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Metastatic Spine Disease Alters Vertebral Load-To-Strength Ratios in Cancer Patients Compared to Healthy Individuals.

PurposeThis study investigated the effect of bone metastasis on the biomechanical environment of human vertebrae in patients with metastatic spine disease through the metric of load-to-strength ratio (LSR). Specifically, we compared the patients' LSRs to age and sex-similar noncancer controls from the Framingham Heart Study.MethodsDerived from clinical CT data of 135 metastatic spine disease patients planned for radiotherapy and 246 normative controls from the Framingham Heart Study, individualized spinal musculoskeletal models and vertebral strength estimates were used to compute level-specif

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… Peus D., Newcomb N., and Hofer S., “Appraisal of the Karnofsky Performance Status and Proposal of a Simple Algorithmic System for Its Evaluation,” BMC Medical Informatics and Decision Making 13 (2013): 72. 31. Hoffmann U., Massaro J. M., Fox C. …

From Time-Limited Therapy to Treatment-Free Observation: The Evolving Role of MRD in CLL Management.

The integration of measurable residual disease (MRD) into the management of chronic lymphocytic leukemia (CLL) has emerged as a major advance in risk stratification and trial design, particularly in the context of time-limited, targeted regimens. High-sensitivity MRD assessment, enabled by multicolor flow cytometry, allele-specific oligonucleotide PCR, and next-generation sequencing (NGS), provides a robust, quantifiable measure for depth of remission and long-term outcomes. Landmark trials-including CLL14, MURANO, CAPTIVATE, and GLOW-have consistently demonstrated that achieving undetectable

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… E., and Alhaq A., “Systematic Review of Machine Learning Applications in the Early Prediction and Management of Chronic Lymphocytic Leukemia,” Health Informatics Journal 31, no. 3 (2025): 14604582251342178. …

Cardiovascular Symptom Tracking Among Patients With Cancer in Cardio-Oncology Care: Qualitative Study Using the Capability, Opportunity, Motivation-Behavior (COM-B) Framework.

BACKGROUND: Cardiovascular disease is a leading noncancer cause of morbidity and mortality among individuals diagnosed with cancer. Although modern cancer therapies have improved survival, many are associated with cardiotoxic effects that increase the risk of cardiovascular complications. Early identification of cardiovascular symptoms and signs may support timely clinical management. However, tracking cardiovascular health during cancer care can be complex for both patients and medical team participants, and important indicators, such as blood pressure changes, heart rate variability, fluid r

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… From an informatics perspective, this underscores the importance of systems that support interpretation within clinical workflows rather than treating data as isolated data entries [ 21 ]. …

Delving into Molecular Pathways: Analyzing the Mechanisms of Action of Monoclonal Antibodies Integrated in IMGT/mAb-DB for Myasthenia Gravis.

BackgroundMyasthenia Gravis (MG) is a rare autoimmune disease presenting with auto-antibodies that affect the neuromuscular junction. In addition to symptomatic treatment options, novel therapeutics include monoclonal antibodies (mAbs). IMGT®, the international ImMunoGeneTics information system®, extends the characterization of therapeutic antibodies with a systematic description of their mechanisms of action (MOA) and makes them available through its database for mAbs and fusion proteins, IMGT/mAb-DB.MethodsUsing available literature data combined with amino acid sequence analyses from mAbs m

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… It is affiliated with notable organizations such as the Confederation of Laboratories for Artificial Intelligence Research in Europe (CLAIRE), the International Medical Informatics Association (IMIA), and the Global Alliance for Genomics and Health (GA4GH). …

Feasibility of a tailored and virtually supported home exercise program for people with multiple myeloma using a novel eHealth application.

INTRODUCTION: eHealth exercise interventions have the unique ability to leverage the benefits of in-person programming (tailoring and supervision) with the benefits of home programming (flexibility). There may be a role for eHealth-delivered exercise for people with multiple myeloma (MM), as exercise tailoring and supervision are critical for successful outcomes due to the significant impacts/risks of myeloma-related side effects. The purpose of this study was to determine the safety, feasibility, and preliminary efficacy of a 12-week virtually supported eHealth exercise program. METHODS: Par

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… Research electronic data capture (REDCap)—A metadata-driven methodology and workflow process for providing translational research informatics support. J Biomed Inform 2009; 42: 377–381. 42. Bohannon RW, Crouch RH. …

ROS 2020 Abstract

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… Clinical audit/service evaluation Subcategory: Hip fracture Best foot forwards: balancing the risks of suffering a hip fracture AJ Johanasen 1 , DI Inman 1 , LF Fagan 1 , TB Bunning 2 , SH Hawley 3 , AJ Judge 3 1 National Hip Fracture Database (NHFD), Royal College of Physicians, London, UK, 2 Crown Informatics … AJ Johansen 1 , DI Inman 1 , LF Liz Fagan 1 , TB Bunning 2 , SH Hawley 3 , AJ Judge 3 1 National Hip Fracture Database (NHFD), Royal College of Physicians, London, UK, 2 Crown Informatics, Nottinghamshire, UK, 3 NDORMS, University of Oxford, Oxford, UK Introduction : Hip fracture typically affects …

Emerging therapeutic strategies in glioblastsoma: drug repurposing, mechanisms of resistance, precision medicine, and technological innovations.

Glioblastoma (GBM) is an aggressive Grade IV brain tumor with a poor prognosis. It results from genetic mutations, epigenetic changes, and factors within the tumor microenvironment (TME). Traditional treatments like surgery, radiotherapy, and chemotherapy provide limited survival benefits due to the tumor's heterogeneity and resistance mechanisms. This review examines novel approaches for treating GBM, focusing on repurposing existing medications such as antipsychotics, antidepressants, and statins for their potential anti-GBM effects. Advances in molecular profiling, including next-generation

Уменьшившийся уровень видимости сигналов, указывающих на разрыв и дегенерацию тканей при прогрессивном многоразовом склерозе: воздействие на клинические испытания.

ИСТОРИЯ ВОПРОСА И ЦЕЛИ: Повреждения парамагнитных ободов (ПЗК) при множественном склерозе (МС) указывают на хроническое врожденное воспаление иммунной системы, способствующее прогрессированию заболеваний. Исчезновение или ослабление обода интерпретируется как реакция на лечение; однако остается неясным, действительно ли снижение степени уязвимости - похожее отражение сокращения железа в ободном отсеке - дает реальное разрешение на хроническое воспаление, старение естественного повреждения и/или дегенерацию продвинутой ткани. В поперечном разрезе PRL демонстрируют изменяющуюся видимость обода,

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… Status Scale echo-planar imaging false discovery rate fluid-attenuated inversion recovery high angular resolution diffusion imaging parallel imaging acceleration factor mean diffusivity magnetization-prepared rapid acquisition gradient echo multiple sclerosis neurite density index Neuroimaging Informatics …

Скринэтон 2.0:: Проведение совместного обследования с участием человека и АИ на основе данных о состоянии здоровья пациентов.

Систематические обзоры имеют важное значение для проведения исследований, основанных на фактических данных, однако традиционный процесс отбора требует много времени и его трудно масштабировать. Скрининг, проводимый исключительно для человека, может привести к непоследовательности, в то время как полностью автоматизированные подходы с использованием моделей Большого языка зачастую не имеют контекстуального суждения, необходимого для принятия сложных решений. Для решения этой проблемы мы внедряем методологию скрининга на основе толпы, которая сочетает человеческий опыт и адаптивное машинное обуч

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… Health Informatics Symp. 819–824 (2012). 10.1145/2110363.2110464 28. Harrison, H. et al. Software tools to support title and abstract screening for systematic reviews in healthcare: an evaluation. BMC Med. Res. Methodol. 20 , 7 (2020). 29. Rayyan https://www.rayyan.ai/ 30. Smela, B. et al. …

A Novel Telehealth Exercise Program Designed for Rural Survivors of Cancer With Cancer-Related Fatigue: Single-Arm Feasibility Trial.

BackgroundExercise interventions are among the best-known interventions for cancer-related fatigue (CRF). Rural survivors of cancer, however, report specific barriers to engaging in exercise programs and lack overall access to effective programs.ObjectiveThe purpose of this investigation was to assess the feasibility of a novel telehealth exercise program designed specifically for rural survivors of cancer with CRF.MethodsA single-arm clinical trial of the BfitBwell Telehealth Program was performed. Based on an established clinical program, this adapted 12-week program addressed barriers previ

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… Research Electronic Data Capture (REDCap)—a metadata-driven methodology and workflow process for providing translational research informatics support. …

Acceptability and Effectiveness of a Fully Web-Based Nutrition and Exercise Program for Individuals With Chronic Disease During COVID-19: Randomized Controlled Trial.

BackgroundIn-person nutrition and exercise interventions improve physical function in chronic diseases, yet the acceptability and effectiveness of web-based delivery, especially with different levels of personnel support, require further investigation.ObjectiveThis study aims to evaluate a web-based nutrition and exercise intervention delivered entirely digitally from recruitment to trial completion.MethodsA randomized controlled trial was conducted using the Heal-Me version 1 platform across 2 levels of personnel support (Light and Intensive). Eligible adults with a history of cancer, chronic

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… disease Contemp Clin Trials 2022 118 106791 10.1016/j.cct.2022.106791 35569753 S1551-7144(22)00117-3 35569753 5 Harris PA Taylor R Thielke R Payne J Gonzalez N Conde JG Research electronic data capture (REDCap)—a metadata-driven methodology and workflow process for providing translational research informatics …

Study Design and Rationale for The Breathe Easier With Tadalafil Therapy for Exercise-Related Dyspnea in COPD-PH (BETTER COPD-PH).

Dyspnea, a debilitating symptom of COPD, worsens health-related quality of life (HRQL), reduces daily physical activity, increases health care utilization, and is more closely associated with survival than airflow limitation. Thus, having treatments that reduce dyspnea in COPD is important. Pulmonary hypertension (PH) is a common complication of COPD that is associated with severe dyspnea, more frequent COPD exacerbations, and increased mortality. Multiple causes of PH, including a reduction in bioavailable vasodilator nitric oxide (NO), are associated with COPD (COPD-PH). Phosphodiesterase ty

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… Recruitment Eligible participants are identified through (1) in‐clinic referrals; (2) medical record review of echocardiography, lung cancer screening and right heart catheterization databases (3) utilization of the Corporate Data Warehouse (CDW) through VA Informatics and Computing Infrastructure ( …

MyPainPal, a Novel mHealth App to Improve Pain in Patients With Advanced Cancer: Single-Arm Pilot Study.

BackgroundPain is common among patients with advanced cancer and is often inadequately controlled. Opioids are central to treatment; yet, self-management is challenging, and clinicians lack scalable tools to monitor and support patients between visits.ObjectiveThis study aimed to evaluate the feasibility and acceptability of MyPainPal (Dana-Faber Cancer Institute), a novel mobile health app designed to optimize cancer pain management. MyPainPal combines daily surveys assessing symptoms and analgesic use, algorithmic self-management support, tailored psychoeducation, and clinician monitoring. S

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… Research electronic data capture (REDCap)--a metadata-driven methodology and workflow process for providing translational research informatics support. …

A mixed methods evaluation of patient perspectives on the implementation of an electronic health record-integrated patient-reported symptom and needs monitoring program in cancer care.

BACKGROUND: As cancer centers have increased focus on patient-centered, evidenced-based care, implementing efficient programs that facilitate effective patient-clinician communication remains critical. We implemented an electronic health record-integrated patient-reported symptom and needs monitoring program ('cPRO' for cancer patient-reported outcomes). To aid evaluation of cPRO implementation, we asked patients receiving care in one of three geographical regions of an academic healthcare system about their experiences. METHODS: Using a sequential mixed-methods approach, we collected feedbac

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… Research electronic data capture (REDCap)—a metadata-driven methodology and workflow process for providing translational research informatics support. J Biomed Inform. 2009;42(2):377–381. doi: 10.1016/j.jbi.2008.08.010. 42. …

Rationale and development of an e-health application to deliver patient-centered care during treatment for recently diagnosed multiple myeloma patients: pilot study of the MM E-coach.

BACKGROUND: Patients with multiple myeloma (MM) increasingly face complicated treatment regimens. E-health may support patients and healthcare providers in enhancing a patient-centered healthcare approach. Therefore, we aimed to develop a patient-centered multi-modality e-health application, to assess the application for usability and end-user experiences. METHODS: The application was developed following an iterative "action-based" methodology using the design thinking approach. Key end users participated, and relevant stakeholders were consulted in the development process. First, the care pa

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… Jagannath S Mikhael J Nadeem O Raje N Digital health for patients with multiple myeloma: an unmet need JCO Clinical Cancer Informatics 2021 5 1096 1105 10.1200/CCI.20.00145 34735265 13. …

Development of a Patient-Centered Preference Tool for Patients With Hematologic Malignancies: Protocol for a Mixed Methods Study.

BackgroundThe approval of novel therapies for patients diagnosed with hematologic malignancies have improved survival outcomes but increased the challenge of aligning chemotherapy choices with patient preferences. We previously developed paper versions of a discrete choice experiment (DCE) and a best-worst scaling (BWS) instrument to quantify the treatment outcome preferences of patients with hematologic malignancies to inform shared decision making.ObjectiveWe aim to develop an electronic health care tool (EHT) to guide clinical decision making that uses either a BWS or DCE instrument to capt

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… Journal of the American Medical Informatics Association. 2009 Sep 01;16(5):660–669. doi: 10.1197/jamia.m3154. 70. Cole A, Khasawneh A, Adapa K, Mazur L, Richardson DR. …

Centromere protein E as a novel biomarker and potential therapeutic target for retinoblastoma.

Retinoblastoma is the most common intraocular malignancy during childhood. Currently, there is no effective treatment for metastatic retinoblastoma. We investigated potential biomarkers of retinoblastoma by utilizing three datasets from a public database. Functional enrichment analysis, including gene ontology, Kyoto encyclopedia of genes and genomes, gene set enrichment analysis and variation analysis, suggested that differentially expressed genes in retinoblastoma were enriched in accelerated cell cycle events. Protein-protein interaction analysis constructed a network consisting of six hub

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… As a multidisciplinary field, integrative bioinformatic analysis, combining computational biology, informatics, statistics, and mathematics, has emerged as a promising and increasingly important method for investigating promising targets. …

Oncology Nursing During a Pandemic: Critical Reflections in the Context of COVID-19.

ObjectivesTo provide a critical reflection of COVID-19 in the context of oncology nursing and provide recommendations for caring for people affected by cancer during this pandemic.Data sourcesElectronic databases, including CINAHL, MEDLINE, PsychINFO, Scopus, professional web sites, and grey literature were searched using Google Scholar.ConclusionNurses are key stakeholders in developing and implementing policies regarding standards of care during the COVID-19 pandemic. This pandemic poses several challenges for oncology services. Oncology nurses are providing a pivotal role in the care and ma

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… Health Informatics J. 2019 doi: 10.1177/1460458219863604. [Epub ahead of print] 68. Zhou X., Snoswell C.L., Hardling L.E. The Role of Telehealth in Reducing the Mental Health Burden from COVID-19. Telemedicine and e-Health. 2020;26(4):377–379. doi: 10.1089/tmj.2020.0068. 69. Wu Q., Kue J., Zhu X. …

Global, regional, and national disability-adjusted life-years (DALYs) for 315 diseases and injuries and healthy life expectancy (HALE), 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015.

BACKGROUND: Healthy life expectancy (HALE) and disability-adjusted life-years (DALYs) provide summary measures of health across geographies and time that can inform assessments of epidemiological patterns and health system performance, help to prioritise investments in research and development, and monitor progress toward the Sustainable Development Goals (SDGs). We aimed to provide updated HALE and DALYs for geographies worldwide and evaluate how disease burden changes with development. METHODS: We used results from the Global Burden of Diseases, Injuries, and Risk Factors Study 2015 (GBD 20

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… Abbafati PhD); Virginia Tech, Blacksburg, VA, USA (Prof K M Abbas PhD); Department of Neurology, Cairo University, Cairo, Egypt (Prof F Abd-Allah MD); NMSM Government College Kalpetta, Kerala, India (Prof B Abraham MPhil); Institute for Global Health (Prof I Abubakar PhD), Farr Institute of Health Informatics …

Methyl jasmonate: putative mechanisms of action on cancer cells cycle, metabolism, and apoptosis.

Methyl jasmonate (MJ), an oxylipid that induces defense-related mechanisms in plants, has been shown to be active against cancer cells both in vitro and in vivo, without affecting normal cells. Here we review most of the described MJ activities in an attempt to get an integrated view and better understanding of its multifaceted modes of action. MJ (1) arrests cell cycle, inhibiting cell growth and proliferation, (2) causes cell death through the intrinsic/extrinsic proapoptotic, p53-independent apoptotic, and nonapoptotic (necrosis) pathways, (3) detaches hexokinase from the voltage-dependent

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… Transactions of the Integrated Bio-Medical Informatics & Enabling Technologies Symposiums. 2004;1:34–42. 47. Ezekwudo DE, Wang RC, Elegbede JA. Methyl jasmonate induced apoptosis in human prostate carcinoma cells via 5-lipoxygenase dependent pathway. …