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Phytochemicals in Cancer Treatment and Cancer Prevention-Review on Epidemiological Data and Clinical Trials.

Phytochemicals are a non-nutritive substances that are present in plants and contribute significantly to their flavor and color. These biologically active compounds are classified into five major groups, namely phenolics, carotenoids, organosulfur compounds, nitrogen-containing compounds, and alkaloids, and are known for their potential health benefits in the prevention of various diseases, including cancer. The purpose of this review article is to explore the potential therapeutic benefits of the dietary phytochemicals, such as flavonoids, phenolic acids, phytosterols, carotenoids, and stilbe

Citizen participation in patient prioritization policy decisions: an empirical and experimental study on patients' characteristics.

Health systems worldwide are grappling with the need to control costs to maintain system viability. With the combination of worsening economic conditions, an aging population and reductions in tax revenues, the pressures to make structural changes are expected to continue growing. Common cost control mechanisms, e.g. curtailment of patient access and treatment prioritization, are likely to be adversely viewed by citizens. It seems therefore wise to include them in the decision making processes that lead up to policy changes. In the context of a multilevel iterative mixed-method design a quanti

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… Lifestyle The lifestyle measure we employ is based on 1) smoking habits (non-smokers vs. smokers); 2) alcohol consumption habits (none/little, moderate, heavy); 3) weight and height of participants, converted to the Body Mass Index (BMI) (underweight (BMI<18.5), normal weight (18.5≤BMI<25), overweight … Lifestyle The lifestyle distribution measured in term of smoking habits, alcohol consumption, BMI, and exercise, is as follows: 29.8% of the sample are smokers and 71.2% non-smokers; 48.9% of the sample reported none/little, 49.2% moderate and 1.9% heavy alcohol consumption. …

Adjuvant A-PRF Application in Patients with Various Stages of Medication-Related Osteonecrosis of the Jaw (MRONJ): Case Series.

Background and Clinical Significance: Medication-related osteonecrosis of the jaw (MRONJ) is a severe complication of antiresorptive therapies such as Zolendronic acid, used for bone metastases. Its management remains challenging, with outcomes often unpredictable. Platelet-rich fibrin (PRF), rich in growth factors, has been proposed as a potential adjunct to surgical treatment, aiming to promote tissue regeneration and improve patient outcomes. Case Presentation: We reported three clinical cases of MRONJ in patients previously treated with Zolendronic acid. All patients underwent surgical seq

CRISPR application in hematological disorders: from bench to bedside.

AbstractClustered regularly interspaced short palindromic repeats (CRISPR)-associated protein genome editing has advanced from an experimental tool to a clinically validated therapeutic platform in hematology. Landmark successes in inherited blood diseases, including sickle cell disease, β-thalassemia, and severe combined immunodeficiency, have demonstrated that precise and durable genetic modifications can be safely and effectively implemented in human hematopoietic cells, positioning hematology at the forefront of translational genome editing. Beyond monogenic disease, CRISPR-based approache

Patients' quality of life improves after surgical intervention of stage III medication-related osteonecrosis of the jaw.

PURPOSE: The treatment of advanced stages of medication-related osteonecrosis of the jaw (MRONJ) remains challenging. In order to improve decision making concerning the therapy, we examined the change of patients' quality of life (QoL) after surgical treatment of MRONJ stage III. METHOD: The primary outcome variable was patients' QoL. It was preoperative (T0), 6 weeks postoperative (T1) and 6 months postoperative (T2) assessed by the European Organisation for Research and Treatment of Cancer QoL-H&N35 (EORTC QoL-H&N35) and the Oral Health Impact Factor-G14 (OHIP-G14) questionnaire in a prospe

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… Smokers showed a significant higher risk of developing a relapse that lasts longer than 6 months compared with non-smokers ( p = .05). The location of the MRONJ did not show a significant impact on the risk of developing a relapse (T1 p = .624; T2 p = .652). …

Periodontal inflamed surface area in oral cavity associated with febrile neutropenia in patients with hematologic malignancy undergoing chemotherapy.

Febrile neutropenia (FN) is an infectious complication that develops during chemotherapy. Although the oral cavity can be an important infection route, it is unknown whether the oral environment is associated with FN. The present study examined the relationship between the oral environment using periodontal inflamed surface area (PISA), a new periodontal disease parameter, and FN in hematologic cancer patients undergoing chemotherapy. In this retrospective cohort study, 157 patients were divided into FN onset during chemotherapy (n = 75) and the FN negative groups (n = 82). The associations of

Злоумышленные преобразования у пациентов с моноклонной гаммопатией неизвестного значения, обработанных терипаротидом для остеопороза: ретроспективное исследование двухцентра и анализ французской национальной базы данных о фармакологической бдительности.

UNLABELLED: Была проведена оценка злокачественных трансформаций у пациентов с моноклональной гаммопатией неопределенного значения, обработанных терипаратидом. Среди 29 только пациенты two Перешел к гематологическому искусству.one Множественная миелома, one Макроглобулинемия Уолденстрёма). Эти выводы обнадеживают и свидетельствуют о том, что ТПТ может оставаться одним из вариантов для отдельных пациентов с тяжелым остеопорозом и MGUS. ЦЕЛЬ: Остеопороз является широко распространенным заболеванием костей с ограниченными терапевтическими возможностями, особенно у пациентов, страдающих множественн

Реальное наблюдение в мире усталости в множестве склерозов, сравнивая эгоистическую когнитивную поведенческую терапию с психообразованием.

Усталость является распространенным симптомом у людей с множественным склерозом (pwMS), имеющим серьезные последствия. Самоуправляемое, основанное на Интернете вмешательство в целях сокращения усталости в MS, основанное на когнитивной поведенческой терапии (CBT), было одобрено в качестве цифрового прикладного программного обеспечения в области здравоохранения (DIGA) в системе здравоохранения Германии. Однако реальных данных об эффективности не хватает. МЕТОДЫ: 165 - пациентов, прошедших проверку на усталость с использованием шкалы утомления моторных и когнитивных функций (FSMC), 129 у них диаг

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… Higher FSMCt was also observed in smokers compared with non-smokers (77.0 [63.2–85.0] versus 70.0 [54.5–81.0]; p = 0.039) and in patients who were retired or retired early compared with full-time employed individuals (employed full time: 70.0 [52.25–79.0], retired: 91.5 [77.5–98.75], p = 0.02; in early …

Bridging the Gap: Pregnancy-And Lactation-Associated Osteoporosis.

Early diagnosis of pregnancy- and lactation-associated osteoporosis (PLO) is mandatory for a good outcome. Standard care is not a matter of conventional guidelines, rather it requires an individualized strategy while true overall incidence and pathogeny remain open issues. This is a narrative review based on full-length English articles, published between January 2021 and March 2023 and accessed via PubMed (no traumatic fractures or secondary osteoporosis are included). Our case-sample-based analysis included 836 females with PLO (the largest cohort based on published cases so far) through 12

Financial Toxicity in Patients With Breast Cancer Treated at Private Medicine Institutions in Brazil.

Financial toxicity (FT) refers to the negative impact of the financial burden of cancer diagnosis and treatment on patients' well-being. With rising global costs of oncologic therapies, diagnostics, and supportive care, FT has become a key concern in cancer care, influencing adherence, quality of life, and outcomes. Breast cancer, given its high prevalence and socioeconomic implications, is notably associated with FT. Beyond direct medical expenses, patients often face income loss and out-of-pocket costs for supportive care, which can significantly affect their therapeutic trajectory. Addressi

Cancer status in the Occupied Palestinian Territories: types; incidence; mortality; sex, age, and geography distribution; and possible causes.

Cancer is a disease in which some cells of the body grow uncontrollably and occasionally spread to other parts of the body. With a group of more than 100 different types, cancer can start almost anywhere in the body. Defective cells may form a mass called a tumor which can be cancerous (malignant), which grows and spreads to other parts of the body, or benign that can grow but not spread throughout the body. In 2021, more than 10 million people died of cancer worldwide (1 out of 6 deaths). This paper has thoroughly investigated the cancer status in the Occupied Palestinian Territories (OPT), i

Risk and Outcome of Breakthrough COVID-19 Infections in Vaccinated Patients With Cancer: Real-World Evidence From the National COVID Cohort Collaborative.

PurposeTo provide real-world evidence on risks and outcomes of breakthrough COVID-19 infections in vaccinated patients with cancer using the largest national cohort of COVID-19 cases and controls.MethodsWe used the National COVID Cohort Collaborative (N3C) to identify breakthrough infections between December 1, 2020, and May 31, 2021. We included patients partially or fully vaccinated with mRNA COVID-19 vaccines with no prior SARS-CoV-2 infection record. Risks for breakthrough infection and severe outcomes were analyzed using logistic regression.ResultsA total of 6,860 breakthrough cases were

Pertussis in high-risk groups: an overview of the past quarter-century.

Infectious diseases can impact chronic medical conditions. However, it is currently not clear how pertussis correlates with preexisting or underlying disorders. We reviewed literature from the last 25 years to describe the burden and impact of pertussis infection in specific risk groups in individuals aged ≥11 years. Our literature search returned 543 hits, of which 18 were eligible for this review. Adolescents and adults with underlying conditions, such as asthma, chronic obstructive pulmonary disease (COPD), or obesity are potentially at increased risk of pertussis infection. Immunodeficienc

Polymorphisms in the promoter region of the CRBN gene as a predictive factor for the first-line CTD therapy in multiple myeloma patients.

Cereblon is a primary molecular target for immunomodulatory drugs. The aim of this study was to evaluate the influence of selected clinical and molecular factors including single nucleotide polymorphisms (SNPs) in CRBN gene on the efficacy of first line CTD (cyclophosphamide, thalidomide, dexamethasone) chemotherapy in patients with multiple myeloma. Study group consisted of 68 patients. Analysis of CRBN gene SNPs (rs6768972, rs1672753) was performed using Real-Time PCR genotyping technique. Median progression free survival (PFS) was 15 months and overall survival (OS) 79 months. Factors assoc

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… 24 (61,5) | 0,6082 Women | 13 (44,8) | 14 (48,3) | 2 (6,9) | 0,0981 | 3 (10,3) | 11 (37,9) | 15 (51,7) | 0,120 Age <65 | 25 (54,4) | 18 (39,1) | 3 (6,5) | 0,5817 | 4 (8,7) | 15 (32,6) | 27 (58,7) | 0,7104 ≥65 | 9 (40,9) | 11 (50) | 2 (9,1) | 0,1250 | 1 (4,5) | 9 (40,9) | 12 (54,5) | 0,0998 Smoking Non-smokers … Progression free survival | Overall survival Median (months) | p HR (95% CI) | Median (months) | p HR (95% CI) 15 | 79 Sex Men | 12 | 0,6938 | 50 | 0,0585 Women | 15 | 0,89 (0,50-1,61) | 79 | 2,45 (1,06-5,63) Age <65 | 15 | 0,5942 | 82 | 0,2853 ≥65 | 17 | 0,85 (0,44-1,64) | 38 | 0,63 (0,23-1,70) Smoking Non-smokers …

Impact of e-cigarettes as cancer risk: A protocol for systematic review and meta-analysis.

BackgroundThe use of electronic cigarettes is one of the current public health problems on increasing alert, has been growing at an accelerating rate, and has become a public health emergency. Its importance is explained by the continuous growth and acceleration of oncological rates among all ages versus the absence of high-quality evidence, correlated to the use of nicotine derived products, being at their regular versions or the new ones. Available preclinical data indicate that activation of the sympathetic nervous system by nicotine inhaled from e-cigarettes may stimulate cancer developmen

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… Search items 1 | Vaping 2 | E-Cigarette use 3 | E-Cisg use 4 | ECig use 5 | ECigarette use 6 | Eletronic cigarette use 7 | Nicotine vaping 8 | Vape 9 | Nonsmokers 10 | Non-smokers 11 | Nonsmokers 12 | Neoplasmss 13 | Neoplasms, malignant 14 | Malignancy 15 | Malignancies 16 | Tumors 17 | Cancer 18 | … Observational study 19 | Cohort studies 20 | Retrospective studies The medical subject heading (MESH) terms will be: (Vaping OR E-Cigarette Use OR E-Cig Use OR ECig Use OR E Cigarette Use OR Eletronic Cigarette Use OR Nicotine Vaping OR Vape) AND (Nonsmokers OR Non-Smokers OR Nonsmoker) AND (Neoplasms …

Treatment landscape and disease burden of patients with multiple myeloma in Japan: a real-world survey.

AIM: Multiple myeloma (MM) is a hematological malignancy associated with poor health-related quality of life (HRQoL). Safe and effective treatments for MM are limited. There is a need for real-world data to improve understanding of treatment patterns and sequencing in routine clinical practice in Japan. This study evaluated disease burden, treatment patterns, treatment sequencing, and reasons for treatment selection in patients with MM in Japan. METHODS: This analysis used survey data of hematologists or hemato-oncologists and their adult patients with MM who received active treatment in a re

Long-Term Clinical Outcomes of Optimizing Combination Therapy for Primary Pulmonary Mucosa-Associated Lymphoid Tissue Lymphoma: A Retrospective Study.

INTRODUCTION: Pulmonary mucosa-associated lymphoid tissue (MALT) lymphoma progresses with advancing disease stage. However, no standard treatment approach has been established. This single-center retrospective study evaluated clinical and radiological characteristics, treatment modalities, and long-term prognosis of pulmonary MALT lymphoma. METHODS: The study included 42 patients diagnosed with pulmonary MALT lymphoma between October 2004 and July 2019. Primary therapeutic modalities were determined using modified Ann Arbor staging. Therapeutic response was evaluated via computed tomography a

Cancer prevention programmes in Mexico: are we doing enough?

Cancer has increased in all the countries of the world and Mexico is no exception. The recognised risk factors for the main types of cancer are reviewed and searched through the Mexican government web pages and cancer prevention programmes to tackle the risk factors in the population. The Mexican government, a member of the World Health Organization, shows that the main approach is an early diagnosis rather than prevention, forgetting that an ounce of prevention is better than a pound of cure. Effective public programmes should be promoted to reduce preventable risk factors in the population (

The effect of conditioning regimen intensity on periodontal health in haematopoietic cell transplantation recipients: a 5-year multicentre prospective cohort study.

ObjectivesTo evaluate periodontal health and its association with conditioning intensity over five years post-HCT.Materials and methodsThis multicentre prospective study included 104 patients from two Dutch centres. Probing pocket depth (PPD), bleeding on probing (BOP), and buccal gingival recession (GR) were assessed pre-HCT and at three (n = 34), six (n = 45), twelve (n = 46), eighteen months (n = 30), and five years (n = 36) post-HCT. Regression models evaluated associations with conditioning intensity and time since HCT.ResultsHCT recipients had a median age of 58 years; 56% were male, and

Risks of Solid and Lymphoid Malignancies in Patients with Myeloproliferative Neoplasms: Clinical Implications.

In the past decade, several studies have reported that patients with chronic myeloproliferative neoplasms (MPNs) have an increased risk of second solid cancer or lymphoid hematological cancer. In this qualitative review study, we present results from studies that report on these cancer risks in comparison to cancer incidences in the general population or a control group. Our literature search identified 12 such studies published in the period 2009-2018 including analysis of more than 65,000 patients. The results showed that risk of solid cancer is 1.5- to 3.0-fold elevated and the risk of lymp