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Comorbidities and mortality rate in COVID-19 patients with hematological malignancies: A systematic review and meta-analysis.

IntroductionThe global pandemic of coronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It seems that there is an association between blood cancer and an increased risk of severe COVID-19. This study aimed to review the literature reporting the COVID-19 outcomes in patients with hematological malignancies.Material and methodsIn this systematic review and meta-analysis, Pubmed, Embase, and Web of Science databases were searched using the following keywords: COVID-19, SARS-CoV-2, blood cancer, myeloma, lymphoma, and leukemia. All the

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… RT‐PCR, CT scans | antibiotics 3, anakinra 3, IVIg 2, oxygen support 3 | Cough 2, rhinorrhea 1, sore throat 1, diarrhea 2, fever 3, rash 2, dyspnea 1 | Increased: Ferritin 3, triglycerides 3, CRP 1 Decreased: PLT 3, RBC 2, WBC 2, lymphocyte 1 | Previous seizures | Discharged 3 Bellmann‐Weiler 44 | Austria …

A Tailored Approach for Appendicular Impending and Pathologic Fractures in Solid Cancer Metastases.

Advances in medical and surgical treatment have played a major role in increasing the survival rates of cancer patients with metastatic bone disease. The clinical course of patients with bone metastases is often impaired by bone complications, such as bone fractures, which have a substantial negative impact on clinical outcomes. To optimize clinical results and prevent a detrimental impact on patients' health, a tailored approach should be defined for any given patient. The optimal management of impending or pathologic fractures is unknown and relies on a multidisciplinary approach to tailor c

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… IAEA; Vienna, Austria: 2007. 54. Lutz S., Balboni T., Jones J., Lo S., Petit J., Rich S.E., Wong R., Hahn C. Palliative radiation therapy for bone metastases: Update of an ASTRO Evidence-Based Guideline. Pract. Radiat. Oncol. 2017;7:4–12. doi: 10.1016/j.prro.2016.08.001. 55. …

A bibliometric research based on hotspots and frontier trends of denosumab.

Denosumab is a monoclonal antibody that targets and inhibits the osteoclast activating factor receptor activator for nuclear factor-κB ligand (RANKL). It has been widely used in the treatment of osteoporosis, giant cell tumors of bone, and in the prevention of malignant skeletal-related events (SREs). We collected the research results and related MeSH terms of denosumab from 2011 to 2021 through the Web of Science and PubMed, respectively. The literature was visualized and analyzed by CiteSpace and bibliometric online analysis platforms. The MeSH terms were biclustered using the Bibliographic

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… Republic | 0.32 4 | England | 132 | 9.46 | 60.88 | 49 | 4 | Israel | 0.32 5 | Italy | 130 | 9.32 | 44.48 | 49 | 5 | Australia | 0.29 6 | Germany | 120 | 8.60 | 65.06 | 28 | 6 | Sweden | 0.29 7 | Switzerland | 114 | 8.17 | 53.09 | 35 | 7 | Saudi Arabia | 0.27 8 | Belgium | 94 | 6.74 | 75.64 | 38 | 8 | Austria …

Fracture Risk Evaluation of Bone Metastases: A Burning Issue.

Major progress has been achieved to treat cancer patients and survival has improved considerably, even for stage-IV bone metastatic patients. Locomotive health has become a crucial issue for patient autonomy and quality of life. The centerpiece of the reflection lies in the fracture risk evaluation of bone metastasis to guide physician decision regarding physical activity, antiresorptive agent prescription, and local intervention by radiotherapy, surgery, and interventional radiology. A key mandatory step, since bone metastases may be asymptomatic and disseminated throughout the skeleton, is t

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… Failure Prediction of Metastatic Bone with Osteolytic Lesion in Mice; Proceedings of the 25th Congress of the European Society of Biomechanics; Vienna, Austria. 7–10 July 2019; [(accessed on 12 December 2020)]. Available online: https://hal.archives-ouvertes.fr/hal-02441862 . 101. …

Venous Thromboembolism in Cancer Patients on Simultaneous and Palliative Care.

Simultaneous care represents the ideal integration between early supportive and palliative care in cancer patients under active antineoplastic treatment. Cancer patients require a composite clinical, social and psychological management that can be effective only if care continuity from hospital to home is guaranteed and if such a care takes place early in the course of the disease, combining standard oncology care and palliative care. In these settings, venous thromboembolism (VTE) represents a difficult medical challenge, for the requirement of acute treatments and for the strong impact on an

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… AUPACS group Thromboprophylaxis in patients receiving inpatient palliative care: A survey of present practice in Austria Support. Care Cancer. 2012 20 2183 2187 10.1007/s00520-011-1330-6 22119936 97. Centeno C. Lynch T. Garralda E. Carrasco J.M. Guillen-Grima F. Clark D. …

Highlights lecture EANM 2016: "Embracing molecular imaging and multi-modal imaging: a smart move for nuclear medicine towards personalized medicine".

The 2016 EANM Congress took place in Barcelona, Spain, from 15 to 19 October under the leadership of Prof. Wim Oyen, chair of the EANM Scientific Committee. With more than 6,000 participants, this congress was the most important European event in nuclear medicine, bringing together a multidisciplinary community involved in the different fields of nuclear medicine. There were over 600 oral and 1,200 poster or e-Poster presentations with an overwhelming focus on development and application of imaging for personalized care, which is timely for the community. Beyond FDG PET, major highlights inclu

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… Leisser et al. from Vienna, Austria, reported high contrast PET/MRI with this tracer in patients with the indolent MALT lymphoma, even when the lesion was undetectable by MRI [ 8 ] (Fig. 2 ). The clinical development of antibody vectors for CAIX was also highlighted. …

New developments in the management of relapsed/refractory multiple myeloma - the role of ixazomib.

Ixazomib is the first oral proteasome inhibitor to be approved, in combination with lenalidomide and dexamethasone, for the treatment of patients with multiple myeloma who have received at least one prior therapy. Approval was on the basis of results from the phase 3, double-blind, placebo-controlled TOURMALINE-MM1 study, which demonstrated a 35% improvement in progression-free survival with the all-oral combination of ixazomib plus lenalidomide-dexamethasone versus lenalidomide-dexamethasone alone (median: 20.6 vs 14.7 months; hazard ratio: 0.74, p=0.012; median follow-up 14.7 months). The ad

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… Real-world use of 3rd line therapy for multiple myeloma in Austria: an Austrian Myeloma Registry (AMR) analysis of the therapeutic landscape and clinical outcomes prior to the use of next generation myeloma therapeutics. PLoS One. 2016;11:e0147381. doi: 10.1371/journal.pone.0147381. 14. …

Monoclonal antibodies in the treatment of multiple myeloma: current status and future perspectives.

The treatment landscape for patients with multiple myeloma (MM) is constantly evolving. Over the past decade, the introduction of novel agents such as proteasome inhibitors and immunomodulatory drugs has led to notable changes in therapeutic strategy, and improvements in survival, yet MM remains incurable in the vast majority of cases. More recently, a targeted approach to MM treatment has emerged, using monoclonal antibodies (mAbs) to target antigens expressed on the surface of MM cells. MAbs tested to date kill MM cells via the host's immune system and/or by promoting apoptosis, and appear t

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… Vienna, Austria, 11–14 June 2015 (abstract P275). Lokhorst H, Plesner T, Gimsing P, Nahi H, Lisby S, Richardson P. …

A multicountry ecological study of cancer incidence rates in 2008 with respect to various risk-modifying factors.

Observational and ecological studies are generally used to determine the presence of effect of cancer risk-modifying factors. Researchers generally agree that environmental factors such as smoking, alcohol consumption, poor diet, lack of physical activity, and low serum 25-hdyroxyvitamin D levels are important cancer risk factors. This ecological study used age-adjusted incidence rates for 21 cancers for 157 countries (87 with high-quality data) in 2008 with respect to dietary supply and other factors, including per capita gross domestic product, life expectancy, lung cancer incidence rate (an

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… A meta-analysis of observational studies PLoS One 2013 8 e78999 10.1371/journal.pone.0078999 24260143 PMC3832519 Appendix The 87 countries with level 1 or 2 quality and life expectancy for males in 1990 >60 years: Albania, Argentina, Armenia, Australia, Austria, Azerbaijan, Bahamas, Barbados, Belarus …

Неделя ГЭЭ 2018 Презентации на плакате

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… Ferlitsch Medical University of Vienna, Internal Medicine III, Division of Gastroenterology and Hepatology, Vienna, Austria Contact E-Mail Address: rafael.paternostro@meduniwien.ac.at Introduction: Data on the predictive capability of cirrhosis through transient elastography (TE) in Wilson disease … Coimbra, Pulmonology, Coimbra, Portugal 17 Hospital Central do Funchal, Research Centre, Funchal, Portugal 18 Hospital Central do Funchal, Clinical Pathology, Funchal, Portugal 19 Medical University of Vienna, Department of Gastroenterology and Hepatology, Department of Internal Medicine III, Vienna, Austria …

The 44th Annual Meeting of the European Society for Blood and Marrow Transplantation: Physicians Oral Session

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ESCP 36th European Symposium on Clinical Pharmacy ‘Implementing Clinical Pharmacy in Community and Hospital Settings: Sharing the Experience’, Istanbul, Turkey 25–27 October 2007; Abstracts

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… of depression in elderly Martina Anditsch 1 , Gudrun Lang 2 , Rosa Lemmens-Gruber 2 , Majidreza Kamyar 2 , Peter Fischer 3 1 Hospital Pharmacy, Donauspital, 2 Pharmacology and Toxicology, University of Vienna, 3 Ludwig Boltzmann Institute for Aging Research, Ludwig Boltzmann Gesellschaft, Vienna, Austria … Setting : Co-operation of the Ludwig Boltzmann Institute for Aging Research (Vienna, Austria) with the 1000-bed general hospital Donauspital (Vienna, Austria) and the Department of Pharmacology and Toxicology at the University of Vienna. …

Материалы Международного общества по картированию раковых заболеваний (ИСИС) 18th Ежегодный учебный курс: Ментон, Франция. 7-9 октябрь 2018

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… A7 GIST – Imaging of Gastrointestinal Stromal Tumors Dietmar Tamandl Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria Imaging requirements for Gastrointestinal Stromal Tumors (GIST) are quite challenging due to the spare occurrence of this tumor …

Trend Analysis of Medically Related Osteonecrosis of the Jaw in the United States Using US National Inpatient Data From 2016 to 2022.

OBJECTIVES: This study presents a trend analysis of Medication-Related Osteonecrosis of the Jaw (MRONJ) using US National Inpatient Sample (NIS) data from 2016 to 2022, providing insights into its epidemiology, comorbidities, and economics. METHODS: A retrospective cross-sectional analysis was performed using US MRONJ hospital admissions. Prevalence rates were calculated relative to Bisphosphonate patient numbers in the United States and hospital-based denominators. Statistical analyses included two-sample proportion (Z) tests, Cochran-Armitage trend tests, Welch t-tests, and multivariable li

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… A 20‐year multicenter study from Tyrol, Austria, reported an overall 8.8% cumulative incidence of MRONJ among breast cancer patients with bone metastases—2.8% among those treated with bisphosphonates alone, 11.6% among those receiving denosumab, and 16.3% among patients who received sequential bisphosphonate …

Реальная эффективность обслуживания бортезомиба после введения VMP в санитарную миелому: целевое экспериментальное исследование эмуляции.

Bortezomib-melphalan-prednisone (VMP) — установленный вводный режим для сноса трансплантации, недавно диагностированный несколькими миеломами (NDMM), однако оптимальные стратегии после введения остаются неясными. В ходе этого исследования была проведена оценка эффективности обслуживания бортезомибной системы с использованием пробной эмуляции мишеней. Мы сравнили предполагаемую группу поддержки.KMMWP-174 ) с внешней контрольной когортой из многоцентрового реестра. Число пациентов, прошедших курс лечения 9 Циклы VMP, полученные ≥ частичная реакция и без движения 60 днями. Индексом была дата нача

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… All analyses were performed using R version 4.4.0 (R Foundation for Statistical Computing, Vienna, Austria). Result Baseline characteristics After 1:1 PSM, 54 patients in each cohort were analyzed. All covariates achieved adequate balance (Supplementary Fig. 1 ). …

Epidemiological profile and clinical outcomes of patients with mucormycosis: the multicenter retromucor study from Türkiye (2004-2024).

PURPOSE: Mucormycosis is a rapidly progressive angioinvasive fungal infection with limited large-scale outcome data. We aimed to describe the epidemiology, clinical spectrum, treatment strategies, and predictors of outcomes in adult patients with proven mucormycosis in Türkiye. METHODS: We conducted a nationwide, retrospective study of 280 adults diagnosed with proven mucormycosis between 2004 and 2024 across 27 tertiary centers. Case definitions were applied according to the European Organization for Research and Treatment of Cancer and the Mycoses Study Group Education and Research Consortiu

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… Analyses were performed using R version 4.2.1 (R Foundation for Statistical Computing, Vienna, Austria) with the packages survival, survminer, and broom. Results Study characteristics A total of 280 adults with proven mucormycosis were included. …

Регулярная молекула-а регулирует ответные реакции, связанные с нейтрофильом TH17 в CNS автоиммунитет.

МЯСО И АЙМ: Отталкивающая молекула наведения-А (RGMA) хорошо известна своей ролью в нейро-воспалении и ремонте CNS с помощью Т-образных клеток. Врожденные иммунные взаимодействия, особенно между нейтрофилами и клетками TH17, становятся критическими движущими силами нейроинфламматической патологии в множестве склерозов (MS). Вопрос о том, регулирует ли РГМ эти связанные с нейтрофильом ответы TH17, остается в значительной степени неизвестным. Уточнение этого механизма может выявить новые терапевтические цели для НР. МЕТОДЫ: Уровни сера РГМ, БМП4, нейтрофильная эластаза (NE), IL-17A, и подстрекат

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… Edited by: Jinming Han , Capital Medical University, China Reviewed by: Jehan Alrahimi , King Abdulaziz University, Saudi Arabia Sizhu Gong , Medical University of Vienna, Austria Data availability statement The raw data supporting the conclusions of this article will be made available by the authors …

FmocFF Peptide Hydrogel Is a Promising Matrix for Encapsulation and Controlled Release of the Anticancer Peptide Drug Bortezomib.

One major public health issue is cancer chemotherapy; despite constant progress in the area, administration of anticancer drugs to patients is often associated with serious side effects. It is therefore imperative to develop vehicles for encapsulation and controlled delivery of such drugs. Anticancer drugs include small peptide drugs, such as Bortezomib (BTZ). Self-assembling peptides have been recently reported as promising drug delivery agents. The research reported here proposes the encapsulation of BTZ into peptide hydrogels formed by the self-assembling FmocFF dipeptide as delivery vehicl

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… Measurements were performed with an Anton Paar (Anton Paar GmbH, Graz, Austria) MCR501 shear rheometer equipped with a stainless-steel parallel plate geometry of 25 mm diameter. Evaporation was mitigated by an ethanol–water vapor saturated solvent trap. …

Перспективное исследование иммуногенности SARS-CoV-2 :: вакцины для ускорителей в нескольких миеломах и в Уолденстрёме, макроглобулиномии.

Углубление риска сильного заболевания коронавирусом в результате аббревиатуры с множественной миеломой (ММ) и макроглобулиной Уолденстрёма (ВМ) 2019. Поврежденные юморальные реакции на серию первичных прививок от острого острого респираторных синдрома коронавируса 2 (В тыс.SARS-CoV-2) были зарегистрированы у пациентов с MM и WM, однако о воздействии экспресс-прививок и функциональном состоянии полученных антител неизвестно. Мы провели перспективное когортное исследование SARS-CoV-2 вакцинация пациентов MM (n = 93) и WM (n = 48). Главным конечным моментом было эффективное иммунное реагирование

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… All analyses were performed in the R software (R Foundation for Statistical Computing, Vienna, Austria). …

Заболеваемость ломками и ее связь со смертностью у нескольких пациентов, страдающих миеломой: общенациональное когортное исследование ( " Microma " )CAREMM-2105 - обучение).

Множественная миелома (ММ), как известно, подрывает целостность костей, что ведет к повышению риска переломов, что подрывает качество жизни и увеличивает смертность. В ходе этого исследования были исследованы случаи переломов у пациентов, страдающих ММ, и была изучена связь между переломами после диагностирования ММ и смертностью с использованием базы данных Корейской национальной службы медицинского страхования. Повреждения были сопоставлены между пациентами MM (n = 9365) и 1::1 Сопоставимая контрольная группа с общим населением. Пациенты MM продемонстрировали значительно более высокую кумуля

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… Analyses were conducted using SAS version 9.4 (SAS Institute Inc.) and R version 4.0.3 (R Foundation for Statistical Computing, Vienna, Austria). …