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Changes in Cancer Care for Patients Aged 80 and Above: A Cohort Study from Samsung Comprehensive Cancer Center in South Korea.

Background/Objectives: With an estimated 70% of new cancer diagnoses expected to be in older adults within the next decade, cancer care for this population has attracted increasing global attention. Additionally, older patients are less likely to receive optimal cancer treatments. Methods: This retrospective cohort study utilized data from the Samsung Medical Center Cancer Registry, which includes patients diagnosed with cancer between 2008 and 2022. A 15-year cohort analysis was conducted to examine trends and survival outcomes by cancer type and stage in patients aged 80 years and older. Res

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… In South Korea, oncologists have been able to use immune checkpoint inhibitors for patients with advanced-stage cancer in routine clinical practice. Our data likely reflect the medical landscape during this period. … Generally, most clinical trials have inclusion criteria that limit age, and oncologists are often reluctant to enroll elderly patients in trials involving new investigational drugs. …

Implementing comprehensive geriatric assessment in an academic hematologic outpatient setting: experiences from medical doctors and patients.

IntroductionThe incidence of most cancers increases with age and cancer is a leading cause of morbidity and mortality in the older population. Older cancer patients frequently have additional co-morbidities and functional decline, which can substantially affect treatment outcomes. Major oncology societies recommend a screening for geriatric impairments in patients at risk (e.g. G8), followed by a comprehensive geriatric assessment (CGA). Nevertheless, CGA is often not established in routine care. We describe the implementation process of CGA in patients with hematological cancers at the Univer

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… CGA Eligible patients were referred for CGA at the discretion of the treating hemato-oncologist based on age and clinical impression. … Therefore, earlier and closer collaboration between oncologists/hematologists and geriatricians appears to improve routine care of older patients. Integration of a CGA into the routine hematologic/oncologic practice may lower the barrier to referring patients. …

Telehealth and Health Care Contact Days Among Patients With Advanced Cancer After COVID-19.

ImportanceThe COVID-19 pandemic led to widespread telemedicine adoption, but its impact on time toxicity, ie, the time burden of interacting with the health care system, among patients with advanced cancer remains unclear.ObjectiveTo evaluate the association of the COVID-19 pandemic with time toxicity for patients with advanced cancer who died within 1 year of diagnosis, focusing on changes in health care use, including telehealth.Design, setting, and participantsThis retrospective cohort study included patients with stage 4 cancer who died within 1 year of diagnosis, with follow-up limited to

Characteristics of patients with newly diagnosed hematological malignancies referred for echocardiography.

ObjectiveThe importance of cardio-hemato-oncology programs is increasing. The main aim of the study was to identify all coexisting cardiovascular disorders in patients with new hematological malignancies referred for echocardiography during baseline evaluation before anticancer therapy.Material and methodsThe study was based on 900 echocardiographic examinations performed within 12 months at the Institute of Hematology and Transfusion Medicine in Poland: 669 tests (74.3%) were dedicated to hemato-oncology patients at the different stages of cancer therapy, however almost a third of the tests (

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… This period constituted the first 12 months of work of the new team of cardiologists at the Institute of Hematology and Transfusion Medicine in Warsaw, who are also members of the International Cardio-Oncology Society and certified cardio-oncologists. … This type of arrhythmia will undoubtedly focus the attention of cardio-oncologists on both the implementation of rhythm control strategies and antithrombotic prophylaxis ( 30 ). …

Determination of drug-related problems in the hematology service: a prospective interventional study.

BackgroundPatients with hematological malignancies often require multidrug therapy using a variety of antineoplastic agents and supportive care medications. This increases the risk of drug-related problems (DRPs). Determining DRPs in patients hospitalized in hematology services is important for patients to achieve their drug treatment goals and prevent adverse effects. This study aims to identify DRPs by the clinical pharmacist in the multidisciplinary team in patients hospitalized in the hematology service of a university hospital in Turkey.MethodsThis study was conducted prospectively betwee

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… Medication problems were mostly related to anti-infective agents, and oncologists’ acceptance of interventions was found to be high (96%). In a study conducted in Korea [ 5 ], a total of 1187 DRPs were identified in 438 (23.9%) of 1836 hospitalized patients with hematological malignancy. … Oncologist. 2006;11(1):51–61. doi: 10.1634/theoncologist.11-1-51. 46. Ho M, Moscvin M, Low SK, Evans B, Close S, Schlossman R, et al. Risk factors for the development of orthostatic hypotension during autologous stem cell transplant in patients with multiple myeloma. …

The Ambulatory Medical Assistance (AMA) programme during active-phase treatment in patients with haematological malignancies: A cost-effectiveness analysis.

ContextThe need for patient navigator is growing, and there is a lack of cost evaluation, especially during survivorship.ObjectiveThe objective of this study is to evaluate the cost-effectiveness of an Ambulatory Medical Assistance (AMA) programme in patients with haematological malignancies (HM).DesignA cost-effectiveness analysis of the AMA programme was performed compared to a simulated control arm.SettingAn interventional, single-arm and prospective study was conducted in a French reference haematology-oncology centre between 2016 and 2020.ParticipantsAdult patients were enrolled with hist

Towards a unified approach for multiple myeloma care in Kenya - proceedings of the Inaugural Multiple Myeloma Congress.

The rising burden of multiple myeloma in Kenya has not been met by a commensurate effort for control. Patients and practitioners struggle with unavailability and unaffordability of diagnostics, drugs and stem cell transplant leading to presentation at advanced stages and under-treatment with increased morbidities and mortality. A concerted effort among stakeholders is urgently needed to develop strategies for myeloma control. The scarcity of providers also carries grave consequences for Kenyan patients. The Academic Model Providing Access To Healthcare (AMPATH) multiple myeloma program organiz

Prognostic Significance of a Novel Score Model Based on Preoperative Indicators in Patients with Breast Cancer Spine Metastases (BCSM).

BackgroundSurgery remains the mainstay of treatment for breast cancer spinal metastasis (BCSM) to relieve symptoms and improve the quality of life of BCSM patients. Therefore, it is important to effectively predict the prognosis of patients to determine whether they can undergo surgical operation. However, the prevalent methods for prognosis evaluation lack specificity and sensitivity for indicated malignancies like breast cancer because they are built on a relatively small number of heterogeneous types of primary tumors. The aim of the present study was to explore a novel predictive model bas

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… using the surgery-based multidisciplinary treatment strategy has percolated into the mainstream and gained good prognosis of patients. 1 However, extension of the patients’ lifespan may in turn increase the risk of spinal metastasis of the primary cancer, which is a dilemma in front of the clinical oncologists … All patients underwent surgical resection and subsequent chemotherapy, radiotherapy, endocrine/targeted therapy and/or bisphosphonate therapy according to the advice of the attending oncologists ( Table S1 ). …

Identifying Hemostatic Thresholds in Cancer Patients Undergoing Coronary Angiography Based on Platelet Count and Thromboelastography.

Objectives: To evaluate the role of platelet count and thromboelastogram (TEG) in the treatment of thrombocytopenic cancer patients with suspected coronary artery disease (CAD). Background: Cancer patients with CAD and thrombocytopenia are often treated non-invasively (i.e., without coronary angiography when clinically indicated) due to perceived high risk of bleeding. We sought to evaluate coagulability based on TEG and determine if platelet count and TEG could predict bleeding risk/mortality among cancer patients undergoing coronary angiography (CA). Methods: Baseline demographics, platelet

The concept of multidimensional frailty in geriatric oncology: a systematic scoping review.

BACKGROUND: One of the major challenges in geriatric oncology is to estimate the risk-benefit balance of any therapeutic proposal for each patient and frailty is one of the key components of Comprehensive Geriatric Assessment (CGA)and can also be assessed using stand-alone screening tools that predicts functional decline, treatment-related complications and mortality. This study aimed to provide an overview of the existing literature on the concept of multidimensional frailty in older adults with cancer, to clarify the dimensions included in multidimensional frailty, and the components of frai

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… (v) The significance of frailty assessment is to help oncologists determine or adjust cancer treatment plans [ 25 – 27 , 30 , 35 , 37 , 38 , 40 , 42 – 46 , 48 ]. … Memory impairment, such as complaining about one’s poor memory because of treatment strategies such as chemo-radiotherapy, memory impairment was considered by geriatric oncologists to be the most common component of cognitive frailty [ 25 – 27 ]. …

Adverse drug reactions and drug-related problems with supportive care medications among the oncological population.

AimThe current study emphasizes the impact of adverse drug reactions (ADRs) and Drug-Related Problems (DRPs) caused by supportive care medications administered with chemotherapy.MethodThis is a longitudinal observational study carried out at the Ramaiah Medical College Hospital in Bengaluru, Karnataka, India, at the Department of Oncology. The data was recorded using a specifically created data collecting form. Based on the PCNE (Pharmaceutical Care Network Europe), DRPs are identified. The WHO probability scale, Modified Hartwig and Siegel for ADR severity assessment, Naranjo's algorithm for

Management of Patients with Relapsed and/or Refractory Multiple Myeloma Treated with Novel Combination Therapies in Routine Clinical Practice in Germany.

IntroductionMultiple myeloma remains an incurable plasma cell malignancy which, despite improvements in overall survival over the last decade, is characterized by recurrent relapse and is associated with a poor prognosis. This study investigates the use of novel agents in current real-world clinical practice in the management of relapsed and/or refractory multiple myeloma (RRMM) in Germany over different lines of therapy.MethodsA retrospective chart review was conducted for patients with RRMM treated at multiple centers across Germany between May 2017 and June 2018. Variables included patient

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… Data were collected from case report forms completed by hematologists, oncologists, or hemato-oncologists engaged in the treatment of RRMM in Germany between October 2019 and February 2020, providing an insight into the therapeutic strategies in different lines of therapy in routine clinical practice … Notably, in 2008 there were 1717 medical oncologists registered in Germany as a whole and this was predicted to increase to 3806 in 2020 [ 40 ]. …

Cancer-Associated Thrombosis: A Clinical Scoping Review of the Risk Assessment Models Across Solid Tumours and Haematological Malignancies.

Cancer-associated thrombosis (CAT) is a leading cause of death in cancer patients receiving outpatient chemotherapy. The latest guidelines emphasize stratifying the patients in terms of CAT risks periodically. Multiple risk assessment models (RAMs) were developed to classify patients and guide thromboprophylaxis to high-risk patients. This study aimed to discuss and highlight different RAMs across various malignancy types with their related advantages and disadvantages. A scoping review was conducted using predefined search terms in three scientific databases, including Google Scholar, Science

Lifestyle considerations in multiple myeloma.

As the prognosis for multiple myeloma (MM) has significantly improved and patients remain on therapy longer, there is a need for supportive care interventions to optimize patient quality of life (QOL) and functional status over the course of cancer treatment. MM is characterized by a significant symptom burden and a relatively lower QOL compared to other cancers. This review evaluates the role of healthy lifestyle behaviors in improving both the physical functioning and psychological well-being of the MM population. We (1) describe the current literature on physical activity, weight management

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… Jones et al. [ 34 ] ( N = 311) found that most cancer patients prefer that their oncologist initiate discussions about exercise. … Oncologist-initiated conversations not only resulted in a stronger belief in exercise ( p < 0.001) among the cancer patients but also in longer ( p < 0.07) and more frequent ( p < 0.001) physical activity participation [ 34 ]. Oncologists may also need guidance in terms of appropriate exercises. …

Ocular toxicities associated with anticancer drug therapy in Asian patients: a literature review and practical management recommendations for non-ophthalmologic settings.

BACKGROUND: Ocular toxicities associated with anticancer therapies, including cytotoxic chemotherapy, hormonal agents, molecular targeted therapies, immune checkpoint inhibitors, and antibody-drug conjugates, are increasingly recognized and may substantially impair visual function and quality of life. However, ethnicity-specific data for Asian populations and practical management strategies applicable to non-ophthalmologic settings remain limited. METHODS: A literature review of publications up to December 2025 was conducted using PubMed to identify studies reporting incidence, mechanisms, pr

Гипертрофическая кардиомиопатия, открывающая множественные миеломы: диагностический вызов.

Гипертрофическая кардиомиопатия может быть редкой иллюстрацией гематологических магнатов, таких, как множественная миелома, вызванная неконтролируемым клональным распространением плазменных клеток. Мы сообщаем о случае 65-year-old человек, показывая с заточенной сердечной недостаточностью, в которой EKJ и эхокардиография указывают на сердечный амилоидоз, и этиологическая оценка выявила множественные миеломы в качестве основной причины. В этом случае мы показываем, что сердечный амилоидоз в качестве вторичной амилоидозной миеломы может появиться в качестве недавно диагностированной и быстро про

Improved functional assessment in cancer patients using home-based digital technologies.

Accurate assessment of performance status (PS) in oncology care is crucial for improving clinical decisions, therapy selection and anticipated risks of treatment toxicity. While physical function is traditionally assessed in the clinic, in-clinic instruments do not capture the full spectrum of daily functioning. Digital health technologies (DHTs) can address this limitation by passively monitoring patients in their daily environment. Our study showed at-home physical activity and gait metrics from DHTs were associated with self-reported PS in participants with cancer, and these metrics had gre

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… Additionally, advancements in wearable technology and data analytics could further enhance the accuracy and utility of these devices particularly in areas where access to oncologists may be limited. … Prognostic value of performance status assessed by patients themselves, nurses and oncologists in advanced non-small cell lung cancer. Br. J. Cancer . 85 (11), 1634–1639 (2001). 8. Sargent, D. J. et al. …

Neurotoxicity associated with cancer chemotherapy: the first study in the Palestinian healthcare system.

BackgroundChemotherapy-induced neurotoxicity is a significant concern in cancer treatment as it adversely affects treatment outcomes. However, research on this subject within the Palestinian healthcare system is limited. This study aimed to evaluate the prevalence, clinical manifestations, and associated factors of neurotoxicity in cancer patients receiving chemotherapy in Palestine.MethodsThis retrospective cohort study included 196 cancer patients who underwent chemotherapy at multiple hospitals across Palestine. Data on patient demographics, cancer characteristics, chemotherapy regimens, an

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… The face and content validity of the data collection form was confirmed through a review by a panel of experts comprising oncologists, neurologists, and pharmacologists. After reaching consensus among the panelists, the final version of the form was developed. … Moreover, the current collaboration between oncologists and neurologists in Palestine is limited, representing a critical gap in care. …

Trends in surgical management of spinal metastases in a Singaporean tertiary referral center: a 17-year retrospective review.

IntroductionSurgical treatment is increasingly the treatment of choice in cancer patients with epidural spinal cord compression and spinal instability. There has also been an evolution in surgical treatment with the advent of minimally invasive surgical (MIS) techniques and separation surgery. This paper aims to investigate the changes in epidemiology, surgical technique, outcomes and complications in the last 17 years in a tertiary referral center in Singapore.MethodsThis is a retrospective study of 383 patients with surgically treated spinal metastases treated between January 2005 to January

Assessment of Patient Reported Outcomes (PROs) in Outpatients Taking Oral Anticancer Drugs Included in the Real-Life Oncoral Program.

Background In previous studies, patient-reported outcomes (PROs) have been shown to improve survival in cancer patients. The aim of the present study was to assess symptoms potentially related to adverse events experienced by cancer outpatients treated by oral anticancer agents (OAAs) using PROs. Methods Between September 2018 and May 2019, outpatients starting OAAs were included in a 12-week follow-up to assess 15 symptoms listed in the National Cancer Institute PRO Common Terminology Criteria for Adverse Events, using a 5-point scale of severity or frequency. Patients were requested to alert