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Impact of Navigation Assistance on Perioperative Outcomes in Sacroiliac Joint Arthrodesis: A Comparative Study.

Background Navigation systems are increasingly applied to enhance precision and reduce radiation exposure in sacroiliac joint (SIJ) arthrodesis. However, evidence comparing navigated and conventional procedures remains limited. This study evaluated perioperative outcomes of navigation-assisted versus non-navigated SIJ arthrodesis using the DIANA implant system (Signus GmbH, Alzenau, Germany). Methods A retrospective comparative study was conducted on 30 patients who underwent SIJ arthrodesis between 2011 and 2021 at the Department of Neurosurgery, Hospital of the Order of Merciful Brothers, Re…

Documented End-of-Life Preferences of People With Parkinson's Disease or Parkinsonism Across Europe.

BACKGROUND: Parkinson's disease and atypical parkinsonism are characterized by motor and non-motor symptoms. As the disease advances, planni … rovide an overview of the status of EoL care documentation in selected regions of Austria, Estonia, Germany, Greece, Italy and Sweden. METHODS: Individuals diagnosed with moderate to severe parkinsonism, participating in the PD_Pal trial were enrolled. We reviewed participants' electronic health records (EHRs) and other documentation (eg, advance directi …

Attitudes toward and regional utilization of age-specific vaccinations from the age of 60 in Saxony-Anhalt.

BACKGROUND: Saxony-Anhalt (ST) has the oldest population in Germany, with partly above average and increasing prevalences of chronic diseases and multimorbidity. Vaccinations are crucial to prevent infections and severe disease outcomes in older adults, especially in rural areas. However, national immunisation recommendations for individuals aged 60 and above are only partially followed. This research aims to examine (1) actual vaccination utilization and (2) the determinants, reasons, and barriers to vaccination uptake in ST's elderly population (≥ 60 years). METHODS: (1) Vaccination utiliza…

" Перспективы пациентов в отношении использования медицинских услуг во время пандемии COVID-19 у людей с множественным склерозом-продольным анализом " .

Пандемия COVID-19 сорвала системы здравоохранения во всем мире, изменив управление хроническими заболеваниями, такими, как множественный склероз (MS), и прервав регулярный мониторинг и поддержку, в которых обычно нуждаются люди с MS (PwMS). Цель этого исследования состояла в том, чтобы изучить изменения в использовании ресурсов здравоохранения в различных периодах во время пандемии COVID-19 в 2020 и 2021 годах, а также оценить, каким образом эти изменения повлияли на представление о том, как они влияют на их уход. МЕТОДЫ: Продольное обследование было проведено в Центре MS в университетском гос

Совпадение в аннотации оригинала
BACKGROUND/OBJECTIVES: The COVID-19 pandemic disrupted healthcare systems globally, altering the management of chronic conditions like multi … ODS: A longitudinal survey study was conducted at the MS Center at the University Hospital Dresden, Germany, involving four survey periods from April 2020 to December 2021. The study assessed the use of healthcare resources, including consultations with specialists, the use of rehabilitative therapy facilities, and unmet healthcare needs, across various p …

[Colorectal cancer screening with virtual colonography].

BACKGROUND: Since 2003, a decline in the age-standardized incidence rates of colorectal cancer (CRC) has been observed in Germany. Nonetheless, one in eight cancer cases still affects the colon or rectum. The prognosis has improved, with the relative 5‑year survival rate for CRC being approximately 65%. METHODS: This positive trend is probably a result of preventive measures introduced over the last 20 years. This could be further improved, however, as CRC can not only be detected early but in almost all cases also prevented through the identification of benign precursors. Less than half of a…

Helicobacter pylori infection associated with an increased incidence of cholelithiasis: A retrospective real-world cohort study of 50 832 patients.

BACKGROUND AND AIM: Helicobacter pylori (H. pylori) infection is a bacterial disease of the stomach that has been associated with an increased incidence of cholelithiasis. While the updated German guideline emphasizes the relevance of H. pylori as a pathogen and recommends eradication therapy, systematic data on the association between H. pylori infection, its eradication, and the subsequent diagnosis of cholelithiasis in Germany are missing. METHODS: A total of 25 416 patients with and 25 416 propensity score-matched individuals without H. pylori infection were identified from the Disease An…

Patterns of aortic valve replacement in Europe and adoption by sex.

OBJECTIVE: Management of patients with severe aortic stenosis (AS) may differ according to the patient sex. This study aimed to describe patterns of aortic valve replacement (AVR) for severe AS across Europe, including stratification by sex. METHODS: Procedure volume data for surgical aortic valve replacement (SAVR) and transcatheter aortic valve implantation (TAVI) for six years (2015-2020) were extracted from national databases for Austria, Czech Republic, Denmark, England, Finland, France, Germany, Norway, Poland, Spain, Sweden, and Switzerland and stratified by sex. Patients per million p…

Clinical utility of two-step hepatitis E virus IgM antibody testing in a low-prevalence setting: A 10-year retrospective multicenter study.

BACKGROUND: Diagnostic uncertainty caused by the low positive predictive value of HEV-specific IgM antibody (Ab) testing in a low-prevalence setting. We investigated the utility of a two-step HEV IgM Ab testing approach for diagnosing HEV infection. METHODS: We retrospectively reviewed all adults who underwent HEV IgM Ab and/or HEV RNA testing from July 2013 through June 2023 at Mayo Clinic. Two-step HEV IgM testing involved initial testing using recomWell HEV IgM ELISA (Mikrogen, Neuried, Germany), with reflex to recomLine HEV IgM Strip (Mikrogen, Neuried, Germany) on all recomWell HEV IgM-r…

Visual analysis of global hemorrhagic fever with renal syndrome research from 1980 to 2022: Based on CiteSpace and VOSviewer.

OBJECTIVE: The development and current state of hemorrhagic fever with renal syndrome (HFRS) over the past 40 years are analyzed in this stu … in the field of HFRS displayed an overall upward trend from 1980 to 2022. The United States, China, Germany, Sweden, and France are the top 5 countries in terms of publishing volume, with high intermediate centrality mainly concentrated in Europe and the United States. The top 10 co-occurring keywords were hemorrhagic fever, renal syndrome, infection, vir …

Non-alcoholic fatty liver disease (NAFLD) is associated with an increased incidence of chronic kidney disease (CKD).

BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease in the western world. The excess mortality in NAFLD patients is strongly related to extrahepatic comorbidities. Recently, an association between NAFLD and chronic kidney disease (CKD) has been reported in various populations. METHODS: Based on the IQVIA Disease Analyzer database, this retrospective study examined two cohorts from Germany matched for sex, age, index year, annual visit frequency, hypertension, and diabetes, including 92,225 patients with and without NAFLD. The incidence of CKD wa…

Analysis of Various Modalities for Intraocular Pressure Measurement in Relation to Keratoconus Severity in 246 Eyes of the Homburg Keratoconus Center.

PURPOSE: Intraocular pressure (IOP) measurement may be difficult in keratoconus (KC) due to corneal protrusion and irregular astigmatism. This study aimed to assess which IOP measurement modality is least affected by KC severity. METHODS: Data from 246 corneas of 246 patients with KC were retrospectively analyzed. KC stages were determined using the Topographic KC (TKC) and ABCD KC classifications derived from Pentacam (Oculus, Germany). IOP was measured using Goldmann applanation tonometry (GAT), Ocular Response Analyzer (ORA, Reichert Instruments, USA), and Corvis ST (CST, Oculus, Germany).…

Revealing the reporting disparity: VigiBase highlights underreporting of clozapine in other Western European countries compared to the UK.

BACKGROUND: Pharmacovigilance studies indicate clozapine history is marked by adverse drug reactions (ADRs). OBJECTIVE: In a 2021 article, … top 10 causes of fatal outcomes. The UK was compared with 11 other top reporting Western countries (Germany, Denmark, France, Finland, Ireland, Italy, Netherlands, Norway, Spain, Sweden and Switzerland). Nine countries (except Ireland and Switzerland) were compared after controlling for population and clozapine prescriptions. RESULTS: The UK accounted fo …

Extended-spectrum beta-lactamases found in Escherichia coli isolates obtained from blood cultures and corresponding stool specimen.

With extended-spectrum β-lactamases (ESBLs) and CTX-M enzymes being on the rise, antimicrobial treatment of enterobacterial infections is becoming more and more challenging. Our study aimed at a molecular characterization of phenotypically ESBL-positive E. coli strains obtained from blood cultures of patients of the University Hospital of Leipzig (UKL), Germany. The presence of CMY-2, CTX-M-14 and CTX-M-15 was investigated using Streck ARM-D Kit (Streck, USA). Real-time amplifications were performed by QIAGEN Rotor-Gene Q MDx Thermocycler (QIAGEN, Thermo Fisher Scientific, USA). Antibiograms a…

Continuous surveillance of potentially zoonotic avian pathogens detects contemporaneous occurrence of highly pathogenic avian influenza viruses (HPAIV H5) and flaviviruses (USUV, WNV) in several wild and captive birds.

Three avian viral pathogens circulate in Germany with particular importance for animal disease surveillance due to their zoonotic potential, their impact on wild bird populations and/or poultry farms: Highly pathogenic (HP) avian influenza virus (AIV) of subtype H5 (HPAIV H5), Usutu virus (USUV), and West Nile virus (WNV). Whereas HPAIV H5 has been mainly related to epizootic outbreaks in winter, the arthropod-borne viruses USUV and WNV have been detected more frequently during summer months corresponding to peak mosquito activity. Since 2021, tendencies of a potentially year-round, i.e. enzoo…

[Shaded places for skin cancer prevention in kindergartens and schools].

BACKGROUND: Excessive UV radiation from the sun may lead to skin cancer, the most common type of cancer in Germany. Therefore, among other things, the World Health Organization recommends seeking shade during the midday hours from a UV index of 3 (3 to 5 = "moderate"). However, this important preventive measure can only be taken if sufficient shaded areas are available. The aim of the study is to record shaded areas in kindergartens and schools nationwide. METHODS: An epidemiological cross-sectional study with two samples was carried out. Management of kindergartens and schools were surveyed …

Accuracy of indirect bonding trays - a measurement algorithm.

AIM: To present an image-processing measurement algorithm to evaluate the transfer accuracy of indirect bonding (IDB) trays, exemplified by a CAD/CAM-based IDB tray integrated into a digital orthodontic workflow. MATERIALS AND METHODS: Plaster casts of 24 patients with full dentition and different malocclusions were scanned with an intraoral scanner (Trios; 3Shape, Copenhagen, Denmark) to obtain digital models, which served for the virtual placement of orthodontic brackets in simulation software (OnyxCeph; Image Instruments, Chemnitz, Germany). The resulting STL files were sent to a dental la…

Nonalcoholic fatty liver disease is associated with a higher incidence of coeliac disease.

BACKGROUND: Recently the incidence of nonalcoholic fatty liver disease (NAFLD) has risen to become the most frequent liver disease worldwide. NAFLD is not a disease limited to the liver, but rather represents a systemic inflammatory disease involving multiple organ systems. Previous studies have suggested an association between NAFLD and coeliac disease, another disease related to inflammation. As the available clinical data is scarce and at least partially contradictory, we aimed at investigating a potential association between NAFLD and celiac disease in outpatients in Germany. METHODS: Usi…

Incidence of Pediatric Celiac Disease Varies by Region.

INTRODUCTION: The Environmental Determinants of Diabetes in the Young study follows an HLA risk selected birth cohort for celiac disease (CD) development using a uniform protocol. Children under investigation come from 6 different regions within Europe and the United States. Our aim was to identify regional differences in CD autoimmunity and CD cumulative incidence for children born between 2004 and 2010. METHODS: Children (n = 6,628) with DQ2.5 and/or DQ8.1 were enrolled prospectively from birth in Georgia, Washington, Colorado, Finland, Germany, and Sweden. Children underwent periodic study…

Home monitoring of arterial pulse-wave velocity during COVID-19 total or partial lockdown using connected smart scales.

AIMS: To investigate the impact of coronavirus disease 2019 lockdown on trajectories of arterial pulse-wave velocity in a large population of users of connected smart scales that provide reliable measurements of pulse-wave velocity. METHODS AND RESULTS: Pulse-wave velocity recordings obtained by Withings Heart Health & Body Composition Wi-Fi Smart Scale users before and during lockdown were analysed. We compared two demonstrative countries: France, where strict lockdown rules were enforced (n = 26 196) and Germany, where lockdown was partial (n = 26 847). Subgroup analysis was conducted in us…

Serological and molecular characterisation of the most prevalent weak D variants in Croatian population.

INTRODUCTION: Existence of hundreds of RHD gene variants contributes to variable D antigen expression and inconsistencies in reporting the R … lend, and 0,2% (n = 263) confirmed weak D antigen expression. After genomic DNA extraction (Qiaqen, Germany), RHD genotyping was performed using in house reagents and PCR-SSP kits (Inno-Train, Germany). RESULTS: The prevalence of serologically weak D in blood donor population was 0.2% (n = 263). RHD genotyping confirmed weak D allele in 92.4% and partial …