Результаты поиска

Frailty Indices and Their Importance in Elderly Patients: A Perspective Review.

The aging demographic landscape of the United States highlights a concomitant rise in chronic conditions and infectious diseases. Older adults face a heightened susceptibility to infections, particularly pneumonia and urinary tract infections, and comorbidities such as cancer, cardiovascular disease, and dementia. Frailty, defined by a set of phenotypic criteria, emerges as a crucial predictor of adverse outcomes in infections, affecting hospitalization and post-care interventions. In the context of cancer, various frailty indices demonstrate their utility in predicting complications, mortalit…

Молекуляризация допанта в β-Ga2O3: образование N2 в условиях неравновесия.

Микроскопическая судьба допингов, вводимых в условиях неравновесия, остается в значительной степени нерешенной в отношении оксидов широкополосного раствора. С помощью спектроскопии рентгеновского поглощения N-конечного N-K, мы непосредственно решим местную конфигурацию связывания имплантированного азота ()100β-Ga2O3. В спектрре доминирует резкий резонанс, присущий NN, который систематически усиливается при аннезе, что дает прямой спектроскопический отпечаток молекулярного образования азота. Первые принципы расчетов и многоразового моделирования воспроизводят эти спектральные особенности и опре

Совпадение в полном тексте источника
… We primarily employed the computationally efficient multiple-scattering muffin-tin approximation (MTA), which proved sufficient for atoms occupying regular lattice sites, including the Ga K-edge and O K-edge of Ga 2 O 3 and the N K-edge of Ga 2 O 3 :N. … X-ray absorption near-edge structure calculations beyond the muffin-tin approximation Phys. Rev. B 2001 63 125120 10.1103/PhysRevB.63.125120 …

Bibliometric analysis of research trends in the relationship between frailty and neoplasms over the past decade.

BackgroundThe relationship between frailty and neoplasms has attracted increasing attention from researchers in recent years. This study aims to identify current research hotspots and status in this field through bibliometric and visualization analysis.MethodsLiterature on the relationship between frailty and neoplasms, meeting the inclusion criteria, was collected from the Core Collection. Bibliometric analysis and visualization were performed using WoS, VOSviewer, and CiteSpace.ResultsOur study included 7410 documents on frailty and neoplasms, authored by 43,605 researchers from 9478 institu…

Acute Kidney Injury in Oncology Patients.

With rapid progress in cancer diagnosis and treatment in the last two decades, outcomes in oncological patients have improved significantly. However, the incidence of acute kidney injury (AKI) in this population has also increased significantly. AKI complicates many aspects of patients' care and adversely affects their prognoses; thus, accurately diagnosing the risk factors for AKI ensures appropriate management. AKI may be caused by pre-renal, intrinsic renal, and post-renal reasons, as well as for combined reasons. This review summarizes the potential etiologies of AKI according to the three

Совпадение в полном тексте источника
… A case of nivolumab-induced acute granulomatous TIN in a patient with gastric cancer has been reported. Treatment with methylprednisolone (1.0 mg/kg daily) led to rapid improvement in renal function and decreased numbers of circulating cluster of differentiation 4-positive T cells 43 . … Medications most often associated with TIN are CNIs, antibiotics, and proton pump inhibitors 65 . …

Электрохимические датчики на основе полимера для диагностики нейродегенеративных заболеваний.

Острые и хронические нейродегенеративные заболевания (ND), включая множественный склероз (MS), болезнь Альцгеймера (AD) и болезнь Паркинсона (PD), характеризуются нейродегенерацией, которая представляет собой постепенный сбой и повреждение нейронов и аксонов в центральной нервной системе. Благодаря обнаружению соответствующих биомаркеров нейродегенеративных заболеваний (ND) стало возможным совершенствование клинических диагностических исследований, а также разработка и отслеживание успешных методов лечения заболеваний. Важные биомаркеры, такие, как белки тау, амилоид-β и α-синуклеины, имеют ва

Совпадение в аннотации оригинала
Acute and chronic neurodegenerative diseases (NDs), including multiple sclerosis (MS), Alzheimer's disease (AD), and Parkinson's disease (PD … d the development and tracking of successful disease-modifying treatments are made possible by detecting appropriate neurodegenerative disease (ND) biomarkers. Important biomarkers, such as Tau proteins, amyloid-β, and α-synucleins, are essential for precise identification but are often evaluated using time-consuming, expensive, and traditional techni …

Air toxics exposure from vehicle emissions at a U.S. border crossing: Buffalo Peace Bridge Study.

The Peace Bridge in Buffalo, New York, which spans the Niagara River at the east end of Lake Erie, is one of the busiest U.S. border crossin … ays. Other metals (beryllium, sodium, magnesium, potassium, titanium, manganese, cobalt, strontium, tin, cesium, and lanthanum) showed significant increases downwind as well. Sulfur, arsenic, selenium, and a few other elements appeared to be markers for regional transport as their upwind and downwind concentrations were correlated, with ratios near un …

Pathogenesis and treatment of Sjogren's syndrome: Review and update.

Sjogren's syndrome (SS) is a chronic autoimmune disease accompanied by multiple lesions. The main manifestations include dryness of the mouth and eyes, along with systemic complications (e.g., pulmonary disease, kidney injury, and lymphoma). In this review, we highlight that IFNs, Th17 cell-related cytokines (IL-17 and IL-23), and B cell-related cytokines (TNF and BAFF) are crucial for the pathogenesis of SS. We also summarize the advances in experimental treatment strategies, including targeting Treg/Th17, mesenchymal stem cell treatment, targeting BAFF, inhibiting JAK pathway, et al. Similar…

Age, sex, primary tumor type and site are associated with mortality after pathological fractures: an observational study of 1453 patients from the Swedish Fracture Register.

BACKGROUND: Pathological fractures are challenging in orthopedic surgery and oncology, with implications for the patient's quality of life, mobility and mortality. The efficacy of oncological treatment on life expectancy for cancer patients has improved, but the metastatic pattern for bone metastases and survival is diverse for different tumor types. This study aimed to evaluate survival in relation to age, sex, primary tumor and site of the pathological fractures. METHODS: All pathological fractures due to cancer between 1 September 2014 and 31 December 2021 were included in this observation

Совпадение в полном тексте источника
… Validity of humerus fracture classification tin the Swedish fracture register. BMC Musculoskelet Disord. 2020;18(1):251. doi: 10.1186/s12891-017-1612-3. 13. Macedo F, Laderia K, Pinho F, Saraiva N, Bonito N, Pinto L, et al. Bone metastases: an overview. …

ИММУНОТРОПНАЯ ТЕРАПИЯ В ЛЕЧЕНИИ РЕЦИДИВИРУЮЩЕГО РИНОСИНУСИТА

Рецидивирующие риносинуситы протекают на фоне иммунодефицитных состояний, латентно, длительно, без болевого симптома.Цель. Определение показаний к назначению иммунотропной терапии у больных с рецидивирующим риносинуситом.Материалы и методы. Обследовано 85 больных с гнойным рецидивирующим риносинуситом без болевого симптома. Всем больным проведено полное клиническое обследование, иммунограмма, определение уровня IL-1β, IL-4, IL-6, IL-8, IL-10, TNFα, INFγ и субстанции Р (SP) в сыворотке крови. Для коррекции иммунной недостаточности в стандартную схему лечения гнойного риносинусита у части больны

Совпадение в полном тексте источника
… Med vestnik Yuga Rossii [Medical bulle- tin of the South of Russia]. 2014, no 3, pp. 55–59. 4. McMahon S.B., Russa F.L., Bennett D.L. Crosstalk between the nociceptive and immune systems in host defence and disease. Nat. Rev. Neurosci. 2015, V ol. 16, no 7, pp. 389–402. doi: 10.1038/nrn3946. 5. …

Catastrophic health expenditure and 12-month mortality associated with cancer in Southeast Asia: results from a longitudinal study in eight countries.

BackgroundOne of the biggest obstacles to developing policies in cancer care in Southeast Asia is lack of reliable data on disease burden an … on these two outcomes of a range of socio-demographic, clinical, and economic predictors using a multinomial regression model.ResultsThe mean age of participants was 52 years; 64% were women. A year after diagnosis, 29% had died, 48% experienced financial catastrophe, and just 23% were alive with no financial catastrophe. The risk of dying from cancer …

The race is on: bispecifics vs CAR T cells in B-cell lymphoma.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… Palomba ML Gordon LI Two-year follow-up of transcend NHL 001, a multicenter phase 1 study of lisocabtagene maraleucel (liso-cel) in relapsed or refractory (R/R) large B-cell lymphomas (LBCL) Blood 138 suppl 1 2021 2840-2840 10 Kuhnl A Roddie C Kirkwood AA A national service for delivering CD19 CAR-Tin …

Р

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… palmitin [ pal′mľ-tin ] glycerol tripalmitate, one of the common fats in animal fat. A crystallizable and saponifiable substance. palmitoleic acid [ pal″mľ-to-le′ik ] a 16-carbon monounsaturated fatty acid, with a double bond at carbons 7,8. An endogenously synthesized nonessential fatty acid. … pancreatin [ pan′kre- -tin ] a substance from the pancreas of the pig or ox containing digestive enzymes, principally amylase, protease, and lipase; used in the treatment of pancreatic exocrine insufficiency. …

Incidence trends for twelve cancers in younger adults-a rapid review.

Many cancer referral guidelines use patient's age as a key criterium to decide who should be referred urgently. A recent rise in the inciden … , although the mechanisms remain unclear. Cancer investigation and referral guidelines may need updating in light of these trends.

Promising Highly Targeted Therapies for Cholangiocarcinoma: A Review and Future Perspectives.

To overcome the poor prognosis of cholangiocarcinoma (CCA), highly targeted therapies, such as antibody-drug conjugates (ADCs), photodynamic therapy (PDT) with/without systemic chemotherapy, and experimental photoimmunotherapy (PIT), have been developed. Three preclinical trials have investigated the use of ADCs targeting specific antigens, namely HER2, MUC1, and glypican-1 (GPC1), for CCA. Trastuzumab emtansine demonstrated higher antiproliferative activity in CCA cells expressing higher levels of HER2. Similarly, "staphylococcal enterotoxin A-MUC1 antibody" and "anti-GPC1 antibody-monomethyl…

The Protective Effects of Sesamin against Cyclophosphamide-Induced Nephrotoxicity through Modulation of Oxidative Stress, Inflammatory-Cytokines and Apoptosis in Rats.

Cyclophosphamide is an anticancer drug with a wide spectrum of clinical uses, but its typical side effects are multiple complications, inclu … ndialdehyde (MDA) levels. Thus, SM significantly overcame the elevated kidney function markers (creatinine, blood urea nitrogen, and uric acid) by attenuating oxidative stress. The SM also significantly reduced the elevated cytokines (IL-1β and TNFα) and caspase-3 in the treated group. Histopathological studies confirmed the protective effect of sesam …

The Use of Imaging in Management of Patients with Low Back Pain.

Lower back pain (LBP) is one of the most common chief complaints encountered in primary care. Advanced imaging studies, including computerized tomography (CT) and magnetic resonance imaging (MRI), are frequently ordered in the setting of LBP. Structural abnormalities are commonly identified by CT and MRI in patients complaining of low back pain, however, these findings are also found in asymptomatic patients. In the past decade, multiple guidelines have been published to help providers identify patients in whom the use of advanced imaging is appropriate. In this article, we review common condi…

Transplant oncology and anti-cancer immunosuppressants.

Organ transplantation is a life-saving intervention that enhances the quality of life for patients with end-stage organ failure. However, long-term immunosuppressive therapy is required to prevent allogeneic graft rejection, which inadvertently elevates the risk of post-transplant malignancies, especially for liver transplant recipients with a prior history of liver cancer. In response, the emerging field of transplant oncology integrates principles from oncology and immunology to improve outcomes for patients at high risk of tumor occurrence or recurrence following transplantation. Therefore,

Совпадение в полном тексте источника
… Willoughby JS, Sundar SN, Cheung M, Tin AS, Modiano J, Firestone GL. Artemisinin blocks prostate cancer growth and cell cycle progression by disrupting Sp1 interactions with the cyclin-dependent kinase-4 (CDK4) promoter and inhibiting CDK4 gene expression. … Tin AS, Sundar SN, Tran KQ, Park AH, Poindexter KM, Firestone GL. Antiproliferative effects of artemisinin on human breast cancer cells requires the downregulated expression of the E2F1 transcription factor and loss of E2F1-target cell cycle genes. …

C

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… cachectin [ k -kek′tin ] tumor necrosis factor-alpha. cachet [ kă-sha′ ] [Fr.] a dish-shaped wafer or capsule enclosing a dose of medicine. cachexia [ k -kek′se- ] a profound and marked state of constitutional disorder; general ill health and malnutrition. …

Infectious complications after CAR T-cell therapy: mechanisms, risk stratification, and prevention.

Chimeric antigen receptor (CAR) T-cell therapy is an established treatment for relapsed or refractory B-cell malignancies. Despite therapeutic success, infectious complications remain a major contributor to non-relapsed morbidity and mortality. The risk of infection reflects a prolonged and multifactorial state of immunosuppression resulting from lymphodepleting chemotherapy, treatment-related cytopenia, sustained CD4+ T-cell lymphopenia, B-cell aplasia with hypogammaglobulinemia, and the use of corticosteroids or cytokine-directed therapies for the management of immune effector cell-associate…

Уникальные диагностические и терапевтические функции порфиринов и фтальокянинов в области фотодинамической терапии, визуализации и термостимы.

Порфиринические молекулы играют уникальную тераностическую роль в лечении болезней; они используются для отображения, обнаружения и лечения различных форм заболевших тканей, в том числе в связи с возрастной маркулярной дегенерацией и рядом различных видов рака. В настоящее время основное внимание уделяется клинической съемке опухолей; целенаправленной доставке фотосенитеров и потенциалу фотоэнцедентов в мультимодальных биомедицинских наноплатформах. В настоящем Обзоре подчеркиваются роли порфириновых молекул в области съемки и пдта, а также исследования по совершенствованию их селективного пог

Совпадение в полном тексте источника
… Tin etiopurpurin (Purlytin ® , figure 12 ), a chlorin-based photosensitiser, is a derivative of the porphyrin chromophore with a reduced exocyclic double bond and an intensified long-wavelength absorption - the tin atom chelated in the central cavity further increases the red shift (20-30nm) of the drug … Tin-etiopurpurin, benzoporphyrin derivatives and zinc PCs have all been successfully encapsulated in order to demonstrate this technique 4 , 14 , 42 . …