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Opportunities for prevention of alcohol-related death in primary care: results from a population-based cross-sectional study.

The mortality rate from alcohol-related conditions has risen sharply in the United Kingdom and it is not known whether opportunities for preventive interventions could be improved. The purpose of our study was to identify opportunities to detect, assess, and manage alcohol problems in primary care according to evidence-based guidelines. We carried out a cross-sectional study on patients who died from alcohol-related conditions in the calendar year 2003 within National Health Service Greater Glasgow Health Board area, Scotland (population 920,000). We described patient characteristics and care

Childhood sexual abuse, adolescent sexual behaviors and sexual revictimization.

OBJECTIVE: The aims of this study were to examine the extent to which exposure to childhood sexual abuse (CSA) was associated with increased rates of sexual risk taking behaviors and sexual revictimization during adolescence. METHOD: A birth cohort of 520 New Zealand born young women was studied at regular intervals from birth to the age of 18. At age 18 retrospective reports of CSA were obtained from sample members. Over the course of the 18 year study information was gathered on: (a) childhood, family, and related circumstances; and (b) the young women's history of sexual experiences from 1

Characteristics of prescription opioid abusers in treatment: prescription opioid use history, age, use patterns, and functional severity.

Research has raised the possibility that the length of time one engages in nonmedical use of prescription opioids may be associated with abuse of other drugs, more risky drug-related behavior, and more severe functional problems. This study drew on data from the Addiction Severity Index-Multimedia Version Connect system. A total of 55,341 client assessments at substance abuse treatment centers were analyzed to help understand the impact of length of time one has abused opioids on the patterns of abuse and functional problems. From this larger sample, 5686 individuals who had abused a prescript

Do community mental health teams caring for severely mentally ill patients adjust treatments and services based on patients' antisocial or criminal behaviours?

BACKGROUND: Antisocial behaviour is common among patients with severe mental illness (SMI) requiring hospitalisation. AIM: To determine whether differential treatments and services are provided to patients with SMI who engage in antisocial behaviour. METHOD: A random sample of 161 inpatients with SMI were recruited from general adult wards and assessed at baseline and two years later. Information on symptoms, aggressive behaviour, substance misuse, and service use was obtained from patients and clinical files. RESULTS: Past antisocial behaviours were not associated with type or intensity of

The manipulation of minds:reckoning with the legacy of the american post 9/11 torture program.

In this article, we argue that the government's post 9-11 torture program was a big lie, in that the designers, executors and enablers knew … g them compliant in the extreme. Indeed, the CIA and United States military, who both committed war crimes, knew all along that they propagated falsehoods - our main argument is that the historical record shows that the CIA itself has a long history of studying precisely the effect of techniques like those employed post 9/11. As we shall see, the so cal …

[The Dintilhac report and its implications for forensic neuropsychological evaluation].

BACKGROUND: When preparing neuropsychological expert reports, the neuropsychologist is asked to make a precise assessment of the victims' cognitive dysfunction, generally after traumatic head injury. The expert is usually required to assess the nature of the neuropsychological deficits, their correlation with any brain lesions and their imputability to the accident or crime in question, to estimate a possible date of stabilisation and to evaluate the heads of damage. The basic principle of compensation for personal injury is to consider the circumstances in which the victim would have been if …

A review of big data and medical research.

Universally, the volume of data has increased, with the collection rate doubling every 40 months, since the 1980s. "Big data" is a term that was introduced in the 1990s to include data sets too large to be used with common software. Medicine is a major field predicted to increase the use of big data in 2025. Big data in medicine may be used by commercial, academic, government, and public sectors. It includes biologic, biometric, and electronic health data. Examples of biologic data include biobanks; biometric data may have individual wellness data from devices; electronic health data include t

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… Big data shows trends from shopping, crime statistics, weather patterns, disease outbreaks, and so on. Recognizing the power of big data to effect change, the United Nations (UN) Global Working Group on big data was created under the UN Statistical Commission in 2014. … privacy laws. | Loss of privacy for participants or providers. | An encryption breach of provider data in an Australian study occurred. 52 , 53 Loss of privacy for biological relatives | Indirect loss of privacy was noted in the case of a relative of an ancestry seeker who was arrested for a serious crime …

Mass spectrometry-based metabolomics in health and medical science: a systematic review.

Metabolomics is the study of the investigation of small molecules derived from cellular and organism metabolism, which reflects the outcomes of the complex network of biochemical reactions in living systems. As the most recent member of the omics family, there has been notable progress in metabolomics in the last decade, mainly driven by the improvement in mass spectrometry (MS). MS-based metabolomic strategies in modern health and medical science studies provide innovative tools for novel diagnostic and prognostic approaches, as well as an augmented role in drug development, nutrition science

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… analysis for forensic science The overall objective of forensic science is to provide tools for all actors involved in criminal investigations and procedures in order to achieve fairer tracking, effective investigation of criminal science, and evidence for prosecution for or elimination from a suspected crime … Heroin is the second most popular recreational drug, more abusers die each year from heroin abuse than from any other illicit drug, and it causes a great many people to commit crimes. …

Pharmacological interventions for drug-using offenders.

BACKGROUND: The review represents one in a family of four reviews focusing on a range of different interventions for drug-using offenders. T … tion (one study, 44 participants, RR 1.10 (95% CI 0.37 to 3.26)), and continuous outcome measure of crime MD -0.50 (95% CI -8.04 to 7.04)) or self report drug use MD 4.60 (95% CI -3.54 to 12.74)). AUTHORS' CONCLUSIONS: Pharmacological interventions for drug-using offenders do appear to reduce overall subsequent drug use and criminal activity (but to a …

Ethnicity in systemic AL amyloidosis may impact risk stratification.

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… It is a composite index derived from household postcodes (1-10: most to least deprived), based on seven sub-domains representing deprivation in income, employment, education, health, crime, housing and living environment. …

Targeting the nuclear export receptor exportin-1 in acute myeloid leukaemia: From biology to clinical translation.

BACKGROUND: Exportin-1 (XPO1), a key regulator of nucleocytoplasmic transport, is frequently dysregulated in acute myeloid leukemia (AML) and contributes to leukemogenesis, disease progression and therapeutic resistance. Selective inhibitors of nuclear export (SINEs), especially selinexor and eltanexor, have shown promising antileukemic potential. However, their clinical value, optimal therapeutic positioning and rational use in AML remain to be fully clarified. METHODS: We collected and reviewed relevant literature to summarize the biological roles of XPO1 in AML and the therapeutic potentia

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… suppressor proteins and signalling mediators, disrupts normal regulatory networks and promotes leukaemogenesis and disease progression. 16 Structurally, XPO1 is a ∼123‐kDa karyopherin‐β family protein composed of 21 tandem HEAT repeats arranged into a toroidal, ring‐like architecture, with an N‐terminal CRIME … The N‐terminal CRIME domain is indicated. …

The Cost of Biological Terrorism.

Most Americans are or will be facing a threat more real than crimes or terrorism-it is the threat of cancer. Indeed, one-fourth of all Americans alive today will ultimately die from cancer. Yet the level of funding for cancer research in 1998 and beyond remains in doubt. The Senate Appropriations Committee has proposed a higher funding figure than the House and the difference will be resolved in negotiations this September. President Clinton has recommended a meager 2.5% increase in spending on cancer. This sum is simply not enough. Although Americans may fool themselves into thinking the gove…

[What is the interest of Klinefelter's syndrome for (child) psychiatrists?].

Klinefelter's syndrome (KS) concerns men and is usually characterized by tallness, underdeveloped testes and sterility. It is generally due … t data in litterature proving that the restoration of physiological androgen blood levels increases crimes nor aggressiveness. In the contrary, Miller and Sulkes described four cases of KS men presenting chronic fire-setting behaviors. Testosterone was introduced. For three of them, follow-up was available: their behavior seemed improved and none of the …