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Inherited catalase deficiency: is it benign or a factor in various age related disorders?

Hydrogen peroxide was - and is still - considered toxic for a wide range of living organisms. Oxidative stress occurs when there is an excess of pro-oxidants over antioxidants and it has been implicated in several diseases. Catalase is involved in hydrogen peroxide catabolism and is important in defense against oxidative stress. Acatalasemia means the inherited near-total deficiency of catalase activity, usually in reference to red cell catalase. Acatalasemia was thought at first to be an asymptotic disorder. In the absence of catalase, neither the Japanese, or Hungarian acatalasemics nor acat

A Review of Skin Disease in Schizophrenia.

BACKGROUND: Schizophrenia is a debilitating neuropsychiatric condition that affects 0.5% of the North American population. Skin disease in schizophrenia has not been well described. Identifying skin diseases that are commonly comorbid with schizophrenia may help clinicians address the burden of skin disease in patients with schizophrenia. SUMMARY: We conducted a nonsystematic review of the literature to identify skin diseases that may be associated with schizophrenia. We searched MEDLINE, EMBASE, and PsycINFO for articles published in English from December 2000 through April 2020 using the ke

A NEW RELEVANCE ESTIMATOR FOR THE COMPILATION AND VISUALIZATION OF DISEASE PATTERNS AND POTENTIAL DRUG TARGETS.

A new computational method is presented to extract disease patterns from heterogeneous and text-based data. For this study, 22 million PubMed records were mined for co-occurrences of gene name synonyms and disease MeSH terms. The resulting publication counts were transferred into a matrix Mdata. In this matrix, a disease was represented by a row and a gene by a column. Each field in the matrix represented the publication count for a co-occurring disease-gene pair. A second matrix with identical dimensions Mrelevance was derived from Mdata. To create Mrelevance the values from Mdata were normal

Focus on FOCIS: interleukin 2 treatment associated autoimmunity.

A patient from the University of Pittsburgh is presented who developed autoimmunity during IL-2 based combination therapy. IL-2 was originally described as a "T cell growth factor" capable of expanding previously activated T cells, enhancing the cytotoxicity of antigen-specific cytotoxic T cells and NK cells. High dose Interleukin 2 (HDIL2) is now FDA-approved for therapy of patients with metastatic melanoma and renal cell carcinoma, based on its ability to induce durable responses in 5-10% of patients. The antitumor effect of HDIL2 is incompletely understood, but it appears that this regimen

Schmidt's syndrome in a Saudi family.

We present 3 patients from a Saudi family who are presented with polyglandular autoimmune syndrome type 2. They have Addison's disease with either autoimmune thyroid disease or insulin dependent diabetic mellitus. Although this syndrome is rare, the incidence among Saudi Arabia or the Arab population is not known.

Photomodulation of the melanocyte cell cycle by indoleamines.

Melanocytes are photoresponsive cells which respond to varying doses of UV exposure in the G2 phase of the cell cycle by prominent dendricity. This photoresponse is related to indoleamine light sensitivity. The present study highlights the role of indoleamines in the photomodulation of the melanocyte cell cycle. The study was conducted on 40 whole-skin organ cultures taken from the marginal zone of vitiligo. Twenty organ cultures were subjected to G2-phase arrest, while 20 were incubated in tryptamine. The organ cultures were incubated in the dark, exposed to a pulse of 120 s UV at 2 h of incu…

Emerging light-based strategies in cancer theranostics: Photodynamic therapy, nanomedicine, and precision oncology.

The integration of artificial intelligence (AI) into medical treatments is reshaping precision and personalisation in phototherapy (PT) and photodynamic therapy (PDT). PT, commonly used for conditions like psoriasis and vitiligo, uses light to modulate cellular responses, but traditional approaches often lack precision. PDT, which combines light with a photosensitising agent to destroy targeted cells, is widely applied in oncology. Both therapies benefit significantly from AI-enhanced targeting and monitoring to improve outcomes and minimise side effects. AI, particularly deep learning (DL) mo…

Patient-Centered Teledermatology: Bridging Pharmacies and Dermatologists.

BACKGROUND: The chronic shortage of dermatologists in France results in average waiting times of 3 months, compromising equitable access to … ude suspected melanoma (7), carcinomas (27), actinic keratosis, eczema, atopic dermatitis, rosacea, vitiligo, and shingles. Pharmacist satisfaction reached 72% (NPS 24%; 94% recommending a scale-up with adaptations). Pharmacists reported that 88% of patients were satisfied. Limitations comprised the lack of e-prescriptions and the nonintegration of primary …

Investigating the Gut Microbiota-Inflammatory Cytokine-Skin Axis in Inflammatory Skin Diseases: Evidence from Mendelian Randomization.

BACKGROUND: Previous studies have reported causal associations between gut microbiota and inflammatory skin diseases; however, the underlyin … ke epidermal growth factor-related receptor (DNER) mediated associations involving alopecia areata, vitiligo, seborrheic dermatitis, and rosacea. All identified inflammatory cytokines showed mediation proportions greater than 5%. CONCLUSION: Our findings suggest that specific inflammatory cytokines may mediate the associations between gut microbiota and i …

Различные аутоиммунные полигландские фенотипы у пациентов с заболеваниями щитовидной железы.

ЦЕЛЬ: Характеристика и сопоставление аутоиммунной коморбидности и временной динамики у пациентов с щитовидным гепатитом (HT) и болезнью Грейвса (GD) в рамках аутоиммунного полигениального синдрома (APS). Мы провели ретроспективный анализ пациентов с аутоиммунной болезнью щитовидной железы (АИРТ) и по крайней мере one дополнительные аутоиммунные заболевания, отвечающие критериям АПС, которые следуют в третичном справочном центре АПС между 2000 и 2025. Показатели распространенности сопутствующих аутоиммунных заболеваний были сопоставлены между ГТ и ГД. Время для развития последующих аутоиммунных

Совпадение в аннотации оригинала
PURPOSE: To characterize and compare autoimmune comorbidity patterns and temporal dynamics in patients with Hashimoto’s thyroiditis (HT) and … ctively enriched for systemic sclerosis (OR 51.54, 95% CI 10.96–242.41; FDR-adjusted p < 0.001) and vitiligo (OR 3.46, 95% CI 1.82–6.55; FDR-adjusted p < 0.001). In patients in whom AITD was the first autoimmune manifestation (n = 333), GD was associated with a longer latency to additional autoimmune diseases and a lower hazard of subsequent autoimmunity c …