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Immune Dysfunction in Uremia 2020.

Cardiovascular disease and infections are major causes for the high incidence of morbidity and mortality of patients with chronic kidney disease. Both complications are directly or indirectly associated with disturbed functions or altered apoptotic rates of polymorphonuclear leukocytes, monocytes, lymphocytes, and dendritic cells. Normal responses of immune cells can be reduced, leading to infectious diseases or pre-activated/primed, giving rise to inflammation and subsequently to cardiovascular disease. This review summarizes the impact of kidney dysfunction on the immune system. Renal failur

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… Thesis Medical University of Vienna Vienna, Austria 2018 193. Deshmukh S. Phillips B.G. O’Dorisio T. Flanigan M.J. Lim V.S. Hormonal responses to fasting and refeeding in chronic renal failure patients Am. J. Physiol. Endocrinol. Metab. 2005 288 E47 E55 10.1152/ajpendo.00163.2004 15304376 194. …

The 46th Annual Meeting of the European Society for Blood and Marrow Transplantation: Physicians Poster Session (P001-P706).

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Construction and validation of renal cell carcinoma tumor cell differentiation-related prognostic classification (RCC-TCDC): an integrated bioinformatic analysis and clinical study.

BackgroundRenal cell carcinoma (RCC) is a heterogeneous malignancy with diverse gene expression patterns, molecular landscapes, and differentiation characteristics of tumor cells. It is imperative to develop molecular RCC classification based on tumor cell differentiation for precise risk stratification and personalized therapy.MethodsWe obtained scRNA-seq profiles from GSE159115 and bulk RNA-seq profiles from TCGA-KIRC cohort. We then performed scRNA-seq cluster analysis, monocle2 pseudotime analysis, and prognostic analysis to obtain tumor cell differentiation-related prognostic genes (TCDGs

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… Statistical analysis All statistical analyses were conducted by R version 4.2.2 (Institute for Statistics and Mathematics, Vienna, Austria; www.r-project.org ), Python version 3.6 software ( https://www.python.org/ ), and Strawberry Perl version 5.30.0.1 software ( https://www.perl.org/ ). …

Melanoma bone metastasis-induced osteocyte ferroptosis via the HIF1α-HMOX1 axis.

Osteocytes are the main cells in mineralized bone tissue. Elevated osteocyte apoptosis has been observed in lytic bone lesions of patients with multiple myeloma. However, their precise contribution to bone metastasis remains unclear. Here, we investigated the pathogenic mechanisms driving melanoma-induced osteocyte death. Both in vivo models and in vitro assays were combined with untargeted RNA sequencing approaches to explore the pathways governing melanoma-induced osteocyte death. We could show that ferroptosis is the primary mechanism behind osteocyte death in the context of melanoma bone m

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… The samples were then embedded in Araldite and sectioned using an ultramicrotome (Reichert Ultracut, Vienna, Austria). …

Временные тенденции и различия в показателях смертности от сердечно-сосудистых заболеваний среди взрослых с множественными миеломами в Соединенных Штатах, 1999-2023.

Новелловые лечебные агенты существенно улучшили выживание многих миэлома (ММ), в результате чего сердечно-сосудистые заболевания (КВД) стали основной причиной смертности, не связанной с раком. Потому что MM в основном затрагивает пожилых людей (средний возраст) 69 ) при повышенном сердечно-сосудистом риске мы сосредоточили внимание на взрослых ≥ 45 Годы. Комплексные национальные данные о временных тенденциях и демографических диспропорциях в смертности, связанной с КЖР, среди пациентов с ОМ остаются ограниченными. Methods Мы провели ретроспективный анализ с использованием данных базы данных CD

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… Analyses were conducted using Joinpoint software (version 5.1.0.0) [ 28 ] and R software (version 4.4.2; R Foundation for Statistical Computing, Vienna, Austria). Two-sided P < 0.05 was considered statistically significant. …

The 48th Annual Meeting of the European Society for Blood and Marrow Transplantation: Physicians - Poster Session (P001 - P578).

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The Proceedings of the 19th International Cancer Imaging Society Meeting and Annual Teaching Course : Verona, Italy. 7 - 9 October 2019.

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… Schima Göttlicher Heiland Krankenhaus, Barmherzige Schwestern Krankenhaus, Sankt Josef Krankenhaus, Vinzenzgruppe, Vienna, Austria Differentiation between pancreatic ductal adenocarcinoma (PDAC) and mass-forming pancreatitis is of utmost importance, as the two entities require completely different … Herold Department of Biomedical Imaging and image-guided Therapy, Medical University of Vienna, Vienna, Austria Pulmonary nodules are a common finding in daily clinical practice and occur in patients with or without none underlying diseases or disorders. …

Hematology and Immune-Related Disorders

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… (Southeast) 812 98.5 1.5 0 US (Southwest) 483 97.5 2.5 0 US (West Coast) 812 94.8 4.7 0 Germany (Berlin and Brandenburg area) 372 98.7 1.1 0.3 Denmark (Copenhagen area) 105 98.1 1.9 0 Argentina (Buenos Aires area) 76 96.1 2.6 1.3 Brazil (Rio de Janeiro area) 172 94.8 2.9 2.3 Scotland 70 97.1 2.9 0 Austria … 0 US (West Coast) | 812 | 94.8 | 4.7 | 0 Germany (Berlin and Brandenburg area) | 372 | 98.7 | 1.1 | 0.3 Denmark (Copenhagen area) | 105 | 98.1 | 1.9 | 0 Argentina (Buenos Aires area) | 76 | 96.1 | 2.6 | 1.3 Brazil (Rio de Janeiro area) | 172 | 94.8 | 2.9 | 2.3 Scotland | 70 | 97.1 | 2.9 | 0 Austria …

Global, regional, and national disability-adjusted life-years (DALYs) for 333 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016.

BACKGROUND: Measurement of changes in health across locations is useful to compare and contrast changing epidemiological patterns against health system performance and identify specific needs for resource allocation in research, policy development, and programme decision making. Using the Global Burden of Diseases, Injuries, and Risk Factors Study 2016, we drew from two widely used summary measures to monitor such changes in population health: disability-adjusted life-years (DALYs) and healthy life expectancy (HALE). We used these measures to track trends and benchmark progress compared with e

Oral Presentations

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Bispecific antibodies in the treatment of epithelial ovarian, endometrial, and cervical cancer: an overview of current applications, challenges, and emerging opportunities.

Gynecological cancer remains one of the leading causes of mortality worldwide. Recent advances in genomic and molecular sequencing have significantly enhanced our understanding of the biological pathways that drive tumor progression and resistance to therapy. Targeted therapies, including monoclonal antibodies (mAbs), have revolutionized cancer treatment by selectively interfering with oncogenic proteins expressed on cancer cells. However, the long-term clinical benefit is often limited due to the emergence of drug resistance, frequently mediated by compensatory signaling pathways or immune es

Therapeutic Vaccination in Head and Neck Squamous Cell Carcinoma-A Review.

Therapeutic vaccination is one of the most effective immunotherapeutic approaches, second only to immune checkpoint inhibitors (ICIs), which have already been approved for clinical use. Head and neck squamous cell carcinomas (HNSCCs) are heterogenous epithelial tumors of the upper aerodigestive tract, and a significant proportion of these tumors tend to exhibit unfavorable therapeutic responses to the existing treatment options. Comprehending the immunopathology of these tumors and choosing an appropriate immunotherapeutic maneuver seems to be a promising avenue for solving this problem. The c

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… HB-201 and HB-202 HB-201 and HB-202 are two live-attenuated vectors (TheraT ® Vectors, Hookipa Biotech GmbH, Vienna, Wien, Austria) based on the lymphocytic choriomeningitis virus and Pichinde virus, respectively, that express the same non-oncogenic HPV16 E7E6 fusion protein and infect APCs to induce …

Emerging agents and regimens for multiple myeloma.

The outcomes of multiple myeloma (MM) have been improved significantly with the therapies incorporating proteasome inhibitors (PI), immunomodulatory drugs, monoclonal antibodies (MoAb) and stem cell transplantation. However, relapsed and refractory MM (RRMM) remains a major challenge. Novel agents and regimens are under active clinical development. These include new PIs such as ixazomib, marizomib, and oprozomib; new MoAbs such as isatuximab and MOR202; novel epigenetic agent ricolinostat and novel cytokines such as siltuximab. Recently, the first XPO-1 inhibitor, selinexor, was approved for R

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… A multicenter, open-label phase I/II trial in Germany and Austria on patients with RRMM explored the safety of MOR202 ( NCT01421186 ). …

Patient-reported outcome measures of the impact of cancer on patients' everyday lives: a systematic review.

PurposePatients with advanced disease are living longer and commonly used patient-reported outcome measures (PROMs) may miss relevant elements of the quality of extended survival. This systematic review examines the measures used to capture aspects of the quality of survival including impact on patients' everyday lives such as finances, work and family roles.MethodsSearches were conducted in MEDLINE, EMBASE, CINAHL and PsycINFO restricted to English language articles. Information on study characteristics, instruments and outcomes was systematically extracted and synthesised. A predefined set o

ROS 2020 Abstract

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Lysosomal storage diseases.

Lysosomes are cytoplasmic organelles that contain a variety of different hydrolases. A genetic deficiency in the enzymatic activity of one of these hydrolases will lead to the accumulation of the material meant for lysosomal degradation. Examples include glycogen in the case of Pompe disease, glycosaminoglycans in the case of the mucopolysaccharidoses, glycoproteins in the cases of the oligosaccharidoses, and sphingolipids in the cases of Niemann-Pick disease types A and B, Gaucher disease, Tay-Sachs disease, Krabbe disease, and metachromatic leukodystrophy. Sometimes, the lysosomal storage ca

Advances in the clinical application of bispecific antibodies in cancer therapy.

Cancer immunotherapy has emerged as one of the most groundbreaking advancements. However, the tumor microenvironment (TME) is often dominated by various immunosuppressive factors, compromising the efficacy of single-target therapies, leading to non-responsiveness or resistance. Bispecific antibodies (BsAbs) represent an innovative immunotherapeutic strategy with enormous potential for improving cancer treatment outcomes. Unlike monoclonal antibodies, BsAbs can concurrently inhibit multiple pro-tumor pathways, target immune checkpoints to mitigate resistance, and bind to two distinct antigens,

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… Austria Mislang A.R. Lemech C. Nagrial A. Underhill C. Wang W. Wang Z.M. Li B. Xia Y. Coward J.I.G. Phase 1a dose escalation study of ivonescimab (AK112/SMT112), an anti-PD-1/VEGF-A bispecific antibody, in patients with advanced solid tumors J. Immunother. …

Patient-reported outcome measures to detect intentional, mixed, or unintentional non-adherence to medication: a systematic review.

ObjectiveTo categorise patient-reported outcome measures (PROMs) into their propensity to detect intentional and/or unintentional non-adherence to medication, and synthesise their psychometric properties.DesignSystematic review and regression analysis.EligibilityMedication adherence levels studied at primary, secondary and tertiary care settings. Self-reported measures with scoring methods were included. Studies without proxy measures were excluded.Data sourcesUsing detailed searches with key concepts including questionnaires, reliability and validity, and restricted to English, MEDLINE, EMBAS

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… short or extended period) | Adherent or non-adherent Patients who claimed to be taking medications every day were classified as adherent | Dichotomised scale: yes=0; no=1 | Good determinant validity, no report on reliability | Hypertensives among blue collar employees in 3 central European countries: Austria …

Repurposing anticancer drugs for the management of COVID-19.

Since its outbreak in the last December, coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 has rapidly spread worldwide at a pandemic proportion and thus is regarded as a global public health emergency. The existing therapeutic options for COVID-19 beyond the intensive supportive care are limited, with an undefined or modest efficacy reported so far. Drug repurposing represents an enthusiastic mechanism to use approved drugs outside the scope of their original indication and accelerate the discovery of new therapeutic options. With the emergence of COVID-19, drug repurposing has been la

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… | Measurement of the daily O 2 requirements | January 2021 Saracatinib | Antiviral properties | Possible blockade of endocytic pathways and nucleocapsid protein | No | – | – | – | – Selinexor | Antiviral and anti-inflammatory properties | Blockade of nucleocytoplasmic transport | Yes (USA, France, Austria …

Cyclic Peptides in Modern Drug Discovery: Trends and Therapeutic Directions.

Peptide therapeutics are an important drug modality due to their high specificity, favorable safety, and expanding design potential. Among them, cyclic peptides occupy a space between small molecules and biologics, offering improved rigidity, stability, and target engagement. This report analyzes trends in cyclic peptide research using data from the CAS Content Collection over the past two decades. Results show a steady rise in academic publications and patents, reflecting growing interest across discovery and development. Notably, oral administration is gaining attention, indicating progress

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… . | NCT05210790 | Phase III/Active | Protagonist Therapeutics, USA Solnatide (AP301) | 259206–53–6 | ARDS | 1,923.10 | ENaC | Inhalation | NCT03567577 | Phase II | APEPTICO, Austria Sulanemadlin (ALRN-6924) | 1451199–98–6 | Advanced solid tumors, lymphomas | 1,930.25 | MDM2/MDMX (p53 activator) | I.V …