Результаты поиска

Unusual presentation of chondroid syringoma of the hand: a literature review and case report.

INTRODUCTION AND IMPORTANCE: Malignant chondroid syringoma (CS) is a sporadic skin tumor with slow growth and metastatic potential. Its presentation in the hand is uncommon, and limited cases have been reported in the literature. This case highlights an unusual presentation of malignant CS with delayed diagnosis, bone erosion, and distant metastases, adding to the sparse surgical literature on this tumor's aggressive behavior. CASE PRESENTATION: A 67-year-old male with a 5-year history of a progressively enlarging ulcerative lesion on his left hand, initially mistaken for an insect bite. The

Acute Metastatic Spinal Cord Compression: Urgent Surgery versus Radiotherapy and Treatment Result Prediction versus Actual Results.

Background Context: The role of radiotherapy versus surgery in treating acute metastatic spinal cord compression (AMSCC) has changed over the years. Purpose: Our study evaluates neurological and functional outcomes following urgent surgery and radiotherapy (USFR) versus urgent radiotherapy alone in treating AMSCC. Study Design/Setting: A retrospective cohort of 54 patients with AMSCC with variable neurological deficits. Overall, 32 patients were treated with USFR, and 22 received urgent radiotherapy alone. Outcome Measures: Neurological status regarding the Asia and Frankel scores, continence

Development, Implementation, and Patient Perspectives of the Women's Integrative Sexual Health Program: A Program Designed to Address the Sexual Side Effects of Cancer Treatment.

BackgroundAdvanced practitioners (APs) are a growing demographic in survivorship care. One goal of survivorship care is to manage consequences of cancer treatments. Sexual dysfunction from prior therapies can impact quality of life. Advanced practitioners are perfectly poised to provide care for sexual problems. This article will describe the development and implementation of the Women's Integrative Sexual Health (WISH) program by APs within a comprehensive cancer center and describe patient perspectives of care provided.MethodsTwo physician assistants working in gynecologic oncology at the Un

Совпадение в полном тексте источника
… A gynecologic oncologist played a supportive and administrative role as the medical director of the program without providing direct patient care. The Program for Integrative Sexual Medicine (PRISM) team at the University of Chicago provided mentorship on program development. … Physical examination of the female cancer patient with sexual concerns: What oncologists and patients should expect from consultation with a specialist . CA: A Cancer Journal for Clinicians , 66 ( 3 ), 241 – 263 . 10.3322/caac.21337 26784536 PMC4860140 Miller K. D. , Nogueira L. , Mariotto A. …

Wisely frugal: ensuring sustainable funding for novel cancer therapeutics through a budget impact analysis in resource-limited settings.

IntroductionCancer care in Sri Lanka is predominantly provided through its state health system which is free at the point of delivery. We performed a budget impact analysis of novel cancer drugs with a view to enabling better prioritising of their procurement.MethodsMedian survival gain was obtained for each indication of a novel cancer drug by a review of the literature. The direct cost of drug procurement was obtained from the Ministry of Health of Sri Lanka and the cost per life year gained was computed for each indication. Two thresholds - per capita gross domestic product (GDP) per life y

Совпадение в полном тексте источника
… As such, three oncologists independently estimated the number of patients likely to be treated in each indication during a year. The mean value of the number estimated by the three oncologists was taken for the analysis. … As such, the likely number of cases for each indication for the whole country was determined by taking the mean value of the estimates made by three oncologists. …

Surgical management of spinal metastases: A cross-continental study in the United States and the Netherlands.

BackgroundThere is currently no consensus on the optimal surgical treatment for patients with spinal metastases. Investigating regional variations in surgical management could provide valuable insights to optimize care and refine surgical practices globally.ObjectiveTo investigate differences in patient populations, surgical management, and perioperative outcomes among patients who underwent surgery for spinal metastases in either Boston (United States) or Utrecht (Netherlands).Methods727 patients surgically treated for spinal metastases in Boston (n=539) and Utrecht (n=188) between 2018-2022

Совпадение в полном тексте источника
… This likely stems from multiple factors, including cultural differences regarding end-of-life care, surgeons' training, increased focus on multidisciplinary collaboration between radiation oncologists and spine surgeons, and possible financial incentives, such as reimbursements [32] . … Oncologist 30 2025 10.1093/oncolo/oyae359 PMC11745020 39832131 41 Lin J. Zhu X. Tang Q. Lu J. Xu H. Song G. Deng C. Wu H. Huang Y. Huang A. Xu Y. Chen H. Wang J. …

Efficacy and safety of ruxolitinib in the treatment of chronic graft-versus-host disease: a retrospective analysis.

Steroid-refractory chronic graft-versus-host disease (cGvHD) is associated with significant morbidity and mortality, with ruxolitinib being the first drug approved for its treatment. We retrospectively analyzed the safety and efficacy of ruxolitinib for treatment of cGvHD at our center between 07/2015 and 12/2022 and identified 48 patients receiving ruxolitinib as second (18/48) or advanced (30/48) treatment line. Ruxolitinib was started on median day 340 (range 119-595) after cGvHD onset; median duration of administration was 176 (range, 79-294) days with 16/48 patients continuing treatment a

The use of bisphosphonates in the management of bone involvement from solid tumours and haematological malignancies - a European survey.

Bone metastases in patients with solid tumours (ST) and bone lesions in patients with haematological malignancies (HM) are common. Associated skeletal-related events (SREs) cause severe pain, reduced quality of life and place a burden on health care resources. Bone-targeted agents can reduce the risk of SREs. We evaluated the management of bone metastasis/lesions in five European countries (France, Germany, Italy, Spain and the UK) by an observational chart audit. In total, 881 physicians completed brief questionnaires on 17 193 patients during the observation period, and detailed questionnair

Совпадение в полном тексте источника
… In total, 881 physicians (307 oncologists, 164 haematologists, 196 urologists, 120 oncological haematologists, 41 pulmonologists, 31 gynaecologists, 12 radiation oncologists and 10 internists) who treated patients with advanced cancer were selected to form a representative sample. … Oncologist 15, 1147–1158. …

Cabozantinib Cutaneous Toxicity-Comprehensive Review.

BackgroundIn the context of modern cancer therapy, the management of adverse effects of systemic therapies can lead to the avoidance of underdosing and withdrawal and increases in the quality of the therapeutic act and the quality of life. This review offers an overview of the skin-related toxicities associated with Cabozantinib, a multikinase inhibitor (MKI) that is approved for treating advanced kidney cancer, hepatocellular carcinoma, and medullary thyroid cancer. It covers the most common dermatological side effects, such as palmar-plantar erythrodysesthesia, stomatitis, hair alterations,

Impact of Social Needs and Identity Experiences on the Burden of Illness in Patients with Multiple Myeloma: A Mixed-Methods Study.

Multiple myeloma (MM) is a common hematologic malignancy, but due to its incurable nature, patients experience many relapses in their lifetime and hence face unique challenges. This mixed-methods study consisting of an online survey and subsequent focus groups aimed to understand how social and identity experiences affected the diagnostic, treatment, and care journey for patients with MM. Twenty-three adult patients with MM participated in this study. The survey participants identified common determinants negatively impacting their health, including mental health concerns (experienced by 90.5%

Совпадение в полном тексте источника
… (White patient, 50s) Number of healthcare providers involved | 10 (50.0) | Need for multiple providers including primary care, oncologist or hematologist, and MM specialist | “I surrounded myself with a good team of specialists, hematologists, and oncologists.” … For example, 1 patient reported receiving less attention than expected from her oncologist because of her younger age. However, others said older patients may be offered fewer treatment options due to the perception of frailty. …

Video reflexive ethnography as an intervention to improve oral anti-cancer agent patient education: A pilot study.

ObjectiveOral anticancer agents (OAAs) are associated with side effects that interfere with medication adherence, despite patient education regarding side effect management. Video reflexive ethnography (VRE) captures care processes on video that allow participants to learn from videos. The purpose of this pilot study was to assess the usefulness and impact of VRE on improving OAA education.MethodsThis qualitative study was conducted in a pharmacist-managed OAA clinic: two pharmacists and four patients participated. We filmed each pharmacist providing education to two patients. We conducted pat

Совпадение в полном тексте источника
… I called…and so the oncologist on call…called me back and he said go to the emergency room… I mean, we have become huge advocates of taking your temperature. I don’t understand why we don’t do this all the time. I mean, it really tells a story!” … Patient feedback – minor themes Patient feedback yielded two minor themes that did not align with the major themes: feeling overwhelmed and the need for candor with oncologists. …

Pyridoxine Is Effective for Preventing Hand-Foot Syndrome Induced by Pegylated Liposomal Doxorubicin for Multiple Myeloma: The Results of a Randomized Study.

PURPOSE: Pegylated liposomal doxorubicin (PLD) is highly effective for treating multiple myeloma (MM). Hand-foot syndrome (HFS) is a dose-limiting adverse event of PLD that may reduce a patient's quality of life or prevent certain patients from receiving PLD. Several researchers have discovered that pyridoxine, an activated form of vitamin B6, may prevent PLD-associated HFS. We designed a prospective randomized trial to examine whether prophylactic pyridoxine might prevent the incidence or delay the occurrence of PLD-induced HFS in patients with MM. METHODS: Patients who met the trial's eligi

Совпадение в полном тексте источника
… After allocation, patients were not blinded to their group assignment, nor were their treating oncologists blinded, considering the study characteristics. The allocation sequence was blinded only to data analysts and outcome investigators. … After each cycle, the oncologist completed an on-study sheet to provide all necessary background information so that investigators could conduct the CTCAE assessments and also completed a follow-up sheet to monitor the patients’ response to chemotherapy treatment. …

Blood and marrow transplantation during the emerging COVID-19 pandemic: the Seattle approach.

On January 20, 2020, the first patient with coronavirus disease 2019 (COVID-19) in the United States of America was diagnosed in Washington state, which subsequently experienced rapidly increasing numbers of COVID-19 cases, hospitalizations, and deaths. This placed the Seattle Blood and Marrow Transplant Program at Fred Hutchinson Cancer Research Center (Fred Hutch) in the national epicenter of this pandemic. Here, we summarize the experience gained during our rapid response to the COVID-19 pandemic. Our efforts were aimed at safely performing urgent and potentially life-saving stem cell trans

Совпадение в полном тексте источника
… This allowed us to establish and maintain essential communication with patients and referring oncologists yet minimize COVID-19 exposure during the height of the response. … Many patients already undergoing pretransplant evaluations were discharged back to their local oncologists to receive maintenance chemotherapy in anticipation of later transplant dates. …

The history of cancer pain and bone-targeted agents: 10 most commonly asked questions.

The prevalence of pain and skeletal complications of metastatic bone disease is high and an important factor, which contributes to decreased quality of life and low survival rate. Bone-targeted agents are well-established therapies to reduce the skeletal-related events in patients with bone metastasis. However, the analgesic effect of these medications is still controversial. The objective of this review is to summarize the existing evidence about the use of bone-targeted agents in the treatment of metastatic bone pain, trying to answer to the 10 most commonly asked questions in this matter. T

Bisphosphonates in oncology: evidence for the prevention of skeletal events in patients with bone metastases.

Bone metastases frequently occur in patients with advanced solid tumors, particularly breast and prostate cancers, and nearly all patients with multiple myeloma have some degree of skeletal involvement. The strides made in treating these primary tumors have extended median survival times and thereby increased patient risk for skeletal-related events (SREs), including pathologic fractures, spinal cord compression, need for palliative radiation therapy or surgery to bone, and hypercalcemia. Bisphosphonates, inhibitors of osteoclastic bone resorption that were first established as treatment of os

Совпадение в полном тексте источника
… Although palliation has traditionally been the primary goal of therapy, the introduction of bisphosphonates has afforded oncologists with an effective therapeutic option for preventing and/or treating SREs associated with bone metastases. … Assessing the efficacy of bisphosphonates in patients with bone metastases from breast cancer Oncologist 2006 11 3 227 233 16549806 10.1634/theoncologist.11-3-227 68 Brown JE Cook RJ Major P Bone turnover markers as predictors of skeletal complications in prostate cancer, lung cancer, and other solid …

Teams, Tools, Processes and Resources to Manage Oncologic Clinical Decision Support: Lessons Learned from City of Hope's Multistate, Academic, and Community Oncology Enterprise.

Background/Objectives: Clinical decision support systems (CDSSs) consisting of Computerized Physician Order Entry (CPOE) and oncology pathways serve as the foundation of high-quality cancer care. However, the resources needed to develop and maintain these systems have not been characterized for oncology enterprises. Methods: Executive leadership appointed a medical director and clinical pharmacist to develop and lead a Pathways and Protocols Program for the City of Hope (COH) enterprise. This involved developing a program charter and governance committee and a business case for resources to su

Совпадение в полном тексте источника
… Over 6 months from March 2022 through September 2022, academic disease leads and community oncologists volunteered to provide the clinical content. … New patient potential is calculated from doctors being able to see at least one new patient for every 4 h freed from order development. # = number of hematologists or number of medical oncologists. …

Fit theory: A cancer experience grounded theory emerging from semi-structured interviews with cancer patients and informal caregivers in Manitoba Canada during the COVID-19 pandemic.

BackgroundIt is not clear how changes to healthcare delivery related to the COVID-19 pandemic, including virtual care and social distancing restrictions, have impacted the experience of living with cancer. This study aimed to discover a theory capable of describing the cancer experience, how the pandemic impacted it, and for guiding predictions about how to improve it.MethodsBetween October 2020 and July 2021 digitally recorded semi-structured one-on-one interviews were conducted virtually with adult cancer patients and informal caregivers in Manitoba, Canada. Transcriptions and field notes fr

Совпадение в полном тексте источника
… (Participant #02) Participants also described that the duration between seeing their oncologist in person impacted fit, by decreasing the confidence that everything was going well and that they were being taken care of. … Professional burnout in European young oncologists: results of the European Society for Medical Oncology (ESMO) Young Oncologists Committee Burnout Survey. Ann Oncol. 2017;28(7):1590–6. doi: 10.1093/annonc/mdx196 21. Shanafelt T, Dyrbye L. Oncologist burnout: causes, consequences, and responses. …

Parallel Toxicities: A Comparative Analysis of Chemotherapy-Induced Neutropenia and Alopecia.

Chemotherapy-induced neutropenia (CIN) and chemotherapy-induced alopecia (CIA) are significant toxicities affecting cancer patients. CIN is a potentially fatal complication of chemotherapy caused by myelosuppression and increased infection susceptibility, while CIA, although not fatal, severely affects treatment adherence and mental health. This study provides a comprehensive comparative analysis of CIN and CIA, focusing on patient, disease, treatment, and genetic risk factors. Key risk factors for CIN and CIA include age, poor performance status, body mass index (BMI), laboratory abnormalitie

Treatment Patterns, Goals, and Decision-Making Criteria for Second- and Third-Line Therapies for Multiple Myeloma in Germany.

IntroductionTo document the decision-making criteria physicians use when selecting regimens for second- and third-line therapy for patients with relapsed and/or refractory multiple myeloma (RRMM) in Germany.MethodsExperienced multiple myeloma (MM) physicians extracted data from medical records from 30 June to 8 September 2023 for patients who initiated approved second- and third-line therapy for MM in 2021. Regimens, most important treatment goal, and key reasons for prescribing were reported in addition to patient characteristics. All data were summarised descriptively.ResultsMM physicians (3

Совпадение в полном тексте источника
… Participating haematologists or oncologists must have had at least 4 years of clinical experience, have been personally responsible for managing at least 10 patients per year who have RRMM, spend at least 60% of their time on patient care, and act as the main decision-maker for treatment of their patients … ) 28 (57.1) Large (10 or more haematologists/oncologists) 17 (34.7) No. of years in practice since full qualification, mean (SD) 17.2 (6.0) Approximate no. of patients with MM managed in a typical month, a mean (SD) 36.1 (22.7) SD standard deviation a Including new diagnoses, treatment initiation, and …

Prevalence, Attributes, and Risk Factors of QT-Interval-Prolonging Drugs and Potential Drug-Drug Interactions in Cancer Patients: A Prospective Study in a Tertiary Care Hospital.

Introduction Cancer chemotherapy regimens include multiple classes of adjuvant drugs as supportive therapy. Because of the concurrent intake of other drugs (like antiemetics, antidepressants, analgesics, and antimicrobials), there is a heightened risk for possible QT interval prolongation. There is a dearth of evidence in the literature regarding the usage of QT-prolonging anticancer drugs and associated risk factors that have the propensity to prolong QT interval. The purpose was to explore the extent of the use of QT-interval-prolonging drugs and potential QT-prolonging drug-drug interaction

Targeted Therapies in Advanced Cholangiocarcinoma.

Primary tumor resection and liver transplantation are the only curative treatment options for the management of cholangiocarcinoma (CCA). However, for patients with advanced or metastatic disease, palliative systemic therapy remains the only treatment option. The development of targeted therapeutics has begun to shift the treatment paradigm in CCA. Targets of interest in CCA include mutated isocitrate dehydrogenase-1 (mIDH-1), human epidermal growth factor receptor 2 (HER2) overexpression/amplification, and fibroblast growth factor receptor 2 (FGFR2) fusion, in addition to less frequently obse