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Предсказуемая модель для оценки ежегодного потенциала распространения Эболавируса.

Изменения в лесах, динамика населения человека и метеорологические условия были связаны с зоонотическим распространением Эболавируса на человека. Для получения оценок побочного потенциала и оценки возможных годовых изменений могут использоваться пространственные данные с высоким разрешением по этим переменным. В 2001 - 2021 годах мы разработали модель побочного воздействия Эболавируса с учетом переменных, измеряемых в различных пространственных и временных масштабах. Мы оценили годовую относительную вероятность распространения Эболавируса в 2021 и 2022 годах. Самые высокие относительные побочн

Совпадение в аннотации оригинала
Forest changes, human population dynamics, and meteorologic conditions have been associated with zoonotic Ebolavirus spillover into humans. High-resolution spatial data for those variables can be used to produce estimates of spillover potential and assess possible annual changes. We developed a model of Ebolavirus spillover during 2001-2021, accounting for v…

A promising therapeutic approach for post-Lassa fever sensorineural hearing loss: a case report.

Lassa fever is a viral haemorrhagic illness endemic in West Africa, with Nigeria accounting for a significant proportion of global cases. While most patients recover, sensorineural hearing loss (SNHL) is a serious and often overlooked post-infectious complication. We present the case of a 13-year-old girl who developed sudden profound right-sided SNHL shortly after recovering from Lassa fever, despite a high cycle threshold (Ct) value on PCR, indicating low viral load. She was treated with intravenous mannitol and hydrocortisone, along with oral betahistine and neurovite, and demonstrated nota…

Beyond Mosquitoes: A Review of Pediatric Vector-Borne Diseases Excluding Malaria and Arboviral Infections.

Vector-borne diseases (VBDs) significantly impact global child health, with mosquito-transmitted infections like malaria and arboviruses accounting for a substantial portion of this burden. However, other arthropod-borne diseases-transmitted by vectors such as ticks, fleas, sand flies, lice, and triatomine bugs-also pose serious health risks to children worldwide. This review specifically excludes mosquito-borne diseases to concentrate on these less-discussed yet clinically important pediatric VBDs. We examine their clinical manifestations, diagnostic challenges, and treatment options, highlig…

Isolation of nontuberculous mycobacteria and Nocardia via mycobacterial culture from pulmonary specimens.

Nontuberculous mycobacteria (NTM) and Nocardia are often isolated via mycobacterial culture, yet their prevalence in various pulmonary specimens is uncertain. We retrieved mycobacterial culture results from pulmonary specimens from a tertiary hospital in China between January 2017 and July 2021. The prevalence of non-Mycobacterium tuberculosis (non-Mtb, including NTM and Nocardia) has surpassed Mtb, accounting for 1.7 times the rate of Mtb among all isolates. The frequency of non-Mtb positivity in sputum specimens was significantly higher compared to that in bronchoscopy specimens (3.7% vs 1.9…

Protective effect of scallop-derived plasmalogen against vascular dysfunction, via the pSTAT3/PIM1/NFATc1 axis, in a novel mouse model of Alzheimer's disease with cerebral hypoperfusion.

A strong relationship between Alzheimer's disease (AD) and vascular dysfunction has been the focus of increasing attention in aging societie … ion site for Moloney murine leukemia virus 1 (PIM1)/nuclear factor of activated T cells 1 (NFATc1), accounting for such cerebral vascular remodeling. Moreover, we also found that cerebral HP accelerated pSTAT3-mediated astrogliosis and activation of the nucleotide-binding domain and leucine-rich repeat protein 3 (NLRP3) inflammasome, probably leading to cogn …

PRSS50-mediated inhibition of MKP3/ERK signaling is crucial for meiotic progression and sperm quality.

Serine protease 50 (PRSS50/TSP50) is highly expressed in spermatocytes. Our study investigated its role in testicular development and sperma … 1/2) and elevated levels of MAP kinase phosphatase 3 (MKP3), a specific ERK antagonist, potentially accounting for testicular dysplasia in adolescent Prss50 -/- mice. Taken together, these findings suggest that PRSS50 plays an important role in testicular development and spermatogenesis, with the MKP3/ERK signaling pathway playing a significant role in this …

Nonobstructive azoospermia: an etiologic review.

Azoospermia is the complete absence of spermatozoa in the ejaculate in two or more semen analyses after centrifugation. Nonobstructive azoospermia (NOA) represents the most severe form of male factor infertility accounting for 10%-15% of cases and stems from an impairment to spermatogenesis. Understanding of the hypothalamic-pituitary-testicular axis has allowed NOA to be subcategorized by anatomic and/or pathophysiologic level. The etiologies of NOA, and therefore, the differential diagnoses when considering NOA as a cause of male factor infertility, can be subcategorized and condensed into s…

Successful surgical management of cervical tuberculous spondylitis with tetraparesis in a 17-year-old patient: A case report.

Cervical tuberculous spondylitis is a rare and potentially life-threatening manifestation of spinal tuberculosis, accounting for only 3%-5% of all cases of spinal tuberculosis This report describes a case of a 17-year-old male patient who developed tetraparesis 2 weeks prior to hospital admission, after a 6-month record of progressive neck pain. Magnetic Resonance Imaging revealed tuberculous spondylodiscitis involving multiple vertebrae, with a severe spinal cord compression at C2-C3 due to an intraosseous abscess and paravertebral soft tissue mass. The patient underwent anterior cervical cor…

[Anti-amyloid Antibody Drugs as Disease-Modifying Therapies for Alzheimer's Disease].

Alzheimer's disease (AD) is a common dementia disorder in the elderly individuals, accounting for approximately 60-70% of all dementia cases. Recently, significant progress has been made in developing and approving anti-amyloid antibody drugs as one of the disease-modifying therapies (DMT) that aim to slow the progression of AD by targeting amyloid-beta accumulation in the brain. Notable drugs such as aducanumab, lecanemab, and donanemab have shown potential in clinical trials, leading to the approval of aducanumab and lecanemab, and approval is also expected for donanemab. Other anti-amyloid …

Optimizing Antibiotic Treatment for Urinary Tract Infections Secondary to Escherichia coli in Elderly Diabetic Patients: Considering Age and Blood Glucose Control.

INTRODUCTION: This study aimed to examine the susceptibility profile of Escherichia coli in urinary tract infections (UTIs) among elderly diabetic patients to support judicious and evidence-based antibiotic use. METHODS: From January 2021 to December 2022, urine culture results were analyzed to determine the distribution of pathogens, especially E. coli, and their drug susceptibility. RESULTS: E. coli infection was the most prevalent infection in elderly diabetic patients with UTIs, accounting for 32.6% of cases. Moreover, this bacterium's multiple resistance rate (38.3%) was significantly h…

Aggressive Primary Thyroid Mucoepidermoid Carcinoma with Extensive Pulmonary Involvement.

Mucoepidermoid carcinomas (MECs) represent the most common malignant neoplasms of the salivary glands, but they have also been described in other unusual sites. Primary MECs originating in the thyroid gland are exceedingly rare, accounting for less than 0.5% of thyroid tumors. Owing to their low to medium grade, they are usually associated with an indolent evolution and a good long-term prognosis, generally being managed surgically based on the extent of the disease. However, this does not always apply, as primary thyroid MECs may present as metastatic or locally advanced diseases. While sever…

Metachronous Gastrointestinal Stromal Tumors of Different Histologies: An Unusual Case.

Gastrointestinal stromal tumors (GISTs) are mesenchymal tumors accounting for only a small fraction of all primary malignant tumors of the gastrointestinal tract. Histologically, GISTs are classified as epithelioid, spindle type, or mixed. We present a case of a 66-year-old male incidentally noted to have a pedunculated gastric mass along the lesser curvature of the stomach during a laparoscopic Nissen fundoplication and hiatal hernia repair. A wedge resection was performed and the pathology demonstrated a 3.7 cm GIST of epithelioid type. Four years after the initial surgery, a jejunal mass wa…

A Dermoid Cyst of the Head, Neck, and Face Region: A Case Report.

Dermoid cyst (DC), a rare benign tumor of developmental origin that develops from mesoderm and ectoderm, is frequently identified in children. DC refers to three cysts that are histologically related, namely, DC, epidermoid cyst, and teratoma. About 70% of DCs are discovered in children aged five years or younger, with the majority being congenital. DC of the head and neck are rare, accounting for only 7% of all such cysts. DC, or benign cutaneous tumors, tend to grow and persist. The presence of epithelial cells along the lines of embryonic closure results in a DC. It is always difficult to p…

Deciphering the gastrointestinal carriage of Klebsiella pneumoniae.

Bacterial infections pose a significant global health threat, accounting for an estimated 7.7 million deaths. Hospital outbreaks driven by multi-drug-resistant pathogens, notably Klebsiella pneumoniae (K. pneumoniae), are of grave concern. This opportunistic pathogen causes pneumonia, urinary tract infections, and bacteremia, particularly in immunocompromised individuals. The rise of hypervirulent K. pneumoniae adds complexity, as it increasingly infects healthy individuals. Recent epidemiological data suggest that asymptomatic gastrointestinal carriage serves as a reservoir for infections in …

Giant Sublingual, Submental, and Lingual Dermoid Cyst Restricting Tongue Movement Undiagnosed for Several Years.

(1) Background: Dermoid cysts occurring in the sublingual space are uncommon, typically manifesting as painless, gradually enlarging masses, usually not exceeding 3 cm in diameter. These cysts can resemble various conditions due to their clinical presentation, with a relatively low occurrence rate in the oral cavity, accounting for about 1.6% of all dermoid cysts. (2) Methods: We present the case of a 17-year-old female with a giant dermoid cyst involving the submental, sublingual, and lingual areas, undiagnosed for several years. Diagnosis was achieved through MRI and fine-needle aspiration, …

Social Contributors to Differences in Math Course Attainment Among Adolescents with and without Learning Disabilities and ADHD.

Completing advanced high school math coursework relates to better adulthood outcomes. Our understanding of why youth with learning disabilit … whose parents have a STEM degree, have heightened access to high math course attainment even after accounting for prior achievement. Disparities in access to high math course attainment that persist net of controls for both youth with an LD and youth with ADHD present the possibility of disability-related stratification and stigma during high school.

Post-pandemic trends: Epidemiological and etiological insights into acute respiratory infections in southern China.

Data on people suspected with acute respiratory infections (ARIs) from August 2022 to December 2023 in southern China were analyzed. Following the COVID-19 pandemic, the positive detection rates of respiratory pathogens increased to 56.9%. Influenza A virus (IAV) emerged as the predominant prevalence pathogen (52.1%), followed by Mycoplasma pneumoniae (Mp: 21.2%), and SARS-CoV-2 (11.6%). Mp, IAV, and Human rhinovirus (HRV) infection were the primary etiologies of ARIs patients under age 18, accounting for 49.4%, 48.6%, and 21.7%, respectively. Mp, HRV, Respiratory syncytial virus (RSV), and Ad…

Primary breast lymphoma: A rare case report.

INTRODUCTION AND IMPORTANCE: Primary breast lymphoma (PBL) is an extremely rare neoplasm, accounting for less than 1 % of breast malignancies and less than 2 % of extranodal non-Hodgkin lymphomas (NHLs). CASE PRESENTATION: This case report discusses a 60-year-old female patient presenting with a primary breast lymphoma, specifically diffuse large B-cell lymphoma. The patient had no personal history of breast cancer but exhibited a painless, palpable mass in the left breast with axillary lymphadenopathy. CLINICAL DISCUSSION: Diagnostic challenges in distinguishing PBL from primary breast carc…

Effect of the COVID-19 pandemic on unmet healthcare needs after hospital discharge in acute respiratory failure survivors: A multicenter prospective cohort study.

Survivors of acute respiratory failure (ARF) have complex healthcare needs postdischarge, frequently resulting in unmet needs. This prospect … he median (IQR) percentage of unmet healthcare needs was 26% (17%-36%), with follow-up appointments accounting for most unmet needs. Unmet medication needs were found to be very low at 6%. Despite the challenges in healthcare delivery during the COVID-19 pandemic, our data suggest COVID status had no observable effect on unmet healthcare needs for ARF surviv …

Trade-off between the antiviral and vaccinal effects of antibody therapy in the humoral response to HIV.

Antibody therapy for HIV-1 infection exerts two broad effects: a drug-like, antiviral effect, which rapidly lowers the viral load, and a vac … g GCs and limiting the humoral response. We found signatures of this trade-off in clinical studies. Accounting for the trade-off could be important in optimizing antibody therapy for HIV-1 remission.