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Development and validation of the CHI-CAT score: a novel tool for assessing cancer-associated venous thromboembolism risk in China.

BackgroundIdentifying patients at risk for VTE and stratifying that risk is critical to determine who will benefit from thromboprophylaxis. China's clinical practice still faces limitations, particularly regarding systematic and practical VTE risk assessment tools for cancer patients. This study aims to develop and validate the CHIna's Cancer-Associated venous Thromboembolism risk assessment tool (CHI-CAT score) compared to the Khorana score.MethodsCancer patients aged 18 or older hospitalized in the Third People's Hospital of Chengdu from March 2022 to September 2023 were retrospectively invo

Advances in the use of ECMO in oncology patient.

BackgroundOver the past decade, ECMO has provided temporary cardiopulmonary support to an increasing number of patients, but the use of extracorporeal membrane oxygenation (ECMO) to provide temporary respiratory and circulatory support to adult patients with malignancy remains controversial.ObjectivesThis paper reviews the specific use of extracorporeal membrane oxygenation (ECMO) in oncology patients.MethodsWe searched PubMed, CINAHL, Cochrane Library, and Embase databases for studies on the use of ECMO in cancer patients between 1998 and 2022. Twenty-four retrospective, prospective, and case

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… According to the oncologist, surgical resection is recommended for radical esophageal cancer. In the case of a patient who had only one lung, and with the postoperative complications of esophageal cancer already high, the use of ECMO to support the surgery was proposed. … Such evaluations can be completed through multidisciplinary treatment efforts (e.g., in collaboration with oncologists and surgeons) and should make use of full codes and individualized treatment for patients admitted to the ICU requiring ECMO. …

Preventing Venous Thromboembolism in Ambulatory Patients with Cancer: A Narrative Review.

Venous thromboembolism (VTE) is frequent among patients with cancer. Ambulatory cancer patients starting chemotherapy have a 5% to 10% risk of cancer associated thrombosis (CAT) within the first year after cancer diagnosis. This risk may vary according to patient characteristics, cancer location, cancer stage, or the type of chemotherapeutic regimen. Landmark studies evaluating thrombophrophylaxis with low molecular weight heparin (LMWH) for ambulatory cancer patients have shown a relative reduction in the rate of symptomatic VTE of about one half. However, the absolute risk reduction is modes

Pharmacovigilance in oncology.

Background Side effects of cancer therapy are one of the most important issues faced by cancer patients during their illness. Pharmacovigilance, namely the science and activities aimed at monitoring the safety of drugs, is particularly important in oncology, due to the intrinsic biologic toxicity of antineoplastic agents, their narrow therapeutic windows, and the high doses and rigid timing of treatment regimens. Aim of the review To identify the main issues in carrying out an effective pharmacovigilance activity in oncology. Method We searched PubMed for articles about pharmacovigilance in re

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… Finally, the phenomenon of under-reporting requires great attention in oncology, especially because oncologists often consider adverse reactions caused by cytotoxic drugs as a “normal” phenomenon, or may delegate the reporting to nononcologists or nurses [ 54 ]. … Shachar SS Gallagher K McGuire K Zagar TM Faso A Muss HB Multidisciplinary management of breast cancer during pregnancy Oncologist 2017 22 3 324 334 28232597 10.1634/theoncologist.2016-0208 PMC5344634 33. …

Efficacy and safety of de-escalation bone- modifying agents for cancer patients with bone metastases: a systematic review and meta-analysis.

BackgroundCompared with application of bone-modifying agents (BMAs) every 4 weeks, it is unclear whether 12-weekly de-escalated therapy can be used as a substitute strategy.MethodsA systematic search of PubMed, EMBASE, and the Cochrane Register of Controlled Trials until November 22, 2017, was performed. Randomized controlled trials (RCTs) were included to assess skeletal-related event (SRE) rates, adverse events, and bone turnover biomarkers, comparing 12-weekly de-escalated treatments with standard 4-weekly dosage regimens. Risk ratios (RRs) with 95% CIs were pooled in fixed-effect meta-anal

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… disease Cancer 2007 110 8 1860 1867 17763372 10.1002/cncr.22991 7 Green JR Müller K Jaeggi KA Preclinical pharmacology of CGP 42’446, a new, potent, heterocyclic bisphosphonate compound J Bone Miner Res 1994 9 5 745 751 8053405 10.1002/jbmr.5650090521 8 Coleman RE Bisphosphonates: clinical experience Oncologist … nitrogen-containing bisphosphonates J Dent Res 2007 86 11 1022 1033 17959891 10.1177/154405910708601102 40 Kuchuk I Mazzarello S Butterfield K Appleton A Addison CL Clemons M Oral care and the use of bone-targeted agents in patients with metastatic cancers: A practical guide for dental surgeons and oncologists …

Patient Navigation in Cancer Treatment: A Systematic Review.

Purpose of reviewPatient navigation promotes access to timely treatment of chronic diseases by eliminating barriers to care. Patient navigation programs have been well-established in improving screening rates and diagnostic resolution. This systematic review aimed to characterize the multifaceted role of patient navigators within the realm of cancer treatment.Recent findingsA comprehensive electronic literature review of PubMed and Embase databases was conducted to identify relevant studies investigating the role of patient navigators in cancer treatment from August 1, 2009 to March 27, 2023.

Paraparesis and Disseminated Osteolytic Lesions Revealing Cholangiocarcinoma: A Case Report.

Bone metastases in cholangiocarcinoma are uncommon. We report the case of a patient with disseminated osteolytic lesions who was admitted to the Neurology Department for progressive paraparesis. On the computed tomography examination, specific features for cholangiocarcinoma were described, confirmed later by the histopathological aspect of the bone lesions.

Transplant Programs in APBMT: Blood and Marrow Transplant Activity Report from Myanmar APBMT Meeting 2018, Taiwan.

Hematopoietic stem cell transplantation (HSCT) was introduced in Myanmar in 2014 and was first performed in a patient with multiple myeloma at the North Okkalapa General and Teaching Hospital. From 2014 to 2016,transplantation activities were in the preliminary stage of establishing the infrastructure and gradually developing capacity-building. In 2016, the Yangon General Hospital also commenced autologous transplantation for myeloma. Five autologous transplants were performed in Myanmar during 2016 in patients with myeloma, using high-dose melphalan and non-cryopreserved peripheral blood stem

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… The hematologists leading the transplant team are also experiencing a high burden of malignant and non-malignant hematology cases, while oncologists are overburdened with a high number of solid tumor cases. … Vincent’s Hospital, Sydney, Australia (2015) 6 | Flowcytometry | National University Hospital, Singapore (2017) 7 | Radiation oncologists, physicists for paediatric haemato- oncology and TBI | Tata Memorial Centre, Mumbai, India (2017-18) 8 | Haemato-pathologists & technician. …

Bisphosphonate-related osteonecrosis of the jaw mimicking bone metastasis.

Osteonecrosis of the jaw is usually a potential complication of bisphosphonate therapy. In a cancer patient, this disease entity can be misdiagnosed as a metastatic lesion. Our aim is to make clinicians aware of bisphosphonate associated osteonecrosis of the jaw to prevent misdiagnosis and initiate proper treatment at the earliest. We present the case of a breast cancer patient with multiple bony metastases and a jaw lesion presumed to be metastases. After no response to palliative radiation, repeat radiological imaging studies revealed osteonecrosis of the jaw. Correlating a patient's clinica

Exploiting artificial intelligence in precision oncology: an updated comprehensive review.

Precision oncology considers the genetic makeup of both the tumor and the cancer patient, medical history, clinical metadata, lifestyle and environmental factors. Thus, adoption of precision cancer medicine mandates sophisticated integrative analysis. Being a master in sorting and solving the puzzle pieces, artificial intelligence (AI)-powered frameworks emerged to fill the gap via executing multimodal analysis and generating meaningful outputs. Herein, we systematically discussed the opportunities and challenges of exploiting AI-assisted models in preclinical cancer research and in clinical o

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… Exploiting AI-driven tools in devising treatment protocols of cancer patients Frameworks powered by AI were used to guide medical oncologists towards rational treatment decisions [ 130 ]. … Moderate effectiveness of ChatGPT-4o’s recommendations was reported following the evaluation of a panel of an orthopedic surgeon, plastic surgeon, radiation oncologist, radiologist, and pathologist [ 135 ]. …

Продольное, когортное исследование ЕММИ: реальные данные для описания методов управления миэломой и ее результатов по мере появления более терапевтических вариантов.

Лечение пациентов с множественной миеломой (ММ) носит сложный характер. Несмотря на значительные достижения, MM остается неизлечимым, а управление включает циклы лечения, рецидивы заболеваний и дальнейшую терапию. В настоящее время доказательства, подтверждающие это терапевтическое решение, ограничены. Таким образом, исследование EMMY в продольном, реальном мире было призвано ежегодно оценивать терапевтическое управление MM во Франции с целью получения доказательств в поддержку врачей. В течение года, предопределённого 3-month Период набора пациентов, отвечающих соответствующим требованиям, бу

Catch the Calcium: T-Cell Histiocyte-Rich B-Cell Lymphoma Presenting as Hypercalcemia.

T-cell/histiocyte-rich large B-cell lymphoma (THRLBCL) is an extremely rare and aggressive subtype of diffuse large B-cell lymphoma (DLBCL) that typically presents in middle-aged patients and carries a poor prognosis. Hypercalcemia presenting as the initial manifestation of the disease is rare, with only one other case reported in the literature. We report a case of a 90-year-old male who presented with progressive lethargy and unintentional weight loss. Initial workup showed elevated serum calcium of 14.6 mg/dL, corrected for albumin, and creatinine of 1.51 mg/dL. He had a suppressed iPTH of

Radiation Therapy in Conjunction With Surgical Stabilization of Impending or Pathologic Fractures Secondary to Metastasis: Is There a Difference Between Single and Multifraction Regimens?

PurposePatients who undergo surgical stabilization for impending or pathologic fractures secondary to metastasis are often treated with radiation therapy to the involved site. We sought to retrospectively analyze outcomes from single versus multifraction regimens of radiation therapy in this setting.Methods and materialsFrom our institutional radiation database, we identified 87 patients between 2004 and 2016 who had an impending or pathologic fracture from metastatic disease and who underwent surgical fixation in conjunction with either neoadjuvant (within 5 weeks before surgery) or adjuvant

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… Local failure was defined based on follow-up imaging showing tumor progression or recurrence at the surgical site or development of new or worsening symptoms at the surgical site that were deemed by the surgeon or radiation oncologist to be due to tumor progression, the latter requiring further intervention … This difference seen in the randomized trials may be attributed to an increased willingness of radiation oncologists to offer reirradiation to patients who were previously treated in a single fraction. …

A prospective survey of comprehensive score for financial toxicity in Japanese cancer patients: report on a pilot study.

BackgroundFinancial toxicity (FT) has a negative impact on the quality of life and survival of patients with cancer. The comprehensive score for FT (COST) questionnaire is a tool to measure FT which has already been validated in patients with cancer in the United States. However, the feasibility and validity of assessing FT using the COST questionnaire have not been established in non-US healthcare settings, including that in Japan.MethodsThis is a prospective pilot survey to ascertain the feasibility of using the COST questionnaire to evaluate FT in Japanese patients with advanced solid cance

Adaptation of digital integration of PROMs and PREMs in oncology during implementation: a scoping review.

PurposeDigital tools facilitate the timely collection of patient-reported outcome and experience measures (ePROMs/PREMs), but there is no consistent reporting on the technical and content adaptations made essential to implementing these digital tools in a specific context. Adaptations made to ePROMs/ePREMs can improve data quality, clinical management, and patient outcomes. We explored how studies report on adaptations and the reasons and types of these during an implementation process of ePROMs/ePREMs systems in routine cancer care.MethodsWe conducted a systematic scoping review. We searched

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… 2022 [ 24 ] Three phases with continuous on-site monitoring and team meetings for emerging issues Study staff Quantitative: outcomes; qualitative: notes, observation Usability and Agile Principles Warrington, 2019 [ 36 ] Iterative testing, feedback collection and integration through regular review Oncologists … The studies included a large variety of stakeholders in the adaptation process, ranging from oncologists, nursing and allied staff, clinical and administrative teams, technology partners, study staff, study authors, health informatics experts, researchers, advisory workgroups, etc. …

A rare primary pericardial DLBCL masquerading as an unexplained malignant pleural effusion in an elderly woman: A case report.

IntroductionPrimary cardiac lymphoma (PCL) is an extremely rare and fatal heart neoplasm. Primary cardiac non-Hodgkin lymphoma (NHL) is uncommon, considering the rarity of pericardial diffuse large B-cell lymphoma (DLBCL) with advanced pleural metastasis.Case presentationWe reported an 86-year-old female with primary pericardial DLBCL diagnosed initially by pleural effusion cytology. The chest imaging study revealed multiple pericardial lobulated infiltrative masses and epicardial invasion. Subsequently, she underwent an emergent pericardial window with a pericardial mass biopsy. The final his

Antibody-Drug Conjugates in Contemporary Oncology: A Clinical Perspective on Dose Optimization, Sequencing, and Combination Strategies.

Antibody-drug conjugates (ADCs) have matured from a technically challenging concept into an established therapeutic platform across hematologic and solid malignancies. By linking a monoclonal antibody to a potent cytotoxic payload, ADCs seek to increase tumor-directed drug delivery while limiting systemic exposure; however, clinical performance depends on much more than target expression. Target accessibility, antigen density and heterogeneity, internalization, intracellular trafficking, linker stability, payload properties, drug-to-antibody ratio, bystander effect, tumor penetration, and host

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… These adverse events may appear more familiar to oncologists because they overlap with conventional cytotoxic therapy, but their timing, reversibility, and relationship to cumulative exposure may differ by ADC construct, payload class, and schedule. … Antibody drugs conjugates in non–small cell lung cancer: Current status and challenges Oncologist 2025 30 oyaf331 10.1093/oncolo/oyaf331 41052301 PMC12634406 7. Saleh K. Raman A. Zanoni M. Editorial: Antibody-drug conjugates in solid and hematologic malignancies Front. …

Navigating Hope and Illness Cognition in Advanced Ovarian Cancer Patients: A CSM-Based Phenomenological Study.

BACKGROUND: Advanced ovarian cancer patients face profound psychosocial challenges in maintaining hope amidst terminal illness and treatment uncertainty. Understanding mechanisms supporting adaptive hope could inform psychosocial interventions. METHODS: Phenomenological qualitative study of 16 women with advanced ovarian cancer receiving platinum-based and/or targeted therapies at a tertiary center in southern China. Semi-structured interviews conducted across 11-month observation period; thematic analysis guided by Leventhal's Common-Sense Model (CSM). RESULTS: Participants demonstrated a t

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… Expert Consensus Validation Five specialists (two psycho‐oncologists, two nurse researchers, and one qualitative methodologist) assessed item relevance on a 5‐point scale. … When my oncologist asks, 'What matters most to you right now?' I feel like a partner, not just a patient. …

Developing the Breast Utility Instrument to Measure Health-Related Quality-of-Life Preferences in Patients with Breast Cancer: Selecting the Item for Each Dimension.

Introduction. Generic preference-based instruments inadequately measure breast cancer (BrC) health-related quality-of-life preferences given advances in therapy. Our overall purpose is to develop the Breast Utility Instrument (BUI), a BrC-specific preference-based instrument. This study describes the selection of the BUI items. Methods. A total of 408 patients from diverse BrC health states completed the EORTC QLQ-C30 and BR45 (breast module). For each of 10 dimensions previously assessed with confirmatory factor analysis, we evaluated data fit to the Rasch model based on global model and item

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… Data A cross-sectional convenience sample of women 18 y and older with invasive BrC attending medical oncologists’ outpatient clinics at the Sunnybrook Odette Cancer Centre were enrolled to complete paper questionnaires of QLQ C30 and the BR45. … The 13 clinicians who completed importance ratings were 5 medical oncologists, 1 radiation oncologist, 1 surgical oncologist, 2 medical oncology fellows, 2 nurses, 1 physician assistant, and 1 social worker, predominantly representing the medical oncology clinical staff. …

Current management of cancer pain in Italy: Expert opinion paper.

IntroductionChronic pain and breakthrough cancer pain (BTcP) have a high prevalence in all cancer types and cancer stages, combined with a significant physical, psychological, and economic burden. Despite efforts to improve appropriate management of cancer pain, a poor assessment and guilty undertreatment are still reported in many countries. The purpose of this expert opinion paper is to contribute to reduce and clarify these issues with a multidisciplinary perspective in order to share virtuous paths of care.MethodsCommon questions about cancer pain assessment and treatment were submitted to

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… Only 13% of the oncologists and palliativists require the expertise of a pain specialist for pain assessment. Despite background pain being adequately controlled, patients frequently experience episodes of acute pain exacerbation known as BTcP. … Oncologists have more opportunities to make an early diagnosis of BTcP, as they see patients early and more often through the course of disease. …