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Is there any relationship between functional dyspepsia and chronic gastritis associated with Helicobacter pylori infection?

BACKGROUND/AIMS: The relationship between functional dyspepsia, H. pylori infection and chronic gastritis is controversial. Our aims were 1) … y the obtaining of 6 biopsies (cardia, corpus, antrum) at baseline, 3 and 6 months after treatment (pantoprazole 40 mg, once daily, amoxycillin 100 mg b.i.d., clarithromycine 500 mg b.i.d.). Inflammation, activity, H. pylori presence and other mucosal alterations were evaluated semi-quantitatively according to the Sydney system, before treatment and 6 months f …

Acute Esophageal Necrosis: A Case Series From a Safety Net Hospital.

Acute esophageal necrosis (AEN) or "black esophagus" is a rare clinical condition, endoscopically characterized by diffuse circumferential black esophageal mucosa. Etiologies include hypoperfusion, infections, and corrosive injury. Consideration of this condition as a differential diagnosis is important, as early diagnosis and treatment has implications on survival. In this article, we present four unique cases of acute esophageal necrosis who were managed conservatively.

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… He was transferred to the medical intensive care unit for upper gastointestinal bleeding and initially managed with intravenous fluids, intravenous pantoprazole, and octreotide drip. … He improved with intravenous pantoprazole and fluids, and was kept nil per os. He was discharged home following cystoscopic left ureteral stent placement. Repeat EGD after 20 days revealed only a single distal esophageal ulcer at the gastroesophageal junction. …

High prevalence of potential drug interactions affecting mycophenolic acid pharmacokinetics in nonmyeloablative hematopoietic stem cell transplant recipients.

ObjectiveMycophenolic acid (MPA) exposure is associated with clinical outcomes in hematopoietic cell transplant (HCT) recipients. Various dr … den of 2 (range 0 - 4). The most common PDI, in descending order, were cyclosporine, omeprazole and pantoprazole.ConclusionOnly a minority of medications (5.9%) have a PDI affecting MPA pharmacokinetics. However, the majority of nonmyeloablative HCT recipients had a PDI, with cyclosporine and the proton pump inhibitors being the most common. A better understan …

Early follow-up of outpatients with oral anticancer therapy in the ONCORAL multidisciplinary community-hospital program.

BackgroundHealthcare professionals are faced with the new challenges of preventing and managing drug-related problems (DRPs) with oral anticancer therapy (OAT): side-effects, drug-drug interactions (DDIs), non-adherence, or medication errors. This study aims to assess the impact of ONCORAL, a real-life multidisciplinary care plan for cancer patients based on community and hospital follow-up, for the first OAT cycle.MethodsA prospective cohort study was conducted between October 1, 2021 and October 1, 2022 including all outpatients starting OAT treatment. During the first OAT cycle, the program

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… | ↓ Capecitabine absorption | Ibrutinib | Pantoprazole | ↓ Ibrutinib absorption | Imatinib | Garlic | CYP 3A4 induction—↓ plasma levels of imatinib | Lenalidomide | Vitamin C | Vitamin C may reduce the effectiveness of some antineoplastic agents | Nilotinib | Esomeprazole | ↓ Nilotinib absorption … | Niraparib | Vitamin C | Vitamin C may reduce the effectiveness of some antineoplastic agents | Palbociclib | Pantoprazole | ↓ Palbociclib absorption | Pomalidomide | Pantoprazole | ↓ Pomalidomide absorption | Sotorasib | Esomeprazole | ↓ Sotorasib absorption Risk of ↘ usual treatment efficacy …

Determination of drug-related problems in the hematology service: a prospective interventional study.

BackgroundPatients with hematological malignancies often require multidrug therapy using a variety of antineoplastic agents and supportive care medications. This increases the risk of drug-related problems (DRPs). Determining DRPs in patients hospitalized in hematology services is important for patients to achieve their drug treatment goals and prevent adverse effects. This study aims to identify DRPs by the clinical pharmacist in the multidisciplinary team in patients hospitalized in the hematology service of a university hospital in Turkey.MethodsThis study was conducted prospectively betwee

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… Dasatinib-pantoprazole | Since pantoprazole may reduce the concentration of dasatinib, an antacid agent (with a 2-hour time difference) was recommended. Amikacin-vancomycin | Vancomycin may increase the risk of nephrotoxicity of amikacin. … Pantoprazole-methotrexate | Pantoprazole may increase the concentration of methotrexate. The prescriber was informed. Methotrexate was monitored for toxicity. Bortezomib-tamsulosin | The blood pressure lowering effect may be increased when both drugs are used together. …

The effect of eradicating Helicobacter pylori infection on the course of adenomatous and hyperplastic gastric polyps.

OBJECTIVE: Histopathological and clinical data strongly suggest that Helicobacter pylori is the cause of chronic gastritis and peptic ulcera … ent of H. pylori infection consisted of a 1-week course of either omeprazole (20 mg twice daily) or pantoprazole 40 mg twice daily), and a 1-week course of amoxicillin 2g twice daily) and metronidazole (400 mg three times daily), and clarithromycin (500 mg twice daily). Eradication of H. pylori infection was assessed by repeated histology and rapid urease test …

Rethinking the Combination of Proton Exchanger Inhibitors in Cancer Therapy.

Microenvironmental acidity is becoming a key target for the new age of cancer treatment. In fact, while cancer is characterized by genetic heterogeneity, extracellular acidity is a common phenotype of almost all cancers. To survive and proliferate under acidic conditions, tumor cells up-regulate proton exchangers and transporters (mainly V-ATPase, Na⁺/H⁺ exchanger (NHE), monocarboxylate transporters (MCTs), and carbonic anhydrases (CAs)), that actively extrude excess protons, avoiding intracellular accumulation of toxic molecules, thus becoming a sort of survival option with many similarities

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… Our group focused the attention on another class of promising V-ATPase inhibitors, the family of proton pump inhibitors (PPIs), that include omeprazole, esomeprazole, lansoprazole, pantoprazole, and rabeprazole [ 95 ]. … Pantoprazole inhibits human gastric adenocarcinoma SGC-7901 cells by downregulating the expression of pyruvate kinase M2 Oncol. Lett. 2016 11 717 722 10.3892/ol.2015.3912 26870273 PMC4727057 107. Feng S. Zheng Z. Feng L. Yang L. Chen Z. Lin Y. Gao Y. Chen Y. …

Multiple Facets of Autophagy and the Emerging Role of Alkylphosphocholines as Autophagy Modulators.

Autophagy is a highly conserved multistep process and functions as passage for degrading and recycling protein aggregates and defective organelles in eukaryotic cells. Based on the nature of these materials, their size and degradation rate, four types of autophagy have been described, i.e. chaperone mediated autophagy, microautophagy, macroautophagy, and selective autophagy. One of the major regulators of this process is mTOR, which inhibits the downstream pathway of autophagy following the activation of its complex 1 (mTORC1). Alkylphosphocholine (APC) derivatives represent a novel class of a

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… HCQ is a tolerable inhibitor of autophagy. | ( Haas et al., 2019 ) Phase II, Simon’s two-stage design; N = 21 NCT01748500 | Pantoprazole: 240 mg/3w Docetaxel: 75 mg/m 2 /3w | mCRPC/not assessed | PR = 31%; mOS = 15.7 m; median PFS = 5.3 m. … Encouraging responses were obtained. | ( Bilger et al., 2014 ) Phase I, OL N = 24 | Pantoprazole: 80, 160, 240, and 360 mg iv prior to doxorubucin (60 mg/m2) | Solid tumors/not assessed | Pantoprazole 240 mg with doxorubicin 60 mg/m 2 every 3 weeks: toxicity was predictable and manageable. | ( Brana …

Cardiac Amyloidosis: A Rare TTR Mutation Found in an Asian Female.

BACKGROUND: Transthyretin cardiac amyloidosis (ATTR) is a life-threatening, debilitating disease caused by abnormal formation and deposit of transthyretin (TTR) protein in multiple tissues, including myocardial extracellular matrix. It can be challenging to diagnose due to the myriad of presenting signs and symptoms. Additionally, numerous TTR mutations exist in certain ethnicities. Interestingly, our patient was discovered to have a very rare Gly67Ala TTR mutation typically not found in individuals of Asian descent. Recent advances in cardiovascular imaging techniques have allowed for earlier

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… Medication History Prior to the diagnosis of cardiac amyloidosis, the patient was taking 40 mg pantoprazole twice daily for acid reflux symptoms and metoclopramide as needed for nausea. 2.4. … Initially, she was diagnosed with reflux esophagitis, but with repeat imaging studies, she was eventually also diagnosed with gastroparesis, for which she was continued on metoclopramide and pantoprazole. …

Safety and efficacy of proton pump inhibitors in preterm infants with gastroesophageal reflux disease.

BACKGROUND: Although physiological reflux is seen in nearly all newborns to varying degrees, symptoms can be severe and cause gastroesophage … -randomized trials that assessed the use of PPIs (including esomeprazole, lansoprazole, omeprazole, pantoprazole, or rabeprazole) alone or in combination. Infants had to receive treatment for a minimum of three days. We considered the following comparisons: (1) PPIs versus no treatment, (2) PPI versus positioning changes (elevated head of bed or prone position …

Chemotherapy-induced acute kidney injury: epidemiology, pathophysiology, and therapeutic approaches.

Despite significant advancements in oncology, conventional chemotherapy remains the primary treatment for diverse malignancies. Acute kidney injury (AKI) stands out as one of the most prevalent and severe adverse effects associated with these cytotoxic agents. While platinum compounds are well-known for their nephrotoxic potential, other drugs including antimetabolites, alkylating agents, and antitumor antibiotics are also associated. The onset of AKI poses substantial risks, including heightened morbidity and mortality rates, prolonged hospital stays, treatment interruptions, and the need for

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… The recommended dose of Pantoprazole is 40 mg intravenously, administered concurrently with cisplatin ( 48 ). However, this protective effect of Pantoprazole was not observed in children with Osteosarcoma treated with a combination of Cisplatin, Methotrexate, and Doxorubicin ( 51 ). … Pantoprazole, an inhibitor of the organic cation transporter 2, does not ameliorate cisplatin-related ototoxicity or nephrotoxicity in children and adolescents with newly diagnosed osteosarcoma treated with methotrexate, doxorubicin, and cisplatin. …

The Association Between Anticholinergic Burden and Treatment-Related Complications in Older Adults with Cancer.

BackgroundOlder adults constitute more than 50% of newly diagnosed cancer cases and polypharmacy is highly prevalent in this population. The Anticholinergic Burden (ACB) score quantifies the cumulative anticholinergic effects of all medications. Few studies link high ACB to adverse health outcomes in this population, and its effect on treatment outcomes remains largely unknown.ObjectiveThis study investigates the association between the ACB-score and treatment-related toxicity (grade ≥ 3), functional decline, and emergency room (ER) visits or hospitalization in older adults with cancer receivi

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… The most frequently used medications with anticholinergic properties were pantoprazole (30.0%), omeprazole (20.5%), and metformin (15.9%), as presented in Table 2 . … 36.5%) Unknown | 12 (2.8%) | 9 (2.4%) | 3 (4.8%) Frailty | | | | 0.004 No | 182 (41.9%) | 166 (44.7%) | 16 (25.4%) | Yes | 252 (58.1%) | 205 (55.3%) | 47 (74.6%) Table 2 The 10 most frequently used medications with anticholinergic properties Medication | ACB score | Indication | Prevalence (%) Pantoprazole …

Impact of lanadelumab in hereditary angioedema: a case series of 12 patients in Canada.

BackgroundHereditary angioedema (HAE) is a rare autosomal dominant disease resulting in recurring episodes of swelling, leading to considerable patient morbidity and mortality. Lanadelumab is a plasma kallikrein inhibitor that is approved as 1st line therapy in Canada for long term prophylaxis of HAE attacks.ObjectiveTo describe our clinical findings from a case series of adult patients with HAE type 1/2 who have been initiated on lanadelumab.MethodsA chart review of HAE type 1/2 patients at three academic centers in Canada was undertaken with demographic and clinical data extracted. Patients

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… GERD, Chronic Pain Methadone 23 25 7 59 F 1 Nil Nil 26 59 8 34 F 1 Depression Citalopram 11 11 9 50 F 1 Nil Nil 47 48 10 74 F 1 Multiple Myeloma, HTN Revlimid, Telmisartan Unknown 55 11 44 F 1 Raynaud’s, GERD, Cervical Stenosis Esomeprazole 15 33 12 65 M 1 T1DM, Primary Adrenal Insufficiency Insulin Pantoprazole … F | 1 | Depression | Citalopram | 11 | 11 9 | 50 | F | 1 | Nil | Nil | 47 | 48 10 | 74 | F | 1 | Multiple Myeloma, HTN | Revlimid, Telmisartan | Unknown | 55 11 | 44 | F | 1 | Raynaud’s, GERD, Cervical Stenosis | Esomeprazole | 15 | 33 12 | 65 | M | 1 | T1DM, Primary Adrenal Insufficiency | Insulin Pantoprazole …

Acquired Methemoglobinemia Associated with Topical Lidocaine Administration: A Case Report.

A 55-year-old male was admitted to the hospital with pneumonia. During an intubation procedure, the patient received an application of endobronchial lidocaine (4% gel). Within 2 h of intubation, the patient developed worsening hypoxia, and investigation of arterial blood gasses revealed a pH of 7.21, carbon dioxide partial pressure (PaCO2) of 3.3 kPa, oxygen partial pressure (PaO2) of 55.1 kPa, and measured oxygen saturation of 49%. Co-oximetry of this sample returned a methemoglobin level of 53%. Intravenous methylthioninium chloride (1% solution at 1 mg/kg) was delivered, and subsequent arte

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… He was admitted to the hospital and treated with cefepime and azithromycin for presumed pneumonia; further home medications continued during admission included acyclovir, allopurinol, fluconazole and pantoprazole. …

Redefining Breast Cancer Care by Harnessing Computational Drug Repositioning.

Breast cancer faces significant therapeutic challenges, particularly for triple-negative breast cancer (TNBC), due to limited targeted therapies and drug resistance. Drug repositioning leverages existing safety and pharmacokinetic data to expedite the identification of new indications with cost-effective benefits compared to de novo drug discovery. In this critical narrative review, we examine recent advances in computational repositioning strategies for breast cancer, focusing on network-based methods, computer-aided drug design, artificial intelligence and machine learning, transcriptomic si

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… From this pipeline, rabeprazole and pantoprazole emerged as top candidates, exhibiting predicted binding affinities in the low micromolar range. … These results identify pantoprazole and rabeprazole as novel FOXM1 inhibitors, highlighting their potential for repurposing in FOXM1-driven breast cancers [ 63 ]. The structure-based drug-repositioning methodology developed by S. …

Use of therapeutic plasma exchange to treat nonsteroidal anti-inflammatory drug overdose in dogs.

BACKGROUND: Therapeutic plasma exchange (TPE) may be an effective technique for treatment of accidental nonsteroidal anti-inflammatory drug (NSAID) overdose, but information regarding the use of this technique in veterinary medicine is currently limited. OBJECTIVES: To evaluate the overall outcome for dogs with NSAID overdose treated with TPE and to determine if any presenting factors can predict or influence overall outcome. Secondary objectives included investigating TPE complications as well as the utility of other adjunctive treatments. ANIMALS: Eleven client-owned dogs presented for NSA

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… All 11 dogs received IV fluid therapy, IV lipid infusions, and pantoprazole (Protonix; Wyeth Pharmaceuticals Inc, Philadelphia, Pennsylvania). … All patients received IV fluids, IV lipid infusion, and pantoprazole. Most patients had similar decontamination protocols including induction of emesis (81.8%) and 1‐5 doses of activated charcoal (81.8%). …

Колониальная ишемия без мезентерического оккулирования: случай, имплицитирующий интерферон-β.

Интерфероны типа I являются широко используемыми иммунодуляторными агентами. Интерферон-α (интерферон-α) связан с ишемическим колитом, но случаи, связывающие интерферон-β (IFN-β) с ишемическим колитом, редки. Мы представляем 66-year-old Женщина с множественным склерозом лечила IFN-β, у которой возникли острая боль в животе и диарея. Воображение продемонстрировало правую колонную воспаление пневматозом. Колоноскопия с биопсией тканей подтвердила ишемический колит, несмотря на патентную мезентерическую васкулатуру на ангиографической съемке. Ее симптомы устранены после прекращения действия IFN-β

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… Home medications included aspirin 81 mg daily, bisoprolol-hydrochlorothiazide, metformin, tirzepatide, pravastatin, verapamil, and pantoprazole. The patient was not receiving anticoagulation at presentation. She denied tobacco use or other identifiable precipitating factors. …

Pregabalin-associated myoclonic encephalopathy without evidence of drug accumulation in a patient with acute renal failure.

Pregabalin, used for treating partial epilepsy and neuropathic pain, is usually well tolerated. Patients with impaired renal function are at risk to develop more serious adverse events. A 64-year-old woman was admitted in the Emergency Department for altered consciousness and abnormal movements. She recently started to take pregabalin (150 mg/day) for neuropathic pain. The drug was withdrawn 36 h before hospitalization following worsening of neurological symptoms. At physical examination, myoclonus was noted as main finding in the limbs and head, with encephalopathy. Laboratory investigations

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… Her current medications included clonazepam, amlodipine, L-thyroxin, metformin, repaglinide, spironolactone, furosemide, minoxidil, irbesartan, hydrochlorothiazide, acyclovir, pantoprazole, and fenofibrate. …

To Bleed or Not to Bleed.

The location of gastrointestinal (GI) bleeding can be characterized based on the characteristics of the bowel movements these patients present with. Bright red blood per rectum is usually associated with a lower bleed; if brisk and significant enough, however, upper bleeds can present similarly. Melenic or "tar-colored" bowel movements are more likely to occur from upper bleeds as the color is secondary to digestion of hemoglobin as it passes through the GI tract. At times, there can be a mix of the two which can make a clinical decision for intervention less obvious. To make matters more diff

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… Intravenous (IV) crystalloids and pantoprazole infusion were initiated. Despite being transfused packed red blood cells, platelets, and fresh frozen plasma (FFP), he remained hemodynamically unstable. On evaluation blood pressure was noted to be 92/65 mmHg with a heart rate of 117 beats per minute. …

Cardiotoxicity after cancer treatment: a process map of the patient treatment journey.

Background/aimCardiotoxicity is a potential complication of anticancer therapy. While guidelines have been developed to assist practitioners, an effective, evidence based clinical pathway for the treatment of cardiotoxicity has not yet been developed. The aim of this study was to describe the journey of patients who developed cardiotoxicity through the healthcare system in order to establish baseline data to inform the development and implementation of a patient-centred, evidence-based clinical pathway.MethodsMixed-methods design with quantitative and qualitative components using process mappi

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… candesartan, carvedilol, cephalexin, cholecalciferol, clonidine, clopidogrel, digoxin, diltiazem, enalapril, enoxaparin, eprosartan, exemestane, frusemide, ibandronate, irbesartan, itraconazole, ivabradine, letrozole, lisinopril, metoprolol, telmisartan/hydrochlorothiazide, nebivolol, olmesartan, oxycodone, pantoprazole … candesartan, carvedilol, cephalexin, cholecalciferol, clonidine, clopidogrel, digoxin, diltiazem, enalapril, enoxaparin, eprosartan, exemestane, frusemide, ibandronate, irbesartan, itraconazole, ivabradine, letrozole, lisinopril, metoprolol, telmisartan/hydrochlorothiazide, nebivolol, olmesartan, oxycodone, pantoprazole …