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Association Between Joint Pain and Cancer in 8.45 Million Korean Adults: Insights from a National Cross-Sectional Study.

Background: Joint pain, a multifactorial musculoskeletal symptom, is rising globally due to an aging population. Simultaneously, cancer is increasingly considered a chronic condition with growing prevalence and improved survival rates, similar to hypertension and diabetes. Although the association between chronic diseases such as diabetes and joint pain has been well studied, the relationship between cancer and joint pain remains underexplored, especially as cancer's chronic disease status evolves. Methods: This study analyzed data from the Korean National Health and Nutrition Examination Surv

New horizons in systemic sclerosis treatment: advances and emerging therapies in 2025.

Systemic sclerosis (SSc) is a rare, multisystem autoimmune disease characterised by vasculopathy, immune dysregulation, and progressive fibrosis, leading to significant morbidity and mortality. While recent EULAR recommendations have updated the standard of care for SSc, the field is rapidly evolving with novel therapeutic strategies and precision medicine approaches.Traditional immunosuppressive therapies-including mycophenolate mofetil, cyclophosphamide and rituximab-remain essential for controlling skin and lung involvement while autologous haematopoietic stem cell transplantation offers a

Oral salt loading combined with postural stimulation tests for confirming and subtyping primary aldosteronism.

OBJECTIVES: Primary aldosteronism (PA) is an underdiagnosed yet important condition. This study aimed to evaluate the diagnostic performance of a combined protocol using oral salt loading and postural stimulation tests (PST), named the balance study, to confirm and subtype PA. METHODS: We retrospectively analyzed the data of 402 patients with either confirmed PA or essential hypertension who underwent the balance study. Biochemical markers were measured using liquid chromatography-tandem mass spectrometry. Receiver operating characteristic curves were used to assess the diagnostic performance…

Adaptive Servo-Ventilation for Central Sleep Apnea in an Anemic Patient with Cardiac Disease: A Case Report.

Background and Clinical Significance: Obstructive sleep apnea (OSA) is a common comorbidity in patients with cardiac and metabolic disorders … 74-year-old male with a history of type 2 diabetes mellitus, paroxysmal atrial fibrillation, HFpEF, essential hypertension, and bladder carcinoma. He was referred for pre-operative OSA screening, reporting excessive daytime sleepiness, insomnia, and witnessed apneas. Initial respiratory polygraphy revealed severe sleep-disordered breathing with dominant CSA-CSB and mode …

Chronic Kidney Disease Following Cardiac Arrest Manifesting as Dyspnoea and Peripheral Oedema in Cardiovascular Multimorbidity: Case Analysis and Brief Literature Review.

BACKGROUND/AIM: Chronic kidney disease (CKD) contributes significantly to morbidity, mortality, and healthcare costs. CKD is not only an independent risk factor for cardiovascular disease (CVD) but also a severe complication for patients with CVD, impacting substantially their prognosis and quality of life. CASE REPORT: A 79-year-old male with a complex medical history, including asthma, hypertension, myocardial infarction, ischaemic heart disease, and recent atrial fibrillation, presented with new-onset exertional breathlessness and peripheral oedema following cardiac arrest and pacemaker in

Lingual necrosis in giant-cell arteritis: a case-based review.

Lingual necrosis is a rare but serious complication of giant cell arteritis (GCA). Diagnosis can be difficult due to its atypical presentation, particularly when it occurs without the usual GCA symptoms. We present the case of a 59-year-old female with a history of migraines and smoking, who developed severe tongue pain and neck discomfort. Glucocorticoid therapy was promptly initiated due to clinical suspicion of GCA. However, when the steroid dosage was reduced, the patient's symptoms worsened despite initial improvement. Tocilizumab was subsequently introduced, and by discharge, there was a

Heart Failure With Reduced Ejection Fraction Update: A Review Of Clinical Trials and New Therapeutic Considerations.

Heart failure with reduced ejection fraction (HFrEF) is a prevalent and complex condition characterized by the heart's inability to pump sufficient blood, leading to significant morbidity and mortality. It is primarily caused by ischemic heart disease, hypertension, and dilated cardiomyopathy. The pathophysiology of HFrEF involves myocardial remodeling, neurohormonal activation, and resultant systolic dysfunction, contributing to symptoms like dyspnea and fatigue. Comorbidities such as diabetes, obesity, and chronic kidney disease exacerbate its progression. Diagnosis relies on clinical sympto

A study on the efficacy and safety of anlotinib in patients with metastatic pheochromocytoma and paraganglioma.

Metastatic pheochromocytoma and paraganglioma (MPP) currently lack definitive curative therapies. The treatment of MPP presents a formidable challenge. Anlotinib hydrochloride, characterized as a multi-targeted tyrosine kinase receptor inhibitor, has demonstrated potential in this domain. This study, a phase 2 trial (NCT04860700), aimed to evaluate the efficacy and safety profiles of anlotinib hydrochloride in patients suffering from MPP. The primary objective was to determine the disease control rate (DCR) and objective response rate (ORR) as determined by the RECIST 1.1 criteria. Secondary o

Trends in Corneal Transplantation at a Mexican Ophthalmological Center: 12 Years of Experience.

PURPOSE: To analyze the trends and characteristics of eye banking and corneal transplantation over a 12-year period at an ophthalmological center in Mexico City. METHODS: We performed a retrospective, descriptive study including all patients who underwent corneal transplantation at a Mexican ophthalmology reference center between January 2011 and December 2022. Statistical analyses were conducted with data reported as complete counts or mean with standard deviations. Comparisons were made using independent t-tests. P -values less than 0.05 were considered statistically significant. RESULTS:

A Rare Culprit or an Elusive Culprit in Disguise? Unraveling Wild-Type ATTR Cardiac Amyloidosis in Heart Failure With Reduced Ejection Fraction.

Cardiac amyloidosis (CA) is a rare disorder caused by the deposition of abnormal proteins called amyloid in the myocardium, leading to dysfunction. The 2 most common forms of amyloidosis are AL (light chain) and ATTR (transthyretin). Diagnosing amyloidosis is challenging, especially in its early stages, due to its nonspecific symptoms and overlap with other conditions. Recent studies suggest that the incidence of wild-type transthyretin amyloidosis is rising, likely due to improved diagnostic techniques and an aging population. We present the case of a 72-year-old male with lower extremity ede

An Unusual Presentation of Multifactorial Hypocalcemia as Myopathy: A Case Report.

Hypocalcemia is a common metabolic disturbance with a broad spectrum of clinical presentations, ranging from asymptomatic laboratory findings to severe, life-threatening complications. While neuromuscular irritability is a well-known feature, myopathy as a primary presentation is rare and often under-recognized. We report the case of a 45-year-old female with type 2 diabetes and hypertension who presented with progressive lower limb weakness and generalized body aches. She had a recent history of an abdominal skin abscess and had received blood transfusions without calcium correction. On exami

Severe psoriasis vulgaris complicating pemphigus vulgaris: A case report.

RATIONALE: Currently, the main comorbidities of psoriasis are cardiovascular, metabolic, liver and kidney, autoimmune, and psychological dis … r discontinuing medication, which seriously affected his daily life and sleep. The patient also had essential hypertension, nail psoriasis, tinea pedis, and onychomycosis. DIAGNOSES: The patient was diagnosed with psoriasis vulgaris with coexisting pemphigus vulgaris. INTERVENTIONS: The patient was treated with modest doses of glucocorticoids combined with secukinumab …

Epidemiological Trends in Pulmonary and Extra pulmonary Tuberculosis: A 5 year Retrospective Analysis of Acid Fast Bacilli.

BACKGROUND: Tuberculosis (TB) remains a major public health issue globally, presenting in pulmonary tuberculosis(PTB) and extra PTB(EPTB) forms. Acid-Fast Bacilli (AFB) testing is crucial for detecting Mycobacterium tuberculosis. Understanding TB epidemiology, including positivity rates, demographic patterns, and comorbidities, is essential for effective control. This study analyses AFB testing trends for TB over 5 years, focusing on PTB and EPTB cases, gender and age distribution, and associated comorbidities to inform public health and clinical practices. METHODS: This retrospective study a

Окулистические и нейро-офтальмические проявления хронического воспламенения демилилинизации Полиневолюции.

Хроническая воспламенительная демиелинация полирадикулонэропропотии (CIDP) — иммунопосредованная неврапатия, характеризующаяся демиелинацией и аксонной травмой периферийных нервов. В то время как его отличительная характеристика включает в себя прогрессивные сенсорные недостатки, недопризнанная подгруппа пациентов развивает окулярные и нейро-офтальмические проявления. К ним относятся оптический неуриит, оптическая атрофия, потеря зрения, офтальмоплегия, экстраокульное расширение мышц с проптозом, внутричерепная гипертония и маленькая волокнопатология. Электрофизиологические и визуальные исслед

Эпинефрин как терапевтический агент по гиперферритинемии в диабете и гипертенции.

ПЕРВЫЙ РАЗДЕЛ НЕИЗБИРАТЕЛЬНОГО БЕДСТВИЯ, ИСПОЛЬЗУЕМОГО 21st Пандемия века. Тип 2 диабет (T2DM) является результатом повышенного сопротивления инсулину (IR) или относительного дефицита инсулина. IR препятствует удалению глюкозы, что приводит к компенсационному гиперинсулимическому состоянию. Увеличение запасов железа, нашедшее отражение в высокой сыворотке феррита (SF), было связано с разработкой T2DM и оказывает воздействие на глюкозу гомеостаз, ослабляя реакцию тканей на инсулин. Железная перегрузка (IO) широко распространена в основной гипертонии (HTN). Первый клинический эффект эпинефрина н

Совпадение в аннотации оригинала
BACKGROUND Diabetes mellitus was the first non-communicable disease to be recognized as a 21st century pandemic. Type 2 diabetes (T2DM) resu … glucose homeostasis by impairing tissue response to insulin. Iron overload (IO) is quite common in essential hypertension (HTN). The first clinical effect of epinephrine on SF was reported in 2024, showing that epinephrine resulted in normalization of SF and recovery from severe COVID-19 infection. CASE REPORT A patient with T2DM, HTN, and dyslipidemia associated with …

Relationship between the AGT M235T genetic variant and the characteristics and prognosis of coronary atherosclerosis in patients with acute myocardial infarction.

BACKGROUND: Along with environmental components, genetic factors play an essential role in the pathophysiology and progression of acute myocardial infarction (AMI). There is limited and conflicting data on the influence of the AGT M235T genetic variant on coronary atherosclerosis and death in AMI patients. METHODS: We carried out a prospective cohort study among 504 Vietnamese AMI patients selected between January 2020 and May 2021. All patients underwent invasive coronary angiography, had AGT M235T genetic variant genotyped using the polymerase chain reaction method, and were followed up for

Combined exercise training decreases blood pressure in OLDER women with NOS3 polymorphism providing changes in differentially methylated regions (DMRs).

The mechanisms by which the ageing process is associated to an unhealthy lifestyle and how they play an essential role in the aetiology of systemic arterial hypertension have not yet been completely elucidated. Our objective is to investigate the influence of NOS3 polymorphisms [-786T > C and (Glu298Asp)] on systolic blood pressure (SBP) and diastolic blood pressure (DBP) response, differentially methylated regions (DMRs), and physical fitness of adult and older women after a 14-week combined training intervention. The combined training was carried out for 14 weeks, performed 3 times a week, t

A Review of Fetal Development in Pregnancies with Maternal Type 2 Diabetes Mellitus (T2DM)-Associated Hypothalamic-Pituitary-Adrenal (HPA) Axis Dysregulation: Possible Links to Pregestational Prediabetes.

Research has identified fetal risk factors for adult diseases, forming the basis for the Developmental Origins of Health and Disease (DOHaD) hypothesis. DOHaD suggests that maternal insults during pregnancy cause structural and functional changes in fetal organs, increasing the risk of chronic diseases like type 2 diabetes mellitus (T2DM) in adulthood. It is proposed that altered maternal physiology, such as increased glucocorticoid (GC) levels associated with a dysregulated hypothalamic-pituitary-adrenal (HPA) axis in maternal stress and T2DM during pregnancy, exposes the fetus to excess GC.

Successful Kidney Donation Following Long-Term Normothermic Regional Perfusion: Challenges of the First Uncontrolled Donation After Circulatory Death in Iran.

The global organ donation crisis continues to escalate despite advancements in medical procedures. Uncont-rolled donation after circulatory death provides an alternative method to increase the donor pool, especially for kidney transplants. This case study from Iran offers insights into the complex, yet essential, facets of organ procurement under uncontrolled donation after circulatory death protocols. A 38-year-old woman experienced a severe cerebrovascular accident and subsequent cardiac arrest. She was declared for uncontrolled donation after circulatory death, and her organs were preserved

Race, Sex, and Ejection Fraction-Based Differences in Transthyretin Amyloid Cardiomyopathy (ATTR-CM) Risk Prediction.

Background: The early detection of transthyretin cardiac amyloidosis (ATTR-CM) is essential, with Tc-99m pyrophosphate scintigraphy (PYP scan) being a key diagnostic tool. Although a previously validated score has shown promise in predicting PYP scan positivity among patients with HFpEF, further evaluation in diverse cohorts is necessary. Objectives: To assess the effectiveness of the ATTR-CM score in predicting PYP scan positivity within our patient population. Methods: We analyzed patients referred for PYP with SPECT at the Cleveland Clinic from January 2012 to January 2020, all of whom had