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Urological management in people with traumatic and non-traumatic spinal cord injury in Brazil.

Despite the critical need for data to support public health policies in Brazil, there is a glaring lack of national epidemiological studies on neurogenic lower urinary tract dysfunction (NLUTD). This study aimed to illuminate the factors associated with the urological management of NLUTD among individuals with traumatic spinal cord injury (TSCI) and non-traumatic spinal cord injury (NTSCI). Employing a quantitative, cross-sectional, and descriptive design, this study analyzed electronic medical records of NLUTD and SCI patients monitored within the SARAH network from 2007 to 2017. Sociodemogra…

Gut Microbes and Inflammation: Their Role in Spinal Cord Injury Progression and Secondary Damage.

This review article describes recent research advances in the relationship between spinal cord injury (SCI) and the gut microbiota and each other's inflammatory response. SCI is a serious neurological disease that directly damages physiological function. Recent studies have shown that SCI significantly affected the composition and function of the gut microbiota, and even caused intestinal inflammation. The gut microbiota, a community of microorganisms inhabiting the intestinal tract, is closely related to the human health. Recent studies have indicated that the disordered gut microbiota was st…

Comprehensive guide to the diagnosis, management, and treatment of metastatic spinal cord compression syndrome.

Spinal metastases are the most common tumors found in the neuraxis. They correspond to 90 % of all tumors at this level. The thoracic region is the most frequently affected area, followed by the lumbar region, with the cervical region being the least frequently affected place. Back pain is the most common symptom, appearing in up to 95 % of patients who present with spinal cord compression syndrome. The evaluation of patients with spinal cord compression syndrome is complex and requires an entire multidisciplinary team for diagnosis, management, and treatment. In the medical part, treatment is…

[Intraoperative Monitoring of Cerebral and Spinal Cord Perfusion in Thoracic and Thoracoabdominal Aortic Surgery].

Neurological complications during thoracic and thoracoabdominal aortic surgery remain significant issues affecting both postoperative quality of life and long-term survival. Inadequate cerebral and spinal cord perfusion, as well as embolic events, are major contributors to such outcomes. Near-infrared spectroscopy (NIRS)-based regional cerebral oxygen saturation (rSO2) monitoring allows continuous, non-invasive assessment of cerebral perfusion and has become a routine adjunct in high-risk procedures. Factors such as mean arterial pressure, arterial carbon dioxide tension (PaCO2), hemoglobin le…

Exploring synthetic controls in rare diseases with a proof of concept in spinal cord injury.

BACKGROUND: Successfully completing clinical trials for rare and heterogeneous disorders, like spinal cord injuries (SCI), remains challenging, thereby reducing the ability to test and translate promising preclinical findings. We propose synthetic controls, derived from data-driven predictions of recovery in patients undergoing standard treatments, to mitigate these challenges, in particular related to patient recruitment. METHODS: Based on data from the European Multicenter Study about Spinal Cord Injury (EMSCI) and the Sygen trial, we construct synthetic controls from personalized predictio…

Back Pain as a Clue to Spinal Cord Involvement in Sjögren's Syndrome: An Uncommon Case.

Sjögren's syndrome (SS) is an autoimmune disease with systemic manifestations. Neurological manifestations of SS include vasculitis, dorsal … in the lower limbs, and absent bilateral plantar reflexes. MRI revealed a longitudinally extensive spinal cord lesion (from D4 to the conus medullaris) with T2 hyperintensity, contrast enhancement, and meningeal and cauda equina root thickening. Lumbar puncture showed lymphocytosis, hypoglycorrhachia, and hyperproteinorrachia, suggestive of lymphocytic menin …

Sexuality in people assigned female at birth with spinal cord injury: the challenges encountered.

BACKGROUND: Spinal Cord Injury (SCI) can impact sexual function negatively, and although most people continue to be sexually active post-injury, they often report decreased satisfaction in various aspects of sexual life. AIM: To gain insight into the sexual experience and functioning of people assigned female at birth (AFAB) with a SCI. METHODS: This study is part of an international observational questionnaire examining the reproductive health outcomes of individuals AFAB with SCI. The questionnaire was distributed to SCI organizations and support groups in 33 countries in four languages be…

Evaluation and management of autonomic functions in patients with spinal cord injury: A scoping review.

CONTEXT: Individuals with high-level spinal cord injury (SCI) face serious cardiovascular (CV) autonomic complications, contributing to increased mortality and morbidity. The assessment of CV autonomic function in SCI is challenging and varies widely across studies, with no clear or definitive interventions to restore hemodynamic stability or prevent complications. OBJECTIVES: This review outlines available clinical data on measuring and managing CV autonomic dysfunction after SCI and identifies gaps in these domains. METHODS: A scoping review was conducted, using a search strategy targeting…

Influence of Dietary Quality on Neurogenic Bowel Dysfunction in Individuals With Spinal Cord Injury.

BACKGROUND: Neurogenic bowel dysfunction (NBD) occurs in up to 95% of individuals with spinal cord injury (SCI) and negatively impacts the quality of life. Although diet is an important component in the management of NBD, the relationship between diet quality and NBD is understudied in the SCI population. OBJECTIVES: To assess the diet quality of individuals with chronic SCI and explore possible relationships between diet quality, especially fiber, and symptoms of NBD, and to evaluate whether individuals with SCI themselves recognize relationships between dietary intake and NBD symptoms. MET…

Spinal cord metabolism in multiple sclerosis: a decade of missed opportunities and future directions.

STUDY DESIGN: Review article. BACKGROUND: Despite spinal cord pathology driving progressive disability in multiple sclerosis (MS), research has disproportionately focused on brain imaging. The clinical manifestations most relevant to MS patients-mobility impairment, fatigue, and autonomic dysfunction-derive primarily from spinal cord involvement, yet spinal cord metabolism remains virtually unexplored. OBJECTIVE: To quantify the research gap in spinal cord metabolic imaging and evaluate scientific rationale, technological readiness, and implementation potential for establishing this approach…

СинСпайн: автоматизированный рабочий процесс для получения данных синтетического МРТ о продольном спинном мозге.

Атрофия спинного мозга является ключевым биомаркером для отслеживания развития заболеваний в неврологических расстройствах, включая множественный склероз, амиотропический боковой склероз и повреждение спинного мозга. Последние достижения в области МРТ позволили улучшить диагностику атрофии, особенно в области шейки матки, облегчив продольные исследования. Однако проверка атрофических алгоритмов количественной оценки по-прежнему сопряжена с трудностями из-за ограниченности наземных данных. ЦЕЛЬ: Настоящее исследование представляет SynSpine - рабочий поток для получения данных МРТ синтетического

Совпадение в аннотации оригинала
BACKGROUND: Spinal cord atrophy is a key biomarker for tracking disease progression in neurological disorders, including multiple sclerosis, amyotrophic lateral sclerosis, and spinal cord injury. Recent MRI advancements have improved atrophy detection, particularly in the cervical region, facilitating longitudinal studies. However, validating atrophy quantif…

A Scoping Review of Acute Sedentary Behaviour Studies of People with Spinal Cord Injury.

People with a spinal cord injury (SCI) report less physical activity than other populations and may engage in more sedentary behaviour (SB), especially sitting time. SB negatively impacts physiological and psychosocial outcomes in the general population, yet minimal research has explored the effects in people with SCI. The goal of this scoping review was to catalogue and describe the effects of acute SB among people with SCI. We searched four databases before February 2024 for studies in which people with any SCI sat, laid, or reclined for more than one hour in a day, and any physiological, ps…

Synergistic effects of curcumin and stem cells on spinal cord injury: a comprehensive review.

Spinal cord injury (SCI) is damage to the spinal cord that permanently or temporarily disrupts its function, causing considerable autonomic, sensory, and motor disorders, and involves between 10 and 83 cases per million yearly. Traumatic SCI happens following primary acute mechanical damage, leading to injury to the spinal cord tissue and worsening clinical outcomes. The present therapeutic strategies for this complex disease fundamentally rely on surgical approaches and conservative remedies. However, these modalities are not effective enough for neurological recovery. Therefore, it is necess…

A Study of Hypertension and Fitness of Individuals with Spinal Cord Injury: A Cross-Sectional Study.

Background/Objectives: Individuals with spinal cord injuries have a higher incidence of chronic conditions such as hypertension and cardiovascular diseases due to a sedentary lifestyle and low levels of physical activity caused by their disability. Additionally, their physical fitness levels are lower compared to those without disabilities. This cross-sectional study aimed to investigate the relationship between hypertension and the fitness of individuals with spinal cord injuries in South Korea while considering differences across sexes and spinal cord injury levels. Methods: This study used …

Revisiting the Emerging Role of Light-Based Therapies in the Management of Spinal Cord Injuries.

The surge in spinal cord injuries (SCI) attracted many neurobiologists to explore the underlying complex pathophysiology and to offer better therapeutic outcomes. The multimodal approaches to therapy in SCI have proven to be effective but to a limited extent. The clinical basics involve invasive procedures and limited therapeutic interventions, and most preclinical studies and formulations are yet to be translated due to numerous factors. In recent years, photobiomodulation therapy (PBMT) has found many applications in various medical fields. In most PBMT, studies on SCI have employed laser so…

Spinal Cord Infarction Thrombolysed at Seven Hours: A Case Report and Review of Literature.

We report a case of acute spinal cord infarction treated with intravenous (IV) thrombolysis at seven hours from symptom onset. Nineteen previously thrombolysed cases are reviewed. The patient underwent a clinical assessment, followed by an MRI of the spine. He was thrombolysed with a recombinant tissue plasminogen activator. Neurological severity was assessed at presentation and 24 hours using the National Institute of Health Stroke Scale (NIHSS), and disability at three months was evaluated using a modified Rankin scale (mRS). A middle-aged man presented with acute-onset paraplegia (NIHSS 9).…

Reprogramming of astrocytes to neuronal-like cells in spinal cord injury: a systematic review.

STUDY DESIGN: A Systematic Review OBJECTIVES: To determine the therapeutic efficacy of in vivo reprogramming of astrocytes into neuronal-like cells in animal models of spinal cord injury (SCI). METHODS: PRISMA 2020 guidelines were utilized, and search engines Medline, Web of Science, Scopus, and Embase until June 2023 were used. Studies that examined the effects of converting astrocytes into neuron-like cells with any vector in all animal models were included, while conversion from other cells except for spinal astrocytes, chemical mechanisms to provide SCI models, brain injury population, an…

The Epidemiology of Sport-Related Spinal Cord Injuries in the Gulf Region: A Systematic Review.

Traumatic spinal cord injuries (TSCIs) can lead to life-threatening consequences and neurological deficits. Sports activities significantly contribute to the incidence of these injuries. It is important to understand the epidemiology of sport-related spinal cord injuries (SCIs) in the Gulf region to improve patient care and increase awareness among this population. While studies from Saudi Arabia and Qatar have addressed SCIs related to both cycling and diving, we believe there is still significant scope for improvement in research on this topic. Special attention should be given to conducting…

An Unidentified Infiltrative Etiology of Spinal Cord Compression: A Case Report and Literature Review.

Spinal cord compression is a neurosurgical emergency. Symptoms of this disorder are highlighted as back pain, ambulatory difficulties, and bladder/bowel incontinence. Diagnostic imaging is not indicated in many circumstances of nonspecific back pain; however, the addition of neurologic deficits in the setting of back pain justifies radiologic imaging. Various pathologies can cause constriction of the spinal cord due to the delicate nature of spinal cord anatomy. Etiologies may include trauma, neoplasms, and infections. In this report, we present an unusual case of a 31-year-old male who presen…

Urinary Tract Infections in Relation to Bladder Emptying in Patients with Spinal Cord Injury.

Background/Objectives: Spinal cord injuries are debilitating conditions with significant impacts on physical function and patient quality of life. The high incidence of urinary tract infections in these patients can be attributed to neurogenic bladder-a major complication of spinal cord injuries. The aim of this study is to investigate the incidence of urinary tract infections in patients with spinal cord injuries and their relation to the method of bladder emptying. Methods: A retrospective analysis on 560 patients admitted for rehabilitation at the Clinic for Rehabilitation "Dr Miroslav Zoto…