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[The changes of LCHAD in preeclampsia with different clinical features and the correlation with NADPH P47-phox, p38MAPK-α, COX-2 and serum FFA and TG].

OBJECTIVE: To investigate the changes of fatty acid oxidase in the placenta of preeclampsia cases with different clinical features, and the relationship with oxidative stress and inflammatory response. To study the correlation of serum free fatty acid (FFA) and triglycerides (TG) level in early second trimester with the molecular changes of the long-chain fatty acid oxidase in the third trimester. METHODS: This was prospective cohort study, in which cases with singleton pregnancies who archived in Haidian Maternal and Children's Hospital, Beijing, from January 1st 2012 to May 31st, with regul…

Rack1-mediated ferroptosis affects hindgut development in rats with anorectal malformations: Spatial transcriptome insights.

Anorectal malformation (ARM), a common congenital anomaly of the digestive tract, is a result of insufficient elongation of the urorectal septum. The cytoplasmic protein Receptor of Activated C-Kinase 1 (Rack1) is involved in embryonic neural development; however, its role in embryonic digestive tract development and ARM formation is unexplored. Our study explored the hindgut development and cell death mechanisms in ARM-affected rats using spatial transcriptome analysis. We induced ARM in rats by administering ethylenethiourea via gavage on gestational day (GD) 10. On GDs 14-16, embryos from b

Совпадение в полном тексте источника
… Blocking was conducted using serum (ZSGB‐BIO, Beijing, China) at 25°C for 1 h, followed by incubation with primary antibodies for 16 h at 4°C. … Intracellular ferrous ion detection Intracellular ferrous iron was detected using the FerroOrange fluorescent probe (Dojindo, Beijing, China). …

Effects of hsa-miR-28-5p on Adriamycin Sensitivity in Diffuse Large B-Cell Lymphoma.

BackgroundAdriamycin (doxorubicin) is an important traditional drug that exhibits cytotoxicity in Diffuse Large B-cell Lymphoma (DLBCL). Doxorubicin affects the DLBCL cells at all stages of their cell cycle. Combined with our previous results, this study discovered that the overexpression of hsa-miR-28-5p inhibited the proliferation, promoted apoptosis, and triggered cell cycle arrest at the S-phase in DLBCL cells. However, the effect of (Homo sapiens, hsa)-microRNA (miR)-28-5p on doxorubicin sensitivity in DLBCL has not been investigated. This study aims to reveal the effects of hsa-miR-28-5p

Совпадение в полном тексте источника
… Cell Counting Kit-8 (CCK-8) Cell proliferation was practiced with the use of the CCK-8 reagent ( N20821 , FC101-03, Beijing, China). Seed OCI-LY1 cells into 96-well plates at the density of 5 × 10 3 cells/well. … We resuspended cells resuspended in 500 μ L of PBS (ZLI-9062, Beijing, China). Meanwhile, 3.5 mL of anhydrous ethanol was used for fixation overnight. The suspension was centrifuged for a 5 min period at 2,000 rpm to separate cells (1 × 10 6 ). …

[Medicinal Alcohol in Treating Sixty diseases and the Qi Harmony Decoction Method in the Tian Hui Yi Jian].

Treating Sixty diseases and the Qi Harmony Decoction Method (hereafter He Qi Tang Fa) in the Tian Hui Yi Jian presents abundant information on medicinal substances and formula construction, in particular, the fully-developed use of medicinal alcohols. This paper examines He Qi Tang Fa in this book, The Prescriptions for Fifty-Two Diseases and The Prescriptions for Nourishing Life from the Mawangdui tombs, analyses the various terms and types of fermented liquors recorded in the texts, explores their functional differentiation in medical practice from the perspectives of modes of application an

[The Comparison of disease names of Atrophic Rhinitis between TCM and Western Medicine with TCM concept filiation].

Withered Nose (Bi Gao) is a modern name for dry nose drawn from classical traditional Chinese medicine texts, for the condition atrophic rhinitis. Based on these texts before the Tang Dynasty, dry nose and its relevant symptoms were not identified as a single disease. Withered Nose was recorded in the Huangdi's Inner Canon (Huangdi Neijing) and Classic of Difficult Issues (Nan Jing), but referred to external nasal desiccation due to acute heat illness, having nothing to do with atrophic rhinitis. The symptoms such as "dry nose without nasal discharge" and "dry nose " were reduced to independen

[Training of nursing staff in the Central Soviet Area (Fujian)].

During the period of the Agrarian Revolutionary War, the war led to a sharp increase in the number of wounded and sick in the Central Soviet Area (Fujian) and the epidemic of infectious diseases. Therefore, the Red Army and the Soviet government needed to quickly establish a nursing team. Nursing staff are trained through various means, such as nursing schools, nursing training teams in Red Army rear hospitals, and training classes for female nurses. In order to make up for the serious shortage of nursing staff, local people were also widely mobilized to organize nursing teams to help the medi

[Exploring the drawings and the evolution of human body diagrams about Zang-Fu organs and meridians].

Human body diagrams of Zang-Fu organs and meridians are believed to be vehicles to visualise traditional Chinese medicine theories. Their drawing methods and content evolution indicate the interaction among anatomical knowledge, medical theories, and cultural cognition. This paper examined Chan Jing, Tong Ren Shu Xue Zhen Jiu Tu Jing, Cun Zhen Huan Zhong Tu, and Shang Han Lun Da Fang Tu Jie and explored their evolution process. It was found that the diagrams in Chan Jing focused on the "theory of fetal nourishment", influenced by the Five Elements theory and the concept of the interaction betw

[The practice of Chinese Medicine in the health work of the New Fourth Army].

The core issue of the New Fourth Army in their health work was the shortage of doctors and medicine and the enemy blockade during the full-scale War of Resistance against Japan (1937-1945). The New Fourth Army implemented the policies of 'integrated Chinese medicine with Western medicine' and 'scientificisation of traditional Chinese medicine', and developed systematic Chinese medicine practice based in the enemy-occupied rear areas controlled by China. The New Fourth Army started traditional Chinese medicine training classes and promoted the mentor- apprentice training model, making up for th

[Examining doctor-patient interaction in the late Qing and early Republican periods: centering on Zhong Guo Gu Jin Yi An Hui Bian in gynecology and pediatrics].

The nature of medical practice involves both technical dimension of pathology and treatment and the socio-cultural dimension in terms of doctor-patient interaction, as a core components of the human health protection system. The gynecological and pediatric treatment narratives in the Class Compilation of Ancient and Modern Medical Cases of China (Zhong Guo Gu Jin Yi An Hui Bian) in the late Qing Dynasty and early Republic of China is believed to provide a typical sample for exploring multidimensional interactions in the traditional medical field at that time. With the increasing popularization

[Examining Wang Jiufeng and his works].

Wang Jiufeng, a renowned physician in Zhenjiang in the period of Qianjia in the Qing Dynasty, transitioned from Confucianism to medicine and became proficient in the art of healing. The existing records of his life and works are rarely seen and often inconsistent. This paper examined his family background, life events, disciples, friends and works based on the genealogy compiled by Wang Jiufeng himself, and investigated some contentious issues in current literature materials, such as the differentiation between the North Wang Jiufeng and the South Wang Jiufeng, his year of death, his alternati

[John Glasgow Kerr and the Compilation of Zhong Dou Jie Fa and Niu Dou Qian Shuo].

Zhong Dou Jie Fa and Niu Dou Qian Shuo were written by John Glasgow Kerr, a missionary from America, trained local smallpox practitioners in Guangzhou in the second half of the 19th century. The two books Zhong Dou Jie Fa and Niu Dou Qian Shuo introduced simple and easy ways for practical inoculation. The books suggested that it was not necessary to consider acupoints and seasons for vaccination. They introduced the method of storing vaccine in capillary tubes and made use of microscopes and vaseline, popularly used in Europe at the time, promoting the development of vaccination technology obj

[Interpreting the pulse diagnosis diagrams and the pulse principles in Nan Jing in both Chinese and Japanese editions].

This paper systematically reviewed the evolvement and development of pulse diagnosis illustrations in the annotated versions of Nan Jing in both Chinese and Japanese editions. It compared and analysed the content and characteristics of the three pulse diagram systems - the Ding, the Hua and the Zhang in China with that in the annotated edition of Nan Jing in the Japanese edition in the Edo period of Japan. The paper demonstrated the core function of pulse diagrams in interpreting the theories of pulse in Nan Jing. It was found that the pulse diagram illustrations evolved through multiple dynas

[Mary Esther Ferguson in China: History and Memory].

Mary Esther Ferguson (1897-1989) was the daughter of John Calvin Ferguson, a renowned American social activist, educator, and collector in the early period of the Republic of China. Together with her father, she made an outstanding contribution to the cultural heritage preservation in China. M.E. Ferguson joined the Peking Union Medical College (PUMC) as the Registrar in 1928. She had served as the secretary to the Board of Trustees for nearly 20 years thereafter. She personally witnessed a series of major historical events, in this period, including the administrative reforms of the "Old PUMC

[The epidemic in Wenzhou area recorded in Zhang Gang's Diary (1888-1942)].

Zhang Gang's Diary (1888-1942) was a private document that recorded the social and public life in Wenzhou during the late Qing Dynasty and the period of the Republic of China, providing resources and historical materials of local epidemics in this period. This paper examines/reviews the epidemic-related content in the diary and the responses of the authorities and the public to the epidemic. It was found that the epidemic triggered panic among the public, and many people turned to seeking blessings and protection from gods and Buddhas. It was also found that traditional Chinese medicine played

[The development models of Shanghai Fo Ci Pharmaceutical Factory and Cui Hua Pharmaceutical Factory in the Republic of China].

Fo Ci Pharmaceutical Factory, founded in Shanghai in 1932, was the first modern joint-stock enterprise to successfully commercialize 'Chinese medicine made in the western way'. It pioneered the 'condensed pill' technology according to traditional Chinese medical theories, gaining wide recognition for its remarkable efficacy. It emphasized laboratory analysis, experimental research and formula transparency. It maximised its influence domestically and exported its products overseas with flexible market strategies. It survives today despite obstacles like industry resistance and the War of Resist

[Yi Jing Hui Yuan written by Wu Jiayan: its academic features and influence on the following generations].

This paper focused on the Yi Jing Hui Yuan, written by Wu Jiayan, analysed the academic features of the book , and explored its influence on the following generations drawing on the reference of the work by Gong Tingxian. It was found that this book has many remarkable characteristics. It was rooted in Su Wen and Nan Jing academically, synthesizing theories from various medical schools. The book highlighted fitness regime, temperance and spiritual cultivation because it was deeply influenced by Taoism which was the religious belief of Wu Jiayan in his later years. The book attached equal impor

[Food Materia Medica: books with the same name in the Ming Dynasty].

In the Ming Dynasty some medical books were named Food Materia Medica, but with different authors, unidentified authorship or inconsistent volumes. This paper examined and compared the versions and content in these books with archival methods, bibliographic examination and textual criticism. It was found that the original authors of Food Materia Medica in the Ming Dynasty were Lu He and Wang Ying. A total of four versions of this book remain now. The other books with the same name were those with deletions or additional pictures.

[Examining syndrome differentiation and treatment of 'Gu Zhang' and 'Xue Ku' in Fu Zhong Lun, Su Wen].

The syndrome differentiation and treatment of'Gu Zhang'() and 'Xueku' () in Fu Zhong Lun, Su Wen was examined with the approach of exegesis and textual criticism. The four findings were as follows. 'Guzhang'() in the section of Fu Zhong Lun in Su Wen should be a misnomer. The key pathogenesis of this disease lies in the failure of food transforming into heat and the deficiency and weakness of spleen-stomach. Therefore, Ji Shi Li has to be used for treatment to help digestion, clear heat, tonify essence and replenish Qi. Then, the definition given by later-generation to 'Gu Zhang' () as one of

[Examining the origin and evolution of 'Jiao Chang'].

Jiao Chang was a disease, recorded in both ancient and contemporary medical literature. However, its conceptual understanding remained inconsistent and even fallacious. This paper systematically examines the origin and evolution of Jiao Chang in terms of connotation by drawing on methodologies from philology, historiography and conceptual history. The concept of Jiao Chang originated from the linguistic descriptions of its physical symptom "hemorrhoids connecting with the Qian Yin (perineum region anterior to acupoint Hui Yin or urogenital triangle)", and the symptom "urinating with feaces or

[Reexamining the authorship of Wen Yi Ming Bian].

The authorship of the book Wen Yi Ming Bian and Guang Wen Yi Lun, a historical controversy, have the same content but different names. It was widely believed that Dai Tianzhang was the author of the two books rather than Zheng Dianyi. This study examined the two authors' biography, diverse versions of authors notes and other relevant materials that remained, and the compatibility between the content and the book names. It was found that Zheng Dianyi was a physician with excellent medical skills and ability to compile the book, whereas Dai Tianzhang was a local celebrity and gentleman who had s