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Noncoding RNAs improve the predictive power of network medicine.

Network medicine has improved the mechanistic understanding of disease, offering quantitative insights into disease mechanisms, comorbidities, and novel diagnostic tools and therapeutic treatments. Yet, most network-based approaches rely on a comprehensive map of protein-protein interactions (PPI), ignoring interactions mediated by noncoding RNAs (ncRNAs). Here, we systematically combine experimentally confirmed binding interactions mediated by ncRNA with PPI, constructing a comprehensive network of all physical interactions in the human cell. We find that the inclusion of ncRNA expands the nu

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… Arthritis Rheum. 50 , 968 – 976 ( 2020 ). 32906033 10.1016/j.semarthrit.2020.07.015 82 Y. H. Sheen , Association of asthma with rheumatoid arthritis: A population-based case-control study . J. Allergy Clin. Immunol. … Rheum. Dis. 77 , 510 – 514 ( 2018 ). 29217620 10.1136/annrheumdis-2017-212086 88 G. Gridley , Incidence of cancer among patients with rheumatoid arthritis . J. Natl. Cancer Inst. 85 , 307 – 311 ( 1993 ). 8426374 10.1093/jnci/85.4.307 89 M. …

A PRoliferation-Inducing Ligand (APRIL) in the Pathogenesis of Immunoglobulin A Nephropathy: A Review of the Evidence.

A PRoliferation-Inducing Ligand (APRIL), the thirteenth member of the tumor necrosis factor superfamily, plays a key role in the regulation of activated B cells, the survival of long-lived plasma cells, and immunoglobulin (Ig) isotype class switching. Several lines of evidence have implicated APRIL in the pathogenesis of IgA nephropathy (IgAN). Globally, IgAN is the most common primary glomerulonephritis, and it can progress to end-stage kidney disease; yet, disease-modifying treatments for this condition have historically been lacking. The preliminary data in ongoing clinical trials indicate

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… Arthritis Rheum. 2009;60:2083–2093. doi: 10.1002/art.24628. 44. Chu V.T., Enghard P., Riemekasten G., Berek C. In vitro and in vivo activation induces BAFF and APRIL expression in B cells. J. Immunol. 2007;179:5947–5957. doi: 10.4049/jimmunol.179.9.5947. 45. … Rheum. Dis. 2023;82:90–91. 77. Kano T., Suzuki H., Makita Y., Nihei Y., Fukao Y., Nakayama M., Lee M., Kato R., Aoki R., Yamada K., et al. Mucosal immune system dysregulation in the pathogenesis of IgA nephropathy. Biomedicines. 2022;10:3027. doi: 10.3390/biomedicines10123027. 78. …

Skin manifestations associated with systemic diseases - Part I.

The skin demonstrates what is happening in the body in many diseases, as it reflects some internal processes on the surface. In this sense, … that will cover large groups of diseases. In this first part, cutaneous manifestations of the main rheumatologic diseases are described, which are the ones with the greatest interface with dermatology. The authors also talk about vascular manifestations and granulomatous diseases. In the second part, endocrinological, hematological, oncological, cardio …

Osteoclasts in Tumor Biology: Metastasis and Epithelial-Mesenchymal-Myeloid Transition.

Osteoclast is a specialized cell that originates from monocytic lineage, communicates closely with osteoblasts under physiological conditions, participates in bone modeling and re-modeling, contributes to calcium homeostasis and osteoimmunity. In pathological conditions, it is involved in many tumors such as giant cell bone tumor (osteoclastoma), aneurysmal bone cyst, osteosarcoma, and metastatic cancers, and it usually causes local spread and progression of the tumor, working against the host. Since osteoclasts play an active role in primary bone tumors and bone metastases, the use of anti-os

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… Ann Rheum Dis ( 2010 ) 69 ( 12 ): 2152 – 9 . 10.1136/ard.2010.132852 20858621 24. … J Rheum Dis ( 2016 ) 23 : 148 – 53 . 10.4078/jrd.2016.23.3.148 27. D'Oronzo S Coleman R Brown J Silvestris F . Metastatic bone disease: pathogenesis and therapeutic options: up-date on bone metastasis management . …

Long-Term Outcomes of Pituitary Gland Preservation in Pituitary Macroadenoma Apoplexy: Case Series and Review of the Literature.

Introduction  For patients presenting with neurological changes from pituitary tumor apoplexy, urgent surgical intervention is commonly performed for diagnosis, tumor resection, and optic apparatus decompression. Although identification and preservation of the pituitary gland during the time of surgery can be challenging, it may lead to improve endocrine outcomes. Methods  A retrospective case series of all patients with macroadenomas presenting with apoplexy at Loyola University Medical Center from 2016 to 2018 was studied. Demographic, radiographic, and intraoperative characteristics were co

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… Semin Arthritis Rheum . 2017 ; 47 : 1 – 8 . doi: 10.1016/j.semarthrit.2017.02.008 28320529 30. Ito S , Kobayashi D , Murasawa A , Narita I , Nakazono K . An analysis of the neuropathic pain components in rheumatoid arthritis patients . … Arthritis Rheum . 2013 ; 65 : 1494 – 1503 . doi: 10.1002/art.37920 23460087 91. Fallon MT . Neuropathic pain in cancer . Br J Anaesth . 2013 ; 111 : 105 – 111 . doi: 10.1093/bja/aet208 23794652 92. Coluzzi F , Raffa RB , Pergolizzi J , et al. …

Эндоскопический диагностический и клинический курс по изолированному верхнему кишечному амилоидозу: ретроспективное исследование.

ЦЕЛИ: Ранняя диагностика амилоидоза верхней части желудочно-кишечного кишечника (УГИ) и разработка соответствующих стратегий лечения и последующей деятельности по-прежнему сопряжены с трудностями. Цель этого исследования заключалась в выяснении эндоскопических характеристик и клинических курсов пациентов с изолированным амилоидозом УГИ. МЕТОДЫ: Мы провели ретроспективный обзор 11 У пациентов был диагностирован изолированный амилоидоз УГИ в больнице Национального университета им. Чоннама и в больнице Национального университета им. Чоннама Хвасуна. Ни у одного из пациентов не было системного уча

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… 268 292 32929754 10.1111/joim.13169 3 Benson MD Buxbaum JN Eisenberg DS Amyloid nomenclature 2018: recommendations by the International Society of Amyloidosis (ISA) nomenclature committee Amyloid 2018 25 215 219 30614283 10.1080/13506129.2018.1549825 4 Hazenberg BP Amyloidosis: a clinical overview Rheum …

Chronic recurrent wheals - If not chronic spontaneous urticaria, what else?

Chronic urticarial rash, mostly due to chronic spontaneous urticaria (CSU), is seen in up to 1 - 4% of the general population. Urticarial vasculitis (UV) and autoinflammatory syndromes, i.e., cryopyrin-associated periodic syndromes (CAPS) and Schnitzler syndrome (SchS), can mimic CSU-like rash but represent rare disorders with systemic symptoms including fever, headache, conjunctivitis, and arthralgia. Clinical and laboratory features can point to the presence of any of these diseases in patients initially presenting with chronic urticarial rash. These include long-lasting wheals (> 24 hours),

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… Arthritis Rheum. 2008; 58: 2443–2452. 17. Lachmann HJ Kone-Paut I Kuemmerle-Deschner JB Leslie KS Hachulla E Quartier P Use of canakinumab in the cryopyrin-associated periodic syndrome. N Engl J Med. 360. United States: 2009 Massachusetts. Med Soc. 2009; 2416–2425. 18. …

Primary hyperparathyroidism-induced brown tumors caused by parathyroid carcinoma: a case report and literature review

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

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… Clin Rheum Dis 1986 ; 12 : 691 – 705 . 3078779 2 Can Ö Boynueğri B Gökçe A , et al . Brown Tumors: A Case Report and Review of the Literature. Case Rep Nephrol Dial 2016 ; 6 : 46 – 52 . DOI: 10.1159/000444703. 27066494 10.1159/000444703 PMC4821153 3 Hoshi M Takami M Kajikawa M , et al . …

Osteoporotic Vertebral Compression Fracture and Single Balloon Extrapedicular Kyphoplasty: Findings and Technical Considerations.

ObjectiveTo evaluate the functional and radiological outcome of balloon kyphoplasty and to endorse the unilateral single balloon extrapedicular kyphoplasty as practically more feasible and safer method in comparison to the conventional methods.MethodsTotally, 81 patients were presented to our center with osteoporotic vertebral compression fracture. Among these, 59 patients (61 vertebrae) were enrolled with stable wedge osteoporotic compression fracture. Pre-operatively percentage of vertebral height loss and kyphotic angle were calculated and single balloon extrapedicular kyphoplasty was perfo

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… vertebral compression fractures: far-lateral extrapedicular approach J Korean Neurosurg Soc. 2009 45 2 122 6 19274126 10.3340/jkns.2009.45.2.122 PMC2651548 14 Cook DJ Guyatt GH Adachi JD Clifton J Griffith LE Epstein RS Quality of life issues in women with vertebral fractures due to osteoporosis Arthritis Rheum …

The impact of incident vertebral and non-vertebral fractures on health related quality of life in postmenopausal women.

BACKGROUND: Little empirical research has examined the multiple consequences of osteoporosis on quality of life. METHODS: Health related quality of life (HRQL) was examined in relationship to incident fractures in 2009 postmenopausal women 50 years and older who were seen in consultation at our tertiary care, university teaching hospital-affiliated office and who were registered in the Canadian Database of Osteoporosis and Osteopenia (CANDOO) patients. Patients were divided into three study groups according to incident fracture status: vertebral fractures, non-vertebral fractures and no fract

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… Arthritis Rheum. 1993;36:750–756. doi: 10.1002/art.1780360603. Helmes E, Hodsman A, Lazowski D, et al. A questionnaire to evaluate disability in osteoporotic patients with vertebral compression fractures. J Gerontol. 1995;50A:91–98. doi: 10.1093/gerona/50a.2.m91. …

Personalized Management of Chronic Rhinosinusitis in the Context of Immune Deficiency.

Primary and secondary immunodeficiency as a cause of recalcitrant or difficult to treat chronic rhinosinusitis (CRS) and recurrent acute rhinosinusitis (RARS) are under-appreciated etiologies. Patients with persistent symptoms, frequent exacerbations despite appropriate medical therapy, or other sinopulmonary conditions known to be related to an immunodeficient state warrant further testing for immunodeficiency, as up to 20% of this cohort of patients may have underlying immunodeficiency. Testing for immunodeficiency includes CBC with differential, immunoglobulin levels, and pneumococcal vacci

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… Ann Rheum Dis . 2021;80(7):865–875. doi: 10.1136/annrheumdis-2020-219012 34. Vähämurto P, Mannisto S, Pollari M, Karjalainen-Lindsberg ML, Mäkitie AA, Leppä S. Clinical features and outcome of the patients with sinonasal tract diffuse large B-cell lymphoma in the pre-rituximab and rituximab eras. …

Fertility management and outcomes after CAR T-cell therapy: an international survey from the Cellular Therapy and Immunobiology working party of the European Society for Blood and Marrow Transplantation.

BACKGROUND: CAR T-cell therapy has become a highly effective treatment for hematological malignancies, and emerging evidence indicates promising benefits for non-oncohematological conditions. As its clinical use broadens, understanding long-term outcomes and late complications is crucial. One critical yet understudied area is fertility, for which current evidence remains limited and no formal guidelines provide direction for patients undergoing CAR T-cell therapy. METHODS: To address this gap, we conducted a cross-sectional survey on behalf of the Cellular Therapy and Immunobiology Working Pa

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… Effect of pregnancy on disease flares in patients with systemic lupus erythematosus Ann Rheum Dis 77 6 2018 855 860 29463519 10.1136/annrheumdis-2017-212535 PMC6037310 Supplementary data Supplementary Table S1 Supplementary Table S2 Translated Abstracts Acknowledgements Artificial intelligence tools …

Знания, отношение и практика в отношении множественной миеломы среди медицинского персонала в регионе Энши.

Исследование в районе Энши между Сент-Новым 2023 Оценивая знания, отношение и практику медицинского персонала в отношении множественной миеломы. Это заболевание оказывает значительное воздействие на физическое здоровье, качество жизни и психическое здоровье. Медицинские работники играют важнейшую роль в его профилактике и лечении. При анализе использовались корреляция Пирсона, логистическая регрессия и модель структурных уравнений (SEM). Всего 229 действительные вопросники были собраны вместе с 68.6% :: женщин-участников и 42.4% возраст 31-40 Годы. Знания, отношение и практические оценки 36.27

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… Rheum. Dis. 79 , 800–810 (2020). 24. Breckenridge, A. et al. Poor medication adherence in clinical trials: consequences and solutions. Nat. Rev. Drug Discov . 16 , 149–150 (2017). 25. Carls, G. S. et al. …

Tocilizumab Dosing for Management of T Cell-Engaging Bispecific Antibody-Related CRS in Patients With R/R B-Cell NHL.

The recent surge in T-cell-engaging and chimeric antigen receptor (CAR) T-cell therapies is changing the landscape of cancer therapy. Cytokine release syndrome (CRS) is a systemic inflammatory response syndrome that is a well-known complication of these therapies, of which interleukin-6 (IL-6) is a key mediator. Tocilizumab, an IL-6 receptor (IL-6R) antagonist, is approved for the management of CAR T-cell therapy-induced CRS in adults and in pediatric patients aged ≥ 2 years old. However, the approved dosing schedule was not based on IL-6R occupancy and may not be the most suitable schedule fo

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… Rheum. Dis. 80(Suppl. 1), 911–912 (2021). 43. COLUMVI . …

Изучение взаимосвязи между гутт-здоровьем и аутоиммунными заболеваниями: систематический обзор и мета-анализ.

Аутоиммунные заболевания (АИД) представляют собой многогранные хронические заболевания, характеризующиеся иммунной дисрегулированием и системным воспалением. Более свежие данные указывают пальцем на микробиоту человеческого кишечника, триллионную популяцию микроорганизмов, обитающих в человеческом тракте GI, в качестве главного влиятельного модулятора иммунной реактивности и важного фактора аутоиммунной патогенез. Цель этого систематического обзора будет заключаться в изучении вопроса о том, каким образом литература соотносится с систематическими изменениями в микробиоте кишечника в АИД, а так

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Autoimmune diseases (AIDs) are multifaceted, chronic illnesses characterized by immune dysregulation and systemic inflammation. Newer eviden … 10 studies, encompassing various autoimmune diseases, including systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), multiple sclerosis (MS), type 1 diabetes mellitus (T1DM), autoimmune thyroid diseases (AITDs), and psoriasis. Familiar patterns of microbiome dysbiosis were identified, such as a reduction in microbial diversity, increased intes …

Efficacy and safety of biosimilar Peg-filgrastim after autologous stem cell transplant in myeloma and lymphoma patients: a comparative study with biosimilar Filgrastim, Lenograstim, and originator Peg-filgrastim.

Data about biosimilar Peg-filgrastim (bioPEG) in autologous stem cell transplant (ASCT) are still scarce. The aim of this study has been to assess efficacy and safety of bioPEG among lymphoma and myeloma patients undergoing ASCT, comparing these data with historical controls receiving other G-CSFs. Furthermore, an economic evaluation has been included to estimate the savings by using bioPEG. This is a prospective cohort study comparing lymphoma and myeloma patients undergoing ASCT and receiving bioPEG (n = 73) with three historical consecutive cohorts collected retrospectively who received oth

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… Semin Arthritis Rheum. 2022;52:151939. doi: 10.1016/j.semarthrit.2021.11.009. 31. Singh SC, Bagnato KM. The economic implications of biosimilars. Am J Manag Care. 2015;21(16 Suppl):s331–340. 32. Moorkens E, Broux H, Huys I, et al. …

Drug repurposing-a promising approach for patients with angina but non-obstructive coronary artery disease (ANOCA).

In today's era of individualized precision medicine drug repurposing represents a promising approach to offer patients fast access to novel treatments. Apart from drug repurposing in cancer treatments, cardiovascular pharmacology is another attractive field for this approach. Patients with angina pectoris without obstructive coronary artery disease (ANOCA) report refractory angina despite standard medications in up to 40% of cases. Drug repurposing also appears to be an auspicious option for this indication. From a pathophysiological point of view ANOCA patients frequently suffer from vasomoto

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… Rheum Dis Clin North Am. (2010) 36(2):405–26. 10.1016/j.rdc.2010.02.002 12. Patel MR, Peterson ED, Dai D, Brennan JM, Redberg RF, Anderson HV, et al. Low diagnostic yield of elective coronary angiography. N Engl J Med. (2010) 362(10):886–95. 10.1056/NEJMoa0907272 13. …

Sarcoidosis and autoimmunity: In the depth of a complex relationship.

Sarcoidosis is a chronic granulomatous disease that can virtually affect any organ. Its etiology is unknown, although it has been proposed that environmental or biological agents can act as triggers, ultimately leading to chronic inflammation in genetically predisposed individuals. The main component of sarcoid inflammation is represented by an exaggerated T- lymphocytic cellular response to a putative antigen that could not be efficiently cleared in the patient. However, several clinical and immunological observations, such as the association of sarcoidosis to autoimmune diseases or the prese

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… Arthritis Rheum. ( 2002 ) 46 : 2673 – 7 . 10.1002/art.10541 12384926 42. Randall KL . Rituximab in autoimmune diseases . Australian prescriber. ( 2016 ) 39 : 131 – 4 . 10.18773/austprescr.2016.053 27756976 PMC4993704 43. Krause ML Cooper LT Chareonthaitawee P Amin S . …

Clinical Trials of Stem Cell Therapy in Japan: The Decade of Progress under the National Program.

Stem cell therapy is a current world-wide topic in medical science. Various therapies have been approved based on their effectiveness and put into practical use. In Japan, research and development-related stem cell therapy, generally referred to as regenerative medicine, has been led by the government. The national scheme started in 2002, and support for the transition to clinical trials has been accelerating since 2011. Of the initial 18 projects that were accepted in the budget for preclinical research, 15 projects have begun clinical trials so far. These include the transplantation of retin

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… Comparison of human stem cells derived from various mesenchymal tissues: Superiority of synovium as a cell source Arthritis Rheum. 2005 52 2521 2529 10.1002/art.21212 16052568 9. Koga H. Muneta T. Ju Y.J. Nagase T. Nimura A. Mochizuki T. Ichinose S. von der Mark K. Sekiya I. …

Cytopenia after CAR-T Cell Therapy-A Brief Review of a Complex Problem.

Chimeric Antigen Receptor T-cell (CAR-T) immunotherapy has emerged as an efficacious and life extending treatment modality with high response rates and durable remissions in patients with relapsed and refractory non-Hodgkin lymphoma (NHL), follicular lymphoma, and B-cell acute lymphoblastic leukemia (B-ALL) as well as in other diseases. Prolonged or recurrent cytopenias after CAR-T therapy have increasingly been reported at varying rates, and the pathogenesis of this complication is not yet well-understood but is likely contributed to by multiple factors. Current studies reported are primarily

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… Arthritis Rheum. 2003;48:455–459. doi: 10.1002/art.10764. 20. Shimony S., Bar-Sever E., Berger T., Itchaki G., Gurion R., Yeshurun M., Lahav M., Raanani P., Wolach O. Late onset neutropenia after rituximab and obinutuzumab treatmet-characteristics of a class-effect toxicity. Leuk. …