Результаты поиска

The Herba Patriniae (Caprifoliaceae): A review on traditional uses, phytochemistry, pharmacology and quality control.

ETHNOPHARMACOLOGICAL RELEVANCE: Herba Patriniae has been used for thousands of years in China as a traditional Chinese medicine with heat-clearing and detoxicating effects. It is applied widly for the treatment of rheumatoid arthritis, diarrhea, acute hepatitis, pelvic inflammatory disease and ulcerative colitis in clinic. Two species, namely Patrinia scabiosaefolia Fisch. (PS) and Patrinia villosa Juss. (PV) from the Caprifoliaceae family, are considered as Herba Patriniae in the pharmaceutical industry. AIM OF THE REVIEW: This paper aims to comprehensively outline the traditional uses, bota

Каннабиноиды в раке: Молекулярные механизмы смерти клеток и возможности перевода.

Каннабиноиды представляют собой терпенофенолические соединения, полученные из Cannabis sativa L., которые осуществляют широкий спектр биологической и фармакологической деятельности. Растущие данные свидетельствуют об их потенциале как модуляторов развития рака, особенно посредством подавления роста клеток опухоли, ангиогенеза и метастаза в различных моделях опухоли. В настоящем обзоре содержится всеобъемлющий обзор молекулярных механизмов, с помощью которых природные и синтетические каннабиноиды вызывают регулируемую смерть раковых клеток. Текущие данные свидетельствуют о том, что каннабиноиды

Совпадение в полном тексте источника
… The metabolic enzymes consist of fatty acid amide hydrolase and monoacylglycerol lipase [ 11 , 12 , 13 , 14 ]. CB1 and CB2 receptors are the primary mediators of cannabinoid-induced biological effects. …

Artificial Intelligence and Machine Learning Technology Driven Modern Drug Discovery and Development.

The discovery and advances of medicines may be considered as the ultimate relevant translational science effort that adds to human invulnerability and happiness. But advancing a fresh medication is a quite convoluted, costly, and protracted operation, normally costing USD ~2.6 billion and consuming a mean time span of 12 years. Methods to cut back expenditure and hasten new drug discovery have prompted an arduous and compelling brainstorming exercise in the pharmaceutical industry. The engagement of Artificial Intelligence (AI), including the deep-learning (DL) component in particular, has bee

The IL-17 family in diseases: from bench to bedside.

The interleukin-17 (IL-17) family comprises six members (IL-17A-17F), and recently, all of its related receptors have been discovered. IL-17 was first discovered approximately 30 years ago. Members of this family have various biological functions, including driving an inflammatory cascade during infections and autoimmune diseases, as well as boosting protective immunity against various pathogens. IL-17 is a highly versatile proinflammatory cytokine necessary for vital processes including host immune defenses, tissue repair, inflammatory disease pathogenesis, and cancer progression. However, ho

Совпадение в полном тексте источника
… C. albicans secretes Lip2 lipase, which promotes invasive disease by suppressing the lipid-mediated IL-17 response. 114 Bacterial infections IL-17 has complex roles in bacterial infections. …

Metabolic reprogramming in cancer and senescence.

The rising trend in global cancer incidence has caused widespread concern, one of the main reasons being the aging of the global population. Statistical data show that cancer incidence and mortality rates show a clear upward trend with age. Although there is a commonality between dysregulated nutrient sensing, which is one of the main features of aging, and metabolic reprogramming of tumor cells, the specific regulatory relationship is not clear. This manuscript intends to comprehensively analyze the relationship between senescence and tumor metabolic reprogramming; as well as reveal the impac

Совпадение в полном тексте источника
… related to lipid metabolism, which increases the synthesis of lipids in the tumor cells to meet the metabolic needs of the tumor cells for abnormal proliferation. 126 NF‐κB signaling pathway: Activation of NF‐kB signaling pathway inhibits triglyceride catabolism by inhibiting the genes of triglyceride lipase …

Clinical Posters From JADPRO Live 2024

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… The average initial PERT dose prescribed to patients was 44,700 units lipase with meals. Weight loss from baseline (time of diagnosis) to 3, 6, and 9 months was 5.30%, 6.28%, and 8.97%, respectively. …

Targeting FGFR for cancer therapy.

The FGFR signaling pathway is integral to cellular activities, including proliferation, differentiation, and survival. Dysregulation of this pathway is implicated in numerous human cancers, positioning FGFR as a prominent therapeutic target. Here, we conduct a comprehensive review of the function, signaling pathways and abnormal alterations of FGFR, as well as its role in tumorigenesis and development. Additionally, we provide an in-depth analysis of pivotal phase 2 and 3 clinical trials evaluating the performance and safety of FGFR inhibitors in oncology, thereby shedding light on the current

Совпадение в полном тексте источника
… Everolimus | VEGFR, FGFR, PDGFR, mTOR | No previous systemic therapy | NCT02811861 | III | Advanced RCC | PFS: 14.7 months (Lenvatinib + Everolimus) versus 9.2 months (Sunitinib) HR for disease progression or death: 0.65 HR for death: 1.15 | Grade 3–4 TRAEs > 10% of patients: Hypertension Diarrhea Elevated lipase …

Role of Bruton's tyrosine kinase in B cells and malignancies.

Bruton's tyrosine kinase (BTK) is a non-receptor kinase that plays a crucial role in oncogenic signaling that is critical for proliferation and survival of leukemic cells in many B cell malignancies. BTK was initially shown to be defective in the primary immunodeficiency X-linked agammaglobulinemia (XLA) and is essential both for B cell development and function of mature B cells. Shortly after its discovery, BTK was placed in the signal transduction pathway downstream of the B cell antigen receptor (BCR). More recently, small-molecule inhibitors of this kinase have shown excellent anti-tumor a

Совпадение в полном тексте источника
… Fully activated BTK phosphorylates PLCγ2 at Y753 and Y759, which is important for its lipase activity [ 51 ]. Activated PLCγ2 hydrolyses PIP2 into inositol triphosphate (IP3) and diacylglycerol (DAG). …

Impact of physical exercise in cancer survivors during and after antineoplastic treatments.

Cancer patients experience symptoms and adverse effects of treatments that may last even after the end of treatments. Exercise is a safe, non-pharmacological and cost-effective therapy that can provide several health benefits in cancer patient and survivors, reducing cancer symptoms and cancer treatment side effects. The purpose of this review is to describe how the physical exercise is capable to reduce cancer symptoms and cancer treatment side effects. We realized a pragmatic classification of symptoms, dividing them into physical, psychological and psycho-physical aspects. For each symptom

Совпадение в полном тексте источника
… Concerning the lipid metabolism, interleukin-1 (IL-1) and IFN-γ have been related to stimulation of lipolysis and TNF-α is a potent inhibitor of lipogenesis, since it decreases lipoprotein lipase (LPL) activity and reduces the synthesis of transcription factor essential for the adipocyte differentiation …

Metabolic Cooperation and Competition in the Tumor Microenvironment: Implications for Therapy.

The tumor microenvironment (TME) is an ensemble of non-tumor cells comprising fibroblasts, cells of the immune system, and endothelial cells, besides various soluble secretory factors from all cellular components (including tumor cells). The TME forms a pro-tumorigenic cocoon around the tumor cells where reprogramming of the metabolism occurs in tumor and non-tumor cells that underlies the nature of interactions as well as competitions ensuring steady supply of nutrients and anapleoretic molecules for the tumor cells that fuels its growth even under hypoxic conditions. This metabolic reprogram

Совпадение в полном тексте источника
… CAAs thus supply energy to cancer cells through fatty acids as cancer cells induce metabolic alterations in the CAAs like increased activity of hormone-sensitive lipases that results in increased production of fatty acids from CAAs, which is then used by cancer cells ( 120 ). …

33rd Annual Meeting & Pre-Conference Programs of the Society for Immunotherapy of Cancer (SITC 2018) : Washington, D.C., USA. 7-11 November 2018.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Oxidative Stress: Signaling Pathways, Biological Functions, and Disease.

The dysregulated accumulation of reactive oxygen species (ROS) and reactive nitrogen species disrupts redox homeostasis, triggering oxidative stress (OS) and driving pathophysiological changes across multiple organ systems. OS modulates critical signaling pathways, induces inflammation, impairs mitochondrial function, alters metabolic homeostasis, and dysregulates autophagy, contributing to disease progression. While prior research has largely focused on OS within single-organ diseases (e.g., neurodegenerative, cardiovascular, and oncological disorders), the systemic role of OS in pan-organ di

Резюме докладов 2017 Ежегодное совещание Общества общей внутренней медицины.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

The sirtuin family in health and disease.

Sirtuins (SIRTs) are nicotine adenine dinucleotide(+)-dependent histone deacetylases regulating critical signaling pathways in prokaryotes and eukaryotes, and are involved in numerous biological processes. Currently, seven mammalian homologs of yeast Sir2 named SIRT1 to SIRT7 have been identified. Increasing evidence has suggested the vital roles of seven members of the SIRT family in health and disease conditions. Notably, this protein family plays a variety of important roles in cellular biology such as inflammation, metabolism, oxidative stress, and apoptosis, etc., thus, it is considered a

Совпадение в полном тексте источника
… ACE2 angiotensin-converting enzyme 2, ATGL adipose triglyceride lipase, Bnip3 BCL2 interacting protein 3, CERKL ceramide kinase-like protein; circ, circular RNA; CUL4B, cullin 4B, eEF2 eukaryotic elongation factor-2, eEF2K eukaryotic elongation factor-2 kinase, EGFR epidermal growth factor receptor, … ACE2 angiotensin-converting enzyme 2, ATGL adipose triglyceride lipase, Bnip3 BCL2 interacting protein 3, CERKL ceramide kinase-like protein; circ, circular RNA; CUL4B, cullin 4B, eEF2 eukaryotic elongation factor-2, eEF2K eukaryotic elongation factor-2 kinase, EGFR epidermal growth factor receptor, …

Nanomaterials in gene therapy and genome editing: challenges and emerging directions.

Nanomaterials are redefining the landscape of gene and genome editing, yet their translation to clinical reality remains constrained by multiple unresolved challenges. While they provide structural and functional advantages for delivering nucleic acids and CRISPR/Cas systems across biological barriers, their behavior within living systems is often unpredictable, leading to issues such as off-target editing, immune activation, and inconsistent biodistribution. The design of nanocarriers, whether lipid-based, polymeric, inorganic, must therefore balance efficiency with safety, integrating physic

Совпадение в полном тексте источника
… Similarly, Glybera (alipogene tiparvovec; NCT00803319) utilized an adeno-associated viral vector (AAV) to deliver lipoprotein lipase (LPL), becoming the first gene therapy approved in Europe for LPL deficiency. …

Novel agents and regimens for hematological malignancies: recent updates from 2020 ASH annual meeting.

Antibodies and chimeric antigen receptor-engineered T cells (CAR-T) are increasingly used for cancer immunotherapy. Small molecule inhibitors targeting cellular oncoproteins and enzymes such as BCR-ABL, JAK2, Bruton tyrosine kinase, FLT3, BCL-2, IDH1, IDH2, are biomarker-driven chemotherapy-free agents approved for several major hematological malignancies. LOXO-305, asciminib, "off-the-shelf" universal CAR-T cells and BCMA-directed immunotherapeutics as well as data from clinical trials on many novel agents and regimens were updated at the 2020 American Society of Hematology (ASH) Annual Meeti

Совпадение в полном тексте источника
… Dose-limiting toxicities included asymptomatic elevations in the lipase level and clinical pancreatitis [ 102 ]. At ASH 2020, Dr. Cortes presented the updated efficacy and safety results in patients with T315I mutation. A total of 52 patients with T315I mutation received asciminib 200 mg BID. …

Chronic Lymphocytic Leukemia: 2025 Update on the Epidemiology, Pathogenesis, Diagnosis, and Therapy.

Disease overviewChronic lymphocytic leukemia (CLL) is the most frequent type of leukemia. It typically occurs in older patients and has a highly variable clinical course. Leukemic transformation is initiated by specific genomic alterations that interfere with the regulation of proliferation and apoptosis in clonal B-cells.DiagnosisThe diagnosis is established by blood counts, blood smears, and immunophenotyping of circulating B-lymphocytes, which identify a clonal B-cell population carrying the CD5 antigen as well as typical B-cell markers.Prognosis and stagingTwo clinical staging systems, Rai

Совпадение в полном тексте источника
… Treatment‐emergent AEs were reported by 88.5% of pts., the most common being contusion, pyrexia, neutropenia, and lipase increases. No hypertension or atrial fibrillation was observed. Of 18 response‐evaluable pts., 12 (67%) responded, with responses starting at the lowest dose level [ 155 ]. …

Should oncologists trust cannabinoids?

Cannabis enjoyed a "golden age" as a medicinal product in the late 19th, early 20th century, but the increased risk of overdose and abuse led to its criminalization. However, the 21st century have witnessed a resurgence of interest and a large body of literature regarding the benefits of cannabinoids have emerged. As legalization and decriminalization have spread around the world, cancer patients are increasingly interested in the potential utility of cannabinoids. Although eager to discuss cannabis use with their oncologist, patients often find them to be reluctant, mainly because clinicians

Совпадение в полном тексте источника
… More recently, MJN110 (a monoacylglycerol lipase inhibitor) administration alleviated cancer-induced bone pain in an animal model, most likely by increasing the endogenous cannabinoid concentration ( Thompson et al., 2020 ). …

"Smart" drug delivery: A window to future of translational medicine.

Chemotherapy is the mainstay of cancer treatment today. Chemotherapeutic drugs are non-selective and can harm both cancer and healthy cells, causing a variety of adverse effects such as lack of specificity, cytotoxicity, short half-life, poor solubility, multidrug resistance, and acquiring cancer stem-like characteristics. There is a paradigm shift in drug delivery systems (DDS) with the advent of smarter ways of targeted cancer treatment. Smart Drug Delivery Systems (SDDSs) are stimuli responsive and can be modified in chemical structure in response to light, pH, redox, magnetic fields, and e

Совпадение в полном тексте источника
… Many enzymes have been put to work to enhance medication transport to cancer cells, including lipase, protease, trypsin, glycosidase, phospholipase, oxidoreductase, and others ( De La Rica et al., 2012 ). …

Clinical epigenetics settings for cancer and cardiovascular diseases: real-life applications of network medicine at the bedside.

Despite impressive efforts invested in epigenetic research in the last 50 years, clinical applications are still lacking. Only a few university hospital centers currently use epigenetic biomarkers at the bedside. Moreover, the overall concept of precision medicine is not widely recognized in routine medical practice and the reductionist approach remains predominant in treating patients affected by major diseases such as cancer and cardiovascular diseases. By its' very nature, epigenetics is integrative of genetic networks. The study of epigenetic biomarkers has led to the identification of num