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Small-intestinal cell turnover in patients with parasitic infections.

Small-intestinal deoxyribonucleic acid (DNA) loss rates were measured in six patients with Strongyloides stercoralis hyperinfestation, in four patients with hookworm disease, and in eight normal controls. In the four patients with strongyloidiasis having weight loss, hypoproteinaemia, and oedema the mean DNA loss rates were 73.9, 51.6, 58.0, and 62.2 ng atoms DNA-P/min respectively, which was significantly higher than that of patients with hookworm disease (mean 17.3, S.D. 6.6) or in eight control subjects (mean 14.5, S.D. 7.5). In two of three patients with strongyloidiasis the high DNA loss