Результаты поиска

[Challenges in the pharmacotherapeutic management of the hospitalised patient with Parkinson's disease].

Patients with Parkinson's disease (PD) are admitted to hospital more frequently and for a longer time than other patients from the same age group. The reason they are hospitalised is often different from their underlying baseline disease and they are usually attended in services with little knowledge of the disease. Both the errors made when administering levodopa and the inappropriate use of pharmacological agents with a central antidopaminergic action are relatively common during their stay in hospital. This study reports on an analysis of the literature available on the challenges and compl

Complications of laser-assisted uvulopalatopharyngoplasty (LA-UPPP) and radiofrequency treatments of snoring and chronic nasal congestion: a 10-year review of 5,600 patients.

PURPOSE: Recent laser and radiofrequency techniques for the treatment of snoring have provided improvements, but intraoperative and postoperative risks, complications, and long-term results have not been explored in a statistically large enough sample of patients. The goal of this article is to provide practitioners with important data and guidelines to help them in decision-making and prepare them to anticipate problems and recommend a systematic approach to avoid or treat complications. PATIENTS AND METHODS: This investigation was a retrospective review of 5,600 cases, performed over a 10-y

Distal posterior inferior cerebellar artery saccular and giant aneurysms: report of two new cases and a comprehensive review of the surgically-treated cases.

Aneurysms of the distal posterior inferior cerebellar artery are rare comprising less than 0.5 to 3% of all aneurysms. The authors report two cases of distal PICA aneurysms: a case of a ruptured saccular aneurysm arising on the tonsillomedullary segment of the PICA and a case of a giant aneurysm arising on junctional site of lateral-medullary and tonsillo-medullary segments. In the first case subarachnoid and intraventricular hemorrhage was diagnosed by CT and four vessel-angiography visualized the aneurysm which was clipped successfully. In the second case MRI was suggestive for posterior fos

Fetal breathing: a review.

The history, physiology, pharmacology, and clinical application of fetal breathing are reviewed. Early optimism that measurements of fetal breathing would aid in perinatal management decisions has remained unfulfilled. Problems to be overcome include standardization of technique and measurement parameters and allowance for physiologic variations. Recent research developments indicate that the likely role of fetal breathing in perinatal medicine will be in conjunction with other established tests of fetal health.

Long-term outcomes after surgical treatment of pediatric neurogenic thoracic outlet syndrome.

OBJECTIVE Neurogenic thoracic outlet syndrome (nTOS) is an uncommon compression syndrome of the brachial plexus that presents with pain, sen … spontaneously; 1 patient suffered a transient increase in pain requiring consultation, followed by hiccups for a period of 3 hours that resolved spontaneously; and 1 patient fell at home, with transient increased pain in the surgically treated extremity. There were no new neurological deficits, wound infections, deep vein thromboses, or readmissions. CO …

A randomized double-blind trial of ondansetron alone versus in combination with dexamethasone versus in combination with dexamethasone and lorazepam in the prevention of emesis due to cisplatin-based chemotherapy.

OBJECTIVE: To compare the effectiveness and side effects of antiemetic regimens using ondansetron alone (O) versus ondansetron plus dexameth … o 29% who were given ondansetron alone (p < .021). The incidences of headache, flushing, dry mouth, hiccups, and constipation were mild and tolerable and did not differ among the three groups. DISCUSSION: Ondansetron was very effective in the prevention of nausea and vomiting during the acute phase after cisplatin administration. In treating delayed nau …

Safety evaluation of irinotecan: a real-world disproportionality analysis using FAERS and JADER databases during the time period 2004-2024.

INTRODUCTION: Irinotecan is a widely used chemotherapeutic agent for treating colorectal, pancreatic, and ovarian cancers. Despite its thera … penia, stomatitis) and unexpected signals such as second primary malignancies, hyperammonaemia, and hiccups. Notable FAERS-specific signals included skin toxicity (n=100, ROR 33.89 (27.79-41.34), PRR 33.80, EBGM05 28.03, IC025 4.76), aphasia [n=65, ROR 3.57 (2.8-4.55), PRR 3.56, EBGM05 2.90, IC025 1.47], and hepatic failure [n=56, ROR 3.09 (2.38-4.02), P …

Pilot randomized controlled trial evaluating the effect of random nicotine delivery on cigarettes per day and smoke exposure.

BACKGROUND: Many smokers report attempting to quit each year, yet most relapse, in part due to exposure to smoking-related cues. It is hypot … ition, there were no group differences in dependence or craving. Adverse events included heartburn, hiccups, nausea, and to a lesser extent, vomiting and anxiety and there were no differences across groups. CONCLUSION: Overall, this pilot study found that RND via orally dissolving films was feasible and well tolerated by participants. However, RND parti …

Inpatient signs and symptoms and factors associated with death in children aged 5 years and younger admitted to two Ebola management centres in Sierra Leone, 2014: a retrospective cohort study.

BACKGROUND: Médecins Sans Frontières (MSF) opened Ebola management centres (EMCs) in Sierra Leone in Kailahun in June, 2014, and Bo in Septe … ldren were afebrile. Signs significantly associated with death were fever, vomiting, and diarrhoea. Hiccups, bleeding, and confusion were observed only in children who died. INTERPRETATION: This description of the clinical features of Ebola virus disease over the duration of illness in children aged 5 years and younger shows symptoms associated with dea …

Mentha Pulegium: A Plant with Several Medicinal Properties.

The species Mentha Pulegium L. (M. pulegium L.) belongs to the family Lamiaceae, native to Europe, North Africa, and the Middle East, and the genus Mentha. It has been traditionally used in food, cosmetics, and medicines. It is a perennial, fragrant, well-liked, herbaceous plant that can grow up to half a meter tall. It is extensively used as a food flavoring, particularly for Moroccan traditional drinks. Chewing mint and M. pulegium, a relaxing and refreshing plant, can be used to treat hiccups and act as an anticonvulsant and nerve relaxant. Pennyroyal leaves that have been crushed have a pu…

Effect of Sustained Smoking Cessation Counseling and Provision of Medication vs Shorter-term Counseling and Medication Advice on Smoking Abstinence in Patients Recently Diagnosed With Cancer: A Randomized Clinical Trial.

IMPORTANCE: Persistent smoking may cause adverse outcomes among patients with cancer. Many cancer centers have not fully implemented evidenc … nd standard treatment groups, respectively, were nausea (n = 13 and n = 6), rash (n = 4 and n = 1), hiccups (n = 4 and n = 1), mouth irritation (n = 4 and n = 0), difficulty sleeping (n = 3 and n = 2), and vivid dreams (n = 3 and n = 2). CONCLUSIONS AND RELEVANCE: Among smokers recently diagnosed with cancer in 2 National Cancer Institute-designated Com …

Idiopathic CD4 lymphocytopenia: An uncommon but fatal cause of Pneumocystis pneumonia.

Pneumocystis pneumonia (PCP) is a fungal infection with primary occurrence in immunocompromised individuals by the etiologic agent Pneumocystis jirovecii. In those without previously identified risk factors, maintaining an index of suspicion for this diagnosis with search for underlying immunosuppressive cause is of utmost importance. Here, we present a case of fatal PCP in a patient without a known history of immunocompromise subsequently diagnosed with idiopathic CD4 lymphocytopenia (ICL) with an absolute CD4+ T-cell count of 7 cells/uL.

Совпадение в полном тексте источника
… Lower lobe pneumonia presenting as singultus (hiccups) Caspian J Intern Med. 2018;9(4):403–405. doi: 10.22088/cjim.9.4.403. 3. Konno S., Kono H., Kitazono H., et al. Legionellosis presenting as singultus and external ophthalmoplegia. Neurol. … Sinister hiccups. Lancet. 2008;371(9623):1550. doi: 10.1016/S0140-6736(08)60660-1. 12. Yarmohammadi H., Cunningham-Rundles C. Idiopathic CD4 lymphocytopenia: pathogenesis, etiologies, clinical presentations and treatment strategies. Ann. …

An In-Depth Analysis of Medullary Strokes at a Tertiary Care Stroke Center: Incidence, Clinical and Radiological Characteristics, Etiology, Treatment, and Prognosis.

Introduction Medullary infarctions (MI) are a rare medical entity that is classified mainly as the more commonly lateral medullary infarcts … 2.4%), contralateral limb sensory loss (25%), ipsilateral hemiparesis (24%), dysphagia (19.4%), and hiccups (13%). Most strokes reported were either minor (73% with National Institutes of Health Stroke Scale [NIHSS] 1-4) or moderate (26% with NIHSS 5-15). LMIs (87.9%) were the most common, followed by medial paramedian MI (10%). Twenty-five percent had e …

Differential pharmacology and clinical utility of rolapitant in chemotherapy-induced nausea and vomiting.

Chemotherapy-induced nausea and vomiting (CINV) is a debilitating side effect of many cytotoxic chemotherapy regimens. CINV typically manifests during two well-defined time periods (acute and delayed phases). The acute phase is the first 24 hours after chemotherapy and is largely managed with 5-hydroxytryptamine 3 receptor antagonists. The delayed phase, a 5-day at-risk period during which patients are not often in direct contact with their health care provider, remains a significant unmet medical need. Neurokinin-1 (NK-1) receptor antagonists have demonstrated protection against acute and del

Совпадение в полном тексте источника
… The most commonly reported treatment-emergent adverse events (TEAEs) with NK-1 receptor antagonists in clinical trials included headache, constipation, fatigue, and hiccups, which appeared with a similar frequency as seen in active control groups ( Table 4 ). 6 The adverse event (AE) profile of NK-1 … NK-1 receptor antagonist | Chemotherapy | Incidence of drug-related AEs | Difference relative to control | Potential drug–drug interactions | References Rolapitant | HEC | Dyspepsia (<1%) | No | CYP2D6 a | 26 , 42 , 43 Headache (<1%) | | BCRP b | Constipation (<1%) | | | Hiccups (<1%) | | | MEC …

Эффективность интенсивной антиэпидемиологической терапии, включая оланзапин у нескольких пациентов миэломы, лечившихся высокодозированными мелфаланами с аутологической трансплантацией стволовых клеток.

ЦЕЛЬ: Кондиционирование с использованием высокодозированного мелфалана (MEL), за которым следует аутологическая трансплантация стволовых клеток (ASCT), является стандартным методом лечения множественной миеломы (MM). Оптимальный режим предотвращения тошноты и рвоты, вызванных химиотерапией, не ясен. Мы стремились ретроспективно оценить антиеметический эффект и безопасность four- интенсивный наркологический режим, включая оланзапин (ОЛА) на CINV у пациентов MM, получающих MEL/ASCT. МЕТОДЫ: МЕЛ200 мг/м2) в дневное время 1, за которым следует ASCT в день 3. Пациенты были отнесены к стандартной гр

Совпадение в полном тексте источника
… The incidence of any-grade hiccup was significantly higher in the IAR group than in the standard group (57.3% vs. 11.1%, p < 0.001), and 1 patient in the IAR group experienced grade 3 hiccup. There were no grade 4 adverse events or events that led to treatment discontinuation. … The incidence of any-grade hiccup was significantly higher in the IAR group. However, all patients who experienced this recovered within 7 days, suggesting that the condition was manageable. …

Относительная частота первичных головных болей у пациентов с расстройством спектра нейромиелита: перекрестное исследование.

Фон: Нейромиелитное расстройство спектра (NMOSD) представляет собой редкое аутоиммунное воспалительное заболевание, которое в основном затрагивает центральную нервную систему (CNS). Головные боли, хотя и типичные для пациентов с множественным склерозом (MS), были меньше изучены в NMOSD. Цель этого исследования заключалась в изучении распространенности, характеристик и сопутствующих симптомов головной боли у пациентов с NMOSD. Методы: Это межсекторальное исследование включало в себя 120 пациентов НМОСР, набранных в клиниках MS в Исфахан-Сити, Иран, между 2023 и 2024. У пациентов была проведена

Совпадение в полном тексте источника
… These clinical characteristics are related to the involvement of the spinal cord, optic nerve, cerebrum, area postrema, and brainstem. 3 Optic neuritis (ON) and transverse myelitis (TM) are the most common presentations. 3 Other manifestations include area postrema syndrome (APS), characterized by hiccups … , nausea, and/or vomiting. 4 Acute brainstem symptoms include vomiting, hiccups, oculomotor dysfunction, and pruritus, 5 while symptoms of diencephalic involvement include narcolepsy, hypotension, and amenorrhea. 6 Headache is common in patients with multiple sclerosis (MS). …

Ultrasound-Guided Interscalene Brachial Plexus Block for Pathological Humerus Fracture due to Multiple Myeloma with Systemic Manifestation: Useful Option for Management in Low-Income Countries.

Anesthetic management of pathological fracture due to multiple myeloma with systemic manifestation poses a perioperative challenge especially in low-resource setups like Nepal. Regional anesthesia using ultrasound-guided block can improve the accuracy, reduce complications, and improve overall perioperative management of pathological fractures due to malignancy with systemic spread in resource-deprived setups. We present a case of a 53-year-old lady with pathological fracture of left humerus shaft, a diagnosed case of multiple myeloma with compression fracture of multiple lumbar spine with che

Совпадение в полном тексте источника
… Dyspnea, hoarseness of voice, hiccups, or features of Horner's syndrome were not noted. The patient was sedated using propofol injection at a rate of 50 mcg/kg/min via an infusion pump, and supplemental oxygen was given via facemask at 5 L/min. … Complaints of dyspnea, hoarseness, hiccups, and signs of Horner's Syndrome were also not present during the same period. On the second postoperative day, paracetamol was continued with fentanyl as per required basis. Her NRS rating was 2 to 3 and was ambulating comfortably. …

[Comparison of the efficacy of remimazolam and propofol on hemodynamics and quality of early postoperative recovery in elderly patients with frailty undergoing endoscopic retrograde cholangiopancreatography].

Objective: To compare the efficacy of remimazolam and propofol on hemodynamics and quality of early postoperative recovery in elderly patien … ). There was no significant difference in the incidence of bucking or involuntary body movement and hiccuping in both groups (both P>0.05). The awakening time in group R was (11.8±3.0) min, longer than (10.3±3.3) min in group P (P=0.016), and the incidence of emergence agitation was 3.8% (2/53), lower than 16.4% (9/55) (P=0.031). There was no significant …

Effect of modified ShengYangYiwei decoction on painless gastroscopy and gastrointestinal and immune function in gastric cancer patients.

BACKGROUND: Painless gastroenteroscopy is a widely developed diagnostic and treatment technology in clinical practice. It is of great signif … n the control group (P < 0.05). During the examination, the incidence of hypoxemia, hypotension and hiccups in the treatment group was significantly lower than that in the control group (P < 0.01). In terms of gastrointestinal function, the incidences of nausea, vomiting, abdominal distension and abdominal pain in the treatment group after examination we …

Canadian perspectives in multiple myeloma on the use of steroids in clinical practice based on patient and healthcare provider interviews.

Corticosteroid (steroid) medications are associated with challenging adverse effects that can negatively impact patient quality of life. However, owing to a long legacy of effective use in treatment protocols, they remain a cornerstone of multiple myeloma (MM) care. We conducted a roundtable with Canadian healthcare providers (HCPs) with diverse healthcare backgrounds and involvement in MM care as well as with patients with MM. Our goal was to develop clear guidance for steroid management aimed at improving patient quality of life, taking into account patient perspective and experiences with m

Совпадение в полном тексте источника
… (fluid retention) | NA Metabolic and endocrine | Weight gain b ; increased blood sugar levels b , especially in people with diabetes; diabetes complications c | Common Dermatology | Acne a | Common Bruising easily; impaired wound healing; increased hair growth | NA Gastrointestinal | Gastritis a , hiccups …