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Hyperglycaemia as a predictor of morbidity and mortality in patients receiving an allogeneic haematopoietic stem cell transplantation.

Allogeneic haematopoietic stem cell transplantation (allo-HSCT) is an effective treatment for patients with haematological malignancies; however, post-transplant complications, including infections and acute graft-versus-host disease (aGvHD), remain significant issues. Identifying modifiable risk factors is therefore critical to improve patient outcomes. This retrospective study evaluated the impact of hyperglycaemia on post-transplant outcomes in adult patients undergoing allo-HSCT at the University Medical Centre Groningen between 2018 and 2024. Hyperglycaemia was defined as a glucose level …

Allogenic Hematopoietic Stem Cell Transplantation in Children With Transfusion Dependent Thalassemia Using Treosulfan-Thiotepa-Fludarabine Based Conditioning.

INTRODUCTION: Allogenic hematopoietic stem cell transplantation (HSCT) is a potentially curative treatment modality in patients with transfusion-dependent thalassemia (TDT). Over the past decade, there has been a shift towards reduced-toxicity conditioning regimens such as Treosulfan-Thiotepa-Fludarabine (TTF) due to its favorable toxicity profile, potent immunosuppression, and myeloablative effects. This study explores the outcomes of TTF-based conditioning in pediatric TDT patients undergoing allogenic HSCT. METHODS: This is a single-center retrospective analysis of 74 pediatric patients wh…

Impact of lymphocyte p-glycoprotein activity on development of graft-versus-host disease after stem cell transplantation.

Tacrolimus (TAC) is a pivotal immunosuppressant used to prevent graft-versus-host disease (GVHD) following hematopoietic stem cell transplantation (HSCT). However, because lymphocytes express P-glycoprotein (P-gp), which actively effluxes TAC, blood TAC concentrations do not necessarily reflect intracellular drug levels. Rather, the expression and activity of P-gp are influenced by multiple factors that change dynamically after transplantation, including inflammatory cytokines and gut microbiota. This study longitudinally assessed P-gp activity in peripheral blood mononuclear cells from HSCT r…

FAT1-associated membranous nephropathy after hematopoietic stem cell transplantation: a case report and review of the literature.

We report a 55-year-old man who developed nephrotic syndrome 52 months after allogeneic hematopoietic stem cell transplantation for acute lymphoblastic leukemia. He had chronic graft-versus-host disease controlled with low-dose prednisolone and tacrolimus. Asymptomatic proteinuria was detected five months before referral, followed by progressive edema, massive pleural effusion, and ascites. At presentation, laboratory testing showed profound hypoalbuminemia, mildly reduced kidney function, and nephrotic-range proteinuria. Kidney biopsy demonstrated membranous nephropathy, with periodic acid-me…

[Diagnostic utility of small-bowel capsule endoscopy in patients with gastrointestinal symptoms after allogeneic hematopoietic cell transplantation].

We retrospectively evaluated the safety and diagnostic utility of small bowel capsule endoscopy (SBCE) in 45 patients (66 procedures) who developed gastrointestinal symptoms after allogeneic hematopoietic cell transplantation (allo-HCT). Despite a high proportion of patients with poor performance status (≥2: 43 procedures) and thrombocytopenia (platelet counts <20,000/µl in 10 procedures, <50,000/µl in 25 procedures), which are generally considered high-risk conditions for conventional esophagogastroduodenoscopy (EGD) and colonoscopy (CS), SBCE demonstrated a 0% adverse event rate and 89.2% co…

Модель индекса питания для прогнозирования резистентности и прогнозирования в множественных миеломах после аутологической трансплантации стволовых клеток.

Множественная миелома - это one Наиболее распространенные гематологические заболевания во всем мире создают серьезную угрозу для жизни и здоровья населения. В последние годы все больше и больше исследователей включили прогнозный индекс питания (ПНИ) в прогнозные исследования опухолей и провели оценку состояния питания и прогнозировали долгосрочный прогноз пациентов в рамках ПНИ. МЕТОДЫ: Медицинские записи 245 Пациенты с множественными миеломами, получившие автологическую трансплантацию стволовых клеток в нашей больнице с февраля 2011 по июль 2018 был ретроспективно проанализирован. Оптимальное

Совпадение в аннотации оригинала
BACKGROUND: Multiple myeloma is one of the most common haematological malignancies worldwide and poses a serious threat to the life and heal … he medical records of 245 patients with multiple myeloma who received autologous hematopoietic stem cell transplantation in our hospital from February 2011 to July 2018 were retrospectively analyzed. The optimal cut-off value was obtained by drawing the ROC curve, and the influencing factors of low PNI value and its impact on the prognosis of multiple myeloma patients …

Mucosal calprotectin is associated with severity of aGI-GVHD and poor outcomes after allogeneic stem cell transplantation.

Calprotectin, a calcium- and zinc-binding protein that comprises the subunits S100A8 and S100A9, has been extensively studied as a biomarker of gastrointestinal (GI) inflammation through fecal and serum analyses. However, its role in intestinal tissue remains poorly understood because of the limited availability of biopsy specimens. In this study, we analyzed S100A8 and S100A9 messenger RNA (mRNA) expression in 579 intestinal biopsy specimens from allogeneic stem cell transplantation recipients and observed a strong association with acute GI graft-versus-host disease (aGI-GVHD; P< .001). Neutr…

Microbiota-derived short-chain fatty acids in hematopoietic stem cell transplantation: immunomodulation at the host-microbiota interface.

Hematopoietic stem cell transplantation (HSCT) remains a cornerstone treatment for many hematological malignancies, but its clinical success is still challenged by graft-vs.-host disease (GvHD), infectious complications, and the profound microbial disruptions caused by conditioning, antibiotics, and hospitalization. Over the past few years, a growing body of work has highlighted how tightly post-transplant immunity is linked to the state of the gut microbiota. In particular, short-chain fatty acids (SCFAs), especially butyrate, have emerged as key microbial metabolites involved in maintaining …

Multidisciplinary Team Nursing Care During Peri-Transplantation for ALK-Negative Anaplastic Large Cell Lymphoma: A Case Report.

This case report describes the nursing experience of a patient with ALK‑negative anaplastic large cell lymphoma undergoing autologous hematopoietic stem cell transplantation. A multidisciplinary team model was established, integrating professionals from haematology, rehabilitation, nutrition, psychology to deliver comprehensive peri‑transplant care. An individualized treatment and nursing plan was developed for the peri-transplant period. This plan included pre-transplant physical and psychological preparation, environmental readiness, and management of complications during transplantation, su…

Ciprofloxacin prophylaxis in allogeneic haematopoietic cell transplantation reduces bacteraemia but increases antimicrobial resistance without improving patient outcomes.

BACKGROUND: Fluoroquinolone prophylaxis during allogeneic haematopoietic cell transplantation (allo-HCT) is debated due to concerns regarding toxicity and antimicrobial resistance (AMR). METHODS: We compared clinical and microbiological outcomes of all adults undergoing their first allo-HCT for haematological malignancy at two large UK transplantation centres between January 2020 and December 2022. The centres employed differing prophylactic strategies: Site 1 administered ciprofloxacin prophylaxis; Site 2 did not. RESULTS: Among 343 eligible patients, primary allo-HCT indications were acute…

Pulmonary infection caused by Tropheryma whipplei in a child before hematopoietic stem cell transplantation: a case report.

BACKGROUND: Tropheryma whipplei (TW) triggers Whipple's disease (WD), a rare, chronic multisystemic infection with heterogeneous clinical pr … te antibiotic therapy, WD is invariably fatal, especially in patients undergoing hematopoietic stem cell transplantation (HSCT). There is no established consensus on the optimal treatment regimen or duration, particularly for pediatric patients. CASE DESCRIPTION: An 8-year-old boy with primary immunodeficiency due to a genetic mutation presented without respiratory s …

Novel oral chidamide and valganciclovir regimen for EBV-PTLD post-hematopoietic stem cell transplantation: A case report.

RATIONALE: Epstein-Barr virus-related posttransplant lymphoproliferative disorder (EBV-PTLD) is a serious and potentially fatal complication following allogeneic hematopoietic stem cell transplantation (allo-HSCT). PATIENT CONCERNS: We report a case of a 46-year-old male who developed EBV-PTLD 3 months after haploidentical HSCT for refractory acute myeloid leukemia. The patient presented with a persistent cough and a pulmonary nodule that increased in size from 8 mm × 5 mm to 27 mm × 25 mm over 4 weeks. Increased EBV loads were also detected (peripheral blood EBV sorting: EBV-T DNA 2.09E+03, …

Management of donor-specific antibodies in allogeneic hematopoietic cell transplantation: A retrospective single-center case-control study.

Donor-specific antibodies (DSA) are preformed recipient antibodies directed against donor HLA antigens, most frequently observed in haploidentical or mismatched allogeneic hematopoietic cell transplantation (HCT). DSA assessed by multiplexed bead-based immunoassays at mean fluorescence intensity (MFI) values >1 000 are associated with increased risk of graft failure, graft-versus-host disease (GvHD), and mortality, supporting combined pharmacological and plasma-based depletion in absence of matching donors. We retrospectively analyzed all adult HCTs performed between 2009 and 2025 at the Unive…

Liver Transplantation After Prolonged Nab-Sirolimus Therapy for Unresectable Hepatic Perivascular Epithelioid Cell Tumor With Bilobar Involvement.

Primary hepatic perivascular epithelioid cell tumor (PEComa) is rare, and management of unresectable disease is not established. A 47-year-old woman had an 8-cm central hepatic PEComa bridging both lobes with tuberous sclerosis complex 2 alterations. She received albumin-bound sirolimus for 26 months with modest size reduction but durable stability, enabling listing with a nonstandard model for end-stage liver disease exception. She underwent right trisegment orthotopic liver transplantation, and the explant showed a well-circumscribed PEComa without vascular invasion or additional lesions. Th

Safety and Efficacy of Reduced-Intensity Conditioning Allogeneic Hematopoietic Stem Cell Transplantation for Salvage Therapy of Myelofibrosis.

OBJECTIVE: To evaluate the efficacy and safety of reduced-intensity conditioning (RIC) allogeneic hematopoietic stem cell transplantation (allo-HSCT) for a salvage therapy of patients with myelofibrosis (MF). METHODS: We conducted a retrospective study of 17 MF patients with poor performance status, refractory disease, or progressive disease who underwent RIC-allo-HSCT. Overall survival (OS), progression-free survival (PFS), hematopoietic reconstitution, the cumulative incidence of relapse and improvements in myelofibrosis and splenomegaly were analyzed. RESULTS: All 17 patients received RIC…

Population Pharmacokinetics of Melphalan in Pediatric Patients Undergoing Autologous Hematopoietic Stem Cell Transplantation with Various Conditioning Regimens.

BACKGROUND AND OBJECTIVE: Melphalan is an alkylating agent used in conditioning regimens for hematopoietic stem cell transplantation (HSCT) in pediatric patients. In this study, we aimed to develop a population pharmacokinetic (PK) model of melphalan in pediatric patients undergoing various conditioning regimens. METHODS: In total, 20 pediatric patients who received one or two consecutive doses of melphalan were included in this study. PK data were analyzed using a nonlinear mixed-effects model. Evaluated covariates included body weight (WT), sex, estimated glomerular filtration rate (eGFR), …

Protocadherin FAT1-associated membranous nephropathy after hematopoietic stem cell transplantation-a cohort study with clinico-pathological correlations.

BACKGROUND: The identification of causative antigens for membranous nephropathy (MN) has revolutionized the comprehension of the pathophysiology of this autoimmune disease and its management. Recently, some studies described protocadherin FAT1 (FAT1) as a causal antigen in the context of hematopoietic stem cell transplantation (HSCT). The aim of this study was to investigate the large Viennese kidney biopsy collection at the Department of Pathology of the Medical University of Vienna and explore MN cases after HSCT for the causative antigen. METHODS: Fifteen patients were identified with MN i…

A multiparameter whole blood platform for assessment of anti-CMV immunity in allogeneic stem cell transplantation recipients.

Human cytomegalovirus (HCMV) infection remains a major challenge in allogeneic stem cell recipients. Current immune monitoring largely relies on IFN-γ-based readouts following ex vivo stimulation, which cannot fully capture the complex anti-HCMV immune defense. Therefore, we established a multiparameter HCMV-reactive whole blood (WB) assay that can be initiated at the bedside, requires minimal blood volume, preserves physiological cellular interactions, and enables integrated cellular and cytokine readouts within a closed-tube workflow. Using enhanced α-CD40 co-stimulation for robust detection