Результаты поиска

Long term acid suppressing treatment in general practice.

OBJECTIVE: To determine the current practice in selected general practices for prescribing long term (> 6 months) treatment to suppress gastric acid secretion. SETTING: Seven general practices in the Harrow area that always or usually refer to Northwick Park Hospital. SUBJECTS: 60,148 patients on lists of the general practices. DESIGN: Identification of patients receiving long term treatment through repeat prescribing data, followed by a manual and computer survey of patients' notes for indications and investigations. Patient compliance and views on treatment were sought by a postal questio

Нейромиелит Оптика Спектрум С односторонним ретробулбаром Неритом: доклад по делу.

Нейромиелитное расстройство спектра (NMOSD) включает в себя аутоиммунное генезис, проявляющееся в атаках оптического неврата (ON) и поперечного миелита (TM), а также экспрессивное аквапорина 4 (NMO-IgG) или миелин олиго-эндокитного гликотеина (MOGAb). В редких случаях болезнь может также иметь клиническое представление только с ТМ без ТМ и без ТМ. Эти условия также включены в спектр. Мы представляем случай 50-летнего пациента с жалобами на размытое зрение в левом глазу, боль в шее и онемение рук за несколько месяцев до госпитализации.После консультации с офтальмологом была произведена магнитна

Совпадение в аннотации оригинала
Neuromyelitis optica spectrum disorder (NMOSD) includes conditions with autoimmune genesis, which are manifested by attacks of optic neuriti … The treatment plan consisted of methylprednisolone 1000 mg for five days and gastroprotection with famotidine 40 mh p.o. Further consultations with the ophthalmologist were done in the following days to monitor the visual status of the patient. After completion of the diagnostic and treatment plan, slight recovery of the visus and reversal of the pain sympt …

Successful steroid therapy for cefdinir-induced acute tubulointerstitial nephritis with progressive renal failure.

A 58-year-old woman was admitted to our hospital because of renal dysfunction that continued to progress even after withdrawal of cefdinir, the presumed cause of acute renal failure. Renal histologic findings included interstitial fibrosis accompanied by moderate lymphocytic infiltration, and tubular atrophy with reduced numbers of epithelial cells. Mesangial cells and glomerular basement membranes were nearly normal. Scintigraphy with 67gallium disclosed diffuse abnormal accumulation in both kidneys. A lymphocyte stimulation test with cefdinir was positive. The patient was diagnosed with acut

Fluconazole-induced drug rash with eosinophilia and systemic symptoms syndrome: a case report.

BACKGROUND: Drug rash with eosinophilia and systemic symptoms syndrome is a severe T-cell-mediated adverse drug reaction characterized by a … mptoms recurred, including facial swelling and new skin rashes. She was readmitted and treated with famotidine, corticosteroids, and diphenhydramine. Her general condition and skin rashes gradually improved, with complete resolution of the rash 3 months after the initial eruption. CONCLUSION: We present a case of a woman with pulmonary coccidioidomycosis wh …

Analysis of Adverse Events and Intravenous Iron Infusion Formulations in Adults With and Without Prior Infusion Reactions.

IMPORTANCE: Although iron deficiency is common, it remains unclear which iron repletion strategy is associated with the lowest rate of infus … Type of intravenous iron formulation and concurrent administration of diphenhydramine, epinephrine, famotidine, and/or hydrocortisone, used as surrogate maker of infusion reaction. MAIN OUTCOMES AND MEASURES: Incidence of adverse events, including severe events requiring epinephrine, stratified by type of iron formulation, and in patients who received preme …

Discovering repurposable drugs for Alzheimer's disease and related dementias: target trial emulation using decentralised real-world data.

BACKGROUND: Alzheimer's disease and related dementias (ADRD) affect nearly 6.9 million Americans, with the number expected to triple by 2050 … 84; spironolactone: RR 0.43; 95% CI: 0.31-0.60), and histamine-related and gastrointestinal agents (famotidine: RR 0.64; 95% CI: 0.55-0.74). Results were consistent in the independent validation using TriNetX network and sensitivity analysis in PMBB database. INTERPRETATION: 20 widely used medications may be associated with reduced progression from MCI to A …

Lecanemab over a two-year duration: Key insights from a regional specialty medical center.

BACKGROUND AND OBJECTIVES: The anti-amyloid monoclonal antibody lecanemab (Leqembi®) treats patients with mild cognitive impairment (MCI) or … usion. After initiating a pre-infusion oral cocktail of acetaminophen 650 mg, loratadine 10 mg, and famotidine 20 mg, the number of patients who experienced an infusion-related adverse event decreased from 45.2 % to 28.3 %. Thirty-two (17.1 %) patients discontinued lecanemab, primarily due to cognitive decline associated with progressive AD (10 [31.2 %]) and …

Exploration of the Key Factors for Optimizing the in Vivo Oral Delivery of Insulin by Using a Noncovalent Strategy with Cell-Penetrating Peptides.

This present study aimed to determine the optimal oral insulin delivery conditions that would maximize the utility of cell-penetrating peptides (CPPs) by using a noncovalent strategy. We first compared the effectiveness of two potential CPPs, penetratin and its analog PenetraMax, as absorption enhancers for insulin. The combined effect was evaluated under in vivo oral administration conditions. Both D-forms of CPPs were highly effective for increasing the oral absorption of insulin, and D-PenetraMax showed a more rapid onset of absorption enhancement effects compared with those of D-penetratin

Biased TAS2R Bronchodilators Inhibit Airway Smooth Muscle Growth by Downregulating Phosphorylated Extracellular Signal-regulated Kinase 1/2.

Bitter taste receptor (TAS2R) agonists dilate airways by receptor-dependent smooth muscle relaxation. Besides their coupling to relaxation, we have found that human airway smooth muscle (HASM) cell TAS2Rs activate (phosphorylate) extracellular signal-related kinase 1/2 (ERK1/2), but the cellular effects are not known. In the present study, we show in HASM cells that TAS2R agonists initially stimulate phosphorylated ERK1/2 (pERK1/2) but by 24 hours cause a marked (50-70%) downregulation of pERK1/2 without a change in total ERK1/2. It was hypothesized that TAS2R agonists suppress cell growth thr

Effect of lubiprostone on vinca alkaloid-induced constipation in patients with hematological malignancies: a propensity score-matched analysis.

Patients receiving vinca alkaloids for hematological malignancies frequently experience constipation that is unresponsive to laxatives. Research on treatment of vinca alkaloid-induced constipation is limited. This study aimed to determine whether the chloride channel activator lubiprostone ameliorates vinca alkaloid-induced constipation in patients with hematological malignancies. In this retrospective cohort study, vinca alkaloid-induced constipation (grade ≥ 3 using the Common Terminology Criteria for Adverse Events) was investigated in patients treated for hematological malignancies between

In Esophageal Squamous Cells From Eosinophilic Esophagitis Patients, Th2 Cytokines Increase Eotaxin-3 Secretion Through Effects on Intracellular Calcium and a Non-Gastric Proton Pump.

BACKGROUND & AIMS: In upper airway cells, T helper 2 cytokines that signal through interleukin-4 (IL-4) receptor-α have been shown to stimulate eotaxin-3 secretion via a nongastric proton pump (ngH+,K+ATPase). To seek novel targets for eosinophilic esophagitis (EoE) treatments, we evaluated ngH+,K+ATPase expression in EoE squamous cells, and explored molecular pathways involved in eotaxin-3 secretion by IL-4 receptor-α signaling. METHODS: ngH+,K+ATPase expression in EoE cells was evaluated by quantitative real-time polymerase chain reaction and Western blotting. IL-4-stimulated eotaxin-3 secr

Use of medications for gastroesophageal reflux at discharge among extremely low birth weight infants.

OBJECTIVES: Our goals were (1) to determine the use of medications to treat gastroesophageal reflux in extremely low birth weight infants (birth weight of < 1000 g) at discharge; (2) to identify risk factors associated with the use of medications to treat gastroesophageal reflux at discharge; and (3) to assess the contribution of gastroesophageal reflux medication use at discharge to growth and development at corrected ages of 18 to 22 months. METHODS: This retrospective cohort analysis included extremely low birth weight infants enrolled at National Institute of Child Health and Human Develo

Rowell's Syndrome Triggered by Omeprazole.

Dear Editor, Rowell's syndrome is a rare disease, characterized by the appearance of erythema multiforme (EM)-like lesions in patients with … c approach consisted of increasing the hydroxychloroquine dose to 400 mg/day, substituting PPI with famotidine 20 mg/day p.o. and ceftriaxone 2 g/day for the superinfection with Ps. aeruginosa, which led to a clinical improvement (Figure 1, B). The methylprednisolone dose remained unchanged due to already existing severe adverse effects. DISCUSSION The diagn …

A review of potential suggested drugs for coronavirus disease (COVID-19) treatment.

The latest pandemic, coronavirus disease-2019 (COVID-19), is associated with high prevalence and easy transmission, which is expanding globally with no conventional treatment or vaccine. The new virus revealed 79% and 50% genomic similarities with severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV), respectively. Accordingly, since the disease resists testing and adopting new therapeutics, repositioning pre-existing drugs may present a fast and attractive strategy with known safety, characteristics, and dosage used. However, they

Совпадение в полном тексте источника
… H2 blocker Famotidine Famotidine is an H2 receptor antagonist, which inhibits the secretion of gastric acid. There is a hypothesis that Famotidine binds to papain-like protease, and the SARS-CoV-2 genome may encode protease. … A different daily dose of Famotidine was used in the range of 20 mg–320 mg for 5–28 days. Famotidine significantly decreased in-hospital mortality, rate of mortality/intubation, progression to severe disease, and progressively improved radiographic findings ( Sethia et al., 2020 ). …

2018 ACVIM Forum Research Report Program. Seattle, Washington, June 14 - 16, 2018.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… However, famotidine continues to be widely used by veterinary practitioners especially for conditions in which potent acid suppression is not desired. In dogs and humans, the acid suppressing effect of famotidine decreases over time, often within 1‐2 weeks. … Repeated twice‐daily, oral famotidine administration resulted in a diminished effect on gastric pH in cats. The weak, acid‐suppressing effect of famotidine can be prevented by administering the drug EOD or limiting its use to a few days in duration. …

Toxicity management strategies for next-generation novel therapeutics in multiple myeloma.

The therapeutic options available for patients with multiple myeloma have greatly expanded over the past decade and incorporating these novel agents into routine clinical practice has significantly improved outcomes. The next generation of therapeutics is available for relapsed and refractory patients either as standard of care or in clinical trial, and these drugs represent a generational paradigm shift. Patients now have access to a multitude of novel immunotherapeutics, including monoclonal antibodies, an antibody-drug conjugate, chimeric antigen receptor T-cells (CAR-T), and bispecific T-c

Совпадение в полном тексте источника
… Subsequent infusions Famotidine, montelukast (discontinued after cycle 1) | All infusions H2 blocker, diphenhydramine, acetaminophen, dexamethasone Dexamethasone dosing (If > 75 years, 50% reduction) | First dose 20 mg IV C1D1 15–60 min prior to dose and 20 mg PO C1D2 Subsequent dosing 40 mg PO 1–3 … We recommend acetaminophen, diphenhydramine, dexamethasone, montelukast, and famotidine 15–60 min prior to drug administration ( Table 3 ). 31 – 33 After the initial cycle of either daratumumab formulation, famotidine and montelukast may be discontinued and a rapid taper of dexamethasone can be considered …

The clinical features, treatment and prognosis of neutropenic fever and Coronavirus disease 2019 results of the multicentre teos study.

This multicentre (22 centres in Turkey) retrospective cohort study aimed to assess the clinical outcomes of patients with neutropenic fever and SARS-CoV-2 positivity. Study period was 15 March 2020-15 August 2021. A total of 170 cases (58 female, aged 59 ± 15.5 years) that fulfilled the inclusion criteria were included in the study. One-month mortality rate (OMM) was 44.8%. The logistic regression analysis showed the following significant variables for the mentioned dependent variables: (i) achieving PCR negativity: receiving a maximum of 5 days of favipiravir (p = 0.005, OR 5.166, 95% CI 1.63

Совпадение в полном тексте источника
… 11 (15.5%) 5 (26.3%) 0.273 No famotidine 60 (84.5%) 14 (73.7%) Remdesivir 0 (0%) 1 (5.3%) NC No remdesivir 71 (100%) 18 (94.7%) NC not calculated due to low n. … Table 4 presents the overall data and the results of the univariate analysis for favipiravir, plasma therapy, IVIG therapy, hydroxychloroquine, famotidine, and remdesivir in relation to viral clearance (all p > 0.05). …

COVID-19 Therapeutic Options Under Investigation.

Since its emergence in China in December 2019, COVID-19 has quickly spread around the globe causing a pandemic. Vaccination or the development of herd immunity seems the only way to slow down the spread of the virus; however, both are not achievable in the near future. Therefore, effective treatments to mitigate the burden of this pandemic and reduce mortality rates are urgently needed. Preclinical and clinical studies of potential antiviral and immunomodulatory compounds and molecules to identify safe and efficacious therapeutics for COVID-19 are ongoing. Two compounds, remdesivir, and dexame

Совпадение в полном тексте источника
… Famotidine Famotidine is an FDA approved histamine-2 (H2) receptor antagonist indicated for suppressing gastric acid secretion ( Food and Drug Administration, 1986 ). … The clinical impact of famotidine on the prognosis of COVID-19 was accidentally noticed; Janowitz et al demonstrated that a group of 10 SARS-CoV-2–infected patients who received high famotidine doses (240 mg in three divided doses for a median of 11 days) showed significant improvement in symptoms within …

Targeting the P-selectin/PSGL-1 pathway: discovery of disease-modifying therapeutics for disorders of thromboinflammation.

P-selectin is a membrane glycoprotein and a member of the selectin family of cell adhesion molecules. It is prestored in α-granules of platelets and Weibel-Palade bodies of endothelial cells and is rapidly expressed on their surfaces upon activation during the course of an inflammatory response. Although a critical component of the innate immune system, the interaction of P-selectin with its cognate ligand, P-selectin glycoprotein ligand 1 (PSGL-1) may mediate maladaptive events central to the pathophysiology of venous thromboembolism, cardiovascular disease, stroke, metabolic syndrome, and si

Совпадение в полном тексте источника
… The 5-hydroxytryptamine 2A serotonin receptor antagonists, cyproheptadine and pizotifen, inhibit the expression of P-selectin and delay thrombotic occlusion in mice, albeit with an observed increased risk of bleeding. 110 Famotidine, an H2 receptor blocker, has also been noted to reduce P-selectin expression … NCT03860506 To evaluate the safety of an orally administered single dose in patients with scleritis Phase 1 Effective inhibition of leukocyte rolling in scleral blood vessels of individuals with autoimmune scleritis was not achieved NCT00367692 P-selectin expression inhibitors Famotidine 111 To assess …

When tissue is not the only issue: Poorly differentiated lung squamous-cell carcinoma with adrenal, costochondral, and cardiac metastases - case report.

Nonmelanoma skin cancer is the most common cancer in the world, and lung cancer is the leading cause of death from cancer. Histologically, squamous cell carcinoma (SCC) is the second most prevalent type of both skin and lung cancers. We report the case of a 38-year-old female with metastatic, poorly differentiated lung SCC detected on chest X-ray after she presented to the hospital with cough and dyspnea. She had had a 7.5 cm moderately differentiated well-circumscribed posterior scalp SCC completely excised eight years earlier. CT scan showed a large right lung mass, nodular filling defect in

Совпадение в полном тексте источника
… During this admission, she was also started on a Histamine-H 2 -receptor antagonist (Famotidine 20 mg PO twice a day) while on steroids and Dextromethorphan 15 mg PO every 4 hours (antitussive) as needed. … A dermatologist considered it a possible drug reaction likely secondary to Dextromethorphan more than Famotidine but did not think chemo-immunotherapy played a role in her eruptions. …