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Acute Kidney Injury in Oncology Patients.

With rapid progress in cancer diagnosis and treatment in the last two decades, outcomes in oncological patients have improved significantly. However, the incidence of acute kidney injury (AKI) in this population has also increased significantly. AKI complicates many aspects of patients' care and adversely affects their prognoses; thus, accurately diagnosing the risk factors for AKI ensures appropriate management. AKI may be caused by pre-renal, intrinsic renal, and post-renal reasons, as well as for combined reasons. This review summarizes the potential etiologies of AKI according to the three

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… presenting as acute kidney injury in Hodgkin lymphoma - A case report and review of the literature Leuk Res Rep 2018 10 41 43 30225192 10.1016/j.lrr.2018.07.003 PMC6138943 26 Roger A Groh M Lorillon G Eosinophilic granulomatosis with polyangiitis (Churg-Strauss) induced by immune checkpoint inhibitors Ann Rheum …

12-Month Teriparatide Treatment Reduces New Vertebral Compression Fractures Incidence And Back Pain And Improves Quality Of Life After Percutaneous Kyphoplasty In Osteoporotic Women.

PurposeDefine the effectiveness of teriparatide (TPTD) treatment on reducing the incidence of new vertebral compression fractures (NVCFs) and back pain and improving quality of life after percutaneous kyphoplasty (PKP).MethodsTwo years of clinical follow-up data from primary osteoporotic women who had experienced initial osteoporotic vertebral compression fractures (OVCFs) and received PKP plus 12-month TPTD (n=113) or basic treatment (BT) of calcium and vitamin D supplements (n=208) were retrospectively collected. The risk of NVCFs over each 6-month period in the TPTD group was evaluated and

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… Arthritis Rheum . 2009 ; 60 ( 11 ): 3346 – 3355 . doi: 10.1002/art.24879 19877063 41. Nevitt MC , Chen P , Dore RK , et al. Reduced risk of back pain following teriparatide treatment: a meta-analysis . Osteoporosis Int . 2006 ; 17 ( 2 ): 273 – 280 . doi: 10.1007/s00198-005-2013-2 16142502 42. …

Diagnosis and Management of Chronic Pruritus: An Expert Consensus Review.

The aim of this study is to formulate the best clinical practice in the diagnosis and management of chronic pruritus (CP). We searched PubMed, EMBASE, Scopus, Web of Science, and the WHO's regional databases, for studies on "Diagnosis and management of chronic pruritus" from January 1, 2014, to July 31, 2015. We included programmatic reports and hand-searched references of published reviews and articles. Two independent reviewers screened articles and extracted data. We screened 87 of 95 studies that contained qualitative data. Avoid: Dry climate, heat, alcohol compress, ice packs, frequent ba

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… Multidepartment Virus C Arthritis Rheum 1999 42 2204 12 10524695 10.1002/1529-0131(199910)42:10<2204::AID-ANR24>3.0.CO;2-D 13 Kremer AE van Dijk R Leckie P Schaap FG Kuiper EM Mettang T Serum autotaxin is increased in pruritus of cholestasis, but not of other origin, and responds to therapeutic interventions …

Identification of the sAPRIL binding peptide and its growth inhibition effects in the colorectal cancer cells.

BackgroundA proliferation-inducing ligand (APRIL) is a member of the tumor necrosis factor (TNF) super family. It binds to its specific receptors and is involved in multiple processes during tumorigenesis and tumor cells proliferation. High levels of APRIL expression are closely correlated to the growth, metastasis, and 5-FU drug resistance of colorectal cancer. The aim of this study was to identify a specific APRIL binding peptide (BP) able to block APRIL activity that could be used as a potential treatment for colorectal cancer.MethodsA phage display library was used to identify peptides tha

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… Ann Rheum Dis . 2012 ; 71 : 143 – 149 . 10.1136/annrheumdis-2011-200100 21998117 39 Lam KS , Salmon SE , Hersh EM , Hruby VJ , Kazmierski WM , Knapp RJ . A new type of synthetic peptide library for identifying ligand-binding activity . …

Perceived information provision and satisfaction among lymphoma and multiple myeloma survivors--results from a Dutch population-based study.

To improve posttreatment care for (long-term) lymphoma survivors in the Netherlands, survivorship clinics are being developed. As information provision is an important aspect of survivorship care, our aim was to evaluate the current perceived level of and satisfaction with information received by non-Hodgkin's lymphoma (NHL), Hodgkin's lymphoma (HL) and multiple myeloma (MM) survivors, and to identify associations with sociodemographic and clinical characteristics. The population-based Eindhoven Cancer Registry was used to select all patients diagnosed with NHL, HL and MM from 1999 to 2009. In

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… Sangha O Stucki G Liang MH The Self-Administered Comorbidity Questionnaire: a new method to assess comorbidity for clinical and health services research Arthritis Rheum 2003 49 156 163 10.1002/art.10993 12687505 16. …

From undruggable to degradable: A deep learning-enabled framework for precision orthopaedic protein degradation.

BACKGROUND/OBJECTIVE: A fundamental translational impasse in musculoskeletal disorders-from osteoarthritis to bone metastases-is the "undruggability" of critical pathological drivers sequestered within anatomically restricted and avascular skeletal niches. While Targeted Protein Degradation (TPD) offers a revolutionary event-driven modality to eradicate these refractory targets, its clinical translation to orthopaedics is severely hindered by the physicochemical incompatibility of large degraders with dense extracellular matrices and the scarcity of bone-specific E3 ligases. METHODS: In this

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… Global, regional and national burden of osteoarthritis 1990-2017: a systematic analysis of the global burden of disease study 2017 Ann Rheum Dis 79 6 2020 819 828 32398285 10.1136/annrheumdis-2019-216515 2 Huang P. Zhao J. Wang X. Zhang Z. Zhao H. …

The role of tumor types in immune-related adverse events.

Immune checkpoint inhibitors (ICIs) are monoclonal antibodies that block inhibitors of T cell activation and function. With the widespread use of ICIs in cancer therapy, immune-related adverse events (irAEs) have gradually emerged as urgent clinical issues. Tumors not only exhibit high heterogeneity, and their response to ICIs varies, with "hot" tumors showing better anti-tumor effects but also a higher susceptibility to irAEs. The manifestation of irAEs displays a tumor-heterogeneous pattern, correlating with the tumor type in terms of the affected organs, incidence, median onset time, and se

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… Bracamonte-Baran W Kim ST The current and future of biomarkers of immune related adverse events Rheum Dis Clin 2024 50 2 201 227 10.1016/j.rdc.2024.01.004 PMC11232920 38670721 Bracamonte-Baran W, Kim ST. The current and future of biomarkers of immune related adverse events. … Rheum Dis Clin. 2024;50(2):201–27. 10.1016/j.rdc.2024.01.004 PMC11232920 38670721 95. …

Osteoimmunology in bone malignancies: a symphony with evil.

Bone marrow is pivotal for normal hematopoiesis and immune responses, yet it is often compromised by malignancies. The bone microenvironment (BME), composed of bone and immune cells, maintains skeletal integrity and blood production. The emergence of primary or metastatic tumors in the skeletal system results in severe complications and contributes significantly to cancer-related mortality. These tumors set off a series of interactions among cancer, bone, and immune cells, and disrupt the BME locally or distantly. However, the drivers, participants, and underlying molecules of these interactio

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… RANKL expressed on synovial fibroblasts is primarily responsible for bone erosions during joint inflammation Ann Rheum Dis 75 2016 1187 1195 10.1136/annrheumdis-2014-207137 26025971 38 O'Neil L.J. Oliveira C.B. Wang X. … Neutrophil extracellular trap-associated carbamylation and histones trigger osteoclast formation in rheumatoid arthritis Ann Rheum Dis 82 2023 630 638 10.1136/ard-2022-223568 36737106 PMC11302494 39 Schneider A.H. Taira T.M. Públio G.A. …

Monoclonal antibody and protein therapeutic formulations for subcutaneous delivery: high-concentration, low-volume vs. low-concentration, high-volume.

Biologic drugs are used to treat a variety of cancers and chronic diseases. While most of these treatments are administered intravenously by trained healthcare professionals, a noticeable trend has emerged favoring subcutaneous (SC) administration. SC administration of biologics poses several challenges. Biologic drugs often require higher doses for optimal efficacy, surpassing the low volume capacity of traditional SC delivery methods like autoinjectors. Consequently, high concentrations of active ingredients are needed, creating time-consuming formulation obstacles. Alternatives to tradition

The TNF-α/TNFR2 Pathway: Targeting a Brake to Release the Anti-tumor Immune Response.

Newly discovered anti-cancer immunotherapies, such as immune checkpoint inhibitors and chimeric antigen receptor T cells, focus on spurring the anti-tumor effector T cell (Teff) response. Although such strategies have already demonstrated a sustained beneficial effect in certain malignancies, a substantial proportion of treated patients does not respond. CD4+FOXP3+ regulatory T cells (Tregs), a suppressive subset of T cells, can impair anti-tumor responses and reduce the efficacy of currently available immunotherapies. An alternative view that has emerged over the last decade proposes to tackl

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… Rheum. Dis. 64 iv70–iv76. 10.1136/ard.2005.042523 Cohen J. L., Wood K. J. (2017). TNFR2: The new Treg switch? Oncoimmunology 7:1373236. 10.1080/2162402X.2017.1373236 Correale P., Rotundo M. S., Del Vecchio M. T., Remondo C., Migali C., Ginanneschi C., et al. (2010). … Rheum. Dis. 66 320–324. 10.1136/ard.2006.058917 Horwitz D. A., Pan S., Ou J.-N., Wang J., Chen M., Gray J. D., et al. (2013). Therapeutic Polyclonal human CD8+ Fox3+ TNFR2+ PD-L1+ Regulatory Cells Induced ex-vivo. Clin. Immunol. Orlando Fla 149 450–463. 10.1016/j.clim.2013.08.007 Housley W. …

New Approaches for the Treatment of Chronic Graft-Versus-Host Disease: Current Status and Future Directions.

Chronic graft-versus-host disease (cGvHD) is a severe complication of allogeneic hematopoietic stem cell transplantation that affects various organs leading to a reduced quality of life. The condition often requires enduring immunosuppressive therapy, which can also lead to the development of severe side effects. Several approaches including small molecule inhibitors, antibodies, cytokines, and cellular therapies are now being developed for the treatment of cGvHD, and some of these therapies have been or are currently tested in clinical trials. In this review, we discuss these emerging therapi

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… Arthritis Rheum (2009) 60:219–24. 10.1002/art.24186 72. Hernandez-Gea V, Friedman SL. Pathogenesis of liver fibrosis. Annu Rev Pathol (2011) 6:425–56. 10.1146/annurev-pathol-011110-130246 73. Niemann CU, Herman SEM, Maric I, Gomez-Rodriguez J, Biancotto A, Chang BY, et al. … Arthritis Rheum (2009) 60:584–91. 10.1002/art.24221 100. Magro L, Catteau B, Coiteux V, Bruno B, Jouet J-P, Yakoub-Agha I. Efficacy of imatinib mesylate in the treatment of refractory sclerodermatous chronic GVHD. Bone Marrow Transplant (2008) 42:757–60. 10.1038/bmt.2008.252 101. …

Proceedings of the 27th European Paediatric Rheumatology Congress (PReS 2021) : Virtual. 19-21 September 2021

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… Ann Rheum Dis 2016 Rice GI, et al. … Ann Rheum Dis. 2019;78(7):947-56. 6. Tesser A, Piperno GM, Pin A, Piscianz E, Boz V, Benvenuti F, et al. Priming of the cGAS-STING-TBK1 Pathway Enhances LPS-Induced Release of Type I Interferons. Cells. 2021;10(4). …

Serum C-C Motif Ligand 11/eotaxin-1 May Serve as a Candidate Biomarker for Postmenopausal Osteoporosis.

BACKGROUND: The chemokine C-C motif ligand 11, also known as eotaxin-1, has been identified as a novel mediator of inflammatory bone resorption. However, little is known regarding a potential role for CCL11/Eotaxin-1 in postmenopausal osteoporosis. OBJECTIVE: The scope of this study was to explore the relationship between serum CCL11/Eotaxin-1 concentrations and disease progression of postmenopausal females with osteoporosis. METHODS: A total of 83 postmenopausal women diagnosed with osteoporosis were enrolled. Meanwhile, 82 postmenopausal women with normal bone mineral density (BMD) and 85

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… References 1 Alejandro P Constantinescu F A Review of Osteoporosis in the Older Adult: An Update Rheum Dis Clin North Am 2018 44 437 51 30001785 10.1016/j.rdc.2018.03.004 2 Rachner TD Khosla S Hofbauer LC Osteoporosis: now and the future Lancet 2011 377 1276 87 21450337 10.1016/S0140-6736(10)62349- …

Liver resection for hepatocellular carcinoma in patients with hematological malignancies.

BACKGROUND: Improvements in antimetabolite drugs have prolonged the survival of patient with hematological malignancies. However, these drugs may have hepatotoxic side effects and may induce acute liver failure, chronic liver fibrosis, cirrhosis, or even hepatocellular carcinoma (HCC). Although liver resection remains a curative option for HCC, its role in HCC with hematological malignancies has never been fully explored. METHODS: A retrospective review of 1725 patients who underwent curative liver resection for newly diagnosed HCC between 1994 and 2016 was conducted. Among these patients, 16

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… Ann Rheum Dis. 2011;70:1719–1725. doi: 10.1136/ard.2010.148783. 3. Chen YH, Chien RN, Huang YH, et al. Screening and management of hepatitis B infection in rheumatic patients scheduled for biologic therapy: consensus recommendation from the Taiwan Rheumatology Association. …

Histone modifications: Unveiling the epigenetic enigma of degenerative skeletal diseases.

Degenerative skeletal diseases, including osteoporosis, osteoarthritis, and intervertebral disc degeneration, are prevalent age-related conditions characterized by progressive tissue degeneration and functional decline. Histone modifications are covalent modifications of histone residues, catalyzed by specific enzymes, that modulate chromatin architecture and transcriptional activity. Accumulating evidence highlights the critical involvement of histone modifications in orchestrating disease-associated transcriptional programs. In osteoporosis, histone modifications regulate osteoblast and oste

The role of hypoxic microenvironment in autoimmune diseases.

The hypoxic microenvironment, characterized by significantly reduced oxygen levels within tissues, has emerged as a critical factor in the p … the mechanisms by which hypoxia contributes to the development and exacerbation of diseases such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), multiple sclerosis (MS), and dermatomyositis (DM). In these conditions, the hypoxic microenvironment not only disrupts immune tolerance but also enhances inflammatory responses and promotes ti …

Моноклональные антитела: от волшебной пули до точного оружия.

Моноклональные антитела (mAbs) используются для профилактики, обнаружения и лечения широкого спектра неинфекционных и инфекционных заболеваний. За последние несколько лет рынок МП рос экспоненциально, при этом ожидаемый совокупный годовой прирост (CAGR) составил 11.07% от 2024 (В тыс.237.64 млрд. долл. США на конец 2023) к 2033 (В тыс.679.03 млрд. долл. США к концу 2033). С момента появления технологии гибридомы 1975, терапия на базе антител была реализована с использованием муринных антител, которые стали еще более гуманизированными и полностью человеческими антителами, что уменьшило риск имм

Targeting strategies for bone diseases: signaling pathways and clinical studies.

Since the proposal of Paul Ehrlich's magic bullet concept over 100 years ago, tremendous advances have occurred in targeted therapy. From the initial selective antibody, antitoxin to targeted drug delivery that emerged in the past decades, more precise therapeutic efficacy is realized in specific pathological sites of clinical diseases. As a highly pyknotic mineralized tissue with lessened blood flow, bone is characterized by a complex remodeling and homeostatic regulation mechanism, which makes drug therapy for skeletal diseases more challenging than other tissues. Bone-targeted therapy has b

The 2024 UK clinical guideline for the prevention and treatment of osteoporosis.

UNLABELLED: The National Osteoporosis Guideline Group (NOGG) has updated the revised UK guideline for the assessment and management of osteoporosis and the prevention of fragility fractures in postmenopausal women, and men age 50 years and older. This guideline is relevant for all healthcare professionals involved in osteoporosis management. INTRODUCTION: The UK National Osteoporosis Guideline Group (NOGG) first produced a guideline on the prevention and treatment of osteoporosis in 2008, with updates in 2013, 2017 and 2021. This paper presents a minor update of the 2021 guideline, the scope

Plants as a Source of Anticancer Agents: From Bench to Bedside.

Cancer is the second leading cause of death after cardiovascular diseases. Conventional anticancer therapies are associated with lack of selectivity and serious side effects. Cancer hallmarks are biological capabilities acquired by cancer cells during neoplastic transformation. Targeting multiple cancer hallmarks is a promising strategy to treat cancer. The diversity in chemical structure and the relatively low toxicity make plant-derived natural products a promising source for the development of new and more effective anticancer therapies that have the capacity to target multiple hallmarks in

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… Emodin Emodin is a Chinese herb-derived anthraquinone isolated from the roots and rhizomes of several plants such as Rheum palmatum , Polygonum cuspidatum, Polygonum multiflorum, Aloe vera , and Cassia obtusifolia , as well as different fungal species, including Aspergillus ochraceus , and Aspergillus …