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Everolimus-eluting versus biolimus-eluting stents with biodegradable polymers in unselected patients undergoing percutaneous coronary intervention: five-year results of the randomised, non-inferiority SORT OUT VIII trial.

BACKGROUND: Long-term outcomes following implantation of drug-eluting coronary stents are necessary to determine safety and efficacy. AIMS: We aimed to report the 5-year outcomes of the SYNERGY thin-strut biodegradable-polymer everolimus-eluting platinum-chromium stent (EES) versus the BioMatrix NeoFlex biodegradable-polymer biolimus-eluting stainless-steel stent (BES). METHODS: This randomised, multicentre, all-comer, non-inferiority trial was undertaken at three sites in Western Denmark. Patients with a clinical indication for percutaneous coronary intervention were eligible for inclusion.…

A systematic review on distribution, sources and impacts of heavy metals in mangrove ecosystems.

Mangrove ecosystems play a vital role in providing habitat for numerous plant and animal species, protecting coastlines from erosion and sto … amination. The most frequently studied heavy metals were Cadmium followed by Lead, Copper, Zinc and Chromium. The major sources of heavy metals contamination in mangrove ecosystems were industrial effluents (36 %) and rapid land-use conversion (31 %) and sediments (51 %) were the most commonly investigated component of mangrove ecosystem. Heavy metals have …

Recycled crushed concrete as a filter medium for phosphorus and heavy metal removal from semi-synthetic stormwater.

Facing escalating urban drainage issues, cities are increasingly adopting nature-based solutions, which have proven effective for flood prev … retention. Nevertheless, high P removal coincided with an elevated effluent pH (>11) and pronounced chromium (Cr) leaching in the initial phases of both column experiments. While crushed concrete has strong potential to serve as a long-lasting, sustainable, and cost-effective medium for removal of P, Cu, and Zn from urban runoff, these drawbacks could be a …

Patient-centered outcomes of indirect CAD-CAM removable partial denture frameworks: A 2-year follow-up study.

PURPOSE: This study aimed to assess patient-centered outcomes of polyetheretherketone (PEEK) and cobalt chromium (CoCr) removable partial denture (RPD) frameworks, as well as to present detailed technical steps of digital designing and indirect production of metal and PEEK RPD frameworks. MATERIALS AND METHODS: This randomized, controlled, parallel-group clinical trial included 30 patients. The enrolled patients were partially edentulous with mandibular Kennedy Class I. They were randomly assigned to receive an indirect computer-aided design and computer-aided manufacturing (CAD-CAM) PEEK RPD…

Removal of Cr(VI) from aqueous solutions by activated carbon and its composite with P2W17O61: A spectroscopic study to reveal adsorption mechanism.

Molecular scale information is needed to understand ions coordination to mineral surfaces and consequently to accelerate the design of impro … ce of W were more pronounced. Moreover, a monosubstituted compound; i.e. K6P2CrW17 O61·nH2O, having chromium in its maximum oxidation state (Cr(VI)) was formed. These resulted in an improved adsorption capacity of AC-composite towards Cr(VI) in comparison to AC, and could explain the differences in adsorption thermodynamics and capacity of the two studied …

Molecular and trace metal signatures of pristine and anthropogenically altered mangrove sediments.

Mangroves contribute to long-term carbon sequestration and are considered as blue carbon ecosystems; however, they are facing increasing ant … ociated with more biologically labile and less aromatic lipids, whereas other trace metals, such as chromium (Cr), zinc (Zn), arsenic (As), and lead (Pb), are preferentially associated with biologically recalcitrant and aromatic lipids. One possible interpretation is that lipidomic profiles and their binding capacities for these trace metals differ among m …

Dihydroartemisinin Alleviates the Symptoms of a Mouse Model of Systemic Lupus Erythematosus Through Regulating Splenic T/B-Cell Heterogeneity.

UNLABELLED: Background: Systemic lupus erythematosus (SLE) is a complex autoimmune disease with significant therapeutic challenges. Recent s … mice and three control mice underwent single-cell RNA sequencing (scRNA-seq) using the 10× Genomics Chromium system. Comprehensive analyses included cell clustering, signaling pathway enrichment, pseudotime trajectory analysis, and cellular communication assessment using unbiased computational methods. RESULTS: DHA treatment significantly reduced kidney i …

Passivity, torque stability, and fracture resistance in screw-retained and dual-retained metal-ceramic implant-supported restorations: an in vitro study, part II.

BACKGROUND: This study aimed to compare the passivity, screw torque stability, and fracture resistance between dual- and screw-retained implant restorations, before and after thermomechanical loading. METHODS: Twenty metal-ceramic restorations were divided into two groups (n = 10 each). Group 1 (G1) featured dual-retained restorations on prefabricated titanium abutments, while Group 2 (G2) had screw-retained restorations on UCLA chromium-cobalt cast-to abutments. Passivity, adjustment ease, and torque loss were compared, along with fracture resistance and mode, post-fabrication and after ther…

Cadmium exposure and its role in joint disease: A brief review of experimental and population-based evidence.

Cadmium is a toxic metal released into the environment mainly by mining and industrial activities, posing health risks through inhalation an … tis. This may result from its interference with essential metals such as Zinc, Iron, Manganese, and Chromium, which are critical for the extracellular matrix. Cadmium has also been linked to rheumatoid arthritis by disrupting immune function, promoting oxidative stress, and increasing inflammatory mediators like TNF-α, IL-6, and COX-2. It may contribute to …

Biomechanical analysis of 3D correction and bone-screw forces as a function of rod insertion sequence and orientation relative to the sagittal plane in adolescent idiopathic scoliosis instrumentation.

BACKGROUND: In adolescent idiopathic scoliosis instrumentation, rods are typically aligned with the sagittal plane during the initial transl … ollowed by the convex side, and vice versa. The construct included pedicle screws and 5.5-mm Cobalt-Chromium rods contoured to 45° (concave side) and 15° (convex side). Four rod orientations relative to the sagittal plane (0°, 10°, 20°, 30°) were analyzed for 3D correction and bone-screw forces. FINDINGS: Main thoracic Cobb angle correction improved signi …

Adverse pulmonary effects and metallic characteristic of size-resolved welding fumes in human lung epithelial BEAS-2B cells.

Welding produces complex metal fumes containing fine and ultrafine particles that can penetrate different regions of the respiratory tract and cause adverse health effects. Analyses based solely on total particulates overlook the size-dependent toxicity of these aerosols. This study employed human lung epithelial cells to elucidate the effects of different sizes (2.5-10 μm, 1.0-2.5 μm, and < 1.0 μm) of metallic fume particles (MFPs) in a stainless steel arc welding workplace. High concentrations of iron (106.09 μg/m3), chromium (40.94 μg/m3), and manganese (27.43 μg/m3), which are the main com…

Ameliorative Potential of a Lactobacillus Based Probiotic Consortium Against Hepatotoxicity Induced by Combinatorial Exposure to Multiple Heavy Metals.

Heavy metal exposure remains a serious public health concern due to its cumulative, persistent toxicity and strong affinity for vital organs such as the liver. To mimic real-world scenarios, this study developed a murine model of chronic multi-metal toxicity using low- and high-dose mixtures of arsenic (As), cadmium (Cd), lead (Pb), mercury (Hg), and chromium (Cr). Metal exposure resulted in significant hepatic damage, evidenced by elevated serum transaminases (ALT, AST), increased malondialdehyde (MDA), suppressed antioxidant enzymes (SOD, CAT) including non enzymatic enzyme GSH and a shift t…

Исследование взаимосвязи между элементами сериальной трассы и уровнями MSFC в области множественного склероза: перекрестное тематическое исследование.

Воздействие микроэлементов в течение многих лет изучалось в многократной склерозовой (МС) этиологии. Однако общие результаты еще не получены в ходе предыдущих исследований. Поэтому в качестве межсекторального исследования по вопросам контроля за конкретными случаями мы стремились изучить взаимосвязь между микроэлементами и MS в провинции Конья, где загрязнение воздуха является интенсивным. Участники исследования с МЗ были исследованы в отношении расширенных показателей инвалидности (ЭДСС) и множественных функциональных склерозовых композиционных шкал (МСФК). Кроме того, была проведена оценка в

Совпадение в аннотации оригинала
The effects of trace elements have been investigated in multiple sclerosis (MS) etiology for years. However, common results have yet to be o … ssion Inventory (BDI), Facit Fatigue Scale (FFS), Fatigue Severity Scale (FSS), and levels of blood chromium (Cr), manganese (Mn), copper (Cu), zinc (Zn), selenium (Se), cadmium (Cd), and lead (Pb). While there were 49 people in the MS group, 51 individuals constituted the controls. Mn, Zn, Cd, and Pb levels were significantly higher in controls. There was …

BeGraft Aortic Stents: A European Multi-Centre Experience Reporting Acute Safety and Efficacy Outcomes for the Treatment of Vessel Stenosis in Congenital Heart Diseases.

BACKGROUND: Stent implantation has become the preferred method of treatment for treating vessel stenosis in congenital heart diseases. The availability of covered stents may decrease complications and have an important role in the management of patients with complex anatomy. AIM: This study aims to evaluate the feasibility and safety of the pre-mounted cobalt-chromium stent-graft-covered ePTFE Aortic BeGraft in a broad spectrum of vascular lesions. METHODS: This is a multicenter retrospective results analysis of 107 implanted BeGraft stents between 2016 and 2022 in six different European cen…

Health risk assessment of lead, cadmium, heavy metals and metalloids in residential paint flakes from indoor wall surfaces.

Paint components pose risky metals like lead, cadmium, arsenic, and mercury that endanger occupants, mainly children and pregnant women. To assess the levels and health risks of 14 metals in paint flakes from indoor walls of residential houses in four states in South-western Nigeria. Flaked paints were collected from 144 houses where children reside. Metals were analysed using an inductively coupled plasma-optical emission spectrometer. The cadmium (Cd), lead (Pb), arsenic (As), and chromium (Cr) levels (mg/kg) ranged from 1239.9 to 2254.2, 1126.5 to 3080.3, 822.1 to 1492.0, and 2.5 to 60.6 in…

Comparison of trace elements in peripheral blood and bone marrow of newly diagnosed multiple myeloma patients.

Trace elements are essential micronutrients for the human body. Their roles are indispensable, as they are involved in a wide range of vital biological processes. In this study, we aimed to evaluate alterations in trace elements in the blood and bone marrow serum of patients with newly diagnosed multiple myeloma (NMM). The levels of zinc (Zn), copper (Cu), iron (Fe), manganese (Mn), magnesium (Mg), selenium (Se), arsenic (As), boron (B), nickel (Ni), silicon (Si) and chromium (Cr) were analyzed in the venous blood samples of the patient group comprising 70 patients with NMM (41 males and 29 fe…

Leather Waste Hydrolysation, Carbonization, and Microbial Treatment for Nitrogen Recovery by Ryegrass Cultivation.

Leather waste contains up to 10% nitrogen (N); thus, combustion or gasification only for the energy recovery would not be rational, if safety standards are met. On the other hand, the chromium (Cr) content exceeding 5% in half of the waste stream (w/w) is too significant to be applied in agriculture. In this work, four acid hydrolysates from leather waste shavings, both wet-white free of Cr and wet-blue with Cr, were used: two with a mixture of acids and supplemented with Cu, Mn, and Zn, and the other two as semi-products from collagen extraction using hydrochloric acid. Additionally wet-green…

Biomechanical Analysis of One-Piece Postand- Core: High-Performance Polymers vs Conventional Materials.

PURPOSE: To evaluate the stress distribution along a premolar's root dentin, its post, and its post-luting agent when materials with differe … ed polyetheretherketone (CFR-PEEK), gold-palladium alloy (Au-Pd), titanium (Ti), zirconia (Zi), and chromium-nickel (Cr-Ni). Maximum principals stress (MPS) in the post, post-luting agent, and root dentin were determined. A load of 150 N was applied to the buccal cusp in the linguo-labial direction at an angle of 45 degrees oblique to the longitudinal axis …

Long-term efficacy, safety and biocompatibility of a novel sirolimus eluting iron bioresorbable scaffold in a porcine model.

Iron is considered as an attractive alternative material for bioresorbable scaffolds (BRS). The sirolimus eluting iron bioresorbable scaffold (IBS), developed by Biotyx Medical (Shenzhen, China), is the only iron-based BRS with an ultrathin-wall design. The study aims to investigate the long-term efficacy, safety, biocompatibility, and lumen changes during the biodegradation process of the IBS in a porcine model. A total of 90 IBSs and 70 cobalt-chromium everolimus eluting stents (EES) were randomly implanted into nonatherosclerotic coronary artery of healthy mini swine. The multimodality asse…

Nicotine or marijuana vaping exposure during pregnancy and altered immune responses in offspring.

Electronic nicotine delivery systems (ENDS) - which include electronic cigarettes or e-cigarettes, or simply e-cigs, and marijuana vaping ha … only one passive vaping exposure case study on a human fetus, which noted that glycerol, aluminum, chromium, nickel, copper, zinc, selenium, and lead crossed from the mother to the offspring's cord blood. The carcinogens (metals) in that study were at lower concentrations compared to the mother's biological matrices. Lastly, we observed that in utero expo …