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Comparative Safety of Baked Egg, Egg Yolk, and Egg White in Young Children with Egg Allergy.

UNLABELLED: <p>Introduction: Baked egg (BE) is generally well tolerated by children with egg allergy, and heated egg yolk (EY) is considered less allergenic than egg white (EW). Although these findings suggest that both BE and EY may be safer options for reintroduction, no studies have directly compared their safety with each other or with heated EW. This study aimed to compare the safety of oral food challenge (OFC) for reintroducing BE, EY, and EW in children with egg allergy. METHODS: We retrospectively analyzed data from patients who underwent OFCs with BE, EY, or EW at the Department of …

Vaginal host immune-microbiome-metabolite interactions associated with spontaneous preterm birth in a predominantly white cohort.

In order to improve spontaneous preterm birth (sPTB) risk stratification in a predominantly white cohort of non-labouring pregnant women, we analysed their vaginal microbiota, metabolite, cytokine and foetal fibronectin (FFN) concentrations at two gestational time points (GTPs): GTP1 (20+0-22+6 weeks, preterm = 17; term = 32); and GTP2 (26+0-28+6 weeks, preterm = 14; term = 31). At GTP1, the preterm-delivered women showed abundant G. vaginalis (AUC = 0.77) over L. crispatus and L. iners, and upregulation of 10 metabolites. At GTP2, the same women had more lactobacilli- and mixed anaerobes-domi…

Unmasking of Wolff-Parkinson-White syndrome following cardioversion of ventricular tachycardia in pregnancy: a case report.

BACKGROUND: Wolf-Parkinson-White syndrome predisposes patients to tachyarrhythmias and sudden cardiac death, with pregnancy further exacerbating arrhythmia risk due to hemodynamic, hormonal, and autonomic changes. We present a rare case of a pregnant woman with Wolf-Parkinson-White syndrome, which was unmasked after successful cardioversion of unstable ventricular tachycardia. CASE PRESENTATION: A 40-year-old Black Ethiopian pregnant woman in her 35th week of gestation presented with unstable ventricular tachycardia, requiring multiple cardioversions, along with treatment with amiodarone and …

Intra-amniotic infection with Ureaplasma parvum causes serovar-dependent white matter damage in preterm fetal sheep.

Ureaplasma parvum is commonly isolated from the amniotic fluid of pregnancies complicated by infection. While some studies have shown an ass … re among the most common serovars isolated in pregnancies complicated by infection/inflammation, on white matter development in preterm fetal sheep. Pregnant ewes carrying singleton or twin fetuses (55 days gestational age, term = 145 days) were randomly allocated to receive an ultrasound-guided intra-amniotic injection of Ureaplasma parvum serovars 3 ( …

Selenium-Enriched Egg White Protein Alleviates Glucocorticoid-Induced Osteoporosis Mice via Gut Microbiota-Driven Htr1b Inhibition.

Long-term glucocorticoid therapy is known to induce osteoporosis by disrupting bone metabolism and altering gut microbiota. In this study, C57BL/6J mice were used to establish a glucocorticoid-induced osteoporosis (GIOP) model by intramuscular injection of dexamethasone. The mice were then divided into control, GIOP, and experimental groups; the experimental group was orally administered selenium-enriched egg white protein (Se-EWP) in order to evaluate its bone-protective effects and potential mechanisms. The results showed that Se-EWP significantly improved bone strength, trabecular microstru…

The impact of white matter brain lesions on processing speed deficits in systemic lupus erythematosus patients.

BackgroundThe mechanism of cognitive dysfunction in systemic lupus erythematosus (SLE) is still not fully understood. Even though many SLE p … tic criteria.PurposeThe aim of this study was to determine the relationship between the presence of white matter lesions (WMLs) and cognitive dysfunction in patients diagnosed with SLE.Research Design33 SLE patients underwent 3 T brain magnetic resonance imagining (MRI) and an extensive battery of psychological tests, including Automated Neuropsychologi …

Efficient removal of naturally-occurring lipofuscin autofluorescence in human nervous tissue using high-intensity white light.

Background autofluorescence is enhanced in human tissue relative to small animals and presents a barrier to fully realizing the potential of … % of neurons in a typical section. This report describes a straightforward, scalable, pre-staining, white-light photobleaching method that near-totally reduces LF autofluorescence, and improves signal detection across the color spectrum without negatively impacting the multiplex fluorescence detection assay. It is effective for peripheral and central ne …

Subcutaneous white adipose tissue-derived extracellular vesicles maintain intestinal homeostasis via IgA biosynthesis in aging mice.

Intestinal function and white adipose tissue (WAT) function deteriorate with age, but whether and how their deterioration is intertwined remains unknown. Increased gut permeability, microbiota dysbiosis, and aberrant immune microenvironment are the hallmarks of intestinal dysfunctions in aging. Here, we show that subcutaneous WAT dysfunction triggered aging-like intestinal dysfunctions in mouse models. Removal of inguinal subcutaneous WAT (iWAT) increased intestinal permeability and inflammation and altered gut microbiota composition as well as susceptibility to pathogen infection in mouse mod…

Carotid artery atherosclerosis and white matter lesions in the elderly: a community-based MR imaging study.

OBJECTIVES: This study sought to evaluate the relationship between morphological and compositional characteristics of carotid atherosclerotic plaques and white matter lesions (WMLs) in asymptomatic elderly adults using three-dimensional (3D) multicontrast magnetic resonance (MR) vessel wall imaging. MATERIALS AND METHODS: Asymptomatic elderly subjects (≥ 60 years) were recruited from a community-based study. Carotid arteries and the brain were imaged on a 3.0-T MR scanner. The morphological and compositional features of carotid atherosclerotic plaques were evaluated. The WMLs were scored usin…

Beneath the surface: Complete atrioventricular block combined with Wolff-Parkinson-White syndrome and sick sinus syndrome.

The combination of Wolff-Parkinson-White (WPW) syndrome, sick sinus syndrome (SSS), and complete atrioventricular block (AVB) is seldom reported. We present a case of A 61-year-old male who was admitted with syncope and palpitations. His electrocardiogram showed a preexcited QRS pattern consistent with transient cardiac pauses. WPW syndrome with SSS syndrome was diagnosed. The electrophysiologic study demonstrated the preexcitation through the left accessory pathway, but after its blockages, completed atrioventricular block emerged. The patient ultimately required pacemaker implantation, follo…

Disseminated T-cell lymphoma in a free-living white-winged duck (Asarcornis scutulata) under human care.

The white-winged duck (Asarcornis scutulata) is an endangered large, stocky anatid species that originates from South-East Asia. We report an adult, 9-year-old male specimen that presented with a 7-month history of intermittent lethargy and pale mucous membranes. Haematology and plasma biochemistry analyses, performed twice at a 6-week interval, revealed anaemia, lymphocytosis and raised renal and hepatic enzyme activities. These findings initially raised clinical suspicion of either avian tuberculosis (ATB), amyloidosis or neoplasia based on species predilection. Initial blood smear evaluatio…

Alterations of white matter integrity in patients with intracranial tuberculosis: A tract-based spatial statistics study.

OBJECTIVE: Intracranial tuberculosis has high mortality and morbidity. Its physiopathologic mechanism, especially neurocognitive mechanism, remains unclear, and there are few studies on white matter in such patients. This study aimed to investigate the white matter abnormalities in patients with intracranial tuberculosis using tract-based spatial statistics (TBSS) method of diffusion tensor imaging (DTI). METHODS: Fifty patients with intracranial tuberculosis and 49 healthy controls (HCs) were included in this study. Differences in the fractional anisotropy (FA), mean diffusivity (MD), radial…

Targeting HDAC3 Suppresses Ferroptosis and Demyelination in White Matter Injury by Restoring PDK4-Mediated Iron Homeostasis.

AIM: White matter injury (WMI), characterized by white matter degeneration and iron deposition, contributes to neurological dysfunction. Histone deacetylase 3 (HDAC3) is implicated in neurodegenerative processes, yet its role in WMI-associated ferroptosis remains unclear. METHODS: Clinical assessments in WMI patients revealed correlations between serum iron, α-synuclein, and antioxidant levels and MRI-confirmed white matter degeneration. In a cuprizone-induced demyelination mouse model, white matter integrity, oligodendrocyte dysfunction, iron accumulation, and lipid peroxidation were evaluat…

Amyloid detecting dye "Congo Red" induces amorphous aggregates in hen egg white lysozyme at physiological pH.

Congo Red (CR) is an azo dye commonly used for amyloid detection and histological staining. However, its potential influence on protein aggregation remains unclear. In this study, we investigated the effect of CR on the aggregation of Hen Egg White Lysozyme (HEWL) under physiological and variable environmental conditions. At pH 7.4, HEWL remained soluble in the absence of CR; however, the addition of CR at concentrations ≥0.05 mM induced rapid and visible aggregation without a detectable lag phase, suggesting a non-nucleated aggregation mechanism. SDS-PAGE confirmed a marked reduction in solub…

High-Dose Pulse Glucocorticoid Treatment Prevents White Matter Spinal Cord Pseudoatrophy in Newly Diagnosed Multiple Sclerosis.

OBJECTIVE: Spinal cord (SC) atrophy correlates with and predicts the underlying progressive biology in active and non-active multiple sclero … after baseline MRI. SC total cervical cord cross-sectional area (TCA), gray matter area (GMA), and white matter area (WMA) and regional brain volumes were analyzed using mixed effects models. RESULTS: The DMT-HDG, DMT/no-HDG, and no-DMT groups had similar demographic, clinical, and radiological features. Pronounced SC pseudoatrophy was observed based …

Сегментация гиперинтенсивности белой материи в результате множественных склерозов и нейромиелитных нарушений оптического спектра с использованием 2,5D FrC-ResUnet.

ОКРУЖАЮЩАЯ СРЕДА: Оценка гиперинтенсивности белой материи (WMH) имеет важное значение для диагностики, лечения и прогнозирования множественных склерозов (MS) и нарушений оптического спектра нейромиелита (NMOSD). MS и NMOSD представляют собой рассеянные небольшие повреждения наряду с более крупными агрегированными повреждениями, которые имеют нерегулярную форму, что создает проблемы для автоматической сегментации WMH на магнитных резонансных изображениях. Кроме того, исследования по сегментации мозга НМОСР ограничены из-за редкой природы болезни. Цель этого исследования состоит в том, чтобы пре

Совпадение в аннотации оригинала
BACKGROUND: Assessing white matter hyperintensity (WMH) is essential for the diagnosis, treatment, and prognosis of multiple sclerosis (MS) and neuromyelitis optical spectrum disorder (NMOSD). MS and NMOSD present dispersed small lesions alongside larger aggregated lesions that are irregularly shaped, posing challenges for the automatic segmentation of WMH o…

Эксплуатация синептических, митохондриальных, дополняющих и связанных со старением тротуаров.

Внеклеточные везикла (ЭМ) все чаще признаются посредниками функций и патологии центральной нервной системы (ЦНС), включая множественный склероз (МС). Несмотря на то, что в качестве биомаркеров в MS были изучены ЭМ, ЭМ, произведенные в плазме, мало что известно о ЭМ в тканях CNS. Здесь мы характеризуем ЭМ от вскрытия обычного белого вещества (NAWM) MS и контрольных мозгов. ЭМ были отделены дифференциальной центрифугацией, а затем хроматографией, исключающей размер, и характеризовались с использованием цитометрии нанопотока, зондированием одночастотных отражателей (SP-IRIS) и микроскопией переда

Совпадение в аннотации оригинала
Extracellular vesicles (EVs) are increasingly recognized as mediators of central nervous system (CNS) function and pathologies, including multiple sclerosis (MS). While plasma-derived EVs have been explored as biomarkers in MS, little is known about EVs in CNS tissue. Here, we characterize EVs from postmortem normal-appearing white matter (NAWM) of MS and co…

Black and Non-Hispanic White persons with multiple sclerosis: Social determinants of health and health inequities.

OBJECTIVE: Distinctive differences in multiple sclerosis (MS) disease severity, progression, and mortality have been observed among different races. Social determinants of health (SDH) can contribute to such racial disparities. This study aims to: 1) compare Non-Hispanic White (NHW) and Black (Bl) persons with MS in terms of MS and SDH; 2) explore the impact of SDH-adjustment in the association between race and Expanded Disability Status Scale (EDSS), Timed 25-Foot Walk (T25-FW), 9-Hole Peg Test (9-HPT), Symbol Digit Modalities Test (SDMT). METHODS: 120 patients, self-identified as Bl (n = 60…

TSPO-PET Reveals Высочайшее воспаление в белой материи Расторгнуто парамагнитным ободом в множестве склероза.

ЦЕЛЬ: изучить вопрос о том, является ли повышенная побудительная активность в белых трактах (WM), поврежденных в результате повреждения парамагнитного обода (PRL), и связано ли воспаление в PRL-поврежденных трактах WM с инвалидностью у лиц с множественным склерозом (MS). МЕТОДЫ: Forty-four Психиатрические заболевания и 16 Включены меры по охране здоровья. 18 Позитронная эмиссия белкового транслокатора (TSPO-PET) 11C-PK11195 Радиолиганд использовался для измерения нейро-воспалительной активности. Инструмент для модификации сети использовался для идентификации участков WM, поврежденных PRL, и не

Совпадение в аннотации оригинала
OBJECTIVE: To explore whether the inflammatory activity is higher in white matter (WM) tracts disrupted by paramagnetic rim lesions (PRLs) and if inflammation in PRL-disrupted WM tracts is associated with disability in people with multiple sclerosis (MS). METHODS: Forty-four MS patients and 16 healthy controls were included. 18 kDa-translocator protein posi…

Markedly elevated cerebrospinal fluid white blood cell count in multiple sclerosis: How high is too high?

BACKGROUND: The diagnosis of multiple sclerosis (MS) is based on the revised McDonald's criteria, which includes clinical history, neurological examination, MRI findings and cerebrospinal fluid (CSF) analysis necessitating the exclusion of alternative explainable diagnoses. Markedly elevated CSF white blood cells (WBCs) over 50 (units) is considered a "red flag" for an alternative diagnosis apart from MS. OBJECTIVE: To present a man with typical relapsing-remitting MS (RRMS) despite markedly elevated CSF WBCs. CASE: A 33-year-old man presented with progressive bilateral numbness and weakness…