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Hepatic amyloidosis in a patient with chronic liver failure: A case report.

BackgroundAmyloidosis is a rare disorder that can be classified into various types, and the most common type is the systemic light chain type. The prognosis of this disease is extremely poor. In general, amyloidosis mainly affects the kidneys and heart and manifests as abnormal proliferation of clonal plasma cells. Cases in which the liver is the primary organ affected by amyloidosis, as in this report, are less common in clinical practice.Case summaryA 62-year-old man was admitted with persistent liver dysfunction of unknown cause and poor treatment outcomes. His condition persisted, and he d

Длинный процесс у пациентов с множественным склерозом, обработанных с помощью Rituximab: доклад о двух случаях.

Симптомы COVID-19 могут сохраняться в течение более 12 недель у некоторых инфицированных пациентов, причем в этих случаях это состояние характеризуется как продолжительность COVID-19. У этих пациентов есть симптомы, связанные с повреждением нескольких органов. Ученые обнаружили длительную этиологию COVID-19, факторы риска и лечение. Было отмечено, что иммунодепрессия может приводить к затягиванию симптомов COVID-19. Пациенты с множественным склерозом (PwMS), как правило, лечатся с помощью методов, позволяющих модифицировать заболевания, которые подавляют иммунную систему и предрасположены к ин

Эффективное использование BCMA-нацеливаемого би-специализированного T антитела в реанимации LRP4+ yasthenia gravis.

Myastenia gravis (MG) — аутоиммунное заболевание, вызванное антителом, которое воздействует на нейромышечное соединение. Рефракторный MG, особенно в случаях, связанных с редким антинизкоплотным белком, связанным с рецептором липопротеина 4 (LRP4) Антитела сталкиваются со значительными трудностями в лечении. Teclistamab, биконкретный антитело, нацеленное на антигены созревания клеток B (BCMA) и CD3, перенаправляет Т клетки на плазменные клетки и утверждается для лечения нескольких миелом. Растущий интерес связан с использованием методов лечения на основе Т клеток в клеточных заболеваниях с ауто

Role of remdesivir for the treatment of COVID-19 in patients with hematologic malignancy-A narrative review and expert opinion.

BackgroundCOVID-19 remains a potentially severe condition for immunocompromised individuals, such as patients with hematologic malignancy. These patients are at increased risk of progressing to severe-critical or prolonged COVID-19. Prompt treatment with antivirals has proven effective in preventing disease progression and is recommended by current guidelines. We discuss here the position of remdesivir in the management of onco-hematologic patients infected with SARS-CoV-2 and strategies for its use.MethodsNarrative review of current evidence regarding remdesivir in the treatment of COVID-19 i

Molecularly Targeted Therapies in Oncology: Mechanisms, Resistance, and Combination Strategies.

Targeted therapies are reshaping oncology by enabling treatment selection based on actionable molecular alterations, improving precision, and reducing unnecessary toxicity. This review provides an up-to-date overview of current targeted treatment modalities and the medicinal chemistry principles that support their discovery and optimization. We synthesize evidence on small-molecule and biologic strategies spanning receptor and non-receptor kinases and their major signaling axes (PI3K-AKT-mTOR and RAS-RAF-MEK-ERK), apoptosis regulation (BCL-2 family), DNA repair via poly(ADP-ribose) polymerase

Low- and no-calorie sweeteners and beverages and their associated health outcomes: an umbrella review of systematic reviews and meta-analyses.

BackgroundLong-term health effects of low- and no-calorie sweeteners (LNCSs) have not been established.ObjectiveThis review aimed to evaluate the associations between different types of LNCSs and a wide range of health outcomes from observational studies and randomized controlled trials (RCTs).MethodsWe systematically searched PubMed/MEDLINE, Embase, CINAHL, and Google Scholar from inception to December 2024 for meta-analyses. LNCSs were categorized into artificial sweeteners and other non-sugar sweeteners (NSSs), including non-nutritive sweeteners and sugar alcohols, along with their correspo

Safety of bloodless autologous stem cell transplantation in Jehovah's Witness patients.

Due to the curative potential and improvement in progression-free survival (PFS), high-dose chemotherapy followed by autologous stem cell transplantation (ASCT) is considered the standard of care for several hematologic malignancies, such as multiple myeloma, and lymphomas. ASCT typically involves support with blood product transfusion. Thus, difficulties arise when Jehovah's Witness patients refuse blood transfusions. In order to demonstrate the safety of performing "bloodless" ASCT (BL-ASCT), we performed a retrospective analysis of 66 Jehovah's Witnesses patients who underwent BL-ASCT and 1

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… Unfortunately, none of the blood substitutes are approved by the US Food and Drug Administration. Synthetic oxygen transporters currently in development include perfluorocarbons and human or bovine hemoglobin oxygen carriers (HBOC). … Moradi S Jahanian-Najafabadi A Roudkenar MH Artificial blood substitutes: first steps on the long route to clinical utility Clin Med Insights Blood Disord 2016 9 33 41 10.4137/CMBD.S38461 27812292 PMC5084831 22. …

Предлагаемый протокол наблюдений для ранней дифференциации синдрома высвобождения цитокина и сепсиса в реципиентах CAR-T с гематологическими аномалиями с использованием IL-6Соотношение ПХТ: исследование ДРАКАРИС.

Терапия антигенного рецептора T-клеток (CAR-T) произвела революцию в лечении гематологических магнатов, продемонстрировав замечательную эффективность в лейкемиях B-клеток, лимфомах и множестве миелом. Однако синдром сильного токсина, особенно синдрома цитокина (CRS) и сепсиса, сопряженный с серьезными клиническими проблемами. Оба эти условия имеют совпадающие черты, включая лихорадку, гипотенцию и многоорганическую дисфункцию, что делает важную роль своевременной и точной дифференциации. В основе ДУС лежит чрезмерное высвобождение цитокина, главным образом IL-6, и лечится IL-6 Блокада рецептор

Инфекционные токсичные вещества, связанные с биконкретными антителами и клетками CAR-T в множестве миеломы: систематический обзор.

Лечение с перенацеливанием клеток изменило лечение повторной/охлажденной множественной миэломы (RRMM), но связано со значительным риском инфицирования. Мы систематически анализировали инфекционные заболевания после терапии Т-клеток CAR и биконкретных антител (BSAbs) с уделением особого внимания частотности, времени, патогенам, факторам риска и профилактике. Следуя руководящим принципам PRISMA, мы обыскали Паббмеда до мая. 22, 2026, и включает исследования, содержащие информацию о инфекционных результатах у пациентов, проходящих курс лечения с помощью клеток CAR-T или BsAbs. Всего 123 Был прове

Comparable safety profile of BeEAM (bendamustine, etoposide, cytarabine, melphalan) and BEAM (carmustine, etoposide, cytarabine, melphalan) as conditioning before autologous haematopoietic cell transplantation.

IntroductionBEAM (carmustine, etoposide, cytarabine, melphalan) is the most frequently used high-dose chemotherapy regimen for patients with lymphoma referred for autologous haematopoietic cell transplantation (autoHCT). Recently, a novel conditioning protocol containing bendamustine instead of carmustine (BeEAM) has been proposed to potentially increase the efficacy.Aim of the studyThe aim of this study was to retrospectively compare the safety profile of BEAM and BeEAM based on single-centre experience.Material and methodsA total of 237 consecutive patients with lymphoma treated with either

Редактор специального выпуска : Множественный склероз: от диагностических биомаркеров до воображаемых и клинических прогнозов

Множественный склероз (MS) представляет собой хроническое, нейро-воспалительное и нейродегенеративное заболевание центральной нервной системы (CNS), которое может вызывать множество физических и когнитивных расстройств [...]

RNAi-Based Therapeutics and Novel RNA Bioengineering Technologies.

RNA interference (RNAi) provides researchers with a versatile means to modulate target gene expression. The major forms of RNAi molecules, genome-derived microRNAs (miRNAs) and exogenous small interfering RNAs (siRNAs), converge into RNA-induced silencing complexes to achieve posttranscriptional gene regulation. RNAi has proven to be an adaptable and powerful therapeutic strategy where advancements in chemistry and pharmaceutics continue to bring RNAi-based drugs into the clinic. With four siRNA medications already approved by the US Food and Drug Administration (FDA), several RNAi-based thera

Delayed gastric emptying in critical illness: is enhanced enterogastric inhibition with cholecystokinin and peptide YY involved?

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… Blood Substitutes Only one substitute for RBC transfusions has been approved in the United States, a polyfluorocarbon oxygen carrier with significant limitations as a blood substitute. 140 Other preparations that have been explored in clinical trials are cell-free hemoglobin solutions cross-linked or …

Ocular Surface Side Effects of Novel Anticancer Drugs.

Surgery, anticancer drugs (chemotherapy, hormonal medicines, and targeted treatments), and/or radiation are common treatment strategies for neoplastic diseases. Anticancer drugs eliminate malignant cells through the inhibition of specific pathways that contribute to the formation and development of cancer. Given the ability of such pharmacological medications to combat cancerous cells, their role in the management of neoplastic diseases has become essential. However, these drugs may also lead to undesirable systemic and ocular adverse effects due to cyto/neuro-toxicity and inflammatory reactio

Aminopeptidase N: a multifunctional and promising target in medicinal chemistry.

Aminopeptidase N (APN) is a zinc metalloproteinase present in almost all types of organisms and has various functions. Many of them are unrelated to its catalytic activity, which is why APN is sometimes classified as a moonlighting enzyme. APN is involved in carcinogenesis and angiogenesis. It also works as an entrance receptor for some coronaviruses and acts as a mediator during skin inflammation. Additionally, APN removes and helps to recycle regulatory proteins including neuropeptides, which is why its inhibitors hold therapeutic potential for a wide range of diseases, making the design and

Effects of Expanded Hemodialysis with Medium Cut-Off Membranes on Maintenance Hemodialysis Patients: A Review.

Kidney failure is associated with high morbidity and mortality. Hemodialysis, the most prevalent modality of renal replacement therapy, uses the principle of semipermeable membranes to remove solutes and water in the plasma of patients with kidney failure. With the evolution of hemodialysis technology over the last half century, the clearance of small water-soluble molecules in such patients is adequate. However, middle molecules uremic toxins are still retained in the plasma and cause cardiovascular events, anemia, and malnutrition, which significantly contribute to poor quality of life and h

Decoding Waldenström Macroglobulinemia Through Genomics, Epigenomics and Cellular Interactions

Waldenström macroglobulinemia is a rare lymphoplasmacytic malignancy characterized by bone marrow infiltration and monoclonal immunoglobulin M production. Despite its indolent clinical course, the disease exhibits considerable biological complexity driven by recurrent genetic alterations, dysregulated signaling pathways, and a supportive bone marrow microenvironment. The identification of MYD88 and CXCR4 mutations has significantly advanced understanding of disease pathogenesis, clonal evolution, and treatment response. Additional insights from cytogenetic, epigenetic, and microRNA studies hav

The convergent evolution of influenza A virus: Implications, therapeutic strategies and what we need to know.

Influenza virus infection, more commonly known as the 'cold flu', is an etiological agent that gives rise to recurrent annual flu and many pandemics. Dated back to the 1918- Spanish Flu, the influenza infection has caused the loss of many human lives and significantly impacted the economy and daily lives. Influenza virus can be classified into four different genera: influenza A-D, with the former two, influenza A and B, relevant to humans. The capacity of antigenic drift and shift in Influenza A has given rise to many novel variants, rendering vaccines and antiviral therapies useless. In light

Dual COX-2/TNF-α Inhibitors as Promising Anti-inflammatory and Cancer Chemopreventive Agents: A Review.

Cyclooxygenases (COX) play a pivotal role in inflammation and are responsible for the production of prostaglandins (PGs). Two types of COXs have been identified as key biological targets for drug design: Constitutive COX-1 and inducible COX-2. Nonsteroidal anti-inflammatory drugs (NSAIDs) target COX-1, while selective COX-2 inhibitors are designed for COX-2. These COX isoforms are involved in multiple physiological and pathological pathways throughout the body. Overproduction of tumor necrosis factor-alpha (TNF-α) plays a role in COX-2's inflammatory activity. Tumor necrosis factor-alpha can c

NTRK Fusion in Non-Small Cell Lung Cancer: Diagnosis, Therapy, and TRK Inhibitor Resistance.

Neurotrophic tropomyosin receptor kinase (NTRK) gene fusion has been identified as an oncogenic driver of various solid tumors, and it is rare in non-smalll cell lung cancer (NSCLC) with a frequency of approximately less than 1%. Next-generation sequencing (NGS) is of priority for detecting NTRK fusions, especially RNA-based NGS. Currently, the tropomyosin receptor kinase (TRK) inhibitors have shown promising efficacy and well tolerance in patients with NTRK fusion-positive solid tumors, regardless of tumor histology. The first-generation TRK inhibitors (larotrectinib and entrectinib) are reco