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A review of feline infectious peritonitis virus infection.

Feline infectious peritonitis (FIP) is an infectious disease characterized by non-specific laboratory changes and clinical signs. Clinical symptoms include anorexia, jaundice, fever, and weight loss. Moreover, some lesions are found in the digestive and respiratory systems. FIP, whose virulence varies, cannot be distinguished using several diagnostic methods. Moreover, feline coronaviruses (FCoVs) can be classified into two serotypes based on differences in their amino acid sequences, spike (S) protein sequences, and antibody (Ab) neutralization. There are two pathotypes, namely those caused b

The role of LY49 NK cell subsets in the regulation of murine cytomegalovirus infections.

The distributions and functions of NK cell subsets, as defined by the expression of Ly49 NK cell receptors, were examined in murine CMV (MCMV)-infected mice. MCMV induced a reduction in NK1.1+ cell number in the spleen and an increase in the peritoneal exudate cells. Within the splenic NK1.1+ population, proportional increases in Ly49A+ and Ly49G2+ cells but decreases in Ly49C+ and Ly49D+ cells were observed 3 days post-MCMV infection, but within the peritoneal NK1.1+ cell populations there were proportional decreases in Ly49A+ cells and increases in Ly49C+, Ly49D+, and Ly49G2+ cells. Lymphocy

Tenckhoff tunneled peritoneal catheter placement in the palliative treatment of malignant ascites: technical results and overall clinical outcome.

BackgroundTo assess the technical and clinical outcome of percutaneous insertion of tunneled peritoneal catheters in the palliative treatment of refractory malignant ascites and to determine the safety and feasibility of intraperitoneal administration of cytotoxic drugs through the tunneled catheter.Materials and methodsConsecutive patients palliatively treated with a tunneled peritoneal catheter to drain the malignant ascites were identified. Patients' medical history, procedural and clinical follow-up data, including complications and estimated survival, were reviewed. Additionally, a sub an

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… A 0.035 inch hydrophilic guide wire (HydroSteer, St-Jude Medical, St-Paul, MN, USA) was introduced into the peritoneal cavity using a 0.035 inch 4 French (F) Cobra catheter (Slip-cath, Cook Medical, Bjaeverskov, Denmark) positioned in the pelvis ( Figure 1B ). … (D) The 15F peel-away sheath (white arrows) is introduced into the peritoneal cavity over the stiff Amplatz wire (arrowheads). (E) The Tenckhoff catheter (white arrows) is introduced through the 15F peel-away sheath into the peritoneal cavity. …

[Protective effect of tumor necrosis factor receptor-associated factor 6 inhibitor C25-140 on acute kidney injury induced by diquat poisoning in mice].

OBJECTIVE: To investigate the protective effect and mechanism of tumor necrosis factor receptor-associated factor 6 (TRAF6) inhibitor C25-14 … l control group and C25-140 control group were injected with an equal amount of pure water into the peritoneal cavity. After 4 hours of model establishment, the C25-140 intervention group and C25-140 control group were given intraperitoneal injection of C25-140 5 mg/kg. The normal control group and DQ model group were given equal amounts of pure water, once a day f …

Enhanced expression of TACE contributes to elevated levels of sVCAM-1 in endometriosis.

STUDY QUESTION: Are increased sVCAM-1 and sICAM-1 levels associated with tumor necrosis factor-alpha-converting enzyme (TACE) activity in endometriosis? SUMMARY ANSWER: Here we provide the first functional evidence that induced TACE activity in human endometriotic epithelial cells is at least in part responsible for the enhanced release of sVCAM-1 from these cells. WHAT IS KNOWN ALREADY: We and others have shown that serum-soluble (s)VCAM-1 levels are significantly higher in women with endometriosis, compared to disease-free controls. Experimental evidence exists suggesting a role of sICAM-1

Intra-uterine microbial colonization and occurrence of endometritis in women with endometriosis†.

STUDY QUESTION: Is there any risk of intra-uterine bacterial colonization and concurrent occurrence of endometritis in women with endometriosis? SUMMARY ANSWER: An increase in intra-uterine microbial colonization and concurrent endometritis occurred in women with endometriosis that was further increased after GnRH agonist (GnRHa) treatment. WHAT IS KNOWN ALREADY: Higher bacterial contamination of menstrual blood and increased endotoxin level in menstrual and peritoneal fluids have been found in women with endometriosis than in control women. However, information on intra-uterine microbial co

Theatrical fire pursuant exploratory laparotomy.

Fire in the operating theater is a rare but potentially fatal complication. We report igniting an intraperitoneal fire while preforming an exploratory laparotomy for perforated viscus. Fortunately, the patient suffered no injuries as a result.

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… Although preoxygenated, she underwent rapid sequence induction and we do not suspect that any significant amount of 100% oxygen was pumped into her peritoneal cavity. … Gastroenterology 1989 ; 96 : 530 – 1 . 2910765 10.1016/0016-5085(89)91582-5 4 Dhebri AR , Afify SE Free gas in the peritoneal cavity: the final hazard of diathermy . …

Amelioration of severe TNBS induced colitis by novel AP-1 and NF- κ B inhibitors in rats.

AP-1 and NF-κ B inhibitors, namely, DTCM-G and DHMEQ, were investigated in male Wistar rats with severe colitis, induced by TNBS. The animals were randomized into 3 groups. The control group received 0.5 mL of 0.5% of the vehicle i.p., the DTCM-G group received 22.5 mg/kg body weight DTCM-G in 0.5% i.p., and the DHMEQ group received 15 mg/kg body weight DHMEQ i.p., all twice daily for 5 days. The body weight losses and mortality rates were significantly higher in the control group than those in DTCM-G-treated and DHMEQ-treated groups. The endoscopic inflammation scores in the control, DTCM-G-t

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… It has been proposed that DHMEQ does not enter the systemic circulation, instead exerting its effects locally in the peritoneal cavity [ 17 ]. … Umezawa proposed the following hypothesis for explaining the anti-inflammatory effect of DHMEQ at sites distant from the peritoneal cavity: macrophages differentiate in the peritoneal cavity prior to migrating to inflammation sites, and the peritoneal cavity is an extravascular culture chamber for the …

Body Cavity-Based Lymphoma in a Country with Low Human Immunodeficiency Virus Prevalence: A Series of 17 Cases from the Consortium for Improving Survival of Lymphoma.

PurposePrimary effusion lymphoma (PEL) is a type of body cavity-based lymphoma (BCBL). Most patients with PEL are severely immunocompromised and seropositive for human immunodeficiency virus (HIV). We investigated the distinctive clinicopathologic characteristics of BCBL in a country with low HIV burden.Materials and methodsWe retrospectively collected data on the clinicopathologic characteristics, treatments, and outcomes of 17 consecutive patients with BCBL at nine institutions in Korea.ResultsLatency-associated nuclear antigen 1 (LANA1) immunostaining indicated that six patients had PEL, si

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… CR  12  12 peritoneal cavity 11 M 83 Pleural cavity Negative 2 4 None 1st-line R-CVP NA  2  2 12 M 75 Pleural cavity, Negative 1 3 None 1st-line R-CHOP CR  46  49 pericardial cavity 13 F 76 Pleural cavity Unknown 2 2 None 1st-line CHOP CR  5  5 14 F 73 Pleural cavity, Unknown 1 4 HBV 1st-line … CVP PR 10 10 peritoneal cavity 15 M 86 Pleural cavity Unknown 1 4 None 1st-line R-CVP PR  24  24 16 F 66 Pleural cavity, Unknown 1 4 None 1st-line CHOP CR  99  99 peritoneal cavity 17 F 39 Pleural cavity, Unknown 1 3 None 1st-line R-CHOP CR  123  123 lung HHV8, human herpesvirus 8; ECOG PS, Eastern …

The role of technological progress vs. accidental discoveries and clinical experience.

The 50th anniversary of dialysotherapy celebrated by nephrologists around the world in 2012 provided an opportunity for discussion on the role of clinical experience in relation to technological progress in the evolution of dialysis, especially of recently observed inadequate decrease in mortality/morbidity rates of patients on chronic dialysis. My report, based on almost 50 years of career in nephrology, refers the evolution of dialysis, from catharsis to modern dialysotherapy with special attention devoted to nowadays gravely underestimated role of clinical experience and personalized profes

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… In 1958 Mort Maxwell published his paper on the new method of inserting the stylet catheter into the peritoneal cavity and ipso facto establishing the program of intermittent peritoneal dialysis (IPD) [ 24 ]. … RIPD consisted of a increased flow of dialysis fluid and automatisation of the whole dialysis process, in particularly by independent dialysis devices, that regulated cycles of dialysis fluid supply and removal from the peritoneal cavity [ 4 ]. Years 1976 to 1978 were a time when R. …

Частые связи злокачественных эфлуаций в плазмбластической лимфоме: единый институциональный опыт nine дела на Тайване.

ЦЕЛЬ: Плазмабластическая лимфома (PBL) представляет собой редкую, агрессивную лимфому, для которой характерна дифференциация конечной клетки B. На Западе PBL обычно встречается у пациентов с иммунодефицитными расстройствами, в частности в результате инфекции вируса иммунодефицита человека (ВИЧ). Мы изучили клинопатологические особенности PBL в одном институте на Тайване, где ВИЧ-инфекция встречается редко. МЕТОДЫ: В ходе этого ретроспективного обзора были выявлены случаи ПБД, которые рассматривались в одном институте на юге Тайваня в период между 2008 и 2024. Результаты: Мы определили nine (бо

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… Among those with Stage IV PBL, five (patient nos. 1, 3, 6, 8, and 9) demonstrated involvement of body cavities, including lymphomatous pleural effusion, which was noted at disease presentation in four patients, of whom three (nos. 3, 8, and 9) had concurrent involvement of the peritoneal cavity/ascites … Generalized LAP, NP, generalized cutaneous lesions, bones | Negative | No | IV | 4 | CHOP × 3 plus Bortezomib | AWD (6) | Negative 8/M/74 | UB, skin, PE | Generalized LAP, pleural and peritoneal cavities, abdominal and pelvic organs | ND | No | IV | 5 | Supportive care | DOD (0.1) | ND e 9/M/41 | BM …

Is It Time to Inform This Patient that Further Antineoplastic Drug Therapy Will Not Be of Clinical Value?

A woman with heavy pre-treated ovarian cancer sought consultation regarding additional treatments. The case raises the vexing question of whether there may be a time in the course of the disease process where it is most appropriate to state further anti-neoplastic therapy will not be of clinical utility.

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… At this point in time radiographic imaging of the peritoneal cavity revealed no tumor masses. … However, following 2 additional cycles of carboplatin/cyclophosphamide the CA-125 had increased to >1,000 IU/l, ascites returned, and there was evidence of macroscopic disease within the peritoneal cavity. …

Feline Coronavirus Infection

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The Relationship and Expression of miR-451a, miR-25-3p and PTEN in Early Peritoneal Endometriotic Lesions and Their Modulation In Vitro.

BackgroundmiR-451a can function as a tumor suppresser and has been shown to be elevated in both endometriotic lesion tissue and serum from women with endometriosis. To further explore the role of miR-451a in the pathophysiology of endometriosis, specifically, further evaluating its association with the tumor suppressor, phosphatase and tensin homolog (PTEN), we examined their expression in individual endometriotic lesion tissue to gain insight into their relationship and further explore if miR-451a regulates PTEN expression.MethodsA total of 55 red, peritoneal endometriotic lesions and matched

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… Introduction Endometriosis is a chronic, benign inflammatory gynecological disease, in which endometrial glands and stroma establish in the peritoneal cavity [ 1 , 2 ]. … New, red endometriotic lesions develop with each episode of reverse menstruation and seeding of the peritoneal cavity. In these new lesions, expression of miR-451a and PTEN is low while that of miR-25-3p is high. …

Astatine-211 based radionuclide therapy: Current clinical trial landscape.

Astatine-211 (211At) has physical properties that make it one of the top candidates for use as a radiation source for alpha particle-based radionuclide therapy, also referred to as targeted alpha therapy (TAT). Here, we summarize the main results of the completed clinical trials, further describe ongoing trials, and discuss future prospects.

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… The low bone marrow dose was partly due to the addition of an osmotic agent that slows the transport of 211 At-mAb from the peritoneal cavity into the circulation ( 20 ). 4.1.4. …

Methylnaltrexone is safe in cancer patients with peritoneal carcinomatosis.

Opioid-induced constipation (OIC) has become increasingly prevalent with the rise of prescription opioid use and can significantly impact quality of life, especially in patients with advanced illness. Methylnaltrexone has proven effective in treating cancer patients with OIC who have not responded adequately to conventional laxative therapy, though use is relatively contraindicated in those with peritoneal carcinomatosis due to theoretical risk and reported cases of perforation. The aim of this study was to evaluate the safety of methylnaltrexone in patients with carcinomatosis. We performed a

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… Peritoneal carcinomatosis was defined as malignancy disseminating and growing in the peritoneal cavity. Carcinomatosis was confirmed by reviewing radiology and pathology reports. … Computed tomography showed a new frank bowel perforation with large volume pneumoperitoneum, fecal material in the peritoneal cavity, and diffusely thickened small bowel with enhancing peritoneal reflections consistent with peritonitis. …

Case Report: Acute kidney injury due to minimal dilated obstructive nephropathy in the context of gastric cancer.

Postrenal obstruction is a rare but reversible cause of acute kidney injury (AKI), often underrecognized when hydronephrosis is mild or absent. We present a 55-year-old woman with gastric cancer who developed severe AKI requiring hemodialysis. Initial non-contrast abdominal CT revealed only mild bilateral hydronephrosis without obvious ureteral obstruction. Given these subtle radiologic findings and a history of chemotherapy and NSAID exposure. Initially, a multidisciplinary team attributed the AKI to intrinsic renal causes. Subsequent renal biopsy revealed only minimal glomerular changes, ins

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… CLDN18.2 ( 40 ), highly expressed in gastric cancer cells with peritoneal metastasis, facilitates tumor cell adhesion and invasion within the peritoneal cavity. …

PROTEOTOXINS (ANAPHYLATOXINS) AND VIRULENCE.

1. Our experiments show that proteotoxin (anaphylatoxin) produced with typhoid bacilli and active guinea pig serum, by the general method of Friedberger, possesses aggressin-like action in that, when injected together with sublethal doses of bacteria, it renders them lethal. 2. This action is not specific, since even when typhoid bacilli are used in its production, the proteotoxin possesses this property not only for typhoid bacilli, but for staphylococci and prodigiosus bacilli, the only other organisms with which we worked. 3. This action is manifest in the experiment only when quantities of

Kinase Inhibitors and Ovarian Cancer.

Ovarian cancer is fifth in the rankings of cancer deaths among women, and accounts for more deaths than any other gynecological malignancy. Despite some improvement in overall-(OS) and progression-free survival (PFS) following surgery and first-line chemotherapy, there is a need for development of novel and more effective therapeutic strategies. In this mini review, we provide a summary of the current landscape of the clinical use of tyrosine kinase inhibitors (TKIs) and mechanistic target of rapamycin (mTOR) inhibitors in ovarian cancer. Emerging data from phase I and II trials reveals that a

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… Given that the most common serous ovarian cancers are now thought to arise from the fallopian tube, it is unusual to identify patients with earlier stages of ovarian cancer, and the single cells drop off from the fallopian tube and are easily circulated around the peritoneal cavity by peristalsis. …

Feline infectious peritonitis.

The article discusses feline infectious peritonitis (FIP), an important disease frequently seen in veterinary practice. FIP causes many problems to the veterinarian as it can be difficult to definitively diagnose the disease, as there is no effective treatment, and as prophylactic interventions are not very successful. Although intense research has created a lot of new knowledge about this disease in the last years, there are still many unanswered questions. The objective of this article is to review recent knowledge and to increase understanding of the complex pathogenesis of FIP.