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A murine virus (JHM) causing disseminated encephalomyelitis with extensive destruction of myelin.

The isolation of a murine virus causing disseminated encephalomyelitis accompanied by extensive destruction of myelin in the central nervous system, and focal necrosis of the liver has been described. Young mice can be infected by a number of parenteral routes. Both encephalitic and paralytic signs can be observed. After intracerebral inoculation the virus has been isolated from brain, spinal cord, liver, lung, spleen, and kidney, but not from blood or from intestinal walls and contents. Hamsters, cotton rats, and Hisaw rats can be infected by the intracerebral route. Guinea pigs and rabbits a…

Anti-GluK2 antibody-associated autoimmune encephalomyelitis with delayed MRI abnormalities: case report.

To present the first documented case of delayed radiological manifestation in a patient with anti-GluK2 antibody-associated autoimmune encephalomyelitis, and to highlight the clinical significance of this rare yet potentially treatable disorder. We presented a 20-year-old woman with seizures, dizziness, limb weakness and numbness, gait instability, and bladder and bowel dysfunction. Comprehensive evaluations were performed, including blood and cerebrospinal fluid (CSF) analyses (with autoimmune antibody panels), electroencephalography (EEG), and serial brain and spinal cord magnetic resonance …

Shared autonomic phenotype of long COVID and myalgic encephalomyelitis/chronic fatigue syndrome.

INTRODUCTION: Long COVID and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) are relatively common and disabling multisystem disorders that share overlapping features, including post-infectious onset and similar clinical manifestations such as brain fog, fatigue, muscle pain, and dysautonomia with orthostatic intolerance. These similarities suggest that Long COVID and ME/CFS may share common pathophysiological mechanisms, though the underlying mechanisms remain poorly understood, partly due to the difficulty in quantifying many of the symptoms. MATERIALS AND METHODS: This retrospe…

STING-dependent microglial inhibition by irisin ameliorates neuroinflammation in experimental autoimmune encephalomyelitis.

Multiple sclerosis (MS) is a chronic autoimmune demyelinating disorder of the central nervous system (CNS), characterized by microglial activation and polarization as key drivers of disease pathogenesis. Irisin, an exercise-induced myokine, has been reported to exhibit neuroprotective effects, including anti-inflammatory activity and cognitive improvement. To investigate the therapeutic potential of irisin in the experimental autoimmune encephalomyelitis (EAE) mouse model and its effects on microglial behavior along with the underlying molecular mechanisms, we conducted the present study. Resu…

TRANQUIL уменьшает аутоиммунную демииляцию и подавляет нейроинфламматический сигнал в экспериментальном аутоиммунном энцефаломиелите.

Нейроинфламмация, движущаяся автоматически реактивными клетками Т и активированными глиальными популяциями, лежит в основе патогенеза множественного склероза (MS), однако нынешняя иммунодуляторная терапия редко восстанавливает долгосрочную иммунную терпимость и часто вызывает широкое иммуноусилительное воздействие. Ранее мы сконструировали слабый штамм брюселлы ΔvjbR, выражающий tnaA, позволяющий создать производство триптофана метаболита индола, модулятора активации антигенной клетки (APC) и дифференциации Т-клеток. Здесь мы проверили, улучшит ли этот штамм (TRANQUIL - Technology for Reprogra

Совпадение в аннотации оригинала
Neuroinflammation driven by autoreactive T cells and activated glial populations underlies the pathogenesis of multiple sclerosis (MS), yet … toimmunity And Quieting Inflammation, TRQ) ameliorates neuroinflammation in experimental autoimmune encephalomyelitis (EAE). Female C57BL/6 mice with EAE received a single intravenous dose of TRQ, and PBS-treated mice served as comparator controls. TRQ treatment was associated with reduced clinical disease severity during the observation period. Histological analys …

АнтиCD40L предотвращает аутоиммунный энцефаломиелит, абстрагированные клетки B и смягчает его аутоиммунный энцефаломиелит.

Сопоставимое воспаление внутри CNS считается движущей силой прогрессивной иммунопатологии при множественном склерозе (MS) независимо от рецидивов. Менингеиальные лимфоидные конструкции (ТЛС) представляют собой иммунную нишу, связанную с гистологическими признаками иммунопатологии, включая демиелинизацию в прилегающей паренхиме CNS. Здесь мы показываем, что оптикоспайнальная энцефаломиелитная модель мыши (OSE), в которой менингейл TLS спонтанно развивается на основе взаимодействия миелина олигодендроцита гликопротеина (MOG) с трансгенными Т клетками T-рецептора клеток MOG B (BCR) трансгенными к

Совпадение в аннотации оригинала
Compartmentalized inflammation within the CNS is considered to drive progressive immunopathology in multiple sclerosis (MS) independently of … hology, including demyelination in the adjacent CNS parenchyma. Here, we show that the opticospinal encephalomyelitis (OSE) mouse model, in which meningeal TLS develop spontaneously based on the interaction of myelin oligodendrocyte glycoprotein (MOG)-specific T cell receptor (TCR) transgenic T cells with MOG B cell receptor (BCR) transgenic B cells, recapitulates …

Диметил фумарат защищает от экспериментального аутоиммунного энцефаломиэлита путем модуляции колонических иммунных клеток.

Диметилфумарат (DMF) представляет собой пероральную терапию, утвержденную для лечения повторно излучающего многократного склероза, и известно, что она снижает остроту заболеваний при экспериментальном аутоиммунном энцфаломиелите (EAE). Поскольку считается, что самореактивные лимфоциты TH17 активируются в кишечнике до перехода в центральную нервную систему (КНС), мы изучили, как DMF модифицирует кишечную иммунную реакцию во время EAE. Женские мыши C57BL/6J были иммунизированы MOG35-55 для стимулирования EAE и обработки с помощью DMF (7.5 мг/кг, пероральный желудок, каждый 12 h) либо транспортно

Совпадение в аннотации оригинала
Dimethyl fumarate (DMF) is an oral therapy approved for the treatment of relapsing-remitting multiple sclerosis, and it is known to reduce disease severity in experimental autoimmune encephalomyelitis (EAE). Because self-reactive Th17 lymphocytes are thought to become activated in the gut before migrating to the central nervous system (CNS), we investigated …

BioMapAI: Artificial Intelligence Multi-Omics Modeling of Myalgic Encephalomyelitis / Chronic Fatigue Syndrome.

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a chronic illness with a multifactorial etiology and heterogeneous symptomatology, posing major challenges for diagnosis and treatment. Here, we present BioMapAI, a supervised deep neural network trained on a four-year, longitudinal, multi-omics dataset from 249 participants, which integrates gut metagenomics, plasma metabolomics, immune cell profiling, blood laboratory data, and detailed clinical symptoms. By simultaneously modeling these diverse data types to predict clinical severity, BioMapAI identifies disease- and symptom-spe…

Insights into the Complex Biological Network Underlying Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating multisystem disorder characterized by immune dysregulation, metabolic impairments, neuroendocrine disturbances, endothelial dysfunction, and gastrointestinal abnormalities. Immune alterations include reduced natural killer cell cytotoxicity, T-cell exhaustion, abnormal B-cell subsets, and the presence of diverse autoantibodies, suggesting an autoimmune component. Gut dysbiosis and increased intestinal permeability may promote systemic inflammation and contribute to neurocognitive symptoms via the gut-brain axis. Neur…