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The 2024 Saudi Pharmacotherapy Didactic Curriculum Toolkit: A Modified Delphi Study.

BACKGROUND: Several pharmacy schools in Saudi Arabia (S.A.) refer to the American College of Clinical Pharmacy (ACCP) pharmacotherapy toolkit in developing their pharmacotherapy curriculum. However, the ACCP toolkit does not specifically address the healthcare needs of the Saudi population. A tailored pharmacotherapy curriculum that offers graduates the essential competencies to better serve the nation's needs is warranted. This study aims to develop a population-centered didactic pharmacotherapy toolkit for the Saudi population to assist pharmacy schools in designing pharmacotherapy course co

Сайентометрический анализ неврологических публикаций в Иране.

История вопроса: Несомненно, медицина родилась с самого начала сотворения человека. Одной из его важных ветвей является неврология. Нейрофизики в Иране с небольшой задержкой из первого мира, с усилиями исследователей, открыли путь к диагностике и лечению неврологических заболеваний, и мы достигли того места, где мы находимся. Методы: В этом библиометрическом и сайентометрическом исследовании мы провели оценку процесса неврологии в Иране. Сославшись на надежные индексы, мы проверили Web of Science (WOS), PubMed и Scopus начиная с 1963 года. Мы показали опубликованную деятельность иранцев в виде

Data Integration Innovations to Enhance Analytic Utility of Clinical Trial Content to Inform Health Disparities Research.

Project Data Sphere (PDS) is a research platform that provides the research community with broad access to both de-identified patient-level data from oncology clinical trials and related analytic tools. While these data are rich in measures that characterize the clinical trials under study, data providers are required to de-identify patient-level data by removing key demographic data. To address these analytic constraints, the data profiles in selected PDS patient-level cancer phase III clinical datasets have been augmented by linking the social, economic, and health-related characteristics of

Determining the Relationship Between Perceptions of Nursing Care Quality and Satisfaction Status in Multicultural Patients with Hematological Malignancies.

AIM: This study aims to investigate the correlation between multicultural patients with hematologic malignancies' perceptions of nursing care and their level of satisfaction, with the objective of providing recommendations for enhancing the quality of nursing care based on the findings. METHODS: This descriptive and cross-sectional study was conducted with 140 patients aged 18 years and over who were hospitalized in the hematology and bone marrow transplantation unit between January and October 2024, who agreed to participate in the study and were able to communicate. Data were collected usin

Efficacy and Safety of Panitumumab in Patients With RAF/RAS-Wild-Type Glioblastoma: Results From the Drug Rediscovery Protocol.

BackgroundThe prognosis of malignant primary high-grade brain tumors, predominantly glioblastomas, is poor despite intensive multimodality treatment options. In more than 50% of patients with glioblastomas, potentially targetable mutations are present, including rearrangements, altered splicing, and/or focal amplifications of epidermal growth factor receptor (EGFR) by signaling through the RAF/RAS pathway. We studied whether treatment with the clinically available anti-EGFR monoclonal antibody panitumumab provides clinical benefit for patients with RAF/RAS-wild-type (wt) glioblastomas in the D

Evaluation of the Incidence and Stage of Oral Mucositis in Patients Undergoing Hematopoietic Stem Cell Transplantation: A Retrospective Study.

AimThis study aims to retrospectively evaluate the incidence and stage of oral mucositis in patients undergoing hematopoietic stem cell transplantation.MethodsA total of 102 patient records of patients hospitalized between 2014 and 2019 in the adult hematopoietic stem cell transplantation clinic of a tertiary university hospital in Turkey were evaluated. Data were collected through a retrospective evaluation of patient records. Records made according to the WHO Oral Toxicity Scale included in the patient records during hospitalization in the adult hematopoietic stem cell transplantation clinic

Interventions to improve adherence to anti-osteoporosis medications: an updated systematic review.

An earlier systematic review on interventions to improve adherence and persistence was updated. Fifteen studies investigating the effectiveness of patient education, drug regimen, monitoring and supervision, and interdisciplinary collaboration as a single or multi-component intervention were appraised. Multicomponent interventions with active patient involvement were more effective.IntroductionThis study was conducted to update a systematic literature review on interventions to improve adherence to anti-osteoporosis medications.MethodsA systematic literature review was carried out in Medline (

Effect of a community-based nursing intervention on mortality in chronically ill older adults: a randomized controlled trial.

BackgroundImproving the health of chronically ill older adults is a major challenge facing modern health care systems. A community-based nursing intervention developed by Health Quality Partners (HQP) was one of 15 different models of care coordination tested in randomized controlled trials within the Medicare Coordinated Care Demonstration (MCCD), a national US study. Evaluation of the HQP program began in 2002. The study reported here was designed to evaluate the survival impact of the HQP program versus usual care up to five years post-enrollment.Methods and findingsHQP enrolled 1,736 adult

Fulfilling end-of-life dreams: A scoping review of bucket lists in palliative and hospice care.

Abstract Objectives The purpose of this study is to examine the existing literature on end-of-life dream experiences and bucket list fulfillments among terminally ill individuals receiving hospice and/or palliative care. Methods A scoping review registered on Open Science Framework was conducted in accordance with the guidelines for Scoping reviews (PRISMA-ScR). An electronic search of literature was generated from EBSCO databases published until June 2024. Studies were included if they described and evaluated the effects of bucket lists and/or end-of-life wish fulfillment. Results This review

Машинное обучение для уточнения интерпретации изображений магнитного резонанса в управлении множественным склерозом: обзор повествования.

Множественный склероз (MS) — аутоиммунное заболевание мозга и спинного мозга с как воспалительными, так и нейродегенеративными свойствами. Несмотря на то, что достижения в области методов визуализации, в частности магнитно-резонансной съемки (MRI), улучшили процесс диагностики, его причины неизвестны, лекарство по-прежнему остается неизлечимым, а фактологическая база для управления лечением отсутствует. Для понимания MS стали использоваться такие методы расчета, как машинное обучение (ML). Опубликованные вычислительные исследования на основе MS MRI можно разбить на пять категорий: автоматизиро

Abstracts of the 19th International Congress on Neuromuscular Diseases 7th – 11th July 2026

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Interventions for preventing falls in older people in care facilities and hospitals.

BackgroundFalls in care facilities and hospitals are common events that cause considerable morbidity and mortality for older people. This is an update of a review first published in 2010 and updated in 2012.ObjectivesTo assess the effects of interventions designed to reduce the incidence of falls in older people in care facilities and hospitals.Search methodsWe searched the Cochrane Bone, Joint and Muscle Trauma Group Specialised Register (August 2017); Cochrane Central Register of Controlled Trials (2017, Issue 8); and MEDLINE, Embase, CINAHL and trial registers to August 2017.Selection crite

Early palliative care for solid and blood cancer patients and caregivers: Quantitative and qualitative results of a long-term experience as a case of value-based medicine.

IntroductionCancer patients and their caregivers have substantial unmet needs, that negatively impact the clinical outcome and quality of life. However, interventions aimed to address such needs are still suboptimal, failing to answer the recent healthcare call for the adoption of value-based models of care. In the case of incurable oncologic and hematologic cancers, a value-based model of care should plan advanced care on patients' needs and include the quality of death as an outcome. The integration of early palliative care into standard oncologic care for patients with advanced cancers repr

Network approach in liquidomics landscape.

Tissue-based biopsy is the present main tool to explore the molecular landscape of cancer, but it also has many limits to be frequently executed, being too invasive with the risk of side effects. These limits and the ability of cancer to constantly evolve its genomic profile, have recently led to the need of a less invasive and more accurate alternative, such as liquid biopsy. By searching Circulating Tumor Cells and residues of their nucleic acids or other tumor products in body fluids, especially in blood, but also in urine, stools and saliva, liquid biopsy is becoming the future of clinical

Oral Presentations

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The assessment, serial evaluation, and subsequent sequelae of acute kidney injury (ASSESS-AKI) study: design and methods.

BACKGROUND: The incidence of acute kidney injury (AKI) has been increasing over time and is associated with a high risk of short-term death. Previous studies on hospital-acquired AKI have important methodological limitations, especially their retrospective study designs and limited ability to control for potential confounding factors. METHODS: The Assessment, Serial Evaluation, and Subsequent Sequelae of Acute Kidney Injury (ASSESS-AKI) Study was established to examine how a hospitalized episode of AKI independently affects the risk of chronic kidney disease development and progression, cardi

Геномический диагноз детских расстройств: революция и эволюция.

Мощные, последние достижения в технологиях анализа генома оказали глубокое воздействие на практику медицинской генетики как в лаборатории, так и в клинике. Более широкое использование общегеномных тестов, таких, как анализ хромосомных микроарра и последовательность экзомов, привело к переходу к "генотипному" подходу. В настоящее время имеются многочисленные методы диагностики конкретного синдрома или фенотипа, и, хотя традиционные методы остаются эффективными инструментами в некоторых ситуациях, технологии с более высокой производительностью фактически стали лабораторным инструментом диагности

Increased Indoleamine 2, 3-Dioxygenase expression modulates Th1/Th17/Th22 and Treg pathway in humans with Helicobacter Pylori-Infected gastric mucosa.

Introduction and purposeIndoleamine 2, 3- dioxygenase (IDO) plays an importantrole in immunosuppressive pathway, as inhibits responsesof T cells and promotes immune tolerance. Host responsetoHelicobacter pylori (H. pylori) is involved in the infection persistenceand it is also associatedwith different clinical outcomes. The aim of this study was to investigate the role of IDO in H. pylori-infected patients with gastritis diseases and peptic ulcer diseases (PUD) through the assessment of the relationship among IDO protein expression and the numbers of T helper (Th)-1, Th17, Th22, and T regulato

Серые вопросы при множественном склерозе: когнитивное обесценение и структурное МРТ

Множественный склероз (MS) — иммунное заболевание, затрагивающее центральную нервную систему (CNS). Хотя MS классически считается заболеванием белого вещества (WM), участие серых веществ (GM) в патогенном процессе было подтверждено патологическими исследованиями и МРТ. Обесценение таких когнитивных областей, как память, скорость умственной обработки, внимание и исполнительная функция, может происходить с ранней стадии заболевания и, как правило, усугубляться с течением времени, несмотря на устойчивые физические симптомы. Демиелинация WM имеет умеренную корреляцию с CI, что говорит о том, что,

Patients and healthcare professionals' perspectives on the implementation of shared decision making in multiple myeloma: a multinational qualitative study.

BACKGROUND: Shared decision making (SDM) is highly relevant in oncology and cancer care, yet its application within multiple myeloma (MM) remains underexplored. This study aims to (1) investigate SDM implementation in MM clinical practice, (2) assess the role of various stakeholders next to haematologists in the SDM process, and (3) identify barriers and potential solutions to SDM implementation in MM care. METHODS: This qualitative study consisted of semi-structured interviews with patients (n = 39), haematologists (n = 15), and haematology nurses (n = 5) from nine countries in Europe and Is

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… Implementation Science. Volume 14. BioMed Central Ltd.; 2019. 10.1186/s13012-018-0851-5 PMC6339273 30658670 29. Gale NK, Heath G, Cameron E, Rashid S, Redwood S. Using the framework method for the analysis of qualitative data in multi-disciplinary health research. …