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Карта знаний об искусственном интеллекте в нейродегенеративных болезнях: исследование библиометрии и визуализации на протяжении десяти лет.

По мере увеличения заболеваемости нейродегенеративными заболеваниями соответствующие исследования ИИ становятся все более и более передовыми. В этом исследовании мы анализируем литературу в этой области за последнее десятилетие с помощью методов библиометрии и визуализации с целью разработки известных журналов, институтов, авторов и стран в этой области и анализа ключевых слов, с тем чтобы предположить возможные будущие тенденции в области исследований. МЕТОДЫ: Извлечено наше исследование 1,921 соответствующие публикации, охватывающие 2015-2025 из базы данных " Web of Science Core Collect

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… Zone 1 JOURNAL OF ALZHEIMERS DISEASE 10 26 388 Zone 1 FRONTIERS IN NEUROLOGY 11 25 413 Zone 1 PLOS ONE 12 25 438 Zone 1 APPLIED SCIENCES-BASEL 13 24 462 Zone 1 NEUROIMAGE-CLINICAL 14 21 483 Zone 1 DIAGNOSTICS 15 20 503 Zone 1 HUMAN BRAIN MAPPING 16 18 521 Zone 1 IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS …

Sintilimab (anti-PD-1 antibody) combined with high-dose methotrexate, temozolomide, and rituximab (anti-CD20 antibody) in primary central nervous system lymphoma: a phase 2 study.

Primary central nervous system lymphoma (PCNSL) is a rare and frequently fatal lymphoma subtype. The programmed death-1 (PD-1) pathway has emerged as a potential therapeutic target, but the effectiveness of PD-1 antibody sintilimab in combination with immunochemotherapy as a frontline treatment for PCNSL remains to be determined. In this phase 2 trial (ChiCTR1900027433) with a safety run-in, we included patients aged 18-70 with newly diagnosed PCNSL. Participants underwent six 21-day cycles of a SMTR regimen, which includes sintilimab (200 mg, Day 0), rituximab (375 mg/m2, Day 0), methotrexate

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… Detailed information on the sequencing assays and informatics pipeline can be found in the Supplementary file 1 . …

ProTarget: a Danish Nationwide Clinical Trial on Targeted Cancer Treatment based on genomic profiling - a national, phase 2, prospective, multi-drug, non-randomized, open-label basket trial.

BackgroundAn increasing number of trials indicate that treatment outcomes in cancer patients with metastatic disease are improved when targeted treatments are matched with druggable genomic alterations in individual patients (pts). An estimated 30-80% of advanced solid tumors harbor actionable genomic alterations. However, the efficacy of personalized cancer treatment is still scarcely investigated in larger, controlled trials due to the low frequency and heterogenous distribution of druggable alterations among different histologic tumor types. Therefore, the overall effect of targeted cancer

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… Research electronic data capture (REDCap)-a metadata-driven methodology and workflow process for providing translational research informatics support. J Biomed Inform. 2009;42(2):377–381. doi: 10.1016/j.jbi.2008.08.010. 26. Harris PA, Taylor R, Minor BL, Elliott V, Fernandez M, O’Neal L, et al. …

Trametinib in Patients With NF1-, GNAQ-, or GNA11-Mutant Tumors: Results From the NCI-MATCH ECOG-ACRIN Trial (EAY131) Subprotocols S1 and S2.

PURPOSE: NCI-MATCH is a precision medicine trial using genomic testing to allocate patients with advanced malignancies to targeted treatment subprotocols. This report combines two subprotocols evaluating trametinib, a MEK1/2 inhibitor, in patients with Neurofibromatosis 1 (NF1[S1] or GNA11/Q [S2]) altered tumors. METHODS: Eligible patients had tumors with deleterious inactivating NF1 or GNA11/Q mutations by the customized Oncomine AmpliSeq panel. Prior MEK inhibitor treatment was excluded. Glioblastomas (GBMs) were permitted, including malignancies associated with germline NF1 mutations (S1 o

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… Patients were assigned to subprotocols using the National Cancer Institute (NCI) Precision Medicine Platform (MATCHBOX) that runs a prospectively defined, NCI-designed informatics rules algorithm, as previously described. 20 , 21 For subprotocol S1, patients whose tumors contained a deleterious, inactivating …

A Molecular Signature of Circulating MicroRNA Can Predict Osteolytic Bone Disease in Multiple Myeloma.

BACKGROUND: Multiple myeloma bone disease (MMBD) constitutes a common and severe complication of multiple myeloma (MM), impacting the quality of life and survival. We evaluated the clinical value of a panel of 19 miRNAs associated with osteoporosis in MMBD. METHODS: miRNAs were isolated from the plasma of 62 newly diagnosed MM patients with or without MMBD. First-strand cDNA was synthesized, and relative quantification was performed using qPCR. Lastly, we carried out extensive biostatistical analysis. RESULTS: Circulating levels of let-7b-5p, miR-143-3p, miR-17-5p, miR-214-3p, and miR-335-5p

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… X-tile: A new bio-informatics tool for biomarker assessment and outcome-based cut-point optimization Clin. Cancer Res. 2004 10 7252 7259 10.1158/1078-0432.CCR-04-0713 15534099 34. Artemaki P.I. Papatsirou M. Boti M.A. Adamopoulos P.G. Christodoulou S. Vassilacopoulou D. Scorilas A. Kontos C.K. …

Outcomes of patients with hematologic malignancies and COVID-19: a report from the ASH Research Collaborative Data Hub.

Coronavirus disease 2019 (COVID-19) is an illness resulting from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that emerged in late 2019. Patients with cancer, and especially those with hematologic malignancies, may be at especially high risk of adverse outcomes, including mortality resulting from COVID-19 infection. The ASH Research Collaborative COVID-19 Registry for Hematology was developed to study features and outcomes of COVID-19 infection in patients with underlying blood disorders, such as hematologic malignancies. At the time of this report, data from 250 patients with

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… This approach would allow for informatics-based approaches to facilitate case identification through flags in structured electronic health record data. …

Core elements of serious illness conversations: an integrative systematic review.

BackgroundAriadne Labs' Serious Illness Care Program (SICP), inclusive of the Serious Illness Conversation Guide (SICG), has been adapted for use in a variety of settings and among diverse population groups. Explicating the core elements of serious illness conversations could support the inclusion or exclusion of certain components in future iterations of the programme and the guide.AimThis integrative systematic review aimed to identify and describe core elements of serious illness conversations in relation to the SICP and/or SICG.DesignLiterature published between 1 January 2014 and 20 March

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… Health Informatics. 2022 doi: 10.1101/2021.08.20.21262082. Preprint. 67. Xu L, Sommer RK, Nyeko L, et al. Patient perspectives on serious illness conversations in primary care. J Palliat Med. 2022;25:940–4. doi: 10.1089/jpm.2021.0420. 68. Ouchi K, Lawton AJ, Bowman J, et al. …

Effect of recombinant human nerve growth factor treatment on corneal nerve regeneration in patients with neurotrophic keratopathy.

IntroductionNeurotrophic Keratopathy (NK) is a neurodegenerative corneal disease that results in diminished corneal sensation. Previous studies have found that Cenegermin 0.002%, a recombinant human nerve growth factor (rhNGF), improves corneal epithelial healing in stage 2 and 3 NK patients. However, rhNGF effect on corneal sensation and nerve regeneration has not been well established. Thus, this study aims to analyze the effect of rhNGF on corneal nerve regeneration using in vivo confocal microscopy (IVCM) and on corneal sensitivity in NK patients.MethodsThis is a retrospective, longitudina

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… Research electronic data capture (REDCap)--a metadata-driven methodology and workflow process for providing translational research informatics support . J. Biomed. Inform. 42 , 377 – 381 . doi: 10.1016/j.jbi.2008.08.010 , PMID: 18929686 PMC2700030 Holladay J. T. ( 1997 ). …

Finite Element Analysis of Osteoporotic and Osteoblastic Vertebrae and Its Association With the Proton Density Fat Fraction From Chemical Shift Encoding-Based Water-Fat MRI - A Preliminary Study.

PurposeOsteoporosis is prevalent and entails alterations of vertebral bone and marrow. Yet, the spine is also a common site of metastatic spread. Parameters that can be non-invasively measured and could capture these alterations are the volumetric bone mineral density (vBMD), proton density fat fraction (PDFF) as an estimate of relative fat content, and failure displacement and load from finite element analysis (FEA) for assessment of bone strength. This study's purpose was to investigate if osteoporotic and osteoblastic metastatic changes in lumbar vertebrae can be differentiated based on the

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… Segmentation was performed on the PDFF maps using the open-source software MITK ( http://mitk.org/wiki/The_Medical_Imaging_Interaction_Toolkit_(MITK) ; German Cancer Research Center, Division of Medical and Biological Informatics, Medical Imaging Interaction Toolkit, Heidelberg, Germany) ( 63 ). …

Informal caregivers' quality of life and management strategies following the transformation of their cancer caregiving role: A qualitative systematic review.

ObjectivesGlobally, informal caregivers caring for cancer patients meet challenges within their caregiving role, which significantly influence their quality of life. This qualitative systematic review aimed to analyze how cancer caregiving influence the quality of life of informal caregivers and the management strategies of informal caregivers for their role as cancer caregivers.MethodsFollowing the enhancing transparency in reporting the synthesis of qualitative research (ENTREQ) statement, Wanfang database, the China National Knowledge Infrastructure (CNKI), CINAHL, MEDLINE, PubMed, Cochrane

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… Effects of eHealth for patients and informal caregivers confronted with cancer: a meta-review Int J Med Informatics 87 2016 54 67 10.1016/j.ijmedinf.2015.12.013 26806712 55 Doorenbos A.Z. Jang M.K. Li H.J. …

Specialist palliative and end-of-life care for patients with cancer and SARS-CoV-2 infection: a European perspective.

BACKGROUND: Specialist palliative care team (SPCT) involvement has been shown to improve symptom control and end-of-life care for patients with cancer, but little is known as to how these have been impacted by the COVID-19 pandemic. Here, we report SPCT involvement during the first wave of the pandemic and compare outcomes for patients with cancer who received and did not receive SPCT input from multiple European cancer centres. METHODS: From the OnCovid repository (N = 1318), we analysed cancer patients aged ⩾18 diagnosed with COVID-19 between 26 February and 22 June 2020 who had complete sp

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… Research electronic data capture (REDCap)—A metadata-driven methodology and workflow process for providing translational research informatics support. J Biomed Inform 2009; 42: 377–381. 20. World Health Organization. Clinical management of COVID-19: interim guidance. …

Efficacy and safety of venous angioplasty of the extracranial veins for multiple sclerosis. Brave dreams study (brain venous drainage exploited against multiple sclerosis): study protocol for a randomized controlled trial.

BackgroundMultiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system with a disabling progressive course. Chronic cerebrospinal venous insufficiency (CCSVI) has recently been described as a vascular condition characterized by restricted venous outflow from the brain, mainly due to blockages of the internal jugular and azygos veins. Despite a wide variability among studies, it has been found to be associated with MS. Data from a few small case series suggest possible improvement of the clinical course and quality of life by performing percutaneous ball

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… In particular, centers will have access only to data relative to their own center, whereas the center responsible for informatics infrastructure of the CRO and the member of the DCC responsible for quality will have online access to the entire database to perform periodic quality checks. …

Forecasting drug utilization and expenditure in a metropolitan health region.

BackgroundNew pharmacological therapies are challenging the healthcare systems, and there is an increasing need to assess their therapeutic value in relation to existing alternatives as well as their potential budget impact. Consequently, new models to introduce drugs in healthcare are urgently needed. In the metropolitan health region of Stockholm, Sweden, a model has been developed including early warning (horizon scanning), forecasting of drug utilization and expenditure, critical drug evaluation as well as structured programs for the introduction and follow-up of new drugs. The aim of this

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… We particularly express our gratitude to Tore Andersson, Göran Holm, Margaretha Julander, Bo Ringertz and Maria von Witting from the Department of Drug Management and Informatics and Henrik Almkvist and Gunilla Thörnwall-Bergendahl at the Department of Finance and Planning, both Stockholm County Council …

The Proceedings of the 19th International Cancer Imaging Society Meeting and Annual Teaching Course : Verona, Italy. 7 - 9 October 2019.

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… In addition, it is also more difficult for radiologists to learn about these techniques, as the language of engagement is through mathematics and informatics, which are unfamiliar to most radiologists. … Prior (FWPrior@uams.edu) Department of Biomedical Informatics, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA Artificial Intelligence (AI) and machine learning (ML) are not new to medicine or medical imaging. …

Dyslexia Data Consortium Repository: A Data Sharing and Delivery Platform for Research.

Specific learning disability of reading, or dyslexia, affects 5-17% of the population in the United States. Research on the neurobiology of dyslexia has included studies with relatively small sample sizes across research sites, thus limiting inference and the application of novel methods, such as deep learning. To address these issues and facilitate open science, we developed an online platform for data-sharing and advanced research programs to enhance opportunities for replication by providing researchers with secondary data that can be used in their research (https://www.dyslexiadata.org). T

Прогнозирование релапирования и индивидуализированная модель лечения-воздействия при повторном склерозе: систематический обзор.

ВВЕДЕНИЕ: Индивидуальное прогнозирование результатов, связанных с рецидивом, может способствовать отбору и мониторингу лечения при повторном склерозе. Однако существующие исследования существенно отличаются друг от друга по клиническим целям, целевым результатам, подходам к моделированию и стратегиям проверки. МЕТОДЫ: Мы провели систематический обзор в соответствии с ПРИСМА 2020. Пубмед, Web of Science, IEEE Xplore и Scopus были найдены записи на английском языке, опубликованные на английском языке. 1 Январь 2010 в адрес 14 Январь 2026. Были включены исследования по разработке или оценке модел

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… Health Informatics. Cham: Springer International Publishing ( 2024 ). p. 477–524 doi: 10.1007/978-3-031-39355-6_10 39836821 33. Goetz L Seedat N Vandersluis R Van Der Schaar M . …

Machine Learning for Differentiating Essential Tremor: A Scoping Review.

BackgroundEssential tremor (ET) is the most common movement disorder, affecting ~6% of adults over 65 [1]. Differentiating ET from other tremors remains clinically challenging due to overlapping features and variable presentation. Artificial intelligence (AI), particularly machine learning (ML), has emerged a potential tool to support neurologists by enhancing pattern recognition and complementing traditional assessments in complex cases. This is the first scoping review examining ML's potential role in distinguishing essential tremor from other tremor types.MethodsA systematic, scoping search

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… In: 2020 IEEE International Conference on Healthcare Informatics (ICHI). Oldenburg, Germany; 2020. pp. 1–5. DOI: 10.1109/ICHI48887.2020.9374333 53. Shahtalebi S, Atashzar SF, Patel RV, Jog MS, Mohammadi A.. …

Effects of web-based interventions on cancer caregivers’ burden and quality of life: A systematic review and meta-analysis

Abstract Objectives As cancer incidence and survival rates rise, caregivers responsible for providing diverse support face increased burden and reduced quality of life (QoL). Although research on web-based interventions for this group is expanding, the impact of these interventions on caregiver burden and QoL remains unclear. This study aims to investigate the effects of web-based interventions on the caregiver burden and QoL of caregivers of patients with cancer. Methods Searches were conducted in PubMed, Web of Science, Cochrane Library, CINAHL, Embase, and PsycINFO from database inception t

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… International Journal of Medical Informatics 134 , 104003 . doi: 10.1016/j.ijmedinf.2019.104003 . 31790857 Maziyya N , Rahayuwati L , and Yamin A ( 2018 ) Quality of life of family caregiver of cancer patient: a literature review . …

A data-driven model of disability progression in progressive multiple sclerosis.

This study applies the Gaussian process progression model, a Bayesian data-driven disease progression model, to analyse the evolution of primary progressive multiple sclerosis. Utilizing data from 1521 primary progressive multiple sclerosis participants collected within the International Progressive Multiple Sclerosis Alliance Project, the analysis includes 18 581 longitudinal time-points (average follow-up time: 28.2 months) of disability assessments including the expanded disability status scale, symbol digit modalities, timed 25-foot-walk, 9-hole-peg test and of MRI metrics such as T1 and T

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… F.B. received the 2022 Biostatistic/Informatics Junior Faculty Award (grant code BI-2107-38160) awarded by the National Multiple Sclerosis Society. Competing interests S.G., F.B., ML, MPi and AU and have nothing to disclose. …

Abstracts from the World Congress of Cardiology/Brazilian Congress of Cardiology 2022

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