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Access to Chimeric Antigen Receptor T Cell Therapy for Diffuse Large B Cell Lymphoma.

IntroductionGeographic access to novel oncology therapies, and the extent to which it may vary by potential sites of care, regions, and population characteristics, is poorly understood. We examined how expanding access to chimeric antigen receptor (CAR) T cell therapy administration sites impacts patient travel distances and time.MethodsWe used geographic information system techniques to calculate shortest travel distance and time between patients with relapsed/refractory diffuse large B cell lymphoma (DLBCL) and the nearest CAR T cell therapy administration site in three scenarios: academic h

Anemia and Iron Deficiency in Cancer Patients: Role of Iron Replacement Therapy.

Anemia in cancer patients is quite common, with remarkable negative impacts on quality of life and overall prognosis. The pathogenesis is complex and typically multifactorial, with iron deficiency (ID) often being a major and potentially treatable contributor. In turn, ID in cancer patients can be due to multiple concurring mechanisms, including bleeding (e.g., in gastrointestinal cancers or after surgery), malnutrition, medications, and hepcidin-driven iron sequestration into macrophages with subsequent iron-restricted erythropoiesis. Indeed, either absolute or functional iron deficiency (AID

The Missing Link: Integrating Interventional Pain Management in the Era of Multimodal Oncology.

Cancer-related pain (CrP) is one of the most frequent and debilitating issues that affect the quality of life of patients with cancer. Systemic analgesics, particularly opioids, have been the cornerstone of pain management. However, the following shortcomings of the mentioned therapies, such as side effects, tolerance, and inadequate relief in refractory cases, make implementing a more complete, multimodal treatment plan necessary. Interventional pain management (IPM) uses specific invasive procedures, with different degree of invasiveness, such as nerve blocks, neurolysis, neuromodulation, an

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… Multidisciplinary and Personalized Care is Essential : Effective pain management requires collaboration between oncologists, pain specialists, and palliative care teams. … Pharmacologic pain management: what radiation oncologists should know. Semin Radiat Oncol. 2023;33(2):93–103. 138. Fernandez E, Wargo JA, Helmink BA. The microbiome and cancer: a translational science review. …

Cancer care treatment attrition in adults: Measurement approaches and inequities in patient dropout rates - a rapid review.

BackgroundCancer treatment attrition refers to the discontinuation of prescribed cancer therapies before completion. It can significantly impact patient outcomes and cancer survival rates making it a critical concern. There is growing evidence on inequalities in cancer care, the avoidable systematic differences in the health of different groups of people. Understanding the extent of treatment attrition, why it happens, for whom, and associated inequalities may improve cancer care delivery and patient outcomes.MethodsA rapid review was conducted to identify existing evidence on measures of canc

Etiology and management of hypertension in patients with cancer.

The pathophysiology of hypertension and cancer are intertwined. Hypertension has been associated with an increased likelihood of developing certain cancers and with higher cancer-related mortality. Moreover, various anticancer therapies have been reported to cause new elevated blood pressure or worsening of previously well-controlled hypertension. Hypertension is a well-established risk factor for the development of cardiovascular disease, which is rapidly emerging as one of the leading causes of death and disability in patients with cancer. In this review, we discuss the relationship between

Onco-Cardiology: Consensus Paper of the German Cardiac Society, the German Society for Pediatric Cardiology and Congenital Heart Defects and the German Society for Hematology and Medical Oncology.

The acute and long-lasting side effects of modern multimodal tumour therapy significantly impair quality of life and survival of patients afflicted with malignancies. The key components of this therapy include radiotherapy, conventional chemotherapy, immunotherapy and targeted therapies. In addition to established tumour therapy strategies, up to 30 new therapies are approved each year with only incompletely characterised side effects. This consensus paper discusses the risk factors that contribute to the development of a potentially adverse reaction to tumour therapy and, in addition, defines

Review of oncological emergencies in small animal patients.

Oncological emergencies can occur at any time during the course of a malignancy and need to be recognized promptly to maximize successful outcomes. Emergencies are characterized as chemotherapy-induced, paraneoplastic syndromes, or directly related to the neoplasm. Prompt identification with treatment of these emergencies can prolong survival and improve quality of life, even in the setting of terminal illness. This review aims to educate the reader on the pathophysiology, clinical presentation and treatment of some of these emergencies, and to review the current veterinary literature to help

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… Introduction The care of oncology patients, when they develop acute complications either from their underlying neoplasm or secondary to therapy, presents a challenge for veterinary oncologists, general practitioners and emergency clinicians. … Chemotherapy‐induced emergencies Under the direction of a veterinary oncologist, chemotherapy administration is considered a relatively safe procedure with fewer than 25% of animals having adverse effects (AE) (Chun et al . 2001 ). …

Multidisciplinary approach for medication-related osteonecrosis of the jaws: a case report and literature review.

Medication-related osteonecrosis of the jaw (MRONJ) is a relatively rare but well-documented complication of bisphosphonate therapy. Bisphosphonates are prescribed to millions of patients for the treatment of osteoporosis, Paget's disease, multiple myeloma, bone metastases, and other bone-related conditions. These drugs inhibit bone resorption by binding to hydroxyapatite, particularly in areas of active resorption, thereby preventing osteoclasts from attaching to the bone. Long-term bisphosphonate therapy is considered a primary risk factor for MRONJ. Bisphosphonate-induced osteonecrosis typi

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… A multidisciplinary approach involving dental practitioners, oral surgeons, oncologists, and other specialists is essential for comprehensive care and early intervention. … The treatment of the condition requires a multidisciplinary team that includes an oral and maxillofacial surgeon, an oncologist, and a general dentist. After diagnosing the condition, the team evaluates the risks and benefits of either continuing or discontinuing the use of bone-modifying agents. …

Symptom burden in transplant ineligible patients with newly diagnosed multiple myeloma: a population-based cohort study.

Not available.

Antiresorptive medication in oncology: the clinical and dental profile of patients in a reference center.

OBJECTIVES: : The aim of this study was to evaluate the profile of patients on antiresorptive therapies for cancer treatment and assess presence of oral lesions, oral hygiene status, and knowledge regarding medication-related osteonecrosis of the jaw (MRONJ). MATERIALS AND METHODS: This was an observational cross-sectional study that evaluated patients treated with antiresorptive medication at a single cancer hospital. Clinical data were collected and oral examination was performed to assess patient oral health. RESULTS: From July 2017 to December 2018, 90 patients were assessed; 64 were fem

The Association Between Anticholinergic Burden and Treatment-Related Complications in Older Adults with Cancer.

BackgroundOlder adults constitute more than 50% of newly diagnosed cancer cases and polypharmacy is highly prevalent in this population. The Anticholinergic Burden (ACB) score quantifies the cumulative anticholinergic effects of all medications. Few studies link high ACB to adverse health outcomes in this population, and its effect on treatment outcomes remains largely unknown.ObjectiveThis study investigates the association between the ACB-score and treatment-related toxicity (grade ≥ 3), functional decline, and emergency room (ER) visits or hospitalization in older adults with cancer receivi

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… Both oncologists and pharmacists usually have the medication overview readily available. The ACB score can be calculated quickly using an online tool such as http://www.acbcalc.com . … Oncologist. 2020;25(3):e502–11. 8. Nightingale G, Skonecki E, Boparai MK. The impact of polypharmacy on patient outcomes in older adults with cancer. Cancer J. 2017;23(4):211–8. 9. Prithviraj GK, et al. …

Awareness and Knowledge About Preventive Vaccinations Among Patients with Hematological Malignancies.

BackgroundPatients with hematological malignancies, including multiple myeloma (MM) and chronic lymphocytic leukemia (CLL), are at an increased risk of severe infections due to both disease- and therapy-related immunosuppression. This cross-sectional study evaluated awareness of infection risks and vaccination uptake among 150 adults with various hematological malignancies from major Polish centers.MethodsAll participants completed a 30-item questionnaire capturing demographic data, treatment history, infection frequency, and vaccination attitude. Statistical analyses utilized Chi-square and F

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… This is underscored by the fact that 64.7% of respondents identified their oncologists or family physicians as their primary source of vaccination information. … Moreover, healthcare professionals played a crucial role in vaccination uptake in this cohort, with most patients citing their oncologists or family physicians as the primary sources of information. …

Создание барьеров и возможностей для осуществления программ самостоятельной терапии для пациентов с миломой: протокол качественного декриптационного исследования.

Множественная миелома (ММ) связана с наибольшим симптомным бременем всех гематологовых раковых заболеваний и, несмотря на значительное улучшение методов лечения с высокими показателями реагирования и выживаемости, все еще считается неизлечимой, причем пациенты в течение многих лет проходят многочисленные циклы лечения. Инъекции по подкожному методу (СК) являются распространенным способом доставки для текущей и будущей терапии ММ, при этом данные свидетельствуют о том, что программы, наделяющие пациентов или лиц, занимающихся уходом за больными, ответственностью за управление, могут принести по

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… , nurses, pharmacists, and general practitioners (GPs; stratum: health professionals) Focus group 4 HCPs without experience facilitating an NEST-SP Number of participants: minimum of 5 and maximum of 8 Hematologists, oncologists, nurses, pharmacists, and GPs (stratum: health professionals) Focus … group 5 HCPs from a private health service Number of participants: minimum of 5 and maximum of 8 Hematologists, oncologists, nurses, pharmacists, and GPs (stratum: health professionals) Focus group 6 Policymakers Number of participants: minimum of 4 and maximum of 6 Senior hospital administrators …

Temporary halo fixation and radiotherapy as alternative to long-construct spondylodesis in patients with multiple unstable cervical metastases.

Background and purposeCurrently no minimally invasive surgical treatment exists to provide immediate stability for unstable cervical/cervicothoracic metastases. Long-construct spondylodesis carries a high complication risk and has severe impact on residual range of motion. This study explores temporary halo fixation and radiotherapy as an alternative to long-construct cervical spondylodesis.Materials and methodsThis retrospective cohort study included twenty patients with multiple unstable cervical metastases treated between 2013-2023. All patients underwent halo fixation for an intended durat

The UK consensus supporting effective introduction of novel treatments for multiple myeloma in the National Health Service.

IntroductionMultiple myeloma (MM) is a relapsing, debilitating blood cancer which remains incurable despite advances in treatments. Patients typically receive multiple lines of treatment, to which they become refractory, thereby limiting treatment options. B-cell maturation antigen (BCMA) bispecific antibodies (BsAbs) represent a novel modality of treatment that has significant efficacy for relapsed or refractory patients.The objective was to develop consensus statements for the effective implementation of BCMA BsAbs for relapsed or refractory MM patients within the National Health Service (NH

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… Guided by an independent facilitator, a steering group of UK specialists (five consultant haematologists/haemato‐oncologists, one Lead Myeloma Clinical Nurse Specialist, one Lead Haematology Pharmacist and one Chief Pharmacist) experienced in MM care convened in September 2023 to discuss the considerations … The project was designed to capture not only the opinions of haematologists/haemato‐oncologists but also haematology nurse specialists, and pharmacists. The clearly defined inclusion criteria ensured that only the views of relevant stakeholders were sought. …

Osteoblastic bone reaction in non-small cell lung cancer harboring epidermal growth factor receptor mutation treated with osimertinib.

BackgroundOsteoblastic bone reaction (OBR) refers to an increase in bone density at the site of bone metastasis or the appearance of new sclerotic bone lesions after anticancer treatment. OBR can be misunderstood as disease progression. In this study, we aimed to investigate the prevalence and details of OBR and its association with clinical outcomes in patients with epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC) treated with osimertinib.MethodsThis was a single-center, retrospective cohort study. We reviewed patients who were diagnosed with EGFR-mutant NSCLC

Suicide, other externally caused injuries, and cardiovascular disease within 2 years after cancer diagnosis: A nationwide population-based study in Japan (J-SUPPORT 1902).

BackgroundThis study aimed to investigate the risk of death by suicide, other externally caused injuries (ECIs), or cardiovascular disease for patients with cancer.MethodsWe used data from the National Cancer Registry, which include the entire population in Japan. Patients diagnosed with cancer from January 1 to December 31, 2016 were included, and their follow-up period was set to 2 years. The standardized mortality ratio (SMR) of death by suicide, other ECIs, and cardiovascular disease was calculated compared with the general population. Multivariate Poisson or negative binomial regression a

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… Patient‐oncologist alliance as protection against suicidal ideation in young adults with advanced cancer. Cancer. 2014;120:2272‐2281. 20. Fujimori M, Shirai Y, Asai M, Kubota K, Katsumata N, Uchitomi Y. … Effect of communication skills training program for oncologists based on patient preferences for communication when receiving bad news: a randomized controlled trial. J Clin Oncol. 2014;32:2166‐2172. 21. Wang T, Molassiotis A, Chung BPM, Tan JY. …

Impact of Spinal Instrumentation on Neurological Outcome in Patients with Intermediate Spinal Instability Neoplastic Score (SINS).

Background: Adequate assessment of spinal instability using the spinal instability neoplastic score (SINS) frequently guides surgical therapy in spinal epidural osseous metastases and subsequently influences neurological outcome. However, how to surgically manage ‘impending instability’ at SINS 7−12 most appropriately remains uncertain. This study aimed to evaluate the necessity of spinal instrumentation in patients with SINS 7−12 with regards to neurological outcome. Methods: We screened 683 patients with spinal epidural metastases treated at our interdisciplinary spine center. The preoperati

Hypercalcemia of Malignancy: An Emergency Medicine Simulation.

Hypercalcemia is a poor prognostic factor associated with malignancy. The signs and symptoms of hypercalcemia that the patients present to the emergency department are vague and often overlap with the general symptoms of cancer itself or the adverse effects of the chemotherapy. Given that the development of hypercalcemia of malignancy can present with imminent danger to the patient and is a treatable condition, emergency physicians should know how to recognize and treat it. It also marks a time at which discussions regarding plans of care should be initiated with the patients. In this report,

Проект для самостоятельной мотивации: Качественное собеседование по вопросам предприимчивости выживших жертв рака к программам изменения цифрового здоровья.

СПРАВОЧНАЯ ИНФОРМАЦИЯ: Несмотря на повышенный риск рецидива, связанный с изменением образа жизни, многие лица, пережившие рак, не соблюдают рекомендации по укреплению здоровья. Цифровое медико-санитарное вмешательство открывает перспективы для поддержки изменений в поведении, однако лишь немногие исследования предусматривают участие выживших жертв в разработке мер вмешательства, что потенциально ограничивает эффективность реального мира. Понимание предпочтений и потребностей в поддержке выживших жертв рака имеет решающее значение для разработки эффективных мер по изменению поведения в цифровой