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Increasing use of azoles combined with corticosteroids in Denmark.

INTRODUCTION: Superficial fungal infections are of growing concern, especially with the emergence of antifungal-resistant infections. Antifu … years. RESULTS: When analysing topical medications, we found high rates of triazole/corticosteroid prescriptions in all age groups. Topical ketoconazole was the most prescribed topical monotherapy across all ages; topical terbinafine prescription tended to decrease over time. When analysing oral medications, terbinafine was most commonly prescribed in males un …

Freeform vs. Aspheric Spectacle Lenses: A Comprehensive Review of Optical Performance, Clinical Outcomes, and Patient Considerations.

Spectacle lens design has evolved from spherical lenses to aspheric lenses (ASL) and freeform lenses (FFL) to improve peripheral optics and … ges. Adaptation appears faster, and patient satisfaction is higher with FFLs, especially in complex prescriptions and progressive designs. The ASLs are cost-effective for moderate prescriptions and standard fits, while FFLs represent the benchmark for personalized spectacle correction, particularly for high ametropia and PALs, provided there are accurate measur …

Nationwide Trends in the Incidence and Use of Immunosuppressive Therapy for Non-Infectious Non-Anterior Uveitis in South Korea (2010-2021).

PURPOSE: To investigate the incidence of non-infectious non-anterior uveitis (NINAU) based on steroid prescriptions recorded in the Korean National Health Insurance Service (KNHIS) database, covering nearly the entire Korean population. METHODS: Data were collected from patients diagnosed with uveitis who visited clinics between 2010 and 2021. Patients categorized as having NINAU prescribed steroids within one month were defined as "true NINAU." We compared the demographics and underlying comorbidities between patients treated with steroids alone and those receiving immunomodulatory therapy (…

Characterization of Key Aroma Compounds in Botanical Lujiu Based on Jiang-Flavor Baijiu by Comparative Aroma Extract Dilution Analysis, Quantitative Measurements, and Aroma Traceability Analysis.

This study successfully developed a botanical-type Lujiu product based on Jiang-flavor Baijiu (BTLJF) with a distinctive flavor profile. The … bly, 44 compounds showed a significant positive correlation (p < 0.05) with the dosage of medicinal prescriptions. Furthermore, key terpenoids contributing to the herbal aroma in BTLJF, such as DL-Limonene, (-)-α-cedrene, cedrol, nerolidol and α-terpineol, were confirmed to originate from medicinal prescriptions. This study provides valuable insights for the fu …

Exercise Intervention in Autonomic Function, Immunity, and Cardiovascular Health: A Precision Medicine Approach.

The imbalance in the interaction between the autonomic nervous system and the immune system serves as a central mechanism in the onset and p … em-immune axis and examines the potential applications of precision medicine in optimizing exercise prescriptions and clinical translation. Exercise significantly improves cardiovascular function through immunometabolic reprogramming, which includes suppressing sympathetic overactivity, enhancing vagal tone, and modulating the IL-6/IL-10 balance, as well as act …

Analyzing Prescribing Trends of Gastric Acid Suppressants in the UK Using Segmented Regression: Evaluating the Influence of COVID-19 (2019-2024).

BACKGROUND: This study explored the prescribing patterns of proton pump inhibitors (PPIs) and histamine H2-receptor antagonists (H2RAs) acro … dence on prescribing behaviors. RESULTS: The results revealed a significant increase in famotidine prescriptions, from 57.56 to 303.31 per 100,000 population in England post-January 2022, reflecting early adoption of preliminary findings despite the lack of randomized controlled trial confirmation. Ranitidine prescriptions fell to near zero due to contaminatio …

Impact of the COVID-19 pandemic on incident diagnoses in German refugee centres 2018 to 2023.

The COVID-19 pandemic may have affected morbidity patterns of residents in refugee centres, but empirical evidence is scarce. We utilised li … efugees in German centres. Notably, incidents of injuries, mental disorders, psychotherapeutic drug prescriptions, and genitourinary diseases rose, while respiratory diseases decreased, later rebounding. An increase in injury-related diagnoses suggests heightened violence experiences during flight or in centres. Mental disorder diagnoses and psychotherapeutic d …

:: повышенный риск инфицирования в мягких миеломах: результаты проверочного исследования iStopM.

Инфекции являются одной из основных причин заболеваемости и смертности в миеломе (ММ). Хотя повышенный риск инфицирования был продемонстрирован в моноклональной гаммопатии неопределенного значения (MMUS), данные о запятнании множественных миеломы (SMM) ограничены. Мы использовали данные из исследования iStopMM, которые проверяли 75,422 Исландцы в возрасте ≥40 - годы для прекурсоров MM. Лица, диагностированные СММ, в разбивке по возрасту и полу сопоставляются с компараторами, не имеющими СМГС (см.1::5 (соотношение) и с лицами, имеющими MGUS1::1 соотношение). Результаты заражения были получены н

Совпадение в аннотации оригинала
Infections are a major cause of morbidity and mortality in multiple myeloma (MM). While increased infection risk has been shown in monoclona … ction outcomes were derived from nationwide registries of ICD-10 diagnostic codes and antimicrobial prescriptions. Cox proportional hazards models estimated infection risk, adjusted for immunoparesis. 188 SMM individuals were matched to 188 MGUS individuals and 162 SMM individuals were matched to 810 comparators. Individuals with SMM had significantly more infe …

Comparative assessment of rational use of drugs in public and private hospital pharmacies: a multicenter cross-sectional study using INRUD/WHO prescribing indicators.

BACKGROUND: Specific actions to promote the RUD in public and private hospitals are highly needed. The current study aimed to assess RUD based on World Health Organization (WHO) prescribing indicators in selected public and private hospitals in Khartoum state-Sudan. METHODS: A multicenter cross-sectional study was conducted in six public and three private hospitals. After ethics approval, a consecutive random sample of 2880 patient encounter prescriptions was selected. The IRDP indicates adherence to RUD. RESULTS: The average number of drugs per patient encounter prescription was 1.7 ± 0.2 a…

Antibiotic Consumption and Bloodstream Infections in Patients With Chronic-limb Threatening Ischemia Following Endovascular Therapy in East-west Germany, 2019-2020.

Patients with chronic-limb threatening ischemia (CLTI) and peripheral wounds might be predisposed for systemic infections. The study aimed t … (95% CI: 4.1-7.7) comparing RBC 5 and 6 (1.2%) with RBC 1-4 (0.22%, P < .01). Outpatient antibiotic prescriptions were dominated by aminopenicillins with β-lactamase inhibitors, accounting for 34.9%. Clindamycin, cefuroxime, and fluoroquinolones represented 14.9%, 13.5%, and 12.6% of prescriptions, respectively. Infections were responsible for 7.7% of 30-day re …

Use of antidepressant and antipsychotic drugs in subjects with hemophilia of the Umbria Region in the period 2011-2022.

INTRODUCTION: Chronic diseases, such as hemophilia, can evoke psychological sequelae and be associated with a higher risk of mental health disorders. The utilization of antidepressant and antipsychotic drugs in subjects with hemophilia is not completely understood and few data are available. OBJECTIVES: The aim of this analysis is to describe use of antidepressant and antipsychotic drugs in subjects with hemophilia of the Umbria Region in the period 2011-2022. METHODS: A descriptive, cross-sectional, and retrospective analysis based on data on filled prescriptions for antidepressants and ant…

Effects of Valproic Acid Supply Shortage on Pharmacy Operations in a Region of Japan.

Introduction Valproic Acid (VPA) is an essential drug in epilepsy treatment, yet it has faced supply instability in Japan. The extent of the … rent supply situation. Supply stability according to pharmacy characteristics such as the number of prescriptions received per day and primary patient age group was also evaluated. Results Of the 42 pharmacies surveyed, 76.2% reported changes in prescription processing due to VPA supply issues. The main challenges were increased workload in inventory management …

Prescribing trends and rational drug use patterns in cardiovascular patients: A cross-sectional observational study.

Cardiovascular diseases (CVDs), encompassing conditions like coronary artery disease, hypertension and ischemic heart disease, are highly prevalent worldwide. This study analyzed prescribing trends and treatment appropriateness in CVD patients, focusing on adherence to guidelines, essential medicine use and generic drug prescriptions. A cross-sectional observational study was conducted on CVD-diagnosed patients. Data on prescribed medications-including drug classes, generic prescriptions and adherence to the Essential Drug List (EDL)-were collected and analyzed using IBM SPSS version 26.0. The…

Indications for extensively hydrolyzed cow's milk protein in the neonatal period.

A large proportion of prescriptions for extensively hydrolyzed cow's milk protein (CMP) in newborns are not based on any scientific data justifying the indication. Many of these prescriptions are old habits or are based on incomplete data. The aim of this article is to analyze these practices and propose recommendations. The following points are covered: (a) indications for extensively hydrolyzed formula based on studies demonstrating their benefits in these situations-newborns with a proven allergy to CMP and occasional prescription of supplements to breastfeeding; (b) possible indications no…

Urea Level and Depression in Patients with Chronic Kidney Disease.

Depression is common in patients with chronic kidney disease (CKD). Experimental studies suggest the role of urea toxicity in depression. We assessed both the incidence of antidepressant prescriptions and depressive symptoms (measured by CESD (Center for Epidemiologic Depression) scale) in 2505 patients with CKD (Stage 3-4) followed up over 5 years in the Chronic Kidney Disease Renal Epidemiology and Information Network (CKD-REIN) cohort. We used a joint model to assess the association between the serum urea level and incident antidepressant prescriptions, and mixed models for the association …

Value-based procurement in practice: individualised holistic prescribing for incontinence containment pads.

BACKGROUND: Poorly managed incontinence has many negative impacts on the health and wellbeing of care home residents and their carers. This can result from generic continence product prescriptions that are not tailored to individual need. AIMS: A holistic product assessment tool was designed to embody the concept of value-based procurement, facilitate personalised prescriptions and overcome barriers created by the COVID-19 pandemic. METHOD: In May and November 2021, residents with incontinence problems in six care homes underwent a holistic product assessment followed by personalised prescri…

Insurance approval rates for collagenase clostridium histolyticum prior to discontinuation: a Canada-wide analysis.

Collagenase Clostridium histolyticum (CCh), the first approved non-surgical treatment for Peyronie's disease (PD), was withdrawn from the Eu … 18, 2019, and 2020 were 86.5%, 90.1%, and 89.1%, respectively. Of 2921 approved applications, 88.8% prescriptions were filled. For the 376 rejected applications, 66.4% of prescriptions were filled. Overall, 90% of the cost of Xiaflex® was covered in Canada among those with extended health benefits, with an out-of-pocket expense of $210.4. Insurance coverage req …

NSAIDs and Renal Impairment: Deprescribing Chronic NSAID use in General Practice.

Aim NSAIDs are high-risk medicines that can commonly cause adverse renal effects. Recent evidence suggests a rise in the number of patients with acute and chronic renal disease. The aim of this audit is to determine our de-prescribing rate of chronic NSAID use in an Irish general practice. Methods We reviewed NSAID-containing drug prescriptions that were issued over a three month period in 2018. A description analysis was performed to ascertain for the frequency and type of NSAIDs prescribed. An educational session was delivered to clinicians to encourage de-prescribing of NSAIDs if deemed cli…

Trends in Systemic Antifungal Use in Australia, 2005-2016: a Time-Series Analysis.

Data on antifungal utilization trends are important for encouraging antifungal stewardship. This study explored the use of antifungal agents … ates and numerical increases attributed to obstetricians and gynecologists (1,969%; 1,851 dispensed prescriptions), as well as dermatologists (1,723%; 1,689 dispensed prescriptions) in 2010 and 2016. This is the first Australian national longitudinal estimate of systemic antifungal use. Our findings show an overall increase in the prescription of most antifunga …

Two-dose COVID-19 vaccination and possible arthritis flare among patients with rheumatoid arthritis in Hong Kong.

OBJECTIVES: To investigate the relationship between COVID-19 full vaccination (two completed doses) and possible arthritis flare. METHODS: … ultation related to RA or reactive arthritis, based on diagnosis records during the episode. Weekly prescriptions of rheumatic drugs since the launch of COVID-19 vaccination programme were compared to complement the findings from a diagnosis-based analysis. RESULTS: Among 5493 patients with RA (BNT162b2: 653; CoronaVac: 671; non-vaccinated: 4169), propensity-s …