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Well being of obstetric patients on minimal blood transfusions (WOMB trial).

BACKGROUND: Primary postpartum haemorrhage is an obstetrical emergency often causing acute anaemia that may require immediate red blood cell (RBC) transfusion. This anaemia results in symptoms such as fatigue, which may have major impact on the health-related quality of life. RBC transfusion is generally thought to alleviate these undesirable effects although it may cause transfusion reactions. Moreover, the postpartum haemoglobin level seems to influence fatigue only for a short period of time. At present, there are no strict transfusion criteria for this specific indication, resulting in a w…

Obstructive sleep apnoea in a patient with chronic lymphocytic leukaemia.

A 69-year-old Caucasian woman presented with chronic lymphocytic leukaemia (CLL; stage 1-Rai System), significant oropharyngeal lymphoid enlargement, snoring and fatigue. Overnight polysomnography revealed moderately severe obstructive sleep apnoea (OSA), which was managed successfully with oral appliance therapy with resolution of snoring and daytime fatigue. Structural abnormalities of the upper airways are known to cause OSA. Airway narrowing can result from bony structural abnormalities, nasopharyngeal growth, soft tissue redundancy, macroglossia, malignant and benign growth of the upper a…

Postpartum sacral stress fracture: a case report.

BACKGROUND: Stress fractures are classified as insufficiency and fatigue fractures. Insufficiency fractures occur when normal stresses are placed on bone with decreased mineralization and elastic resistance; whereas fatigue fractures occur when abnormal forces are applied to normal bone. CASE PRESENTATION: We report a case of postpartum bilateral sacral fracture in the absence of documented osteoporosis in a 30 year old Lebanese female, thus satisfying the classification of fatigue fractures. Clinical presentation was mainly low back pain, pelvic pain, and abnormal gait. CONCLUSIONS: This ca…

Association between lesion location and symptoms of restless leg syndrome (RLS) among patients with multiple sclerosis (MS).

PURPOSE.: Restless legs syndrome (RLS) is a common but under-recognised non-motor symptom in multiple sclerosis (MS), potentially linked to central nervous system lesion distribution. This study aimed to assess the anatomical distribution of MRI-detected lesions in MS patients with and without RLS. METHODS.: A retrospective cohort study was conducted at King Saud University Medical City between April 2023 and March 2024. MRI lesion patterns, fatigue (Fatigue Severity Scale, FSS), sleep quality (Pittsburgh Sleep Quality Index, PSQI), and vitamin D3 levels were compared between MS patients with …

Real-Time Wearable Cervical Posture Monitoring in Dentistry: A Prospective Usability Trial with Dental Students.

Dentists routinely adopt forward-lean postures that can lead to chronic spinal musculoskeletal disorders. Wearable real-time feedback may prompt microadjustments that preserve spinal health. This article aims to develop a wearable device for real-time detection of forwardleaning posture in dentistry, to assess its usability and alert rate during standardized student tasks, and to estimate cervical-disc fatigue lifetime from the measured headflexion profile using a simplified S-N model.An assistive device was constructed around an Arduino Uno interfaced with a three-axis FC-51 tilt-switch modul…

Association between quadrivalent human papillomavirus vaccination and selected syndromes with autonomic dysfunction in Danish females: population based, self-controlled, case series analysis.

OBJECTIVE: To evaluate the association between quadrivalent human papillomavirus vaccination and syndromes with autonomic dysfunction, such as chronic fatigue syndrome, complex regional pain syndrome, and postural orthostatic tachycardia syndrome. DESIGN: Population-based self-controlled case series. SETTING: Information on human papillomavirus vaccinations and selected syndromes with autonomic dysfunction (chronic fatigue syndrome, complex regional pain syndrome, and postural orthostatic tachycardia syndrome) identified using ICD-10 (international classification of diseases, revision 10) di…

Effectiveness of Resistance Intradialytic Exercise Compared to Aerobic Intradialytic Exercise for Patients With Chronic Kidney Disease: A Randomized Controlled Clinical Trial.

BACKGROUND: Patients with chronic kidney disease undergoing hemodialysis commonly experience reduced physical function, fatigue, poor sleep quality, and impaired health-related quality of life. Intradialytic exercise has been proposed as a non-pharmacological strategy to improve these outcomes. METHODS: Randomized clinical trial with 35 hemodialysis patients randomly allocated to a resistance group (RG) or aerobic group (AG). Exercises were performed during hemodialysis for 12 weeks. The primary outcome was handgrip strength (HGS). Secondary outcomes included the 30-second sit-to-stand test (…

Инвалидность и симптомы, не связанные с младенчеством, в множестве склерозов: изучение ассоциаций и предсказательных факторов.

Связь между множественным склерозом (MS) и совместной немоторной симптоматологией не вполне понятна. В ходе этого исследования изучалась связь между состоянием инвалидности и немоторными симптомами - качеством сна, депрессией, тревогой и усталостью людей с множественным склерозом (MS), а также вклад качества сна в предсказание усталости, депрессии и тревоги в MS. МЕТОДЫ: Межсекциональное исследование охватывало 469 предметов MS и 369 предметов контроля. Инвалидность лиц, изучающих МЗ, оценивалась на основе Расширенной шкалы статуса инвалидов (EDSS), в то время как усталость, депрессия, беспоко

Совпадение в аннотации оригинала
BACKGROUND/OBJECTIVES: The relationship between multiple sclerosis (MS) disability and co-occurring non-motor symptomatology is not well understood. This study examined the association between disability status and non-motor symptoms-sleep quality, depression, anxiety, and fatigue-in people with multiple sclerosis (MS), as well as the contribution of sleep q…

Benefit of Wearing an Activity Tracker in Sarcoidosis.

Sarcoidosis causes many disabling symptoms, including fatigue and exercise limitations, which have been shown to improve by physical activity programs. The aim of this study was to estimate the effect of continuous activity monitoring using an electronic activity tracker (AT) on exercise performance and fatigue of sarcoidosis patients, compared to controls (cohort study), and the effect of additional personal coaching (randomized trial) over a period of 3 months. Fifty-four sarcoidosis patients received an AT (Group Ia: 27 with coaching and Group Ib: 27 without). A historical group of sarcoido…

Determinants of recovery from a 161-km ultramarathon.

The primary study objective was to identify determinants of short-term recovery from a 161-km ultramarathon. Participants completed 400 m runs at maximum speed before the race and on days 3 and 5 post-race, provided a post-race blood sample for plasma creatine kinase (CK) concentration, and provided lower body muscle pain and soreness ratings (soreness, 10-point scale) and overall muscular fatigue scores (fatigue, 100-point scale) pre-race and for 7 days post-race. Among 72 race finishers, soreness and fatigue had statistically returned to pre-race levels by 5 days post-race; and 400 m times a…

Functional Changes after Recombinant Human Growth Hormone Replacement in Patients with Chronic Traumatic Brain Injury and Abnormal Growth Hormone Secretion.

We explored the effects of recombinant human growth hormone (rhGH) replacement on physical and cognitive functioning in subjects with a mode … sing speed, and cognitive flexibility, as well as self-report inventories related to depression and fatigue, were administered at baseline and 1 year after rhGH replacement. Comparison tests were performed with proper post hoc analyses. All analyses were carried out at α < 0.05. Peak O2 consumption, peak oxygen pulse (estimate of cardiac stroke volume), a …

The Claude Organ Memorial Lecture: the practice of surgery: surgery as practice.

Compassion fatigue or "burn out" occurs in all surgeons at some point in their career. Compassion fatigue can be identified, prevented and treated by simple measures of self care. In addition, learning techniques of mindfulness can allow surgeons to see their work in a way that decreases stress.

Feedback from group III/IV afferents in skeletal muscle slows heart rate acceleration when transitioning from rest to low-intensity exercise in males.

Group III/IV skeletal muscle afferents respond to intramuscular mechanical and metabolic stimuli and are more active in fatigued muscle. These afferents project onto the brainstem and motor cortex and modulate cardiovascular and motor responses during exercise. The maximal rate of heart rate (HR) increase (rHRI), a marker of HR acceleration during the rest-to-exercise transition, is linearly related to exercise performance across various training and fatigue states, being faster with better exercise performance and vice versa. This study evaluated the effect of feedback from group III/IV affer…

Quantifying Active and Passive Stiffness in Plantar Flexor Muscles Following Intermittent Maximal Isometric Contractions Using Shear Wave Elastography.

OBJECTIVE: This study aimed: (i) to investigate the impact of fatigue, triggered by maximal isometric contraction exercises, on the active and passive stiffness of plantar flexors (PF), and (ii) to examine the relationship between changes in mechanical parameters and neuromuscular alterations after fatigue. METHODS: A healthy cohort (n = 12; age = 27.3 ± 5.5 y; BMI = 24.4 ± 2.35 kg/m²) was instructed to perform 60 isometric contractions, each lasting 4 s with a 1-s rest interval, using an ergometer. Several measures were taken before and after the fatigue protocol. First, the stiffness of the…

Internet and smartphone-based ecological momentary assessment and personalized advice (PROfeel) in adolescents with chronic conditions: A feasibility study.

OBJECTIVE: Growing up with a chronic disease comes with challenges, such as coping with fatigue. Many adolescents are severely fatigued, though its associated factors exhibit considerable interpersonal and longitudinal variation. We assessed whether PROfeel, a combination of a smartphone-based ecological momentary assessment (EMA) method using the internet, followed by a face-to-face dialogue and personalized advice for improvement of symptoms or tailor treatment based on a dynamic network analysis report, was feasible and useful. STUDY DESIGN: Feasibility study in fatigued outpatient adolesc…

The SIMM study: Survey of integrative medicine in myeloproliferative neoplasms.

Myeloproliferative neoplasms (MPNs) are characterized by significant symptom burden. Integrative medicine (IM) offers unique symptom management strategies. This study describes IM interventions utilized by MPN patients and the association with symptom burden, quality of life, depression, and fatigue adjusted for lifestyle confounders. MPN patients were surveyed online for IM utilization, MPN symptom burden (MPN-Symptom Assessment Form Total Symptom Score), depression (Patient Health Questionnaire), fatigue (Brief Fatigue Inventory), and a single question on overall quality of life. Measures we…

Health-related quality of life in patients with chronic myeloid leukemia receiving first-line therapy with nilotinib.

BACKGROUND: Although a wealth of efficacy and safety data is available for many tyrosine kinase inhibitors used in chronic myeloid leukemia (CML), there is a dearth of information on their impact on patients' health-related quality of life (HRQOL). The primary objective of this study was to evaluate HRQOL and fatigue outcomes in patients with CML receiving first-line therapy with nilotinib. METHODS: This was a multicenter, prospective study enrolling 130 patients with chronic-phase CML. HRQOL and fatigue were evaluated with the European Organization for Research and Treatment of Cancer Qualit…

Mechanomyography responses characterize altered muscle function during electrical stimulation-evoked cycling in individuals with spinal cord injury.

BACKGROUND: Investigation of muscle fatigue during functional electrical stimulation (FES)-evoked exercise in individuals with spinal cord injury using dynamometry has limited capability to characterize the fatigue state of individual muscles. Mechanomyography has the potential to represent the state of muscle function at the muscle level. This study sought to investigate surface mechanomyographic responses evoked from quadriceps muscles during FES-cycling, and to quantify its changes between pre- and post-fatiguing conditions in individuals with spinal cord injury. METHODS: Six individuals w…

High disease impact of myotonic dystrophy type 2 on physical and mental functioning.

The aim of the study was to investigate health status in patients with myotonic dystrophy type 2 (DM2) and determine its relationship to pain and fatigue. Data on health status (SF-36), pain (MPQ) and fatigue (CIS-fatigue) were collected for the Dutch DM2 population (n = 32). Results were compared with those of sex- and age-matched adult-onset myotonic dystrophy type 1 (DM1) patients. In addition, we compared the obtained scores on health status of the DM2 group with normative data of the Dutch general population (n = 1742). Compared to DM1, the SF-36 score for bodily pain was significantly (p…

The effects of theophylline and caffeine on the isolated rat diaphragm.

It is a well known fact that theophylline enhances the force of diaphragmatic contraction and delays fatigue. The action of caffeine which is a methylxanthine analogue on skeletal muscle are complex. It was claimed in few studies that the caffeine was more effective on the diaphragmatic contractility than the theophylline. The aim of this study is to compare the effects of theophylline and caffeine on the tension generated by fresh and fatigued diaphragmatic muscle. Studies were performed in vitro on diaphragmatic muscle strips of rats activated by electrical stimuli applied via the phrenic ne…