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Conus hip prosthesis.

50 years ago, prosthetic replacement of the hip joint ushered in a new epoch in orthopaedics. Total hip replacement made it possible to remo … others: the longest experience has been with metal/metal articulation with articulatory pairings of cobalt/chromium/molybdenum alloy. In recent years, ceramic/ceramic articulations of aluminium oxide-ceramic and pairings of ceramic with highly crosslinked polyethylene have also been used. With these modern articulations, particle erosion can be reduced a …

Update on Occupational Cancer for Better Cancer Prevention and Control.

Occupational cancer remains an ongoing and emerging issue in cancer prevention and control and is more easily preventable in practice than other causes. As of 2024, changes in various aspects, such as methods for estimating the burden of cancer, evidence on novel carcinogens and classification systems, modernization of working conditions, job characteristics, occupational exposure, and societal changes have played a significant role. Furthermore, advances in technology, including wearable devices, exposome, and biomedical technology, offer more precise methods for identifying the associations

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… Metals: | Pesticides: * Cobalt metal (without tungsten carbide or other metal alloys) (Volume 131) | * Aldrin and dieldrin (Volume 117) * DDT (Volume 113) * Soluble cobalt(II) salts (Volume 131) | * Malathion (Volume 112) * Trivalent antimony (Volume 131) | * Glyphosate (Volume 112) Industrial chemicals …

Carbon-Fiber-Reinforced PEEK Intramedullary Nails Defining the Niche.

BackgroundCarbon-fiber-reinforced Polyetheretherketone (CFR-PEEK) nails are gaining interest as they have biomechanical properties potentially capable of overcoming disadvantages of conventional metal nails.Case summaryThree cases are illustrated which required superior mechanical toughness, compatibility with radiotherapy, and postoperative advanced imaging.ConclusionCFR-PEEK nails seem to have a niche role in distinct groups of patients.

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… Introduction There is no doubt that metals like stainless steel, cobalt-chrome, and titanium alloys have changed the face of orthopaedics over the last decades. …

Tridimensional Matryoshka Tattoo: An Important.

Dear Editor, Tattooing is a global and ancient practice that has endured until the present day. It was originally used to indicate religious … chloride 2% in water, potassium dichromate 0.5%, chromium trichloride 2%, aminoazobenzene-p 0.25%, cobalt chloride 1%, aluminum chloride 2%, titanium dioxide 0.1%, zinc 2.5%, mercury chloride 0.05% in water, kathon cg 0.01% in water, phenol 0.5%, ethylenediamine hydrochloride1%, phenylenediamine base-p 1%, formaldehyde 1% in water, phthalic anhydride 1% …

Association of exposure to multiple heavy metals during pregnancy with the risk of gestational diabetes mellitus and insulin secretion phase after glucose stimulation.

BACKGROUND: Epidemiological evidence for the association between heavy metals exposure during pregnancy and gestational diabetes mellitus (GDM) is still inconsistent. Additionally, that is poorly understood about the potential cause behind the association, for instance, whether heavy metal exposure is related to the change of insulin secretion phase is unknown. OBJECTIVES: We aimed to explore the relationships of blood levels of arsenic (As), lead (Pb), thallium (Tl), nickel (Ni), cadmium (Cd), cobalt (Co), barium (Ba), chromium (Cr), mercury (Hg) and copper (Cu) during early pregnancy with t…

Nur77 activated by hypoxia-inducible factor-1alpha overproduces proopiomelanocortin in von Hippel-Lindau-mutated renal cell carcinoma.

Mutation in the von Hippel-Lindau (VHL) protein associated with renal cell carcinoma causes hypoxia-inducible factor (HIF) to stabilize and consequently to induce various HIF-targeting proteins. In this study, we found that proopiomelanocortin (POMC), an adrenocorticotropic hormone precursor, is up-regulated constitutively in VHL-mutated renal cell carcinoma. A critical transcription factor responsible for POMC overproduction was identified as Nur77, a member of the orphan steroid receptor superfamily. Little is known about how VHL mutation leads to activation of Nur77. We report that Nur77 is

Innovations in chemotherapy and radiation therapy: Implications and opportunities for the Asia-Pacific Rim.

New cases of invasive cancer in the United States occur among nearly 1.5 million people annually. In 2007, more than 1,500 people died per day with this diagnosis. Cancer is responsible for nearly one in every four deaths reported in the country. Enormous amounts of money and research have been, and are being spent, in an attempt to improve these numbers. While prevention and early detection remain the key to long-term success, treatment in the neo-adjuvant, adjuvant and metastatic settings still centre around two main treatment modalities - radiation therapy and chemotherapy. This article wil

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… Cobalt-60) mounted in a gantry head. This form of radiation therapy is still widely used in many parts of the developing world today where access to reliable electricity is problematic. … The vast majority of external beam systems in the developing world, including most of Asia, use ionising radiation from a Cobalt-60 source. …

Cytokine release syndrome and tumor lysis syndrome in a multiple myeloma patient treated with palliative radiotherapy: A case report and review of the literature.

UNLABELLED: We present the case of a 53-year-old woman treated with analgesic radiotherapy for a multiple myeloma bone lesion of the forearm. After a first fraction of 5 Gray (Gy), she presented with an acute respiratory syndrome with fever a few hours after the treatment. The same symptoms occurred after the second fraction 3 days later. The patient recovered quickly thanks to intravenous hydration and suspension of the radiotherapy. Biological tests revealed a tumor lysis syndrome. We concluded that the clinical symptoms could be defined as cytokine release syndrome. This is the second time

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… Hemi body irradiation8.5 Gy 1 fraction | 8.5 Gy | Death | 2000 | 100 mg Hydrocortisone500 mL Hydration | [27] Chronic myeloid leukemia | 38y | Splenic irradiation5 fractions | 3 days after the last fraction | Resolved | 1990 | No | [15] Metastatic medulloblastoma | 34y | Abdominopelvic mass0.1 Gy/day (Cobalt …

Accumulation of HIF-1alpha under the influence of nitric oxide.

The key player for adaptation to reduced oxygen availability is the transcription factor hypoxia-inducible factor 1 (HIF-1), composed of the redox-sensitive HIF-1alpha and the constitutively expressed HIF-1beta subunits. Under normoxic conditions, HIF-1alpha is rapidly degraded, whereas hypoxia, CoCl(2), or desferroxamine promote protein stabilization, thus evoking its transcriptional activity. Because HIF-1 is regulated by reactive oxygen species, investigation of the impact of reactive nitrogen species was intended. By using different nitric oxide (NO) donors, dose- and time-dependent HIF-1a

Silencing of SPARC represses heterotopic ossification via inhibition of the MAPK signaling pathway.

Heterotopic ossification (HO), the pathologic formation of extraskeletal bone, can be disabling and lethal. However, the underlying molecular mechanisms were largely unknown. The present study aimed to clarify the involvement of secreted protein acidic and rich in cysteine (SPARC) and the underlying mechanism in rat model of HO. The mechanistic investigation on roles of SPARC in HO was examined through gain- and loss-of-function approaches of SPARC, with alkaline-phosphatase (ALP) activity, mineralized nodules, and osteocalcin (OCN) content measured. To further confirm the regulatory role of S

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… When the cells had covered the slides, they would be fixed using a cold propyl alcohol for 10 min, followed by incubation at 37°C for up to 4–6 h, immersed in 2% cobalt nitrate for 3–5 min, fixed in 1% ammonium sulfide for 2 min, naturally dried, and sealed. … Go-mori cobalt-modified method was applied to measure the activity of Alkaline-phosphatase (ALP), with the positive sites transforming from brown to black. …

Outcome of transforaminal epidural steroid injection for lumbar radiculopathy: initial three-year experience at Upendra Devkota Memorial-National Institute of Neurological and Allied Sciences, Nepal.

INTRODUCTION: Additional risk minimisation measures (aRMMs) for medicinal products are necessary to address specific important safety issues which may not be practically achieved through routine risk management measures alone. The implementation and determination of effectiveness for aRMMs can be a challenge as it involves multiple stakeholders. It is therefore important to have concise objectives to avoid undue burden on patients, healthcare professionals and the healthcare system. AIM: The aim of this study was to examine how aRMMs are implemented and how effectiveness is assessed in the Eu

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… Vadlamani et al. studied the fabrication of low-cost, rapid, and highly sensitive cobalt-functionalized TiO 2 nanotubes (Co-TNTs)-based electrochemical sensors to detect the SARS-CoV-2 virus. … Cobalt functionalization of TNTs was also done by an incipient wetting method called the wet ion exchange process. The system was connected to a potentiostat to record the data obtained from the experiments. …

Advances in Molecular Imaging and Radionuclide Therapy of Neuroendocrine Tumors.

Neuroendocrine neoplasms make up a heterogeneous group of tumors with inter-patient and intra-patient variabilities. Molecular imaging can help to identify and characterize neuroendocrine tumors (NETs). Furthermore, imaging and treatment with novel theranostics agents offers a new, tailored approach to managing NETs. Recent advances in the management of NETs aim to enhance the effectiveness of targeted treatment with either modifications of known substances or the development of new substances with better targeting features. There have been several attempts to increase the detectability of NET

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… Radionuclide | Emitted Particle | Half-Life | Utilization Carbon-11 | beta blus | 20 min | Imaging Cobalt-55 | beta plus | 17.5 h | Imaging Copper-64 | beta plus beta minus | 12.7 h | Imaging Therapy Gallium-68 | beta plus | 68 min | Imaging Fluorine-18 | beta plus | 120 min | Imaging Actinium-225 | … Significantly improved imaging properties with better contrast and detectability in a mice model in comparison to [ 68 Ga]Ga-DOTA-TATE and [ 64 Cu]Cu-DOTATATE could be reached with Cobalt-55-labelled DOTA-TATE. …

After radiotherapy, do bone metastases from gastrointestinal cancers show response rates similar to those of bone metastases from other primary cancers?

PurposeReports investigating whether the response rates to palliative radiation therapy (RT) for painful bone metastases from gastrointestinal (GI) cancers are similar to rates for bone metastases from other primary cancer sites have been limited. The present study evaluated response rates for symptomatic bone metastases from gi cancers after palliative outpatient rt in the Rapid Response Radiotherapy Program (RRRP).Patients and methodsWe identified 69 patients with bone metastases from gi primaries who received palliative rt in the RRRP clinic during 1999-2006. We extracted records for 31 of

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… Patients were typically treated with a linear accelerator or a cobalt machine. Parallel-opposed fields were used to treat pelvis, limbs, and cranium; a direct oppositional field was used for the thoracic cage and spine. …

Survival and functional outcomes following surgical repair of pathological fractures in dogs: A meta-analysis.

BACKGROUND: Pathological fractures result from abnormal bone remodeling caused by local bone lesions, such as malignant tumors, compromising bone strength. Tumor-derived factors disrupt the balance between bone resorption and formation, leading to osteolytic and osteosclerotic lesions that weaken bone integrity. While surgical treatments, including limb amputation and limb-sparing surgery, are commonly used, the therapeutic efficacy of fracture repair remains unclear due to limited evidence. AIM: This study characterized pathological fractures and evaluated survival time and functional progno

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… Treatment of canine appendicular osteosarcoma using cobalt 60 radiation and intraarterial cisplatin J. Vet. Intern. Med 1991 5 313 316 1779423 10.1111/j.1939-1676.1991.tb03143.x Hodge S.C. Degner D. Walshaw R. Teunissen B. …

Human resources for cancer control in uttar pradesh, India: a case study for low and middle income countries.

For addressing the growing burden of cancer in low and middle income countries, an important first step is to estimate the human resources required for cancer control in a country, province, or city. However, few guidelines are available to decision makers in that regard. Here, we propose a methodology for estimating the human and other resources needed in the state of Uttar Pradesh (UP), India as a case study. Information about the population of UP and its cities was obtained from http://citypopulation.de/. The number of new cancer cases annually for the commonest cancers was estimated from G

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… The minimum radiation therapy equipment requirements for every 1000 patients requiring radiation therapy are at least 1 for each of the following: megavoltage teletherapy unit (linac or cobalt), brachytherapy unit, CT Simulator, treatment planning computer system, and dosimetry/Quality Assurance package …

In vitro synergistic cytoreductive effects of zoledronic acid and radiation on breast cancer cells.

IntroductionBisphosphonates are mostly used in the treatment of bone metastases. They have been shown to act synergistically with other chemotherapeutic agents. It is not known, however, whether similar synergistic effects exist with radiation on breast cancer cells.MethodsHuman MCF-7 breast cancer cells were treated with up to 100 microM zoledronic acid, were irradiated with up to 800 cGy or were exposed to combinations of both treatments to determine the antiproliferative effects of zoledronic acid and radiation.ResultsZoledronic acid and radiation caused a dose-dependent and time-dependent

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… In additional experiments, MCF-7 cells were irradiated with doses of 200, 400, 600, and 800 cGy with a Theratron 780 Cobalt 60 Teletherapy Unit (AECL Medical, Ontario, Canada), with or without incubating the cells, with the stated concentrations of zoledronic acid for 24 and 72 hours to determine an …

Staged Correction of Severe Thoracic Kyphosis in Patients with Multilevel Osteoporotic Vertebral Compression Fractures.

Study Design Technical report. Objective Multilevel osteoporotic vertebral compression fractures may lead to considerable thoracic deformity and sagittal imbalance, which may necessitate surgical intervention. Correction of advanced thoracic kyphosis in patients with severe osteoporosis remains challenging, with a high rate of failure. This study describes a surgical technique of staged vertebral augmentation with osteotomies for the treatment of advanced thoracic kyphosis in patients with osteoporotic multilevel vertebral compression fractures. Methods Five patients (average age 62 ± 6 years)

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… Extra-hard 6-mm cobalt-chrome (CoCr) rods were precontoured and attached to the cephalad foundation screws and cross-linked. … The fatigue life of contoured cobalt chrome posterior spinal fusion rods. Proc Inst Mech Eng H. 2011;225(2):194–198. doi: 10.1243/09544119JEIM763. 52. Serhan H, Mhatre D, Newton P, Giorgio P, Sturm P. …

Air toxics exposure from vehicle emissions at a U.S. border crossing: Buffalo Peace Bridge Study.

The Peace Bridge in Buffalo, New York, which spans the Niagara River at the east end of Lake Erie, is one of the busiest U.S. border crossin … ake-wind sampling days. Other metals (beryllium, sodium, magnesium, potassium, titanium, manganese, cobalt, strontium, tin, cesium, and lanthanum) showed significant increases downwind as well. Sulfur, arsenic, selenium, and a few other elements appeared to be markers for regional transport as their upwind and downwind concentrations were correlated, wit …

Гибридные композитные соединения с оксидами металлов: всеобъемлющий обзор синтеза и многофункциональных видов применения.

В ряде передовых технологий может использоваться разнообразное семейство композитных полимерных (CP) составов с особыми физико-химическими свойствами (MO x). В настоящем исследовании представлен всеобъемлющий обзор комплексных подходов к этим гибридным композитным материалам с уделением особого внимания синергической интеграции оксидов металлов с ХП в целях укрепления их структурной основы, а также их электрических и каталитических свойств. Изучается многофункциональное применение этих материалов, в частности в таких областях, как биомедицинское зондирование, энергосберегающие модули и техноло

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… This is approximately twofold as high as other standard SCs based on activated C electrodes. 198 PPy/NiCoHCF (nickel-cobalt hexacyanoferrate) was synthesized by Wu et al. using an electrochemical process with an inexpensive corrosion-resistant steel template. …

The annual conference of National Cancer Institute - Cairo University "Bridging Gaps in Oncology" : InterContinental Citystars Cairo hotel. 3 - 5 November, 2021.

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… Cobalt chloride at 2mM was added for 16h to induce hypoxia in the cell and induce HIF‑1α. Figure 2 Downregulation of HIF‑1α suppress cell growth, colony formation, increased apoptosis, and the sensitivity of cells to IGF1R inhibition. A. … Cobalt chloride at 2mM was added for 16h to induce hypoxia in the cell and induce HIF‑1α. Figure 2 Downregulation of HIF‑1α suppress cell growth, colony formation, increased apoptosis, and the sensitivity of cells to IGF1R inhibition. A. …