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A pilot study to evaluate the feasibility of individualized yoga for inpatient children receiving intensive chemotherapy.

BACKGROUND: Fatigue is an important problem in paediatric cancer patients and yoga may be an effective intervention. The primary objective was to determine the feasibility of individualized yoga for hospitalized children receiving intensive chemotherapy. METHODS: We included English-speaking children and adolescents aged 7-18 years receiving intensive chemotherapy or haematopoietic stem cell transplantation (HSCT). Yoga was conducted three times weekly for three weeks. The primary outcome was feasibility, defined as ability to deliver at least 60% of planned sessions. Secondary outcomes were …

Sleep disorders in patients with multiple sclerosis.

OBJECTIVE: Poor sleep is a frequent symptom in patients with multiple sclerosis (MS). The objective of the study was to assess the relationship between nocturnal polysomnographic (PSG) findings and quality of sleep, fatigue, and increased daytime sleepiness among patients with MS. METHODS: Clinical characteristics were collected. Pittsburgh Sleep Quality Index (PSQI), Fatigue Severity Scale (FSS), Epworth Sleepiness Scale (ESS), and International Restless Legs Syndrome Rating Scale were used to assess quality of sleep, fatigue, excessive daytime sleepiness, and the presence of restless legs s…

Carnosine treatment for gulf war illness: a randomized controlled trial.

About 25% of 1990-1991 Persian Gulf War veterans experience disabling fatigue, widespread pain, and cognitive dysfunction termed Gulf War illness (GWI) or Chronic Multisymptom Illness (CMI). A leading theory proposes that wartime exposures initiated prolonged production of reactive oxygen species (ROS) and central nervous system injury. The endogenous antioxidant L-carnosine (B-alanyl-L-histidine) is a potential treatment since it is a free radical scavenger in nervous tissue. To determine if nutritional supplementation with L-carnosine would significantly improve pain, cognition and fatigue i…

Patient reported outcomes in NMOSD reflect a high disease burden and do not correlate with the EDSS.

BACKGROUND: The Expanded Disability Status Scale (EDSS) is routinely used to evaluate disability in Neuromyelitis Optica Spectrum Disorder (NMOSD), although it has only been validated in multiple sclerosis (MS) and may not capture important aspects of the patient experience in NMOSD. OBJECTIVE: To evaluate the relationship between Patient-Reported Outcomes (PROs), including for pain, fatigue, anxiety, and depression, and EDSS scores in NMOSD. METHODS: This cross-sectional study used baseline visit data from participants with aquaporin-4 antibody positive NMOSD who were enrolled in the multi-…

Alternating Current Is More Fatigable Than Pulsed Current in People Who Are Healthy: A Double-Blind, Randomized Crossover Trial.

OBJECTIVE: Tolerance level and rapid fatigue onset are limitations in the use of neuromuscular electrical stimulation (NMES) as an electrotherapeutic resource in rehabilitation and training protocols; however, it is unclear if pulsed current (PC) and alternating current (AC) produce different fatigue levels when applied at submaximal contraction level. The purpose of this study was to compare fatigue and discomfort levels between PC and AC during a submaximal contraction protocol in people who are healthy. METHODS: In this double-blind, randomized crossover trial conducted in a laboratory set…

Extra-Cerebellar Signs and Non-motor Features in Chinese Patients With Spinocerebellar Ataxia Type 3.

Objectives: Our study attempted to systematically explore the prevalence of extra-cerebellar signs and non-motor symptoms, such as anxiety, depression, fatigue, excessive daytime sleepiness (EDS) and sleep disturbances in a cohort of Chinese patients with spinocerebellar ataxia type 3 (SCA3), and further investigated the correlations between non-motor symptoms and clinical characteristics in SCA3 patients. Methods: This study included 68 molecular-proven SCA3 patients. Extra-cerebellar signs were evaluated with the Inventory of Non-Ataxia Symptoms (INAS). The INAS count indicated the number of…

Sleep and posttraumatic rheumatic pain modulation disorder (fibrositis syndrome).

The clinical features and sleep physiology of 11 female patients with "fibrositis syndrome" or rheumatic pain modulation disorder (RPMD) were compared with 11 female postaccident pain (PAP) patients who complained of widespread musculoskeletal pain, fatigue, and nonrestorative sleep following a nonphysically injurious motor vehicle or work-related accident. Both groups had similar musculoskeletal pain, fatigue, sleepiness and an alpha (7.5-11 Hz) EEG non-rapid eye movement (NREM) sleep anomaly. A psychophysiologic arousal mechanism during NREM sleep induced by the emotional stress of the accid…

Application of Dang Van Model Based on Critical Plane Approach for Rolling Contact Problems.

Analyses of rolling contact fatigue (RCF) problems require the use of multiaxial fatigue criteria, which take into account complex non-proportional stress conditions. One of the most often used criteria to analyse this phenomenon is the Dang Van criterion. However, this criterion is often criticised due to its overestimation of the influence of compressive stresses on fatigue strength, which leads to an underestimation of the equivalent fatigue stress. Due to the high popularity of this hypothesis, in this paper a few modifications of the Dang Van criterion based on the critical plane approach…

Воздействие автономной дисфункции на характеристики множественного склероза: Отчёты из тунисского когортного исследования.

UNLABELELED: Часто о дисфункции автономной нервной системы (ANS) сообщается у людей с множественным склерозом (pwMS), хотя он по-прежнему не диагностирован. Наша цель состоит в том, чтобы оценить частотность дисфункции ANS в PwMS с использованием клинических и электрофизиологических оценок и изучить ее связь с такими характеристиками болезни, как усталость, а также ее воздействие на качество жизни. МЕТОДЫ: В отделении неврологии университетского госпиталя в Рази было проведено перекрестное исследование, в том числе 100 ПТМС. Оценка ANS проводилась с помощью композитного автономного симптома 31

Совпадение в аннотации оригинала
UNLABELLED: Autonomic nervous system (ANS) dysfunction is frequently reported in people with Multiple Sclerosis (pwMS), although it remains underdiagnosed. Our aim is to evaluate the frequency of ANS dysfunction in pwMS using clinical and electrophysiological assessments and to investigate its relationship with disease characteristics, such as fatigue, as we…

Mechanomyography reflects the changes in oxygenated hemoglobin during electrically evoked cycling in individuals with spinal cord injury.

BACKGROUND: Functional electrical stimulation (FES) cycling has been reported to enhance muscle strength and improve muscle fatigue resistance after spinal cord injury (SCI). Despite its proposed benefits, the quantification of muscle fatigue during FES cycling remains poorly documented. This study sought to quantify the relationship between the vibrational performance of electrically-evoked muscles measured through mechanomyography (MMG) and its oxidative metabolism through near-infrared spectroscopy (NIRS) characteristics during FES cycling in fatiguing paralyzed muscles in individuals with …

Impact of Physiotherapy on Shoulder Kinematics in Swimmers with Swimmer's Shoulder Pain.

Swimmer's shoulder is a common condition among elite swimmers, often leading to pain and reduced performance. Fatigue can exacerbate this condition by affecting shoulder strength, proprioception, and range of motion, potentially increasing the risk of overuse injuries. This preliminary study aimed to evaluate the impact of physiotherapy treatment and the effects of fatigue on shoulder kinematics using inertial and magnetic measurement units (IMUs). Five male swimmers (aged 21-27) with at least 3 years of training and suffering from swimmer's shoulder pain participated in the study. The protoco…

The Effect of the Use of Hearing Aids in Elders: Perspectives.

Older adults with hearing loss have difficulties during conversation with others because an elevated auditory threshold reduces speech intelligibility, especially in noisy environments. Listening and comprehension often become exhausting tasks for hearing-impaired elders, resulting in social isolation and depression. The aim of the present study was to investigate the advantages of hearing aid use in relation to relief from listening-related fatigue, which is still controversial. Participants included a sample of 49 hearing-impaired elders affected by presbycusis for whom hearing aids were pre…

Clinical Profile and Aspects of Differential Diagnosis in Patients with ME/CFS from Latvia.

Background and objectives: There is still an uncertainty regarding the clinical symptomatology and the diagnostic criteria in terms of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), as different diagnostic criteria exist. Our aim is to identify the core symptoms of ME/CFS in the outpatient setting in Riga; to distinguish symptoms in patients with ME/CFS and those with symptoms of fatigue; and to investigate patient thoughts on the onset, symptoms, treatment and effect of ME/CFS. Materials and methods: Total of 65 Caucasian patients from an ambulatory care setting were included in…

The impact of occupational psychological hazards and metabolic syndrome on the 8-year risk of cardiovascular diseases-A longitudinal study.

There was little information concerning the combined effect of occupational psychosocial hazards such as long working hours, high job stress, and high fatigue on the risk of cardiovascular and cerebrovascular diseases (CVD). The aim of this study was to investigate the interaction among occupational psychosocial hazards and the impact of metabolic syndrome (MetS) on the risk of CVD among bus drivers. The Taiwan Bus Driver Cohort Study involving 1014 professional drivers was established in 2005 and comprehensively studied. The interactions among occupational psychosocial hazards and the impact …

Gap Formation During Cyclic Testing of Flexor Tendon Repair.

PURPOSE: Substantial gap formation of a repaired finger flexor tendon is assumed to be harmful for tendon healing. The purpose of this study was to investigate the relationship between gap formation and the failure of the repair during cyclic loading. METHODS: Thirty-five porcine flexor tendons were repaired and tested cyclically using variable forces until failure or a maximum of 500 cycles. Depending on the biomechanical behavior during cyclic testing, specimens were divided into 3 groups: Sustained (no failure), Fatigued (failure after 50 cycles), and Disrupted (failure before 50 cycles). …

Lane heading difference: An innovative model for drowsy driving detection using retrospective analysis around curves.

Driving while sleepy is a serious contributor to automobile accidents. Previous research has shown that drowsy drivers produce systematic errors (variability) in vehicle behavior which are detectable using vehicle monitoring technology. The current study developed a new methodological approach using a vehicle heading difference metric to detect drowsy driving more effectively than other more commonly used methods. Twenty participants completed a driving scenario as well as several measures of fatigue in five testing sessions across a night of sleep deprivation. Each simulated highway driving s…

Sustained attention following traumatic brain injury: use of the Psychomotor Vigilance Task.

OBJECTIVE: Deficits in sustained attention are common following traumatic brain injury (TBI), as a result of primary (i.e., neuropathology) and/or secondary factors (i.e., fatigue, sleep disturbance, depressed mood). The extent to which secondary factors play a role in attention deficits is relatively unexamined. Moreover, the Psychomotor Vigilance Task (PVT) is seldom used in TBI assessment despite its sensitivity to secondary factors observed following injury. The primary aim of the current study was to examine the usefulness of the auditory PVT in identifying attentional difficulties in pat…

Relationship between performance validity testing, disability status, and somatic complaints in patients with fibromyalgia.

Fibromyalgia is a chronic pain-related disorder that typically includes cognitive complaints as well as non-specific somatic complaints, such as fatigue and sleep disturbance (Wolfe et al., 2010). Fibromyalgia has also been shown to be associated with a high rate of failure on performance validity testing (PVT), which has not been examined with respect to other self-reported symptoms that are now part of the diagnostic criteria for the disorder. We evaluated 85 patients with fibromyalgia who completed objective measures of pain, sleep, and fatigue along with symptom validity measures (Word Mem…

Post-polio syndrome patients treated with intravenous immunoglobulin: a double-blinded randomized controlled pilot study.

Post-polio syndrome (PPS) is characterized by new muscle weakness, atrophy, fatigue and pain developing several years after the acute polio. Some studies suggest an ongoing inflammation in the spinal cord in these patients. From this perspective, intravenous immunoglobulin (IvIg) could be a therapeutic option. We performed a double-blinded randomized controlled pilot study with 20 patients to investigate the possible clinical effects of IvIg in PPS. Twenty patients were randomized to either IvIg 2 g/kg body weight or placebo. Primary endpoints were changes in pain, fatigue and muscle strength …

Fibromyalgia: Advances in pathophysiology, diagnostic biomarkers, genetic insights, multisystemic involvement, and treatment updates and multidisciplinary interventions.

BACKGROUND: This systematic review examines the pathophysiology, biomarkers, genetic insights, and treatment strategies for fibromyalgia, hi … valuates the effectiveness of pharmacological and non-pharmacological treatments in improving pain, fatigue, sleep quality, and overall quality of life. METHODOLOGY: A systematic review was conducted on fibromyalgia from 2020 to 2025, focusing on pathophysiology, biomarkers, genetic insights, and treatment interventions. Studies were selected from PubMed …