased otoacoustic-emission amplitude secondary to cochlear lesions.

OBJECTIVE: The measurements of transient evoked otoacoustic emissions and distortion-product otoacoustic emissions are being used increasingly, both as an objective hearing test clinically, and as a research tool to investigate the micromechanical aspects of cochlear function. We hypothesized that localized damage in the apical or middle cochlear turns may have an influence on the micromechanics and the function of adjacent, apparently normal cochlea. For that purpose, we used an animal model of localized apical and middle-turn cochlear lesions. METHOD: Extent of damage was assessed by scanni

Investigation of the process intergrowth of bone tissue into the hole in titanium implants (Experimental research).

INTRODUCTION: Despite the use of modern implants, complications such as nonunion and avascular necrosis of the femoral head are observed in … e into the holes of the implant. MATERIALS AND METHODS: The experiment was carried out on fourteen Chinchilla rabbits in accordance with all international standards. A perforated implant specially made of titanium (ChM, Poland) was surgically implanted into the proximal femur. The implant measurements were as follows: length - 6 mm, width - 3 mm, thickness …

[Related noise exposure and auditory consequence during transcranial magnetic stimulation: new insights and review of the literature].

Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive neurostimulation tool with increasing therapeutic applications in neurology, psychiatry and in the treatment of chronic tinnitus, and with a growing interest in cognitive neuroscience. One of its side effects is the loud click sound generated simultaneously to the magnetic pulse, which depends both on the equipment and rTMS intensity. This impulse sound could transiently modify peripheral hearing mechanisms, and hence hearing thresholds, both in patients and in rTMS practitioners. Furthermore, if no precautions are taken, es

Прогресс в лечении множественной миеломы.

Множественная миелома (ММ) является вторым по распространенности гематологической злокачественности в мире. Несмотря на свою репутацию агрессивного и смертельного заболевания, недавние улучшения в лечении значительно улучшили результаты лечения. За последнее десятилетие появились инновационные методы лечения с меньшим числом побочных эффектов, включая протеиновые ингибиторы (например, борцезомиб, карфилзомиб, ixazomib), моноколональные антитела (например, даратумумаб, изатуксимаб, элотузумаб), иммуномуляторы (например, талидомид, линалидомид, помалидомид) и кортикостероиды (например, дексамета

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… Author Contributions Concept and design: Esteban Zavaleta-Monestel, Monserrat Barrantes-López, Sebastián Arguedas-Chacón, Jeimy Campos-Hernández, Carolina Rojas-Chinchilla, Jonathan García-Montero, Josué Castro-Ulloa, José Ricardo Montenegro-Chaves, Ricardo Quesada-Villaseñor, Adriana Anchía-Alfaro … Supervision: Esteban Zavaleta-Monestel, Monserrat Barrantes-López, Sebastián Arguedas-Chacón, Jeimy Campos-Hernández, Carolina Rojas-Chinchilla, Jonathan García-Montero, Josué Castro-Ulloa, José Ricardo Montenegro-Chaves, Ricardo Quesada-Villaseñor, Adriana Anchía-Alfaro References 1 Valor social …

Experimental pleural empyema model in rabbits: Why, how and what are the next steps.

BACKGROUND/AIM: The use of new therapeutic methods to prevent development of fibrothorax as the final complication of the human pleural infections requires research with experimental animals. The aim of this study was to standardize the procedures for the establishment of our own experimental model of empyema in rabbits, since it should be able to offer similar conditions found in human pleural infections. METHODS: This experiment included 15 chinchilla rabbits, weighing from 2.3 to 2.8 kg. There were 12 rabbits in the experimental group, while 3 rabbits formed the control group. On the first…

Comparative study of three intramuscular anaesthetic combinations (medetomidine/ketamine, medetomidine/fentanyl/midazolam and xylazine/ketamine) in rabbits.

OBJECTIVE: To compare the quality of surgical anaesthesia and cardiorespiratory effects of three intramuscular (IM) anaesthetic combinations in rabbits. STUDY DESIGN: Prospective randomized cross-over experimental study. ANIMALS: Nineteen adult female chinchilla mixed-bred rabbits weighing 3.9 +/- 0.8 kg. METHODS: Rabbits were given one of three IM anaesthetic combinations: 0.25 mg kg(-1) medetomidine and 35.0 mg kg(-1) ketamine (M-K), 0.20 mg kg(-1) medetomidine and 0.02 mg kg(-1) fentanyl and 1.0 mg kg(-1) midazolam (M-F-Mz) and 4.0 mg kg(-1) xylazine and 50 mg kg(-1) ketamine (X-K). The …

Development of an Optimal Model of Combined Radiation and Biological Lesions.

Since the search for the effective medication in combined lesions includes the selection of an optimal experimental model for such injuries, there is actually a study aimed at developing an optimal model of combined radiation-biology (Pasteurella) lesions. The pathogen Pasteurella multocida (as one of the most frequent pathogenic agents involved in both isolated and combined radiation-biology lesions of agricultural animals) was used as a model of a biological agent to reproduce experimental biological research. We employed the "Chinchilla" rabbits of 2.5-3.0 kg body weight as a biological mod…

Otitis media: treatment with intranasal aerosolized surfactant.

OBJECTIVES/HYPOTHESIS: The objective was to determine the effect of intranasal surfactant alone and with other medications administered by m … tympanometry were performed on alternate days for 30 days. In experiment 4, AOM was developed in 39 chinchillas via transbullar injection of nontypeable Haemophilus influenzae on day 1. Thirteen animals each received placebo BID or surfactant BID, beginning on day 1. Thirteen animals received surfactant BID beginning on day 3. All administrations were contin …

Feasibility study of chitosan as intravitreous tamponade material.

BACKGROUND: Chitosan can inhibit fibroblastic proliferation by suppressing fibroblast cells, and has the similar physiological characteristi … inflammatory factors fluctuating after chitosan intravitreous tamponade. METHODS: Fifteen healthy chinchilla rabbits were chosen; three of them were a blank (negative) control group without any surgical procedure. The remaining 12 rabbits received vitrectomy on both eyes; all the right eyes (experimental group) were given 1.2-1.8 ml (average 1.5 ml) of chi …

Cement pulmonary embolism after percutaneous kyphoplasty: An unusual culprit for non-thrombotic pulmonary embolism.

Non-thrombotic pulmonary embolism can occur from rare but diverse etiology and is not well understood. Increasing prevalence of osteoporosis in the aging population has contributed to increased utilization of percutaneous vertebral augmentation procedures of vertebroplasty and its recent modification, kyphoplasty. Though these procedures are relatively well tolerated, there is risk of potentially fatal complication of bone cement embolization to distant vasculature. We report a case of symptomatic pulmonary cement emboli developed 2 day's post kyphoplasty and its successful treatment with nove

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… Ruiz Santiago F, Santiago Chinchilla A, Guzmán Álvarez L, Pérez Abela AL, Castellano García Mdel M, Pajares López M. Comparative review of vertebroplasty and kyphoplasty. World J Radiol. 2014;6(6):329–343. doi: 10.4329/wjr.v6.i6.329. 24. Belkoff SM, Sanders JC, Jasper LE. …

Towards Precision Oncology: The Role of Smoothened and Its Variants in Cancer.

The G protein-coupled receptor Smoothened (Smo) is a central signal transducer of the Hedgehog (Hh) pathway which has been linked to diverse forms of tumours. Stimulated by advancements in structural and functional characterisation, the Smo receptor has been recognised as an important therapeutic target in Hh-driven cancers, and several Smo inhibitors have now been approved for cancer therapy. This receptor is also known to be an oncoprotein itself and its gain-of-function variants have been associated with skin, brain, and liver cancers. According to the COSMIC database, oncogenic mutations o

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… Chinchilla P. Chen X. Kim S. Manning D.R. Riobo N.A. Heterotrimeric Gi Proteins Link Hedgehog Signaling to Activation of Rho Small GTPases to Promote Fibroblast Migration J. Biol. Chem. 2011 286 19589 19596 10.1074/jbc.M110.197111 21474452 PMC3103338 44. Chinchilla P. Xiao L. Kazanietz M.G. …

Сайентометрический анализ неврологических публикаций в Иране.

История вопроса: Несомненно, медицина родилась с самого начала сотворения человека. Одной из его важных ветвей является неврология. Нейрофизики в Иране с небольшой задержкой из первого мира, с усилиями исследователей, открыли путь к диагностике и лечению неврологических заболеваний, и мы достигли того места, где мы находимся. Методы: В этом библиометрическом и сайентометрическом исследовании мы провели оценку процесса неврологии в Иране. Сославшись на надежные индексы, мы проверили Web of Science (WOS), PubMed и Scopus начиная с 1963 года. Мы показали опубликованную деятельность иранцев в виде

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… 1060 9 19161078 10 Aria M Cuccurullo C bibliometrix: An R-tool for comprehensive science mapping analysis J Informetr 2017 11 4 959 75 11 Donthu N Kumar S Mukherjee D Pandey N Lim WM How to conduct a bibliometric analysis: An overview and guidelines J Bus Res. 2021 133 285 96 12 Vargas-Quesada B Chinchilla-Rodríguez …

Плазмоцитома в эксклюзивном манифестации Множественной миеломы: доклад по делу.

Внешняя плазменная цитома является необычным проявлением множественной миэломы (ММ) и может включать в себя широкий круг участков с мягкими тканями. Поверхностное участие спины является особенно редким и может быть ошибочно истолковано как доброкачественное повреждение мягких тканей. Мы сообщаем о случае 59-летнего мужчины с диагнозом MM, поставленным в апреле 2024 года, который лечился четырьмя циклами бортезомида, циклофосфамида и дексаметасона (ВЦД), достиг ремиссии с исчезновением сыворотки и мочи М-протеина на иммунофиксе. В октябре 2025 года, несмотря на лечение даратумумаба, болезнь вно

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… PMID: 29391963; PMCID: PMC5748088 . 29391963 PMC5748088 22 Martí A Morón S Chinchilla S González E . PET/CT F18-FDG with soft tissue plasmacytomas in multiple myeloma . …

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Ультразвуковые характеристики развития в Гвинейских свиньях: сходства с беременностью человека.

ИСТОРИЯ ВОПРОСА: Биометрические исследования и анализ кровотока имеют основополагающее значение для оценки развития фетоплацета во время беременности. Гвинейские свиньи были предложены в качестве хорошей модели для изучения развития плода и связанных с этим осложнений, связанных с гестацией; однако продольный рост и изменения кровотока в утробе не были должным образом описаны. Цель этого исследования состояла в том, чтобы описать рост плода и плаценты и кровотечение основных внутриматочных сосудистых кроватей в ходе обычной беременности среди свиней-мореносцев, а также обсудить актуальность эт

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… The Chinchilla as a Novel Animal Model of Pregnancy R. Soc. Open Sci. 2017 4 161098 10.1098/rsos.161098 28484627 PMC5414264 44. Wolf H. Stampalija T. Lees C.C. TRUFFLE Study Group Arabin B. Berger A. Bergman E. Bhide A. Bilardo C.M. Breeze A.C. …