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Toxicology studies of pentaerythritol triacrylate (technical grade) (CAS No. 3524-68-3) in F344/N rats, B6C3F1 mice, and genetically modified (FVB Tg.AC hemizygous) mice (dermal studies).

UNLABELLED: Pentaerythritol triacrylate is used in the production of ultraviolet-curable inks and coatings, electron beam irradiation- curab … Epidermal hyperplasia, hyperkeratosis, sebaceous gland hyperplasia, ulcer, epidermal degeneration, parakeratosis, chronic active inflammation, and suppurative inflammation occurred at the site of application in most dosed groups of rats. 2-WEEK STUDY IN B6C3F(1) MICE: Groups of five male and five female B6C3F(1) mice were administered 0, 12.5, 25, 50, 100, or …

Meyerson Phenomenon as a Component of Melanoma in situ.

Meyerson phenomenon (MP) is characterized by a symmetrical area of erythema and scales encircling a central lesion, which is most commonly a … ing feature was the presence of subacute spongiotic dermatitis around the melanocytic lesions (i.e. parakeratosis, serum/crusting, spongiosis, lymphocyte exocytosis, and acanthosis). Immunohistochemical staining with the Langerhans cell marker, CD1a, revealed an increased cell population in the perilesional, erythematous halo (Figure 1, d). A diagnosis of MP ex …

Cabozantinib Cutaneous Toxicity-Comprehensive Review.

BackgroundIn the context of modern cancer therapy, the management of adverse effects of systemic therapies can lead to the avoidance of underdosing and withdrawal and increases in the quality of the therapeutic act and the quality of life. This review offers an overview of the skin-related toxicities associated with Cabozantinib, a multikinase inhibitor (MKI) that is approved for treating advanced kidney cancer, hepatocellular carcinoma, and medullary thyroid cancer. It covers the most common dermatological side effects, such as palmar-plantar erythrodysesthesia, stomatitis, hair alterations,

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… Histologically, lesions of MKI-associated HFSR present with epidermal acanthosis and papillomatosis, hyperkeratosis, parakeratosis, dyskeratosis, and the vacuolar degeneration of keratinocytes (subepidermal blisters). … Patients on therapy for <30 days demonstrate dyskeratosis in the stratum spinosum and granulosum, whereas patients treated for ≥30 days show hyperkeratosis and parakeratosis in the stratum corneum [ 25 ]. …

Pityriasis liechenoides et varioliformis acuta у пациента, лечащегося cevostamab.

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… An acanthotic epidermis with scattered necrotic keratinocytes shows a confluent neutrophil rich parakeratosis. The dermis contains a mononuclear infiltrate showing extensive exocytosis into the epidermis (Hematoxylin-eosin, 20×). …

Porokeratoses-A Comprehensive Review on the Genetics and Metabolomics, Imaging Methods and Management of Common Clinical Variants.

Porokeratosis is a heterogeneous group of keratinising disorders characterised by the presence of particular microscopic structural changes, namely the presence of the cornoid lamella. This structure develops as a consequence of a defective isoprenoid pathway, critical for cholesterol synthesis. Commonly recognised variants include disseminated superficial actinic porokeratosis, disseminated superficial porokeratosis, porokeratosis of Mibelli, palmoplantar porokeratosis (including porokeratosis palmaris et plantaris disseminata and punctate porokeratosis), linear porokeratosis, verrucous porok

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… Parakeratosis can develop according to two mechanisms—via the disruption of keratinocyte maturation or with accelerated upward migration [ 78 ]. … A single column of parakeratosis and folliculocentrism is rather uncommon [ 108 , 407 , 408 ]. The underlying epidermis is agranulotic, whereas the bordering epidermis is usually atrophic and features basal layer vacuolisation. …

Integumentary System

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… Orthokeratosis and parakeratosis are not mutually exclusive and are often seen in the same section of hyperkeratotic skin. Diffuse parakeratosis can be seen in many chronic dermatoses, especially zinc-responsive dermatosis, dermatophilosis, superficial necrolytic dermatitis, and thallotoxicosis. … The presence of parakeratosis suggests zinc-responsive dermatosis, chronic ectoparasite hypersensitivity, or Malassezia dermatitis. Figure 6-13 Histologic and schematic appearance of superficial perivascular dermatitis. Culicoides insect-bite hypersensitivity in a horse. …

Cutaneous paraneoplastic syndromes in cats: a comparative clinical review.

PRACTICAL RELEVANCE: Cutaneous paraneoplastic syndromes (CPSs) in cats represent a diverse group of rare dermatological manifestations that occur as indirect consequences of underlying neoplasia. These syndromes are thought to arise due to tumour-associated systemic effects, including dysregulation of immune responses, metabolic disturbances and aberrant production of cytokines or growth factors. Recognising CPSs is clinically relevant, as they may serve as early indicators of occult neoplasia, guiding timely diagnosis and intervention. CLINICAL CHALLENGES: Diagnosing CPSs requires a high ind

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… (a,b) Paw pad histopathology illustrating a ‘red, white and blue’ epidermal pattern due to parakeratosis (red), laminar hydropic degeneration (white) and deep epidermal hyperplasia (blue). … The severity of these changes varies in different areas, and mild hydropic degeneration (a) and mild parakeratosis (b) are sometimes observed. (c) Liver mass photomicrograph showing antiglucagon immunohistochemistry. …

Acute graft-versus-host disease and bronchiolitis obliterans after autologous stem cell transplantation in a patient with multiple myeloma.

Sixty-seven-year-old patient, diagnosed with multiple myeloma who had received autologous stem cell transplantation, following bortezomib, dexamethasone and thalidomide conventional regimen, achieving complete response, developed rash, diarrhea, and severe respiratory failure, 80 days after the transplantation procedure. He was diagnosed with graft-versus-host disease and bronchiolitis obliterans syndrome.

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… Initial skin biopsy (interpreted as unspecific toxic/infectious pattern) was repeated, showing spongiosis, parakeratosis, and interface injury images, with vacuolated damage and apoptotic bodies. …

Роль ИЛ-23 в развитии воспламенительных заболеваний.

Interleukin-23 имеет решающее значение для возникновения и развития некоторых подстрекательских расстройств. В качестве ключевого цитокина IL-23 участвует в дифференциации и активации клеток TH17, которые играют определенную роль в широком спектре подстрекательских заболеваний. В настоящем обзоре рассматриваются молекулярные механизмы, с помощью которых IL-23 способствует патогенезу заболеваний, включая псориаз, ревматоидный артрит, воспалительный кишечник и множественный склероз. Разъясняя важную роль ИЛ-23 в воспалении, этот обзор подчеркивает ее важность в качестве терапевтической цели для

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… Among these, IL-22 plays a crucial role in promoting keratinocyte hyperproliferation and impairing normal differentiation, resulting in the epidermal thickening (acanthosis) and abnormal cornification (parakeratosis) observed in psoriatic lesions [ 107 ]. …

Therapeutic Approach in the Treatment of Medication-Related Osteonecrosis of the Jaw: Case Series of 3 Patients and State of the Art on Surgical Strategies.

BACKGROUND: Bisphosphonates and receptor activator of nuclear factor kappa-B ligand inhibitors are currently the most widely used antiresorptive therapies in bone metabolism diseases treatment. Unfortunately they can evoke medication-related osteonecrosis of the jaws. The present case series study proposes to evaluate clinical features, evolution and the surgical therapeutic approaches in three patients affected by medication-related osteonecrosis of the jaw and to review the state of art regarding the management of this complication in light of the most recent literature. METHODS: Three case

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… Histologic examination revealed the presence of necrotic bone with chronic inflammatory cell infiltrate, hyperplasia and parakeratosis of stratified squamous epithelium with underlying hyperplastic granulation tissue ( Figure 6 ). Diagnosis of Stage 2 MRONJ was performed. Figure 6 Case 3. …

Lichenoid mucocutaneous reactions associated with sintilimab therapy in a non-small cell lung adenocarcinoma patient: case report and review.

The immune checkpoint inhibitor (ICI), anti-programmed cell death receptor-1 (PD-1) antibody, has gained widespread approval for treating various malignancies. Among the immune-related adverse reactions (irAEs) during ICI treatment, the lichenoid reaction is noteworthy. Sintilimab, a new PD-1 inhibitor, has secured approval in China for treating refractory non-Hodgkin's lymphoma, and phase I/II clinical trials for other solid tumors are ongoing both domestically and abroad. This paper presents a case of a mucocutaneous lichenoid reaction associated with sintilimab therapy, its diagnosis, and m

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… NB-UVB, Narrow-band ultraviolet B; PUVA, Psoralen plus ultraviolet A; BMZ, basement membrane zone. ① Band-like lymphocytic infiltrate in the upper lamina propria; ② Partial disruption of the BMZ; ③ Hypergranulosis and parakeratosis; ④ Not band-like lymphocytic infiltrate in the upper lamina propria; …

Navigating Stomatologic Complications Secondary to Antineoplastic Agents-A Comprehensive Review.

This review systematically examines the oral complications associated with conventional and novel anti-cancer therapies. It highlights that while molecularly targeted agents including monoclonal antibodies targeting the vascular endothelial growth factor and its receptor, the epidermal growth factor receptor, tyrosine kinase inhibitors, and immune checkpoint inhibitors tend to exhibit a lower overall toxicity profile compared to traditional cytotoxic chemotherapeutics, they are nonetheless linked to significant oral adverse events. These complications encompass inflammatory mucosal reactions k

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… Furthermore, histologic evaluation typically demonstrates features such as eosinophilic infiltration, marked parakeratosis with acanthosis, and vascular inflammation surrounding the deep plexuses—findings that are not observed in LP [ 84 ]. …

Clinical Manifestations of Human Exposure to Fungi.

Biological particles, along with inorganic gaseous and particulate pollutants, constitute an ever-present component of the atmosphere and surfaces. Among these particles are fungal species colonizing almost all ecosystems, including the human body. Although inoffensive to most people, fungi can be responsible for several health problems, such as allergic fungal diseases and fungal infections. Worldwide fungal disease incidence is increasing, with new emerging fungal diseases appearing yearly. Reasons for this increase are the expansion of life expectancy, the number of immunocompromised patien

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… Active dermatophytosis includes parakeratosis, basket weave of the keratin layer, neutrophils in the base layers of the epidermis, spongiotic changes, eosinophils in the dermis, acanthosis or hyperkeratosis, and visualization of hyphae. …

Curcumin Formulations for Better Bioavailability: What We Learned from Clinical Trials Thus Far?

Curcumin has been credited with a wide spectrum of pharmacological properties for the prevention and treatment of several chronic diseases such as arthritis, autoimmune diseases, cancer, cardiovascular diseases, diabetes, hemoglobinopathies, hypertension, infectious diseases, inflammation, metabolic syndrome, neurological diseases, obesity, and skin diseases. However, due to its weak solubility and bioavailability, it has limited potential as an oral medication. Numerous factors including low water solubility, poor intestinal permeability, instability at alkaline pH, and fast metabolism contri

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… oil formulation | T2D | 53 | 10 weeks | 1500 mg/day | ↑adiponectin, ↓TG, ↓hs-CRP | | ( 139 ) 53 | 10 weeks | 1500 mg/day | ↓mean weight, ↓BMI, ↓waist circumference, ↓FBS | no adverse side effects | ( 140 ) curcumin alcohol gel | psoriasis | 10 | 4 weeks | 1% gel | ↓PhK activity, ↓TRR, ↓severity of parakeratosis … waist circumference, FBS, TG, hs-CRP, and increased adiponectin levels in T2D patients compared to administration of the same amount of rice flour as placebo. 139 , 140 Heng and colleagues showed that the application of curcumin alcohol gel reduced phosphorylase kinase activity, TRR, the severity of parakeratosis …

Immune-Mediated Dermatoses in Patients with Haematological Malignancies: A Comprehensive Review.

Haematological malignancies induce important alterations of the immune system, which account for the high frequency of autoimmune complications observed in patients. Cutaneous immune-mediated diseases associated with haematological malignancies encompass a heterogeneous group of dermatoses, including, among others, neutrophilic and eosinophilic dermatoses, autoantibody-mediated skin diseases, vasculitis and granulomatous dermatoses. Some of these diseases, such as paraneoplastic pemphigus, are associated with an increased risk of death; others, such as eosinophilic dermatoses of haematological

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… Additional histopathologic features include dermal oedema, dermal-epidermal detachment, eosinophilic spongiosis and parakeratosis [ 113 ]. …

SEDCYDO - SGER - SEMO ConГРЕСС МАДРИД 2025, 8-10 Возможно. Ход работы и резюме.

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Prurigo Nodularis: Pathogenesis and the Horizon of Potential Therapeutics.

Chronic pruritus that lasts for over 6 weeks can present in various forms, like papules, nodules, and plaque types, with prurigo nodularis (PN) being the most prevalent. The pathogenesis of PN involves the dysregulation of immune cell-neural circuits and is associated with peripheral neuropathies, possibly due to chronic scratching. PN is a persistent and challenging condition, involving complex interactions among the skin, immune system, and nervous system. Lesional skin in PN exhibits the infiltration of diverse immune cells like T cells, eosinophils, macrophages, and mast cells, leading to

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… Characteristic histolopathologic features of PN display thick compact orthohyperkeratosis, pseudoepitheliomatous hyperplasia, focal parakeratosis, and hypergranulosis in the epidermis [ 5 , 109 ]. …

Резюме

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Резюме: 32 Второй Конгресс ЭСП и Международный конгресс XXXIII МПД.

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… Among all histologic features, moderate agreement was obtained only for parakeratosis (ĸ=0.51). Fair agreement was obtained for nuclear features such as atypia discernable under 100X magnification (ĸ=0.39), nuclear angulation (ĸ=0.38), abnormal chromatin (ĸ=0.38), and suprabasal mitoses (ĸ=0.32). … Moderate agreement was obtained only for parakeratosis, and there was only fair agreement for most histologic features. Future studies should focus on ancillary immunohistochemical and molecular biomarkers to facilitate accurate diagnosis. …

Устные бесплатные бумажные сессии.

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