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Effects of Ultracavitation and Radiofrequency on Abdominal Adiposity.

BACKGROUND: The mechanism of fat reduction from radiofrequency occurs via the thermal stimulation of adipocyte metabolism, causing a lipase- … tisfaction. RESULTS: The participants in the UCV+RF group presented a more significant decrease in adipose tissue, which was verified through all the evaluation methods. CONCLUSION: Based on our results, the simultaneous application of ultracavitation and radiofrequency generated a reduction in localized adiposity superior to the isolated use of ultracavitatio …

Mesenchymal stromal cells in spinal fusion: Current and future applications.

Mesenchymal stromal cells (MSCs) have been a promising area of study for regenerative medicine. These cells can be harvested from bone marrow, adipose tissue, and other areas allowing for autologous transplantation of these cells into the area of degeneration or injury. With the proper signals, these cells may be able to regenerate healthy tissue. Recent studies have yielded promising evidence supporting translational mesenchymal stromal cell applications particularly in spinal fusion surgery.

Neonatal high-dose riboflavin attenuates abdominal adiposity and binge eating associated with adipose metabolic remodeling in experimental cerebral palsy.

OBJECTIVES: Maternal immune activation induced by lipopolysaccharide (LPS) exposure is a critical factor in the pathogenesis of cerebral pal … pregulated Slc2a4 (GLUT-4), dysregulated in CP (p < 0.05), and Ppargc1a (PGC-1α) in white and brown adipose tissues (p < 0.01 to p < 0.001), without affecting the hypothalamus, soleus muscle, or liver. DISCUSSION: Collectively, these findings suggest that CP associated with maternal-fetal inflammation and postnatal anoxia leads to persistent systemic metabolic …

Heat-Inactivated Akkermansia muciniphila Improves Gut Permeability but Does Not Prevent Development of Non-Alcoholic Steatohepatitis in Diet-Induced Obese Ldlr-/-.Leiden Mice.

The development of non-alcoholic steatohepatitis (NASH) has been associated with alterations in gut microbiota composition and reduced gut b … obesity and associated metabolic dysfunction in the gut (microbiota composition and permeability), adipose tissue, and liver were studied relative to an untreated HFD control. Treatment with heat-inactivated A. muciniphila did not affect body weight or adiposity and had no effect on plasma lipids, blood glucose, or plasma insulin. Heat-inactivated A. muciniphil …

Lower bone mass in prepubertal overweight children with prediabetes.

Childhood studies of the fat-bone relationship are conflicting, possibly reflecting the influence of metabolic abnormalities in some but not … ue mass (FFST), and fat mass (FM) were measured by dual-energy X-ray absorptiometry (DXA). Visceral adipose tissue (VAT) and subcutaneous abdominal adipose tissue (SAAT) were assessed using MRI. Total-body BMC was 4% lower in overweight children with prediabetes than in those without prediabetes after controlling for sex, race, height, and weight (p = .03). In t …

Attenuation of the cardiovascular and metabolic complications of obesity in CD14 knockout mice.

AIMS: Although toll-like receptors (TLR) are known to mediate the metabolic complications of obesity, the mechanisms underlying its activati … sympathetic activity, non-invasive blood pressure and glucose tolerance were evaluated. Hepatic and adipose tissues were collected for mRNA quantification, histology and LPS incubation. KEY FINDINGS: In both WT and CD14 knockout mice, obesity was accompanied by TLR2 and TLR4 upregulation. However, obese mice lacking CD14 presented decreased lipid and macrophage …

The mechanism of C1q/TNF-related proteins (CTRPs) in atherosclerosis associated with type 2 diabetes mellitus.

Increasing evidence suggests that C1q/tumor necrosis factor-related proteins (CTRPs), as the adipokine superfamily, are secreted by adipose tissues. They play an important role in diabetic cardiovascular pathology. Diabetic vascular complications pose a significant threat to human health and are the primary cause of disability and mortality in diabetes. Adipose tissue dysfunction, including secretion and dysfunction of adipokines, is closely associated with diabetic vasculopathy. However, the expression levels of CTRPs show heterogeneity in different pathophysiological states, and their potent…

Autoimmune mechanisms and inflammation in obesity-associated type 2 diabetes, atherosclerosis, and non-alcoholic fatty liver disease.

Obesity, characterized by the excessive accumulation of white adipose tissue, is a significant global health burden and a major risk factor for a range of diseases, including malignancies and metabolic disorders. Individuals with high visceral fat content are particularly susceptible to severe complications such as type 2 diabetes, cardiovascular diseases, and liver disorders. However, the pathogenesis of obesity-related metabolic diseases extends beyond simple adiposity. Chronic obesity triggers a prolonged inflammatory response, which leads to tissue fibrosis and sustained organ damage, cont…

Hypoxia-Induced Insulin Resistance Mediates the Elevated Cardiovascular Risk in Patients with Obstructive Sleep Apnea: A Comprehensive Review.

Patients with obstructive sleep apnea (OSA) experience insulin resistance and its clinical consequences, including hypertriglyceridemia, red … regulation and peroxisome proliferator-activated receptor-gamma (PPAR- γ ) downregulation. In human adipose tissue, PPAR- γ activity promotes glucose transport into adipocytes, lipid droplet biogenesis, and whole-body insulin sensitivity. Silencing of PPAR- γ in the adipose tissue reduces glucose uptake and fat accumulation into adipocytes and promotes insulin r …

A Soft Tissue Osteochondrolipoma of the Lateral Ankle: A Case Report and Clinical Insight.

Tumors of the foot and ankle are uncommon, accounting for approximately 4%-10% of all musculoskeletal tumors; most are benign soft-tissue lesions. Osteochondrolipoma is an exceptionally rare histological variant of lipoma characterized by mature adipose tissue with cartilaginous and osseous differentiation. It is typically reported in the head, neck, and upper extremities, whereas its occurrence in the lower extremity, particularly the hindfoot, is exceedingly rare. We report a case of osteochondrolipoma of the lateral aspect of the hindfoot of a 54-year-old female who presented with a painles…

The hidden mechanism of vacuum bell therapy: Local fat hypertrophy drives cosmetic outcome in adolescents with pectus excavatum.

PURPOSE: Vacuum bell (VB) therapy is a non-invasive treatment option for pectus excavatum (PE), traditionally considered most effective in c … . Fat-selective T1-weighted Dixon MRI confirmed that the increased subcutaneous tissue consisted of adipose tissue. CONCLUSIONS: The improvement in visual appearance of PE morphology during VB therapy results primarily from localized adipose tissue hypertrophy, while skeletal remodeling is likely to contribute to a much lesser degree. From a cosmetic perspectiv …

Artificial intelligence analysis of the relationship between subcutaneous fat volume in CT images and cervical kyphosis after laminoplasty.

This retrospective observational study aimed to explore the associations of AI-assisted CT-quantified C4/C5 skeletal muscle and adipose tissue indices with postoperative cervical kyphosis and long-term functional outcomes in patients undergoing laminoplasty. Postoperative cervical kyphosis is a prevalent complication of laminoplasty with incompletely elucidated pathogenesis, and the role of neck muscle and adipose tissue in this complication lacks validation via standardized 3D quantification. We enrolled 114 patients with cervical spondylosis who underwent laminoplasty at Wuhan Union Hospital…

Decellularized omentum as novel biologic scaffold for reconstructive surgery and regenerative medicine.

Homologous tissues, such as adipose tissue, may be an interesting source of acellular scaffolds, maintaining a complex physiological three-dimensional (3D) structure, to be recellularized with autologous cells. The aim of the present work is to evaluate the possibility of obtaining homologous acellular scaffolds from decellularization of the omentum, which is known to have a complex vascular network. Adult rat and human omenta were treated with an adapted decellularization protocol involving mechanical rupture (freeze-thaw cycles), enzymatic digestion (trypsin, lipase, deoxyribonuclease, ribon…

Human Loss-of-Function ZNRF3 Mutation Impairs Adipose Thermogenesis and Drives Subcutaneous Fat Expansion.

UNLABELLED: Zinc and ring finger protein 3 (ZNRF3) functions as a transmembrane E3 ubiquitin ligase. Although genome-wide association studie … pocyte-specific Znrf3 deletion leads to progressive adiposity, with expansion of subcutaneous white adipose tissue (sWAT) and improved glucose tolerance after a long-term high-fat diet. Furthermore, Znrf3 deficiency impairs the browning capacity of sWAT and cold-induced thermogenesis. A knock-in mouse model harboring the homologous human p.V228L mutation recapit …

The Impact of Vertical Sleeve Gastrectomy on Behavioral and Reward-Related Outcomes.

INTRODUCTION: Vertical sleeve gastrectomy (VSG) is widely recognized as an effective metabolic surgery for achieving durable weight loss and … asure of thermogenic activity via transponder-monitored activity and temperature in brown and white adipose tissue and behavioral outcomes related to hedonic processing, anxiety-like behavior, motivation, and cognitive flexibility. RESULTS: VSG produced rapid and sustained reductions in body weight, transient decreases in food intake, reduced adiposity, trends …

Integrated CT-based assessment of muscle and adiposity for risk stratification in advanced pancreatobiliary cancer.

BACKGROUND: Pancreatobiliary cancers are highly aggressive, with limited prognostic markers in advanced stages. Cancer-associated malnutrition results in sarcopenia and adipose tissue depletion; however, the prognostic implications of comprehensive body composition metrics are unclear. METHODS: We retrospectively analyzed 1,066 metastatic or recurrent pancreatobiliary cancer patients diagnosed between 2006 and 2017. Baseline clinical, laboratory, and nutritional data were collected. Skeletal muscle index (SMI), subcutaneous adipose tissue index (SATI), visceral adipose tissue index (VATI), an…

Hypothalamic microglial IL-4 signaling mediates cancer-associated cachexia via sympathetic activation.

BACKGROUND: Cancer-associated cachexia (CAC) is a debilitating metabolic syndrome characterized by progressive adipose tissue and skeletal muscle wasting. Emerging evidence implicates the central nervous system (CNS) as a key regulator of systemic catabolism and CAC progression. We identify interleukin-4 (IL-4) as a potential mediator of CAC by investigating its actions on hypothalamic neuroendocrine circuits. METHODS: We manipulated central IL-4 signaling in CAC mice through intracerebroventricular (ICV) delivery of anti-IL-4 antibody or recombinant IL-4. Hypothalamic cell type-specific IL-4…

Disrupting the adiposopathy-inflammation loop: a translational immunometabolic framework for inflammatory disease.

Adipose tissue dysfunction is increasingly recognized as a biologically active contributor to chronic inflammatory disease beyond its traditional role in energy storage. In the context of obesity, adiposopathy is characterized by persistent immunometabolic alterations involving adipokine dysregulation, macrophage infiltration, insulin resistance, and chronic low-grade inflammation. These processes intersect with inflammatory signaling pathways central to immune-mediated diseases, supporting the concept of an immunometabolic phenotype in which metabolic dysfunction and immune activation converg…

Множественная миелома с участием позвоночника: Ренальская дисфункция и альбуминуриа ассоциируются с прогрессивной саркопией в продольном морфометрическом исследовании КТ.

Почечная дисфункция является частым осложнением множественной миэломы (ММ). Однако ее связи с саркопией и вязкой адиозной потерей тканей, возникающими прогнозными маркерами слабости, по-прежнему недостаточно характеризуются в MM. Расчетная морфометрия на основе томографии (КТ) обеспечивает объективную и воспроизводимую оценку состава тела. Альбуминуриа, установившийся маркер повреждений почек, часто недооценивается за пределами нефрологии, несмотря на то, что она может иметь отношение к бремени болезней и физическому спаду. МЕТОДЫ: Мы ретроспективно проанализировали 86 Пациенты MM2009-2024) с

Совпадение в аннотации оригинала
BACKGROUND: Kidney dysfunction is a frequent complication of multiple myeloma (MM). However, its associations with sarcopenia and visceral adipose tissue loss, emerging prognostic markers of frailty, remain insufficiently characterized in MM. Computed tomography (CT)-based morphometry provides an objective and reproducible assessment of body composition. Alb…

CCL2/CCR2 axis suggests a role in bridging obesity-related adipose inflammation to Sertoli cell injury in asthenozoospermia: Integrated multi-omics, machine learning and in vitro validation.

This study established an integrated framework combining multi-omics analysis, machine learning (ML), single-cell RNA sequencing (scRNA-seq) … utions. Gene set enrichment analysis (GSEA), immune infiltration, and scRNA-seq analyses identified adipose tissue macrophages as a major cellular source of Ccl2/CCL2. However, as the scRNA-seq data were derived from mouse adipose tissue rather than human testis, this finding primarily serves to generate the hypothesis that macrophage-derived CCL2/CCR2 signaling …