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Interstitial Lung Disease and Pulmonary Fibrosis: A Practical Approach for General Medicine Physicians with Focus on the Medical History.

Interstitial lung disease (ILD) and pulmonary fibrosis comprise a wide array of inflammatory and fibrotic lung diseases which are often confusing to general medicine and pulmonary physicians alike. In addition to the myriad of clinical and radiologic nomenclature used in ILD, histopathologic descriptors may be particularly confusing, and are often extrapolated to radiologic imaging patterns which may further add to the confusion. We propose that rather than focusing on precise histologic findings, focus should be on identifying an accurate etiology of ILD through a comprehensive and detailed m

Primary Amyloidosis Unmasked by Gastric Biopsy: A Case Report.

Amyloidosis is a broad category of diseases characterized by the extracellular accumulation of misfolded fibrillar proteins, which disrupt organ architecture and causes cellular toxicity. This ultimately results in vascular compromise and progressive organ dysfunction. Despite advances in serum free light chain assays and imaging modalities, diagnostic delays persist due to the underestimation of early signs and the need for multidisciplinary correlation. Our case report highlights a unique case of a patient with systemic AL amyloidosis involving the gastrointestinal (GI) system, who initially

Relevant parameters for recommendations of physical activity in patients suffering from multiple myeloma : A pilot study.

PURPOSE: This pilot study aimed to describe physical performance, self-reported physical activity, health-related quality of life, anxiety and depression in patients who were assigned from Austrian self-help groups for multiple myeloma patients. These parameters were then discussed in the context of clinical decision-making concerning the recommended type of regular physical activity and exercise. METHODS: Members of the self-help groups were invited to participate. Physical performance and physical activity were assessed with the 6 min walk test (6MWT), handgrip strength test, timed up and g

Расследование случайной или причинно-следственной связи церебрального венозного тромбоза и миэлина олигодендроцита гликопротеина противомоскитного заболевания: доклад о деле и обзор литературы.

Myelin oligodendrocyte glycoprotein-сопутствующая антителу болезнь (MOGAD) — синдром демиелинирования центральной нервной системы (DS), обычно содержащий оптический неуриит или миелит. Связь между церебральным венозным тромбозом (CVT) и демиелинизирующими заболеваниями, включая множественный склероз (MS), является редкой. В настоящем исследовании 37-летний мужчина столкнулся с сенсорными нарушениями нижних конечностей и недержанием мочевого мозга в соответствии с миелитом. Диагностика MOGAD была подтверждена результатами наблюдений спинного магнитного резонанса и сывороткой антиМОГ с помощью к

Global Cancer Inequalities.

Social inequalities in cancer are increasingly relevant to research, implementation science, and policy. In this brief perspective we provide an overview of global cancer inequalities by assessing different outcomes according to the Human Development Index (HDI); the HDI is a United Nations Development Programme composite indicator including the following measures: (i) access to education (based on mean and expected years of schooling), (ii) a long and healthy life (based on life expectancy), and (iii) a decent standard of living (based on gross national income per capita). We additionally tou

Exploring the Vasculitis-Tumors Link: Epidemiological Patterns, Mechanistic Insights, and Clinical Implications.

This review systematically examines the association between vasculitis and malignancies by summarizing the risk of tumor-associated vasculitis, their clinical characteristics, and proposed pathogenic mechanisms across different vasculitic subtypes. Relevant case reports and mechanistic studies are integrated to provide a comprehensive overview of this entity. The findings offer practical value for rheumatologists in distinguishing primary vasculitis from malignancy-associated forms and optimizing patient surveillance, and for oncologists in improving recognition of tumor-associated vasculitis

Unlocking the potential of CD70 as a novel immunotherapeutic target for non-small cell lung cancer.

Although normally restricted to activated T and B cells and mature dendritic cells, constitutive expression of CD70, a member of the tumor necrosis family, has been described in both hematological and solid tumors, where it increases tumor cell and regulatory T cell survival by signaling through its receptor, CD27.We have assessed the co-expression of CD70 and CD27 in non-small cell lung cancer (NSCLC) by immunohistochemistry to explore a correlation between expression of the protein and tumor histologic subtype, genetic aberrations and prognosis. Furthermore, we tested the ability of ARGX-110

An unusual cause of gross hematuria and renal dysfunction in a young male.

Monoclonal immunoglobulin deposition disease (MIDD) is an uncommon disease with a peak incidence between the 5(th) and 6(th) decades of life. It is characterized by non-fibrillar, Congo red negative deposition of monoclonal immunoglobulins in various organs, including in the kidneys. MIDD can be of three types depending on the composition of the deposits, and includes light chain deposition disease (LCDD), heavy chain deposition disease and light and heavy chain deposition disease, of which LCDD is the most common. Renal involvement is a universal finding in MIDD, and is in the form of renal i

Skeletal-related events and overall survival of patients with bone metastasis from nonsmall cell lung cancer - A retrospective analysis.

Because of improving treatments and survival, 40% to 58% of patients with bone metastases from nonsmall cell lung cancer (NSCLC) will suffer from at least one skeletal-related event (SRE), affecting their quality of life, but the natural history of SRE is poorly understood. The study aimed to examine the factors involved in SRE-free survival (SRS) and overall survival (OS) of patients with NSCLC and bone metastases.This was a retrospective study of 211 patients with bone metastasis from NSCLC and treated at the Tumor Hospital Affiliated to Harbin Medical University between January 2007 and Jan

Ассоциация неизгладимых неблаговидных мероприятий, связанных с эффективностью иммунных контрольно-пропускных пунктов и общим выживанием в раковых заболеваниях: системный обзор и метаанализ.

ЦЕЛИ: Ингибиторы на контрольно-пропускных пунктах иммунного типа (ИПК) приносят значительные выгоды пациентам, страдающим раком, несмотря на то, что они часто сопровождаются неблагоприятными иммунными явлениями (ОРАЭ). Мы поставили перед собой цель изучить связь IRAE с эффективностью и общим выживанием у больных раком, которые проходят лечение в рамках ICI, и еще больше количественно оценить эту связь за счет стратификации подгрупп. МЕТОДЫ: Пубмед, ЭМБАСЕ и Кокрейнская библиотека с момента создания базы данных 29 Август 2019 систематически подвергались обыску. Были включены статьи, содержащие

Совпадение в полном тексте источника
… The latter study noted that the survival advantage could be partially explained by a higher proportion of non-smokers among Asian patients with lung cancer (proportion of never-smokers was 24.5% in Asian ethnicity, while 14.2% in Hispanic, 7.6% in White and 5.4% in African American ethnicity). …

Targeting the AMP-Activated Protein Kinase for Cancer Prevention and Therapy.

Despite the advances in biomedical research and clinical applications, cancer remains a leading cause of death worldwide. Given the limitations of conventional chemotherapeutics, including serious toxicities and reduced quality of life for patients, the development of safe and efficacious alternatives with known mechanism of action is much needed. Prevention of cancer through dietary intervention may hold promise and has been investigated extensively in the recent years. AMP-activated protein kinase (AMPK) is an energy sensor that plays a key role in the regulation of protein and lipid metabol

Undifferentiated Intimal Sarcoma of the Large Abdominal Arteries Presenting As Acute Mesenteric Ischemia: A Case Report.

Primary malignant tumors of the large arteries are exceedingly rare and diagnostically challenging. Undifferentiated intimal sarcomas and leiomyosarcomas are the major types encountered. Intimal sarcomas are highly aggressive neoplasms characterized by intraluminal growth and a tendency to mimic thromboembolic disease, often resulting in delayed diagnosis and poor outcomes. We report the case of a 63-year-old man who presented with progressive abdominal pain and weight loss and rapidly developed acute mesenteric ischemia due to extensive intraluminal obstruction of the descending and abdominal

SEDCYDO - SGER - SEMO ConГРЕСС МАДРИД 2025, 8-10 Возможно. Ход работы и резюме.

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Многомерное пространственное воздействие на толщину сетчатки АИ с высоким разрешением.

Толщина сетчатки является показателем здоровья сетчатки и в более широком плане рассматривается как перспективный биомаркер многих системных заболеваний. Измерения толщины сетчатки производятся на основе оптической последовательности томографии (OCT) в рамках плановой клинической офтальмологии. Мы обработали снимки Biobank OCT в Великобритании с помощью нервной сети для проведения мелких измерений толщины сетчатки по всей стране. > 29,000 Очки в макуле, часть сетчатки, ответственная за центральное зрение человека. Макула в непропорционально большой степени страдает от таких серьезных заболеван

Development of an Electronic Medical Record-Based Score for Heart Failure Prediction in Cancer Survivors.

BackgroundAwareness of heart failure (HF) as a long-term complication of cancer has led to an interest in HF surveillance among survivors. However, existing HF risk scores are not tailored for survivors and not designed for the use in electronic medical records (EMRs) or administrative data sets where clinical data such as blood pressure and pathology results are often unavailable.ObjectivesThe objective of the study is to develop a cancer-specific incident HF risk score suitable for screening in EMR or administrative data sets.MethodsThe cancer-specific HF prediction from EMRs in survivor hea

Резюме докладов 38th - ежегодное собрание общества общей внутренней медицины.

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… The majority of current smokers and all former smokers were supportive of smoke-free policies because they limited secondhand smoke exposure to non-smokers and children. …

Ларингейл амилоидоз: один центр four- Серия пациентов, освещающих диагностические проблемы и клиническую неоднородность.

Ларингейл амилоидоз является редким заболеванием, которое может имитировать доброкачественные, злокачественные или функциональные расстройства гортани. Мы представляем единый центр four- Серия пациентов, демонстрирующих клиническую неоднородность при анатомическом распределении, амилоидном печатании, системном взаимодействии и управлении. Все four Эти случаи были подтверждены гистологически. Two Пациенты, по результатам специализированной оценки, имели локальный ларингеальный амилоидоз, one У пациента было ларинготражающее амилоидное осаждение в контексте известной множественной миэломы, и one

Lipid Level, Lipid Variability, and Risk of Multiple Myeloma: A Nationwide Population-Based Study of 3,527,776 Subjects.

(1) Background: There is evidence that abnormality in lipid metabolism promotes cancer development. This study investigated whether lipid level and its variability are associated with the development of MM at a population level. (2) Methods: A retrospective cohort study included a total of 3,527,776 subjects aged 40 and above who participated in ≥3 health examinations within the previous five years, including the index year (2012-2013). Total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and triglyceride (TG) were measured, and visi

Resveratrol and Other Natural Oligomeric Stilbenoid Compounds and Their Therapeutic Applications.

The use of natural compounds as an alternative to synthetic molecules has become a significant subject of interest in recent decades. Stilbenoids are a group of phenolic compounds found in many plant species and they have recently gained the focus of a multitude of studies in medicine and chemistry, resveratrol being the most representative molecule. In this review, we focused on the research that illustrates the therapeutic potential of this class of natural molecules considering various diseases with higher incidence rates. PubChem database was searched for bioactivities of natural stilbenoi

Macroglossia due to Systemic Amyloidosis: Is There a Role for Radiotherapy?

BACKGROUND: Macroglossia due to amyloid depositions can cause cosmetic problems and functional disability, and can lead to life-threatening airway obstruction. Management of macroglossia in systemic amyloidosis is controversial, and the role of surgery is unclear. CASE DESCRIPTION: We present a case of a 66-year-old woman affected by macroglossia due to light chain amyloidosis who presented with eating and breathing difficulties. Because of prior successful results of radiotherapy for localized amyloid disease, our patient was treated with external beam radiation therapy (20 Gy in 10 fraction