Результаты поиска

The Most Competent Plant-Derived Natural Products for Targeting Apoptosis in Cancer Therapy.

Cancer is a challenging problem for the global health community, and its increasing burden necessitates seeking novel and alternative therapies. Most cancers share six basic characteristics known as "cancer hallmarks", including uncontrolled proliferation, refractoriness to proliferation blockers, escaping apoptosis, unlimited proliferation, enhanced angiogenesis, and metastatic spread. Apoptosis, as one of the best-known programmed cell death processes, is generally promoted through two signaling pathways, including the intrinsic and extrinsic cascades. These pathways comprise several compone

Совпадение в полном тексте источника
… Qingjie Fuzheng granule (QFG) is comprised of four Chinese medicinal plants, including Hedyotis diffusa Willd, Malt , Astragalus , and Scutellaria barbata D. Don. … Wogonin, a flavonoid-like compound found in Scutellaria baicalensis (known as Baikal skullcap or Chinese skullcap), has been discovered that triggered apoptosis of U-2OS human osteosarcoma cells by augmenting the expression of both intrinsic and extrinsic apoptosis components, including Bax, Bad, cytochrome …

Past, Present, and a Glance into the Future of Multiple Myeloma Treatment.

Multiple myeloma (MM) is a challenging hematological cancer which typically grows in bone marrow. MM accounts for 10% of hematological malignancies and 1.8% of cancers. The recent treatment strategies have significantly improved progression-free survival for MM patients in the last decade; however, a relapse for most MM patients is inevitable. In this review we discuss current treatment, important pathways for proliferation, survival, immune suppression, and resistance that could be targeted for future treatments.

Совпадение в полном тексте источника
… The ethanolic extract of scutellaria, a traditional Chinese herbal remedy, and its derivatives baicalein, wogonin, and baicalin have been shown to decrease the expression level of ABCG2 protein in RPMI-8226 [ 201 ]. …

Targeting Autophagy with Natural Products as a Potential Therapeutic Approach for Cancer.

Macro-autophagy (autophagy) is a highly conserved eukaryotic intracellular process of self-digestion caused by lysosomes on demand, which is upregulated as a survival strategy upon exposure to various stressors, such as metabolic insults, cytotoxic drugs, and alcohol abuse. Paradoxically, autophagy dysfunction also contributes to cancer and aging. It is well known that regulating autophagy by targeting specific regulatory molecules in its machinery can modulate multiple disease processes. Therefore, autophagy represents a significant pharmacological target for drug development and therapeutic

Совпадение в полном тексте источника
… | Cucurbitaceous plants | Induction of ROS formation | Numerous pharmacological actions | A wide range of human cancers | Protection against pressure-overload cardiac hypertrophy by inhibiting the AKT-mTOR pathway [ 131 , 132 ] Initiation, nucleation | Wogonin | | 5,7-Dihydroxy-8-methoxyflavone | Scutellaria … baicalensis Georgi, Scutellaria radix | ER stress, upregulation of LC3-II and Beclin1 | Numerous pharmacological actions | A wide range of human cancers | Modulation of ER stress and autophagy and/or apoptosis in a cell-type- and context-dependent manner [ 133 , 134 ] Initiation | Morusin | | Mulberrochromene …

Neurodegeneration: can metabolites from Eremurus persicus help?

The number of patients affected by neurodegenerative diseases is increasing worldwide, and no effective treatments have been developed yet. Although precision medicine could represent a powerful tool, it remains a challenge due to the high variability among patients. To identify molecules acting with innovative mechanisms of action, we performed a computational investigation using SAFAN technology, focusing specifically on HuD. This target belongs to the human embryonic lethal abnormal visual-like (ELAV) proteins and plays a key role in neuronal plasticity and differentiation. The results high

Совпадение в полном тексте источника
… Flavonoids from stems and leaves of scutellaria baicalensis georgi improve composited aβ-induced Alzheimer’s disease model rats’ memory and neuroplasticity disorders. Comb. Chem. High. …

Emerging agents that target signaling pathways to eradicate colorectal cancer stem cells.

Colorectal cancer (CRC) represents the third most commonly diagnosed cancer and the second leading cause of cancer death worldwide. The modern concept of cancer biology indicates that cancer is formed of a small population of cells called cancer stem cells (CSCs), which present both pluripotency and self-renewal properties. These cells are considered responsible for the progression of the disease, recurrence and tumor resistance. Interestingly, some cell signaling pathways participate in CRC survival, proliferation, and self-renewal properties, and most of them are dysregulated in CSCs, includ

Совпадение в полном тексте источника
… Natural product Baicalin Baicalin is a monomeric flavonoid from the root of Scutellaria baicalensis , a traditional Chinese herb. Baicalin has several pharmacological effects, including anti‐cancer, anti‐inflammatory, antioxidant and neuroprotective effects [ 243 ]. …

Chemopreventive Potential of Caryophyllane Sesquiterpenes: An Overview of Preliminary Evidence.

Chemoprevention is referred to as a strategy to inhibit, suppress, or reverse tumor development and progression in healthy people along with high-risk subjects and oncologic patients through using pharmacological or natural substances. Numerous phytochemicals have been widely described in the literature to possess chemopreventive properties, although their clinical usefulness remains to be defined. Among them, caryophyllane sesquiterpenes are natural compounds widely occurring in nature kingdoms, especially in plants, fungi, and marine environments. Several structures, characterized by a commo

Совпадение в полном тексте источника
… Particularly, an amount higher than 30% was detected in those from Scutellaria californica A. Gray (up to 56.2% in flower), Copaifera langsdorffi Desf. (16.6% in leaves and 53.3% in balsam from bark), Orthodon dianthera Maxim. (up to 52.9% in aerial parts), Nepeta curviflora Boiss. … For instance, the flowers from Scutellaria californica A. …

An Insight into Anticancer Effect of Propolis and Its Constituents: A Review of Molecular Mechanisms.

Propolis is a natural compound collected by honeybees from different parts of plants. Honeybees produce a sticky component besides honey by mixing the tree resin and other botanical sources with saliva called propolis or bee glue. Propolis was traditionally used as a wound healing substance, cosmetic, medicine, and many other conditions. Till now, there is no definite curable treatment for most cancers and chemotherapeutic drugs and drugs used for targeted therapies have serious side effects. According to a recent research, natural products are becoming increasingly essential in cancer prevent

Совпадение в полном тексте источника
… Drug-herb interactions between Scutellaria baicalensis and pharmaceutical drugs: insights from experimental studies, mechanistic actions to clinical applications Biomedicine & Pharmacotherapy 2021 138 111445 10.1016/j.biopha.2021.111445 33711551 67 Sasaki T. Sato Y. Kumagai T. Yoshinari K. …

Genus Sophora: a comprehensive review on secondary chemical metabolites and their biological aspects from past achievements to future perspectives.

Sophora is deemed as one of the most remarkable genera of Fabaceae, and the third largest family of flowering plants. The genus Sophora comprises approximately 52 species, 19 varieties, and 7 forms that are widely distributed in Asia and mildly in Africa. Sophora species are recognized to be substantial sources of broad spectrum biopertinent secondary metabolites namely flavonoids, isoflavonoids, chalcones, chromones, pterocarpans, coumarins, benzofuran derivatives, sterols, saponins (mainly triterpene glycosides), oligostilbenes, and mainly alkaloids. Meanwhile, extracts and isolated compoun

Совпадение в полном тексте источника
… and inducing reactive oxygen species ROS production | Liu et al. ( 2020a , b ) Methanol extract of the flower buds | Treating contact dermatitis | Therapeutic mechanism is explained by relations between major flavonoids and 13 contact dermatitis-related genes | Kim et al. ( 2021 ) Acombination with Scutellaria …

Small molecule metabolites: discovery of biomarkers and therapeutic targets.

Metabolic abnormalities lead to the dysfunction of metabolic pathways and metabolite accumulation or deficiency which is well-recognized hallmarks of diseases. Metabolite signatures that have close proximity to subject's phenotypic informative dimension, are useful for predicting diagnosis and prognosis of diseases as well as monitoring treatments. The lack of early biomarkers could lead to poor diagnosis and serious outcomes. Therefore, noninvasive diagnosis and monitoring methods with high specificity and selectivity are desperately needed. Small molecule metabolites-based metabolomics has b

Properties of Approved Antitumour Chinese Herbal Medicines: Integrating Evidence and Tradition.

The properties and meridian affinities of Chinese herbal medicine are closely associated with their therapeutic efficacy. This review focuses on approved antitumour Chinese medicines listed in the Pharmacopoeia of the People's Republic of China (2020 Edition, Volume I), highlighting their key components. Statistical methods were used to analyse the properties, flavours and channel tropisms of antitumour traditional Chinese medicine (TCM), including both proprietary formulations and commercially available individual herbs. Distinctive patterns were identified by comparing herb profiles with con

Совпадение в полном тексте источника
… Flavonoid- and terpenoid-derived SAs from bitter herbs, including Prunella vulgaris, Hedyotis diffusa and Scutellaria baicalensis , exhibit marked antitumour efficacy against lung, breast, hepatic and colorectal carcinomas across diverse preclinical models. 77 Mechanistically, SAs enhance cytotoxicity …

Natural products targeting ferroptosis in cancer: molecular mechanisms and applications.

Ferroptosis is a novel class of programmed cell death that is mainly dependent on intracellular iron accumulation and lipid peroxidation. Ferroptosis is closely related to a variety of human diseases, especially different kinds of cancer. Several small molecule inducers have been developed to induce ferroptosis in tumor cells, some of which have been used in clinical studies. However, these chemical small molecules have toxic effects that limit its wide application. Natural products, however, have a natural advantage in cancer therapy due to their low toxicity and side effects. Some natural pr

Совпадение в полном тексте источника
… Baicalin, a flavonoid compound extracted from the roots of Scutellaria baicalensis , exhibits significant anti-tumor activity. It induces ferroptosis in tumor cells through multiple mechanisms ( 39 ). …

Mechanistic and Clinical Perspectives on Traditional Chinese Medicine in Thyroid Cancer Management.

Thyroid cancer is one of the most prevalent malignancies of the endocrine system, comprising various subtypes such as papillary thyroid carcinoma (PTC), follicular thyroid carcinoma (FTC), medullary thyroid carcinoma (MTC), and the aggressive anaplastic thyroid carcinoma (ATC). Despite a generally favorable prognosis for PTC, recurrence, metastasis, and resistance to conventional therapies continue to pose significant challenges. The pathogenesis of thyroid cancer involves genetic mutations in BRAF, RAS, and RET, as well as dysregulated molecular pathways such as MAPK, PI3K/Akt/mTOR, and NF-κB

Совпадение в полном тексте источника
… Moreover, some TCM herbs, such as Curcumin and Scutellaria baicalensis (Baikal Skullcap), regulate cytokines such as TNF-α and IL-6, which promote tumor growth and immune evasion. TCM can be used to create a less favorable TME by alleviating chronic inflammation ( Fig. 3 ) ( Su et al. , 2025a ). …

Биологическая роль мономеров традиционной китайской медицины в нейронных расстройствах.

Традиционная китайская медицина (TCM) является биоактивным соединением, извлекаемым из китайских травяных лекарственных препаратов, обладающих определенной биологической активностью и фармакологическими последствиями, и привлекла большое внимание к лечению нейронных заболеваний. Однако применение мономеров ТХМ ограничено их низкой растворимостью и низкой способностью пересекать барьер кровеносного мозга (ББД). Экзосомы представляют собой небольшие внеклеточные везикли (ЭМ) диаметром от 30 до 150 нм и могут использоваться в качестве носителей наркотиков, которые непосредственно предназначены дл

Совпадение в полном тексте источника
… The TCM monomers baicalin (Bai), hederagenin (Hed), and neferine (Nef) were isolated from Scutellaria baicalensis Georgi, Hedera nepalensis K. Koch var. sinensis , and Nelumbo nucifera Gaertn, respectively. …

EP300 as a Molecular Integrator of Fibrotic Transcriptional Programs.

Fibrosis is a condition characterized by the excessive accumulation of extracellular matrix proteins in tissues, leading to organ dysfunction and failure. Recent studies have identified EP300, a histone acetyltransferase, as a crucial regulator of the epigenetic changes that contribute to fibrosis. In fact, EP300-mediated acetylation of histones alters global chromatin structure and gene expression, promoting the development and progression of fibrosis. Here, we review the role of EP300-mediated epigenetic regulation in multi-organ fibrosis and its potential as a therapeutic target. We discuss

Совпадение в полном тексте источника
… Interestingly, AMPK activation through Ca 2+ /calmodulin-dependent protein kinase β (CaMKKβ) phosphorylation reduced the SMAD3/EP300 interaction, therefore suppressing cardiac fibrosis by baicalin treatment, a flavone found in the fungus Baical skullcap (Scutellaria baicalensis Georgi) roots [ 79 ]. …

State of the Art of Pharmacological Activators of p53 in Ocular Malignancies.

The pivotal role of p53 in the regulation of a vast array of cellular functions has been the subject of extensive research. The biological activity of p53 is not strictly limited to cell cycle arrest but also includes the regulation of homeostasis, DNA repair, apoptosis, and senescence. Thus, mutations in the p53 gene with loss of function represent one of the major mechanisms for cancer development. As expected, due to its key role, p53 is expressed throughout the human body including the eye. Specifically, altered p53 signaling pathways have been implicated in the development of conjunctival

Совпадение в полном тексте источника
… Among these agents, baicalein, a flavonoid extracted from the dried root of Scutellaria baicalensis , has demonstrated significant efficacy in the treatment and prevention of many types of cancers. …

Icariin as a potential anticancer agent: a review of its biological effects on various cancers.

Numerous chemical compounds used in cancer treatment have been isolated from natural herbs to address the ever-increasing cancer incidence worldwide. Therein is icariin, which has been extensively studied for its therapeutic potential due to its anti-inflammatory, antioxidant, antidepressant, and aphrodisiac properties. However, there is a lack of comprehensive and detailed review of studies on icariin in cancer treatment. Given this, this study reviews and examines the relevant literature on the chemopreventive and therapeutic potentials of icariin in cancer treatment and describes its mechan

Совпадение в полном тексте источника
… Effect and mechanism of flavonoids from Scutellaria baicalensis Georgi on nicotine induced lung cancer progression . Shanghai, China : Fudan University . Gu Z. F. Zhang Z. T. Wang J. Y. Xu B. B. ( 2017 ). …

Epidemiology and management of osteoporosis in the People's Republic of China: current perspectives.

With the progressive aging of the population, osteoporosis has gradually grown into a global health problem for men and women aged 50 years and older because of its consequences in terms of disabilities and fragility fractures. This is especially true in the People's Republic of China, which has the largest population and an increasing proportion of elderly people, as osteoporosis has become a serious challenge to the Chinese government, society, and family. Apart from the fact that all osteoporotic fractures can increase the patient's morbidity, they can also result in fractures of the hip an

Совпадение в полном тексте источника
… Antiosteopo-rosis effect of radix scutellariae extract on density and microstructure of long bones in tail-suspended sprague-dawley rats. Evid Based Complement Alternat Med. 2013;2013:753703. doi: 10.1155/2013/753703. 154. Liu M, Xiao GG, Rong P, et al. …

The Gut-Bone Marrow Axis: Deciphering the Mechanistic Impact of Microbial Metabolites on Hematopoietic Homeostasis and Disorders.

The gut microbiota is increasingly recognized as a dynamic endocrine-like microbial network that exerts systemic effects far beyond the gastrointestinal tract. Emerging evidence supports the existence of a "gut-bone marrow axis" through which gut-derived signals orchestrate hematopoietic homeostasis. However, shifting from correlative observations to causal mechanisms remains a major challenge in defining precise microbial impacts on hematopoietic outcomes. In this review, we systematically synthesize current knowledge on the molecular mechanisms by which microbial products-specifically short-

Совпадение в полном тексте источника
… Scutellaria baicalensis Georgi polysaccharide ameliorates DSS-induced ulcerative colitis by improving intestinal barrier function and modulating gut microbiota. Int. J. Biol. Macromol. 2021;166:1035–1045. doi: 10.1016/j.ijbiomac.2020.10.259. 62. Markowiak-Kopeć P., Śliżewska K. …

Current Advances in Coptidis Rhizoma for Gastrointestinal and Other Cancers.

Cancer is a serious disease with an increasing number of reported cases and high mortality worldwide. Gastrointestinal cancer defines a group of cancers in the digestive system, e.g., liver cancer, colorectal cancer, and gastric cancer. Coptidis Rhizoma (C. Rhizoma; Huanglian, in Chinese) is a classical Chinese medicinal botanical drug for the treatment of gastrointestinal disorders and has been shown to have a wide variety of pharmacological activity, including antifungal, antivirus, anticancer, antidiabetic, hypoglycemic, and cardioprotective effects. Recent studies on C. Rhizoma present sig

Совпадение в полном тексте источника
… Rhizoma , and Radix Scutellariae at a ratio of 2:1:1 (w/w/w), was reported to regulate p53 signaling pathway related genes and caused apoptosis and DNA damage in the HCC (HepG2) cells. The main pharmacological effect might be due to the presence of C. Rhizoma ( Cheng et al., 2008 ). … Gegen Qinlian Decoction, containing Radix Puerariae , Radix Scutellariae , C. …

MicroRNAs and long non-coding RNAs in pancreatic cancer: From epigenetics to potential clinical applications.

MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs) are two relevant classes of non-coding RNAs (ncRNAs) that play a pivotal role in a number of molecular processes through different epigenetic regulatory mechanisms of gene expression. As a matter of fact, the altered expression of these types of RNAs leads to the development and progression of a varied range of multifactorial human diseases. Several recent reports elucidated that miRNA and lncRNAs have been implicated in pancreatic cancer (PC). For instance, dysregulation of such ncRNAs has been found to be associated with chemoresistance,

Совпадение в полном тексте источника
… Besides, an investigation in which PC cells were treated with baicalein (an active flavonoid present in Scutellaria baicalensis Georgi ) supported that this therapeutic approach enhances apoptosis and cell cycle arrest by altering the expression of at least 59 miRNAs, where the most significantly affected …