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Patient perspectives on BCMA-targeted therapies for multiple myeloma: a survey conducted in a patient advocacy group.

BackgroundAdvances in multiple myeloma (MM) treatment have shifted the therapeutic landscape. Understanding patients' perspectives can assist physicians in helping patients make informed decisions. This study aimed to understand the patient decision-making process and gain insights into patient perspectives on B-cell maturation antigen (BCMA)-targeted therapies for MM.MethodsAn 18-question survey was completed by patients with MM enrolled in HealthTree® Cure Hub, an online portal helping patients with plasma cell dyscrasias navigate their disease.ResultsFrom October 28, 2022, to January 12, 20

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… Other individuals who were reported by respondents as being involved included myeloma specialists (64%), primary and consulting oncologists (60% and 15%, respectively), caregivers, other family members or friends (39%), as well as other healthcare professionals (nurses, 3%; primary care doctors, 3%; … Most participants of the survey reported that they were highly involved in their treatment decision-making, along with their oncologists/hematologists, caregivers, and other family members or friends. …

The impact of chemotherapy-induced inner ear damage on quality of life in cancer survivors: a qualitative study.

PurposeThis study aimed to explore the burden of inner ear damage (ototoxicity) on adults living with and beyond cancer treated with chemotherapy and the impact on their quality of life (QoL). Furthermore, this study aimed to explore patient awareness surrounding chemotherapy-induced inner ear damage, known as ototoxicity, and assess what support they had been offered.MethodsParticipants were adults who had undergone chemotherapy, recruited from cancer clinics, charities and social media. Using semi-structured interviews and fieldnotes, an inductive thematic analysis was used to develop key th

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… Ototoxicity Related Quality of Life | 1.1 Audiological Assessment | No, no I didn’t have any [hearing] baseline, but for other things I did” (P19) 1.2 Clinical Experience | “She [oncologist] talked me through everything, and everything was clear and weighted.” … This study found that those who felt supported by their oncologists spoke less fearfully about their ototoxic symptoms. …

A Focus on CAR T-Cell Therapy and Bispecific Antibodies in Multiple Myeloma.

Significant strides have been made in the management of patients living with myeloma. However, patients with multiply relapsed or refractory multiple myeloma (MM) have a shorter overall survival; therefore, new treatments with novel mechanisms of action are needed in this patient population. Patients with relapsing disease require a full restaging workup, including whole body imaging to evaluate for extramedullary disease and lytic bone lesions, as well as bone marrow biopsy with fluorescence in situ hybridization to determine if the patient has any new chromosomal changes that are present. Th

Patient Perceived Financial Burden in Haematological Malignancies: A Systematic Review.

UNLABELLED: Advances in scientific understanding have led to novel therapies and improved supportive care for many patients with haematological malignancies. However, these new drugs are often costly, only available at centralised health care facilities, require regular specialist reviews and lengthy treatment regimens. This leads to a significant financial burden. Understanding the impact of financial burden on haematological patients is important to appreciate the urgency of alleviating this systemic issue. METHOD: Eligible studies were identified by systematically searching Medline, PsycIN

A recommended practical approach to the management of target therapy and angiogenesis inhibitors cardiotoxicity: an opinion paper of the working group on drug cardiotoxicity and cardioprotection, Italian Society of Cardiology.

The US National Cancer Institute estimates that cardiotoxicity (CTX) from target therapy refers mostly to four groups of drugs: epidermal growth factor receptor 2 inhibitors, angiogenic inhibitors, directed Abelson murine leukemia viral oncogene homolog inhibitors, and proteasome inhibitors. The main cardiotoxic side-effects related to antiepidermal growth factor receptor 2 therapy are left ventricular systolic dysfunction and heart failure. Angiogenesis inhibitors are associated with hypertension, left ventricular dysfunction/heart failure, myocardial ischemia, QT prolongation, and thrombosis

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… Cardiac evaluations of patients at particular risk for CTX should be carried out in conjunction with the oncologist, so that the choice of therapy may be optimized. … Eur J Heart Fail 2013 ; 15 : 482 – 489 . 23325019 10.1093/eurjhf/hft008 40 Ederhy S Izzedine H Massard C Cardiac side effects of molecular targeted therapies: towards a better dialogue between oncologists and cardiologists . …

Baseline Characteristics of Participants in the Alberta Cancer Exercise Hybrid Effectiveness-Implementation Study: A Wake-Up Call for Action.

Background: Alberta Cancer Exercise (ACE) is a hybrid effectiveness-implementation study evaluating a cancer-specific community-based exercise program across urban sites in Alberta, Canada. The purpose of this paper is to describe the baseline characteristics of participants. Methods: Adults with any type and stage of cancer, who were undergoing cancer treatment or up to three years post treatment completion, were eligible. ACE was delivered in person at 18 sites across 7 cities in Alberta, with video conferencing introduced during the COVID-19 pandemic. Participants took part in 60 min of mil

Financial toxicity following surgical treatment for colorectal cancer: a cross-sectional study.

PurposeFinancial toxicity has become a global public health issue. The purpose of the study is to investigate and analyze the influencing factors of financial toxicity in patients with non-metastatic colorectal cancer.MethodsA convenient sample of 250 patients with stage I-III colorectal cancer was investigated in the study. They completed a set of questionnaires, including the Comprehensive Score for Financial Toxicity questionnaire, the Perceived Social Support Scale, and the Hospital Anxiety and Depression Scale. Univariate and multivariate linear regression were performed to investigate th

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… At the same time, it is recommended to increase the communication between oncologists and patients and nurses and patients. Discussion of medical costs is an integral part of high-quality life. … It is essential to strengthen the clinical discussion of costs by popularizing cost-related health literacy among cancer survivors and oncologists. Acknowledgements We thank the participants of the present study for their time and dedication. …

Cancer treatment-related financial toxicity in Japan: a scoping review.

Financial toxicity during cancer survival has been studied mainly in the United States; 47-49% of cancer survivors reported financial hardships and 12-63% reported debt owing to treatment costs. Financial toxicity is influenced by each country's economic status and healthcare system. We aimed to review the evidence on financial toxicity in Japan. A systematic search was performed using PubMed and Ichushi databases. We included English or Japanese peer-reviewed articles that (1) explored the experiences of cancer patients facing financial toxicity due to cancer diagnosis and treatment, (2) were

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… Regarding the influence of medical expenses on treatment decisions by oncologists, 86% considered potential expenses. … Of the 172 experienced Japanese oncologists, 86% considered potential medical expenses when deciding treatment options, and 88% believed that the patients considered potential expenses when deciding their treatment ( Takura et al., 2016 ). …

Refractory Hyperammonemic Encephalopathy as a Paraneoplastic Presentation of Fibrolamellar Hepatocellular Carcinoma: A Case Report.

BACKGROUND Fibrolamellar hepatocellular carcinoma (FLHCC) is a rare liver malignancy affecting adolescents and young adults without underlying liver disease. Hyperammonemic encephalopathy (HAE) is an uncommon but severe complication in advanced FLHCC, resulting from progressive hepatic dysfunction or tumor-related metabolic derangements. Early recognition is essential to prevent neurologic decline and improve outcomes. CASE REPORT A 24-year-old man with metastatic FLHCC presented with worsening confusion for 1 month. His prior treatments included transarterial radioembolization, multiple resec

Management of Multiple Myeloma and Usage of Bortezomib: Perspective from India and Ukraine.

Novel treatment strategies have remarkably improved the multiple myeloma (MM) patients' survival, with associated increased costs. A joint panel meet of international experts from India and Ukraine was held in New Delhi on May 19, 2016 focusing on MM management, bortezomib role, unmet medical needs, and current challenges. The health-care system for oncology in India is majorly private vs. government-based in Ukraine. In India, electrophoresis, serum-free light chain assays, bone marrow tests, and X-rays are available modes of diagnosis. Despite of the numerous cancer centers and stem cell tra

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… Quality cancer care systems should be implemented with more defined networking amongst the health-care providers, medical oncologists, hematologists, surgeons, etc. and strong decision-support strategies. … More transplant or transfusion centers need to be established, and a larger number of oncologists and surgeons are required to be added to the current pool. …

A Case Report on Solitary Extramedullary Plasmacytoma of the Pleura.

Solitary plasmacytoma is an extremely rare form of plasma cell malignancy that presents as a single mass of monoclonal plasma cells located either intraosseous or extramedullary (extraosseous). Extramedullary plasmacytoma can affect any part of the body, but the most common sites of origin are the head and neck region. The involvement of pleura is very rare. Here, we are enlightening this rare presentation and making readers aware of the clinical presentation and management of this rare malignancy.

Mechanical suppression of osteolytic bone metastases in advanced breast cancer patients: a randomised controlled study protocol evaluating safety, feasibility and preliminary efficacy of exercise as a targeted medicine.

BACKGROUND: Skeletal metastases present a major challenge for clinicians, representing an advanced and typically incurable stage of cancer. Bone is also the most common location for metastatic breast carcinoma, with skeletal lesions identified in over 80% of patients with advanced breast cancer. Preclinical models have demonstrated the ability of mechanical stimulation to suppress tumour formation and promote skeletal preservation at bone sites with osteolytic lesions, generating modulatory interference of tumour-driven bone remodelling. Preclinical studies have also demonstrated anti-cancer e

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… Recruitment Patients will be recruited by invitation of their cancer specialist (surgeon, radiation oncologist or medical oncologist) who will provide clinically eligible patients with a study information sheet and refer these patients to an independent study coordinator. … The research team of this study protocol includes a surgical oncologist (CS), radiation oncologists (NAS, RC) and medical oncologists (KTF, DT, HM, TC, ADR) who work with the target population on a daily basis, from which patient priorities, experiences and preferences gleaned from this engagement helped …

Meaningful changes in end-of-life care among patients with myeloma.

Patients with advanced myeloma experience a high symptom burden particularly near the end of life, making timely hospice use crucial. Little is known about the quality and determinants of end-of-life care for this population, including whether potential increases in hospice use are also accompanied by "late" enrollment (≤ 3 days before death). Using the Surveillance, Epidemiology, and End-Results-Medicare database, we identified patients ≥ 65 years diagnosed with myeloma between 2000 and 2013 who died by December 31, 2013. We assessed prevalence and trends in hospice use, including late enroll

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… Finally, while each indicator of medically aggressive care near the EOL was equally weighted in our analysis as in previous studies, 16 , 19 , 39 various stakeholders (patients, hematologic oncologists, policy makers) may assign different levels of importance to each of the indicators. … Odejide OO Salas Coronado DY Watts CD Wright AA Abel GA End-of-life care for blood cancers: a series of focus groups with hematologic oncologists . J Oncol Pract . 2014 ; 10 ( 6 ): e396 – 403 . 25294393 10.1200/JOP.2014.001537 PMC5706135 37. …

Bibliometric and visualization analyses of cancer-related fatigue research published worldwide from 2001 to 2023.

ObjectiveCancer seriously endangers human health and represents a global public health issue. Cancer-related fatigue (CRF) is a distressing and persistent sense of exhaustion caused by cancer or cancer treatment, widely prevalent among cancer patients. This study aims to summarize emerging trends and provide directions for future research of CRF through bibliometric and visualization analyses.MethodsA systematic search in the Web of Science Core Collection database from 2001-01-01 to 2023-05-18 were conducted. Only reviews and articles written in English were considered. CiteSpace and the R we

Differences between physician and patient preferences for cancer treatments: a systematic review.

BackgroundShared decision-making is useful to facilitate cancer treatment decisions. However, it is difficult to make treatment decisions when physician and patient preferences are different. This review aimed to summarize and compare the preferences for cancer treatments between physicians and patients.MethodsA systematic literature search was conducted on PubMed, Embase, PsycINFO, CINAHL and Scopus. Studies elicited and compared preferences for cancer treatments between physicians and patients were included. Information about the study design and preference measuring attributes or questions

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… Ivanova J Patient and oncologist preferences for the treatment of adults with Advanced Soft tissue sarcoma: a Discrete Choice Experiment Patient 2019 12 4 393 404 10.1007/s40271-019-00355-0 30659513 22. … Fernández O Preferences for renal cell carcinoma pharmacological treatment: a Discrete Choice experiment in patients and oncologists Front Oncol 2021 11 773366 10.3389/fonc.2021.773366 35070976 PMC8777125 30. …

Preventive strategies for acute kidney injury in cancer patients.

Acute kidney injury (AKI) is a common complication of cancer that occurs in up to 50% of neoplastic patients during the natural history of their disease; furthermore, it has a huge impact on key outcomes such as overall prognosis, length of hospitalization and costs. AKI in cancer patients has different causes, either patient-, tumour- or treatment-related. Patient-related risk factors for AKI are the same as in the general population, whereas tumour-related risk factors are represented by compression, obstruction, direct kidney infiltration from the tumour as well by precipitation, aggregatio

Venous Thromboembolism in Cancer Patients on Simultaneous and Palliative Care.

Simultaneous care represents the ideal integration between early supportive and palliative care in cancer patients under active antineoplastic treatment. Cancer patients require a composite clinical, social and psychological management that can be effective only if care continuity from hospital to home is guaranteed and if such a care takes place early in the course of the disease, combining standard oncology care and palliative care. In these settings, venous thromboembolism (VTE) represents a difficult medical challenge, for the requirement of acute treatments and for the strong impact on an

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… In a factorial survey conducted in Canada among 62 medical oncologists (MOs) and 73 palliative care physicians (PCPs), MOs were twice more likely to prescribe anti-coagulants in specific VTE risk conditions (OR: 2.09, p < 0.001) [ 105 ]. … Information regarding prognostic VTE-related factors and predictors would assist oncologists in predicting the occurrence of VTE and in determining active cancer treatment as well as anticoagulant therapy in clinical practice. …

Nephrotoxicity in cancer treatment: An overview.

Anticancer drug nephrotoxicity is an important and increasing adverse drug event that limits the efficacy of cancer treatment. The kidney is an important elimination pathway for many antineoplastic drugs and their metabolites, which occurs by glomerular filtration and tubular secretion. Chemotherapeutic agents, both conventional cytotoxic agents and molecularly targeted agents, can affect any segment of the nephron including its microvasculature, leading to many clinical manifestations such as proteinuria, hypertension, electrolyte disturbances, glomerulopathy, acute and chronic interstitial n

The Role of Prognostic Scoring Systems in Assessing Surgical Candidacy for Patients With Vertebral Metastasis: A Narrative Review.

Study designNarrative review.ObjectivesTo review the relevant literature regarding scoring systems for vertebral metastases and quantify the … l Instability Neoplastic Score shows good reliability for predicting instability among surgeons and oncologists.ConclusionsThe increased understanding of cancer pathology and subsequent development of customized treatments has led to prolonged survival. For patients with vertebral metastases, this affects surgical candidacy not only on the basis of prognosis …

Treatment and Prevention of Bone Metastases from Breast Cancer: A Comprehensive Review of Evidence for Clinical Practice.

Bone is the most common site of metastasis from breast cancer. Bone metastases from breast cancer are associated with skeletal-related events (SREs) including pathological fractures, spinal cord compression, surgery and radiotherapy to bone, as well as bone pain and hypercalcemia, leading to impaired mobility and reduced quality of life. Greater understanding of the pathophysiology of bone metastases has led to the discovery and clinical utility of bone-targeted agents such as bisphosphonates and the receptor activator of nuclear factor kappa-B ligand (RANK-L) antibody, denosumab. Both are now

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… Integration of Local and Systemic Therapy The optimal treatment of bone metastases from breast cancer involves the integration of local, systemic anti-cancer therapy, bone-targeted agents and supportive care through a multidisciplinary team of surgeons, radiation oncologists, medical oncologists, palliative … A multidisciplinary team approach with experienced surgeons, radiation oncologists, medical oncologists, palliative care physicians, cancer nurses and coordinators is often necessary. …