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Methods for nutrition monitoring in cancer patients: a cognitive perspective.

In the present medical context, the evaluation and the monitoring of factors other than mere physical symptoms are an urgent demand. In particular, the issue of quality of life (QoL) has become a relevant target in the treatment of cancer. However, the approach towards these aspects is not well standardized and the actual applications in a concrete setting are fragmented, left to personal or local initiative. If this is true for QoL in general, it is particularly relevant in the specific field of nutrition. Indeed, though the growing awareness of a correlation between chronic diseases and diet

The Effect of Relaxation Technique on Fatigue Levels after Stem Cell Transplant.

BackgroundMany patients undergoing hematopoietic stem cell transplant (HSCT) experience fatigue due to their disease process and its long period of treatment. Using nonpharmacological methods to help reduce their fatigue is a reasonable endeavor. The present study was conducted to investigate the effect of Benson's relaxation technique on fatigue levels in patients after HSCT.Materials and methodsThirty-seven patients were randomly selected to the intervention (n = 19) and control group (n = 18). In the intervention group, the participants performed Benson's relaxation exercises for 20 min twi

Integrated palliative nursing interventions for older adults with cancer: Effects on quality of life, psychological outcomes, and symptom burden.

OBJECTIVES: Older adults with cancer frequently experience high symptom burden, psychological distress, and reduced quality of life. Integrating palliative nursing interventions into routine oncology care has the potential to improve these outcomes, yet evidence examining their measurable effects remains limited. This study aimed to examine the effects of integrated palliative nursing interventions on quality of life, psychological outcomes, and symptom burden among older adults with cancer. METHODS: A quasi-experimental one-group pre-test-post-test design was conducted at King Khaled Hospita

Personalized Lifestyle Interventions for Prevention and Treatment of Obesity-Related Cancers: A Call to Action.

The increasing global burden of cancer necessitates innovative approaches to prevention and treatment. Lifestyle factors such as diet, physical activity, and smoking significantly contribute to cancer. At the same time, current guidelines are based on a one-size-fits-all approach, which limits their effectiveness across diverse populations. Obesity is a well-documented risk factor for cancer, directly affecting 13 types of cancer. The complex interplay of genetic, metabolic, hormonal, and environmental factors in obesity's etiology highlights the need for more tailored approaches to obesity-re

Temporal Trends in Cancer Burden and 27 Subtypes Among Women of Childbearing Age Globally from 1990 to 2021.

BackgroundCancer among women of childbearing age (WCBA, 15-49 years) has distinct clinical and public health implications. Using modeled estimates from the Global Burden of Disease Study (GBD) 2021, we assessed temporal and spatial patterns of total cancer and 27 cancer subtypes among WCBA from 1990 to 2021.MethodsWe extracted incidence and mortality estimates for WCBA globally, across five socio-demographic index (SDI) regions, 21 GBD regions, and 204 countries and territories. Age-standardized incidence rates (ASIRs) and age-standardized mortality rates (ASMRs) were calculated. Temporal tren

The effects of a financial navigation intervention on financial toxicity among patients with breast cancer in China: A randomized controlled trial.

BACKGROUND: Financial toxicity (FT) is a common issue faced by breast cancer patients worldwide. Although financial navigation (FN) is a promising approach to alleviate FT, its effectiveness in China's context remains underexplored. OBJECTIVES: To evaluate the effects of a FN intervention on FT, cost-related health literacy (CRHL), shared decision-making (SDM) ability, and perceived stress of patients with breast cancer. METHODS: This was a cluster randomized controlled trial. Participants were randomized to the FN group or control group (n = 41 per group). Outcomes including FT (primary out

Joint Association of Physical Activity and Prognostic Nutritional Index on Survival in US Cancer Survivors: A Study Based on the NHANES Database.

BackgroundNutritional-immune status and physical activity (PA) are key to prognosis in cancer survivors, yet their joint association with mortality remains unclear. Therefore, we examined the independent and combined effects of PA and the Prognostic Nutritional Index (PNI) on mortality outcomes.MethodsWe evaluated the independent and joint associations of PA and PNI with all-cause, cancer-specific, non-cancer, and cardiovascular mortality among 2420 US cancer survivors using data from the 2007-2016 National Health and Nutrition Examination Survey (NHANES). Prognostic Nutritional Index was used

Proteomic alterations in ovarian cancer-Predicting residual disease status using artificial intelligence and SHAP-based biomarker interpretation.

IntroductionHigh-grade serous ovarian cancer (HGSOC) is the most aggressive and prevalent subtype of ovarian Treatment outcomes are significantly influenced by residual disease status following neoadjuvant chemotherapy (NACT). Predicting residual disease before surgery can improve patient stratification and personalized treatment strategies.MethodsThis study analyzed pre-NACT proteomic data from 20 HGSOC patients treated with NACT. Patients were categorized into two groups based on surgical outcomes: no residual disease (R0, n = 14) and suboptimal residual disease (R1, n = 6). From an initial

Longitudinal studies on financial toxicity in cancer patients: a scoping review.

ObjectiveThis scoping review focuses on financial toxicity in cancer patients, aiming to identify its measurement time points, assessment tools, developmental trends, and influencing factors. Based on existing evidence, this review reveals the occurrence trajectory and long-term impacts of financial toxicity among cancer patients. It can provide a reference for improving patients' financial well-being in clinical practice and optimizing the medical security system at the health policy level and also points out key directions for future related research.MethodsThis study strictly followed the m

Agreement between the EQ-5D-5L anxiety/depression dimension and GAD-7/PHQ-9 for psychological distress assessment in patients with hematologic malignancies.

BACKGROUND: Patients with hematologic malignancies (HMs) often experience psychological distress, significantly impairing health-related quality of life (HRQoL) and deteriorating clinical prognosis. Although the widely used instrument EuroQol 5-Dimension 5-Level (EQ-5D-5L) has been validated in the general population for accurately identifying the psychological symptoms, its performance in HM patients remains unclear. We aimed to investigate whether the EQ-5D-5L questionnaire anxiety/depression (A/D) dimension, when already collected for HRQoL assessment, correlates with anxiety and depression

Improvements in the health-related quality-of-life benefit of cancer drugs approved in China, 2005-2020: an observational study.

BackgroundHealth-related quality of life (HRQoL), along with overall survival (OS), is a critical study endpoint for measuring the clinical benefits of cancer drugs. Previous studies have examined the OS benefit of new cancer drugs approved in China. However, their HRQoL benefits have not been systematically evaluated. We aimed to characterise the measurement and improvement of HRQoL associated with cancer drugs approved in China.MethodsThis mixed-methods study comprises of a literature review and a cross-sectional study, including all antineoplastic agents approved in China between January 1,

Uncovering the boundary conditions of the association between concerns about falling and physical activity in adult populations: a scoping review protocol.

IntroductionDespite evidence of variation in how concerns about falling influence physical activity, many of the currently available knowledge syntheses merely assume that this relation is uniform across populations and contexts. Therefore, we propose a scoping review protocol to guide a summary of the bodywork that has examined the association between concerns about falling and physical activity in adult populations, with an eye on the availability of empirical evidence of moderation.Methods and analysesStudies reporting on both the concepts of concerns about falling and physical activity amo

Second- and third-line treatment strategies in multiple myeloma: a referral-center experience.

The treatment landscape for relapsed multiple myeloma (MM) has increased. In this study, we aimed to characterize 2nd (n = 1439) and 3rd (n = 1104) line regimens and compare the results between subgroups based on the year of treatment initiation (2nd line: 2003-2008, 2009-2015, 2016-2021; 3rd line: 2004-2009, 2010-2015, and 2016-2021). In both the second- and third- lines, we observed increasing use of novel agents (from 78 to 95% and from 77 to 95%, respectively) and triplet regimens (from 15 to 69% and from 21 to 71%, respectively). The most frequently used regimens in the last studied perio

Pre-transplant Rehabilitation to Decrease the Post-transplant Length of Stay for Hematological Malignancy Patients Undergoing Allo-HSCT.

ObjectivesPre-transplant rehabilitation for hematological malignancy patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT) helps improve physical capacity. However, its benefit with respect to post-transplant hospital length of stay (LOS) is unclear. Consequently, the aim of this study was to investigate the effect of pre-transplant rehabilitation on post-transplant LOS for hematological malignancy patients undergoing allo-HSCT.MethodsData on patients diagnosed between April 2014 and March 2017 were collected from the Japanese Diagnosis Procedure Combination databa

Pediatric Drug Development: Reviewing Challenges and Opportunities by Tracking Innovative Therapies.

The paradigm of pediatric drug development has been evolving in a "carrot-and-stick"-based tactic to address population-specific issues. However, the off-label prescription of adult medicines to pediatric patients remains a feature of clinical practice, which may compromise the age-appropriate evaluation of treatments. Therefore, the United States and the European Pediatric Formulation Initiative have recommended applying nanotechnology-based delivery systems to tackle some of these challenges, particularly applying inorganic, polymeric, and lipid-based nanoparticles. Connected with these, adv

Retinal neuronal loss and progression independent of relapse activity in multiple sclerosis.

BACKGROUND: In multiple sclerosis (MS), inner retinal thinning measured by optical coherence tomography (OCT) is related to lesional and gray matter changes of the brain. OBJECTIVE: To evaluate the association between OCT markers and progression independent of relapse activity (PIRA). METHODS: Analysis within the Swiss MS Cohort Study, in patients with ≥ 1 OCT. Mean thicknesses of: peripapillary retinal nerve fiber- (pRNFL), macular ganglion cell-inner plexiform- (mGCIPL), and inner nuclear layers (mINL) were assessed, excluding asymmetric eyes. PIRA was investigated during ≥ 4 years before

Assessment and Treatment Outcomes of Pain in Cancer Patients Undergoing Chemotherapy - A Tertiary Care Centre Experience.

ObjectivesPain is a prevalent and debilitating symptom in cancer patients, significantly affecting their quality of life. This study aimed to evaluate pain severity, its management and associated factors in patients undergoing chemotherapy in a tertiary care centre.Materials and methodsA single-centre observational study was conducted at the Department of Medical Oncology, Mahatma Gandhi Medical College and Research Institute, Puducherry, India, from January 2024 to June 2024. One hundred and four chemotherapy patients were assessed using the numerical rating scale to evaluate pain severity. D

Translation of Epigenetics in Cell-Free DNA Liquid Biopsy Technology and Precision Oncology.

Technological advancements in cell-free DNA (cfDNA) liquid biopsy have triggered exponential growth in numerous clinical applications. While cfDNA-based liquid biopsy has made significant strides in personalizing cancer treatment, the exploration and translation of epigenetics in liquid biopsy to clinical practice is still nascent. This comprehensive review seeks to provide a broad yet in-depth narrative of the present status of epigenetics in cfDNA liquid biopsy and its associated challenges. It highlights the potential of epigenetics in cfDNA liquid biopsy technologies with the hopes of enha

Current landscape of gene-editing technology in biomedicine: Applications, advantages, challenges, and perspectives.

The expanding genome editing toolbox has revolutionized life science research ranging from the bench to the bedside. These "molecular scissors" have offered us unprecedented abilities to manipulate nucleic acid sequences precisely in living cells from diverse species. Continued advances in genome editing exponentially broaden our knowledge of human genetics, epigenetics, molecular biology, and pathology. Currently, gene editing-mediated therapies have led to impressive responses in patients with hematological diseases, including sickle cell disease and thalassemia. With the discovery of more e

The Use of Patient-Reported Outcome Measures in Paediatric Haematopoietic Stem Cell Transplant: A Systematic Review.

Background/objectivesChildren and adolescents undergoing Haematopoietic Stem Cell Transplantation (HSCT) experience complex symptoms, often under-reported by patients and undetected by clinicians, which cause distress. Patient-Reported Outcome Measures (PROMs) offer a way to capture symptom experiences directly from patients, with the potential of supporting effective symptom assessment and management, yet their routine use in paediatric HSCT remains unclear. This systematic review synthesises evidence on PROMs used during inpatient paediatric HSCT care, examining their role in symptom monitor

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… Enhancing provider adoption of Patient-Reported Outcome Measures (PROMs) through implementation science: Insights from two international workshops. J. Patient Rep. Outcomes. 2025;9:77. doi: 10.1186/s41687-025-00911-3. 46. …