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Exercise Recommendation for People With Bone Metastases: Expert Consensus for Health Care Providers and Exercise Professionals.

PurposeExercise has been underutilized in people with advanced or incurable cancer despite the potential to improve physical function and reduce psychosocial morbidity, especially for people with bone metastases because of concerns over skeletal complications. The International Bone Metastases Exercise Working Group (IBMEWG) was formed to develop best practice recommendations for exercise programming for people with bone metastases on the basis of published research, clinical experience, and expert opinion.MethodsThe IBMEWG undertook sequential steps to inform the recommendations: (1) modified

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… . : Physical activity and advanced cancer: The views of chartered physiotherapists in Ireland. Physiother Theory Pract 34:534-541, 2018 10. Sheill G, Guinan E, Neill LO, et al. : Physical activity and advanced cancer: The views of oncology and palliative care physicians in Ireland. …

What is the relevance of an ambulatory quick diagnosis unit or inpatient admission for the diagnosis of pancreatic cancer? A retrospective study of 1004 patients.

Quick diagnosis units (QDU) have become an alternative hospital-based ambulatory medicine strategy to inpatient hospitalization for potentially serious illnesses in Spain. Whether diagnosis of pancreatic cancer is better accomplished by an ambulatory or inpatient approach is unknown. The main objective of this retrospective study was to examine and compare the diagnostic effectiveness of a QDU or inpatient setting in patients with pancreatic cancer.Patients with a diagnosis of pancreatic adenocarcinoma who had been referred to a university, tertiary hospital-based QDU or hospitalized between 2

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… [22] Pancreatric Section, British Society of Gastroenterology; Pancreatic Society of Great Britain and Ireland; Association of Upper Gastrointestinal Surgeons of Great Britain and Ireland; Royal College of Pathologists; Special Interest Group for Gastro-Intestinal Radiology. …

Cancer in pregnancy: FIGO Best practice advice and narrative review.

Cancer during pregnancy is relatively rare. The incidence is underestimated due to the lack of international registries covering both high-income and low- and middle-income countries, and is expected to rise with increasing maternal age and increasing global adoption of cell-free DNA testing for aneuploidy. Physiological changes during pregnancy often make the diagnosis challenging and delayed. Lack of experience and knowledge about this condition may also contribute to late diagnosis, suboptimal management, and occasionally inadvertent fetal and/or maternal harm. The principles of cancer mana

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… Saving Lives, Improving Mothers' Care Compiled Report—Lessons Learned to Inform Maternity Care from the UK and Ireland Confidential Enquiries into Maternal Deaths and Morbidity 2020–22. National Perinatal Epidemiology Unit, University of Oxford; 2024. 10. Knight M, Bunch K, Patel R, et al. … Saving Lives, Improving Mothers' Care‐ CORE report lessons learned to inform maternity care from the UK and Ireland Confidential Enquiries into Maternal Deaths and Morbidity 2017–19. Accessed March 9, 2024. 11. Walters B, Chew‐Graham CA, Jordan KP, et al. …

Technology forecast: advanced therapies in late clinical research, EMA approval or clinical application via hospital exemption.

Background: The umbrella term ATMPs (Advanced Therapy Medicinal Products) comprises cell therapies, gene therapeutics and tissue engineered products. After implementation of the Regulation 1394/2007, only a couple of products have obtained a centralized European marketing authorisation. Objectives: The aim of the presented study is to give an overview on ATMPs available within the European Union either via centralized marketing authorisation or via national Hospital exemption. Additionally, a forecast on innovative ATMPs in the process of EMA approval as well as in phase III and IV clinical tr

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… Hungary no no Iceland no no Ireland no yes Limbal stem cells Italy no ? Latvia no no Liechtenstein ? ? Lithuania no yes Dendritic cells, cytokine activated killer cells, T-cells, stromal vascular fraction cells Luxembourg no ? Malta no ? … | Hungary | no | no | Iceland | no | no | Ireland | no | yes | Limbal stem cells Italy | no | ? | Latvia | no | no | Liechtenstein | ? | ? | Lithuania | no | yes | Dendritic cells, cytokine activated killer cells, T-cells, stromal vascular fraction cells Luxembourg | no | ? | Malta | no | ? …

Устранение риска устойчивости к множественным склерозам: роль HLA-E*01 и инфекционный мононуклеоз в коорте населения.

Эпштейн-Барр Вирус (ЭБВ) и его клиническое проявление, инфекционный мононуклеоз (IM), тесно связаны с риском MS. Согласно недавнему исследованию in vitro, HLA-E*01::03в отличие от HLA-E*01::01, может защищаться от MS за счет более эффективной иммунной реакции против клеток, инфицированных ЭБВ. Однако роль ХЛА-Е*01 В НР по-прежнему нет ясности. МЕТОДЫ: Мы расследовали вопрос о том, может ли ХЛА-Е*01::01 был в значительной степени связан с повышенным риском MS у лиц с историей диагностирования IM с использованием 487,144 Люди из группы Биобанка Великобритании. Мы оценили взаимодействие между ХЛА

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… Africa 1789 (2.3%) 4504 (1.9%) 3197 (1.8%) 9490 (1.9%) America 1122 (1.4%) 3248 (1.4%) 2202 (1.3%) 6572 (1.3%) Asia/Oceania 2752 (3.5%) 6208 (2.7%) 3915 (2.2%) 12,875 (2.6%) England 60,855 (77.9%) 181,852 (78.0%) 136,361 (77.5%) 379,068 (77.8%) Europe 1813 (2.3%) 4661 (2.0%) 2805 (1.6%) 9279 (1.9%) Ireland … /North Ireland 1011 (1.3%) 3512 (1.5%) 3249 (1.8%) 7772 (1.6%) Scotland 5567 (7.1%) 18,214 (7.8%) 15,342 (8.7%) 39,123 (8.0%) Wales 2974 (3.8%) 10,258 (4.4%) 8331 (4.7%) 21,563 (4.4%) Missing 282 (0.4%) 672 (0.3%) 448 (0.3%) 1402 (0.3%) Have older siblings No 21,243 (27.2%) 63,743 (27.3%) 47,357 …

Assessing the Influence of Different Comorbidities Indexes on the Outcomes of Allogeneic Hematopoietic Stem Cell Transplantation in a Developing Country.

Although the application of Hematopoietic Cell Transplantation-specific Comorbidity Index (HCT-CI) has enabled better prediction of transplant-related mortality (TRM) in allogeneic hematopoietic stem cell transplants (AHSCT), data from developing countries are scarce. This study prospectively evaluated the HCT-CI and the Adult Comorbidity Evaluation (ACE-27), in its original and in a modified version, as predictors of post-transplant complications in adults undergoing a first related or unrelated AHSCT in Brazil. Both bone marrow (BM) and peripheral blood stem cells (PBSC) as graft sources wer

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… Potter VT, Krishnamurthy P, Barber LD, Lim Z, Kenyon M, Ireland RM, et al. Long-term outcomes of alemtuzumab-based reduced-intensity conditioned hematopoietic stem cell transplantation for myelodysplastic syndrome and acute myelogenous leukemia secondary to myelodysplastic syndrome. … Marsh JC, Gupta V, Lim Z, Ho AY, Ireland RM, Hayden J, et al. Alemtuzumab with fludarabine and cyclophosphamide reduces chronic graft-versus-host disease after allogeneic stem cell transplantation for acquired aplastic anemia. Blood 2011; 118: 2351–57. 10.1182/blood-2010-12-327536 31. …

Prevalence and determinants of polypharmacy among cancer patients: a systematic review and meta-analysis.

BACKGROUND: Polypharmacy (PP) is a rising clinical challenge among patients with a cancer diagnosis. Uncertainty remains regarding its exact burden, exact prevalence estimates, and definitional themes in this vulnerable cohort of patients. METHODS: We searched PubMed, EMBASE, Scopus, the Cochrane Database of Systematic Reviews (CDSR), and Google Scholar, for studies published between 2000 and 2025 for eligible studies reporting on polypharmacy in cancer patients. These were critically appraised for eligibility and inclusion by two independent reviewers. Using quality and random effect models,

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… Two studies each originated from Ireland [ 15 , 27 ], Spain [ 13 , 29 ] France [ 11 , 21 ], and the USA [ 12 , 14 , 26 ]. Single studies were reported from Denmark [ 22 ] the Netherlands [ 16 ] Australia [ 18 ], Qatar [ 20 ], and Croatia [ 10 ]. … study | Country | Setting | Sample size | Number of pp (%) | Males (%) | Mean age in years (± SD) | Types of cancer | Definition of pp Ramsdale 2022 [ 26 ] | RCT | USA | Community | 718 | 440 (61.3%) | 405 (56.4%) | 77.6 | Solid & hematological | ≥ 5 medications Lavan 2021 [ 15 ] | Observational | Ireland …

Cancer mortality by country of birth and cancer type in Sweden: A 25-year registry-based cohort study.

Numerous studies have reported lower overall cancer mortality rates among immigrants compared to native populations. However, limited information exists regarding cancer mortality among immigrants based on specific birth countries and cancer types. We used population-based registries and followed 10 million individuals aged 20 years or older in Sweden between 1992 and 2016. The Cox proportional hazard model was used to explore the disparities in cancer mortality by country of birth and cancer type, stratified by gender. Age-standardized mortality rates were also computed using the world standa

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… large analytical sample size: Nordic (Finland, Norway, Denmark), Non‐Nordic Europe (Turkey, Germany, Austria, Netherlands, France, former Yugoslavia, Bosnia‐Hercegovina, Italy, Spain, Greece, Croatia, Poland, Hungary, former Czechoslovakia, Romania, former Soviet Union, Russia, Estonia, UK and North Ireland … However, the risk of death due to this cancer was higher in female immigrants from Finland (HR f = 1.23: 1.02, 1.49), Somalia (HR f = 5.18: 2.29, 11.72), as well as male immigrants from Denmark (HR m = 1.33: 1.06, 1.67), and the UK and Northern Ireland (HR m = 1.62: 1.03, 2.54) compared to individuals …

The use of smart technologies for enhancing palliative care: A systematic review.

IntroductionWith the rapid advancement of technology, smart technologies have permeated various sectors, including palliative care in healthcare. Based on the available literature, similar studies have elucidated the application of individual and isolated smart technologies in palliative care, with their benefits, and limitations. This research, therefore, focuses on the conceptualisation of various smart technologies and makes holistic recommendations on the effective and efficient use of smart technologies in healthcare to enhance palliative care.PurposeThe purpose of this study is to system

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… Switzerland, Ireland, Taiwan, Germany, Spain, the Netherlands, and China's involvement indicates a diversification in research contributions. This diversity is crucial for global progress in palliative care technologies. … The use of virtual reality and 360° video conferencing to improve the mental health and well-being of elderly patients in palliative care in Ireland; 46 telephone and videoconferences; 50 web-based videoconferences; 55 and video conferencing 56 are all various mobile technologies that were analysed in …

Real-World Evaluation of Talquetamab for the Treatment of Relapsed/Refractory Multiple Myeloma (RRMM): An International Myeloma Working Group Immunotherapy Registry Real-World Analysis.

Talquetamab is a GPRC5D × CD3 bispecific antibody approved for relapsed/refractory multiple myeloma (RRMM). This is the first real-world study to comprehensively report muco-cutaneous toxicities, infections, and efficacy of talquetamab in 151 patients across five countries with the longest follow-up reported enabling better efficacy and toxicity estimates. The median age was 64 years; high-risk cytogenetics were present in 42%; ECOG ≥ 2 in 22%; 12% had creatinine clearance < 30; and 55% would not have met MonumenTAL-1 eligibility. Patients received a median of 6 prior lines of therapy, 53% wer

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… Institute, Boston, Massachusetts, USA Omar Nadeem, Dana‐Farber Cancer Institute, Boston, Massachusetts, USA Chandramouli Nagarajan, Singapore General Hospital, Singapore, SINGAPORE Ajay Nooka, Winship Cancer Institute of Emory University, Atlanta, Georgia, USA Michael O'Dwyer, National University of IRELAND‐Galway … , Galway, IRELAND Rimke Oostvogel, University Medical Center Utrecht, Utrecht, THE NETHERLANDS Alberto Orfao, University of Salamanca, Salamanca, SPAIN Paula Rodriguez Otero, Clinica Universidad de Navarra, Pamplona, SPAIN Darren Pan, University of California San Francisco, San Francisco, California, …

Quality of life assessment & out-of-pocket expenditure in multiple myeloma: An observational study.

BACKGROUND & OBJECTIVES: Prognosis of patients with multiple myeloma (MM) has improved significantly in the past two decades. However, the symptoms burden is high at onset and treatment is generally prolonged with significant financial burden. This study was undertaken to assess the quality of life (QoL) and to analyse out-of-pocket expenditure (OOPE) incurred on MM patients being treated at a tertiary care cancer centre in north India. METHODS: This observational, cross-sectional study included 116 patients (aged >18 yr) of MM (both newly diagnosed and those with recurrent disease). For QoL

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… A population-based study of Eindhoven Cancer Registry from Southern Netherland reported mean QoL score of 55 21 , while mean score was 63.3 in a patients’ self-reported study from Ireland 19 . … In our study, 63.8 per cent of patients had financial difficulties, higher than that reported from Ireland (42%) 19 . …

Crowdfunding for complementary and alternative medicine: What are cancer patients seeking?

BackgroundComplementary and alternative medicine (CAM) is increasingly being integrated into conventional medical care for cancer, used to counter the side effects of conventional cancer treatment, and offered as an alternative to conventional cancer care. Our aim is to gain a broader understanding of trends in CAM interventions for cancer and crowdfunding campaigns for these interventions.MethodsGoFundMe campaigns fundraising for CAM were retrieved through a database of crowdfunding campaign data. Search terms were drawn from two National Institutes of Health lists of CAM cancer interventions

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… The remaining campaigns identified stage 2 (n = 42, 5.2%) and stage 1 (n = 7, 0.9%) cancer diagnoses (see Table 2 ). 10.1371/journal.pone.0242048.g001 Fig 1 US campaigner locations. 10.1371/journal.pone.0242048.g002 Fig 2 UK and Ireland campaigner locations. 10.1371/journal.pone.0242048.g003 Fig 3 … Campaigner Location | Number of Campaigns | Percentage of Campaigns United States | 1032 | 73.92% Canada | 165 | 11.82% United Kingdom | 107 | 7.66% Australia | 57 | 4.08% Germany | 8 | 0.57 Ireland | 8 | 0.57 Spain | 4 | 0.29 Italy | 2 | 0.14 Japan | 2 | 0.14 Switzerland | 2 | 0.14 Costa Rica | 1 | …

Advancements in extensive-stage small cell lung cancer therapy: from molecular profiling to the advent of precision oncology.

Small cell lung cancer (SCLC) is challenging to manage due to its high malignancy and early metastatic spread. Although initial chemoradiotherapy responses are common, resistance rapidly develops, and long-term efficacy remains limited. Immune checkpoint inhibitors (ICIs) overcome previous survival barriers, extending overall survival (OS) and progression-free survival (PFS) in extensive-stage SCLC. Nevertheless, absolute clinical benefits remain modest. To address efficacy limitations, current research focuses on optimizing first-line strategies by exploring multimodal regimens (e.g., adding

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… Ireland et al. demonstrated that MYC activates Notch signaling to drive a subtype shift in SCLC subtypes from ASCL1 through NEUROD1 to YAP1 states, facilitating dedifferentiation from neuroendocrine (NE) to non-neuroendocrine (non-NE) phenotypes ( 41 ). … JAMA Oncol . ( 2023 ) 9 : 1669–77 . doi: 10.1001/jamaoncol.2023.4025 , PMID: 37824137 PMC10570917 44 Sutherland KD Ireland AS Oliver TG . Killing sclc: insights into how to target a shapeshifting tumor . …

Describing financial toxicity among cancer patients in different income countries: a systematic review and meta-analysis.

BackgroundThere is limited evidence of financial toxicity (FT) among cancer patients from countries of various income levels. Hence, this study aimed to determine the prevalence of objective and subjective FT and their measurements in relation to cancer treatment.MethodsPubMed, Science Direct, Scopus, and CINAHL databases were searched to find studies that examined FT. There was no limit on the design or setting of the study. Random-effects meta-analysis was utilized to obtain the pooled prevalence of objective FT.ResultsOut of 244 identified studies during the initial screening, only 64 studi

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… Inguva et al. 2022 ( 39 ) | USA | All types | 2016–2017 | | 53.7 | Cancer Self-Administered Questionnaire of the Medical Expenditure Panel Survey, including FT Sharp and Timmons, 2016 ( 62 ) | Ireland | Breast, prostate, and lung cancer | 2008 | 698 | 48% reported cancer-related financial hardship, … A cost analysis of a community-based support Centre for cancer patients and their families in Ireland: the EVeCANs study . Support Care Cancer . ( 2021 ) 29 : 619 – 25 . doi: 10.1007/s00520-020-05508-8 , PMID: 32415384 57. Ó Céilleachair A Hanly P Skally M O’Leary E O’Neill C Fitzpatrick P . …

Рекомендации Международной группы по работе с миеломой по диагностике и лечению изолированных плазмоклеточных опухолей.

Одиночные плазмоклеточные опухоли (СП) — редкие локализованные опухоли клоновых плазмоклеток, либо в костной ткани (одиночная костная плазмоклеточная опухоль), либо в мягких тканях/экстраоссозных (экстромедуллярные) с отсутствием или минимальным проникновением в костный мозг (КМ) (<10% клоновых плазмоклеток по иммуногистохимии) и отсутствием признаков системного вовлечения или событий, определяющих миелому. Приблизительно 50% СП прогрессируют в симптоматическую миелому в течение 5 лет после начальной определенной локальной радиотерапии. Увеличение доступности улучшенных диагностических и монит

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… Siobhan Glavey, RCSI University of Medicine and Health Sciences, Dublin 9, Ireland 111. Hartmut Goldschmidt, University Hospital Heidelberg, Heidelberg, Germany 112. Wilson I. Gonsalves, Mayo Clinic, Rochester, MN 113. … Michael O'Dwyer, National University of IRELAND-Galway, Galway, Ireland 254. Peter O'Gorman, Mater Misericordiae University Hospital, Dublin, Ireland 255. Enrique Ocio, Marqués de Valdecilla University Hospital, Santander, Spain 256. …

Is the Scope of Costs Considered in Budget Impact Analyses for Anticancer Drugs Rational? A Systematic Review and Comparative Study.

Background: With the increasing disease burden of cancer worldwide, more and more anticancer drugs have been approved in many countries, and the results of budget impact analyses (BIAs) have become important evidence for related reimbursement decisions. Objectives: We systematically reviewed whether BIAs for anticancer drugs consider the scope of costs rationally and compared the results of different cost scopes to provide suggestions for future analyses and decision-making. Methods: Eligible BIAs published in PubMed, Embase, Web of Science, and the Cochrane Library from 2016 to 2021 were iden

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… These had been published by various organizations and countries including the ISPOR, the National Institute for Health and Clinical Excellence (NICE) in the United Kingdom, Canada, France, Ireland, Australia, the Netherlands, Belgium, Thailand, and Poland ( 16 , 19 – 27 ). … Guidelines for the Budget Impact Analysis of Health Technologies in Ireland. Dublin: Health Information and Quality Authority; (2018). 23. Pharmaceutical Benefts Advisory Committee (PBAC) . Guidelines for Preparing a Submission to the PBAC. Version 4. Draft for Public Consultation. (2006). …

The level of knowledge about palliative care in Iranian patients with cancer.

BackgroundPatient awareness plays an important role in integrating palliative care into the patient care process. Lack of awareness can create a negative attitude towards palliative care and affect patients' decisions during the treatment process. The present study was conducted to determine the level of knowledge about palliative care in Iranian patients with cancer.MethodsThe descriptive study was conducted with a convenience sample of 103 cancer patients admitted to an oncology center in Yazd, Iran, A three-part questionnaire including demographic information, sources of palliative care inf

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… A survey of public opinion in Northern Ireland found that most people see the goal of palliative care as reducing pain, providing comfort and maintaining dignity [ 41 ]. … McIlfatrick S Hasson F McLaughlin D Johnston G Roulston A Rutherford L Public awareness and attitudes toward palliative care in Northern Ireland BMC Palliat Care 2013 12 1 1 7 24044631 10.1186/1472-684X-12-34 PMC3848719 43. …

Applications of bio-enhanced cementitious composites for sustainable building materials: emission-reduction and carbon-sequestration pathways.

Ampligen [polyI:polyC12U] is a mismatched double-stranded RNA that acts by inducing interferon production (immunomodulator) and by activatin … d Bioclones, Bioclones has certain marketing rights for Ampligen in the Southern Hemisphere, UK and Ireland. In the US, Ampligen has been granted orphan drug status for the treatment of AIDS, renal cell carcinoma (phase II, completed), chronic fatigue syndrome (phase III) and invasive/metastatic malignant melanoma (phase II). In August 2004, Hemispherx an …

Вторичные аутоиммунные дерматологические расстройства, вызываемые агентами по биологическому иммунотерапии с множественным склерозом: систематический обзор сообщений о случаях.

ONTEXT: Множественный склероз (MS) является разрушительным аутоиммунным нейродегенеративным заболеванием, в связи с которым лекарственные средства для лечения заболеваний (DMD) ассоциируются с вторичными аутоиммунными дерматологическими расстройствами. ЦЕЛИ: Данный систематический обзор докладов по конкретным делам направлен на изучение документально подтвержденных сообщений о случаях применения биологических препаратов при борьбе с нападениями с применением НР и распространением заболеваний, которые коррелируют с такими дерматологическими осложнениями. ИСТОЧНИКИ: Был проведен систематический

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… These reports originated primarily from Germany, Spain, and Italy, with additional cases from Canada, Greece, Ireland, the UK, Iran, the USA, and Croatia. The included studies are summarized in Table 2 . … No improvement /NM | A 49 year-old man | NM/Germany | RRMS Natalizumab | | | | | | | | Durcan et al., 2019 ( 33 ) | Cutaneous sarcoidosis-like reaction | MS since 2017 | Following 4th dose | Topical steroids | Poorly responsive/after 8 weeks subsided/discontinued | A 41 year-old woman | 2019/Ireland …

Распространение остеопороза в хронических заболеваниях: зонтичный обзор 283 наблюдения, полученные в ходе 13 систематического обзора.

ВВЕДЕНИЕ: Остеопороз - это болезнь, характеризующаяся снижением плотности минералов кости и ухудшением микроархитектуры кости, что повышает риск разрушения. В контексте различных хронических патологий это состояние может привести к еще более высокому уровню заболеваемости, смертности и бремени здравоохранения. ЦЕЛЬ: Обобщать и сопоставлять имеющиеся данные, полученные в ходе систематических обзоров распространения остеопороза среди различных хронических заболеваний. МЕТОДОЛОГИЯ: В соответствии с руководящими принципами ПРИСМА был проведен зонтичный обзор с уделением особого внимания систематич

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… on clinical criteria and laboratory tests Diagnosis based on T and Z scores or ICD-10 codes Moshayedi (2022) 57 227,812 Australia, Iran, Argentina, China, Germany, Tunisia, France, Thailand, Greece, Malaysia, South Korea, Kazakhstan, Romania, Italy, Pakistan, Mexico, India, Sweden, Turkey, Colombia, Ireland … Germany Patients with Type 2 Diabetes Mellitus, mean age not specified Systematic review and meta-analysis Diabetes Mellitus Diagnosis based on clinical criteria and laboratory tests Bone densitometry (DXA), T-score <= -2.5 Chhoda (2023) 21 20,155 United States, India, China, Argentina, United Kingdom, Ireland …