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Hypertension, smoking, and preexistence of multiple cardiac risk factors correlate with carfilzomib-induced cardiovascular adverse events in a racially diverse population.

BackgroundUse of the proteasome inhibitor carfilzomib has become a standard of care in patients with relapsed/refractory multiple myeloma. An association between carfilzomib and cardiovascular adverse events has been well documented, but this had not been investigated in a racially diverse population. Black patients in particular are underrepresented in the reported outcomes of treatment with carfilzomib.ObjectiveThe purpose of this study was to identify risk factors for carfilzomib-associated cardiovascular events in a diverse, single-center population.MethodsWe conducted a retrospective revi

Consensus Statement: Importance of Timely Access to Multiple Myeloma Diagnosis and Treatment in Central America and the Caribbean.

BackgroundIn Central America and the Caribbean, multiple myeloma (MM) patients face significant barriers to diagnosis and treatment. The aim of this study is to describe the current situation of MM in the region, discuss the current barriers to timely diagnosis and proper treatment, and develop consensus recommendations to address these issues.MethodsNine experts from five countries took part in a virtual consensus meeting on MM in Central America and the Caribbean. During the meeting, experts analyzed the disease burden, the current conditions for disease management, and access to treatment i

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… barriers to disease diagnosis and management are late diagnosis due to non-specificity of symptoms; lack of general knowledge about the disease or the role of hematologists; lack of timely access to medical specialists; and the absence of a multidisciplinary approach by a team that includes hematologists, oncologists … The symptoms, characteristics, and possible complications associated with the disease often require a multidisciplinary approach, including a team of hematologists, oncologists, orthopedists, neurosurgeons, internists, nephrologists, cardiologists, psychiatrists, psychologists, and palliative care experts …

Joint-preserving palliative surgery using self-locking screws of intramedullary nail and percutaneous cementoplasty for proximal humeral metastasis in the advanced cancer patients.

BackgroundWe introduced a palliative joint-preserving surgery using proximal self-locking screws of intramedullary (IM) nail and percutaneous cementoplasty (PC) in patients with proximal humeral metastases, including the head and neck, and evaluated the outcome of the surgical method.MethodsTwenty-three patients (mean age = 63.0 ± 11.8 years, M:F = 14:9) had IM nailing with a self-locking screw system and PC for the treatment of humeral head and neck metastases. Usually, three proximal locking screws were inserted after IM nailing, and 20.9 ± 8.0 ml of polymethylmethacrylate (PMMA) bone cement

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… Additional therapy The conventional treatment for bone metastasis, radiation therapy, and/or chemotherapy was decided by a multidisciplinary team approach of the hemato-oncologists, radiation oncologists, and orthopedic surgeons [ 18 ]. …

The impact of radiation treatment planning technique on unplanned hospital admissions.

PurposeTreatment burdens and toxicities related to palliative radiation therapy (RT) may lead to unplanned hospital admissions (UHAs). The likelihood for these toxicities may be related to treatment technique. We compared rates of UHA between patients receiving nonconformal (2-dimensional) and conformal (3-dimensional or higher) radiation treatments to bone metastases involving the vertebral column.Methods and materialsWe retrospectively analyzed patients treated with RT for bone metastases at a single tertiary care center between 2010 and 2017. We compared rates of RT-related UHA within 90 da

Efficacy and Effectiveness of Carnitine Supplementation for Cancer-Related Fatigue: A Systematic Literature Review and Meta-Analysis.

BackgroundCarnitine deficiency has been implicated as a potential pathway for cancer-related fatigue that could be treated with carnitine supplementation. The aim of this systematic literature review and meta-analysis was to evaluate the literature regarding the use of supplemental carnitine as a treatment for cancer-related fatigue.MethodsUsing the PRISMA guidelines, an electronic search of the Cochrane Library, MEDLINE, Embase, CINAHL and reference lists was conducted. Data were extracted and independently assessed for quality using the Academy of Nutrition and Dietetics evidence analysis by

Complications After Percutaneous Pedicle Screw Fixation for the Treatment of Unstable Spinal Metastases.

BackgroundComplications after surgical stabilization for the treatment of unstable spinal metastases are common. Less invasive surgical (LIS) procedures are potentially associated with a lower risk of complications; however, little is known regarding the complications after LIS procedures for the treatment of spinal metastases. Our primary objective was to determine the characteristics and rate of complications after percutaneous pedicle screw fixation (PPSF) for the treatment of mechanically unstable spinal metastases. The secondary objective was to identify factors associated with the occurr

Keyword Index for Volume 108

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… non-small-cell lung carcinoma 1415 non-targeted response 1106 Norway 1525 Notch3 1488 NSCLC 265, 1695 obesity 222, 727, 1408 oesophageal squamous cell carcinoma 644 oesophago-gastric cancer 25 oestrogen receptor 155 oestrogen sulphotransferase 1415 off-target effects 450 older women 1042 oncologists … 1602 oncologists' views 2264 oncology 1071, 1273 oncolytic 245 one-carbon metabolism 183 oral contraceptives 234 oral squamous cell carcinoma (OSCC) 370, 1817 oral tongue cancer 638 oropharyngeal 1332 osteosarcoma (OS) 836 osteotropism 2525 outcome 887 ovarian cancer 250, 881, 1231, 1553 …

Analysis of prognostic factors relating to postoperative survival in spinal metastases.

OBJECTIVE: To analyze the prognostic factors thought to be related with survival time after a spinal metastasis operation. METHODS: We retrospectively analyzed 217 patients who underwent spinal metastasis operations in our hospital from 2001 to 2009. Hematological malignancies, such as multiple myeloma and lymphoma, were excluded. The factors thought to be related with postoperative survival time were gender, age (below 55, above 56), primary tumor growth rate (slow, moderate, rapid group), spinal location (cervical, thoracic, and lumbo-sacral spine), the timing of radiation therapy (preopera

The burden and predictors of venous thromboembolic diseases in patients with multiple primary malignancies.

BackgroundVenous thromboembolism (VTE) represents a considerable burden on cancer patients' survival and quality of life, but this burden varies based on the patient's baseline characteristics and cancer-related factors. Although solid evidence on the predictors and effect of VTE in cancer patients exists.AimTo evaluate VTE rate, morbidity, and mortality to develop parameters that could predict VTEs and their associated mortality in patients with multiple primary malignancies (MPMs).Method and resultsThis was a retrospective cohort study that took place at King Abdulaziz Medical City, Riyadh,

Adverse Events of Oncologic Immunotherapy and Their Management.

Over the past two decades, immunotherapy has emerged as a promising treatment option for patients with cancer. However, newer versions of immunotherapy, such as checkpoint inhibitors, may be associated with unusual adverse effects (AEs) that can range in severity from mild to life-threatening. Unlike common AEs of conventional chemotherapy, which have a predictable nadir or cyclic pattern after administration, AEs of these newer immunotherapies are variable, depending on the type of immunotherapy, route of administration, and mechanism of action. The onset and resolution of these AEs may be pr

Роль ДИОТРЕИТОЛ в разрешении предтрансмиссии иммуногематологии у пациентов, получающих anti-CD38 Моноклональные антитела для лечения множественной миеломы.

ВВЕДЕНИЕ: Daratumumab (Darzalex; Janssen-Cilag Pty Ltd), a/ anti-CD38 Моноклональная антитела (MoAb) продемонстрировала высокую эффективность в лечении рецидива и рефрактной множественной миеломы (MM). Она стоит как пионер anti-CD38 Минздрав, утвержденный Управлением лесного хозяйства США (УЛХ)2015) и GGA Australia (Australia)2017). Направляя CD38 на клетки миэломы, Daratumumab создает проблему в проведении предтрансфузионных испытаний, вызывая панреактивность при косвенных тестах на антиглобулин (ИАТ) из-за выражения CD38 на красных клетках. В этом исследовании изучается роль ДИОТРЕИТОЛ (ДТТ)

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… In the era of monoclonal antibody therapy revolutionizing oncology, effective communication between oncologists and transfusion services is paramount. … It is imperative for transfusion services to inform oncologists about DARA’s interference with pretransfusion tests and recommend conducting type and screen evaluations before initiating treatment. Conflicts of interest There are no conflicts of interest. Funding Statement Nil. References 1. …

Assessment of adherence to the guidelines for the management of nausea and vomiting induced by chemotherapy.

ObjectiveTo assess adherence of the prescribing physicians in a private cancer care center to the American Society of Clinical Oncology guideline for antiemetic prophylaxis, in the first cycle of antineoplastic chemotherapy.MethodsA total of 139 chemotherapy regimens, of 105 patients, were evaluated retrospectively from 2011 to 2013.ResultsWe observed 78% of non-adherence to the guideline rate. The main disagreements with the directive were the prescription of higher doses of dexamethasone and excessive use of 5-HT3 antagonist for low risk emetogenic chemotherapy regimens. On univariate analys

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… This study used the ASCO guideline ( 2 ) to assess adherence of oncologists to the recommended procedures. Whereas this information is widely available, we found that adherence to guidelines was low (22%). … The study did not specifically mention the adherence rate of oncologists. ( 13 ) This same study discussed some points that may hinder adherence, as a payment system based on volume rather than performance; the technological barrier, which is still true for some professionals, hindering access to protocols …

Spine surgery for metastatic spine cancer in the era of advanced radiation therapy.

Metastatic spine cancer (MSC), a common complication of advanced malignancies, poses significant challenges due to pain, neurological deficits, and mechanical instability. While radiation therapy is a cornerstone of treatment, the role of spine surgery is evolving, fueled by advances in surgical techniques and radiation modalities such as stereotactic body radiation therapy (SBRT). This review examines the evolving role of spine surgery in MSC management, focusing on separation surgery, surgical innovations, and future directions. The treatment paradigm for MSC shifted with the advent of SBRT,

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… Despite SBRT’s superior local control, radiation oncologists often opt for EBRT due to challenges with SBRT [ 16 ], including the complexity of radiation planning due to spine instrumentation, increased risk of radiation myelopathy from preoperative radiation [ 25 ], and verifying adequate tumor-thecal … Close communication between the surgeon and radiation oncologist, starting preoperatively, is crucial to optimize postoperative radiation therapy and modality [ 60 ]. ERAS protocol for patients with MSC can lead to improved short-term patient recovery [ 22 , 85 – 87 ]. …

Neoplastic Disorders and Cardiovascular Comorbidities in Geriatric Patients: A Simple Association?

Cardiovascular disease (CVD) and cancer frequently coexist in older patients, posing significant challenges in clinical management due to overlapping risk factors and treatment-related complications. This narrative review summarizes current knowledge on the epidemiology, shared pathophysiological mechanisms and clinical impact of neoplastic comorbidities in older adults with cardiovascular diseases. It highlights the increased mortality, morbidity and diminished quality of life resulting from the coexistence of these conditions. The review also discusses personalized management strategies, emp

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… In older patients with cardiovascular comorbidities, oncologists may opt for less aggressive therapies or reduced doses to minimize the risk of cardiac complications. … Furthermore, drug–drug interactions and polypharmacy in older patients complicate treatment planning, requiring close collaboration between oncologists, cardiologists and geriatricians [ 74 ]. …

Время для последующей терапии (TTST) в качестве конечной точки в клинических исследованиях: разработка стандартизованной документации о последующей терапии на основе систематического обзора литературы, опросов экспертов и обследования Делфи.

СПРАВОЧНАЯ ИНФОРМАЦИЯ: конечная точка " Время для последующей терапии " (TTST) является промежуточной точкой, используемой в исследованиях и оценках регулирования. TTST означает начало последующей терапии и является четко определенным, клинически значимым мероприятием для медицинских работников. Однако она не была систематически установлена, в какой степени TTST субъективно значима для пациентов. Цель этого исследования заключалась в том, чтобы определить TTST как промежуточный конечный показатель, учитывающий интересы пациентов.МЕТОДЫ: Изученное исследование five Онкологические пока

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… The first Delphi round targeted physicians, psycho-oncologists, nursing professionals, patient navigators, patients, relatives, advocates, health economists and industry experts. Sample-neutral dropouts included invalid contact details or career changes. … Respondents were grouped as: (1) patients / relatives / advocates; (2) physicians / psycho-oncologists; (3) nursing professionals / patient navigators; (4) health economists; (5) industry professionals. …

Управление неблагоприятными событиями, связанными с комбинациями на основе помалидомида у пациентов с повторной/редактируемой множественной миеломой.

Многоагентные режимы с иммуномодуляционными (IMID) агентами, такими, как палидомид, линалидомид и помалидомид, стали предпочтительным стандартом лечения пациентов с множественной миеломой (MM), что позволило улучшить показатели выживания. В настоящее время существуют three Агенты IMID, утвержденные для лечения MM: талидомид, линалидомид и помалидомид. Леналидомид обычно используется для лечения пациентов с недавно поставленным диагнозом MM, а также для лечения после пересадки стволовых клеток или после рецидива заболевания. Помалидомид, в центре внимания которого находится данный обзор, утверж

Palliative Care and the Management of Common Distressing Symptoms in Advanced Cancer: Pain, Breathlessness, Nausea and Vomiting, and Fatigue.

Good symptom management in oncology is associated with improved patient and family quality of life, greater treatment compliance, and may even offer survival advantages. With population growth and aging, the proportion of patients with multiple symptoms-both related and unrelated to their cancer-is anticipated to increase, supporting calls for a more routine and integrated approach to symptom management. This article presents a summary of the literature for the use of symptom assessment tools and reviews the management of four common and distressing symptoms commonly experienced by people with

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… Medical oncologists’ attitudes and practice in cancer pain management: A national survey. J Clin Oncol. 2011;29:4769–4775. doi: 10.1200/JCO.2011.35.0561. 20. Deandrea S, Montanari M, Moja L, et al. Prevalence of undertreatment in cancer pain. A review of published literature. … The effect of real-time electronic monitoring of patient-reported symptoms and clinical syndromes in outpatient workflow of medical oncologists: E-MOSAIC, a multicenter cluster-randomized phase III study (SAKK 95/06) Ann Oncol. 2016;27:324–332. doi: 10.1093/annonc/mdv576. 47. …

Mindfulness-Oriented Recovery Enhancement Restructures Reward Processing and Promotes Interoceptive Awareness in Overweight Cancer Survivors: Mechanistic Results From a Stage 1 Randomized Controlled Trial.

IntroductionThe primary aims of this Stage I pilot randomized controlled trial were to establish the feasibility of integrating exercise and nutrition counseling with Mindfulness-Oriented Recovery Enhancement (MORE), a novel intervention that unites training in mindfulness, reappraisal, and savoring skills to target mechanisms underpinning appetitive dysregulation a pathogenic process that contributes to obesity among cancer survivors; to identify potential therapeutic mechanisms of the MORE intervention; and to obtain effect sizes to power a subsequent Stage II trial.MethodsFemale overweight

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… Participants were recruited between 2014 and 2015 through direct referrals from oncologists at the Huntsman Cancer Hospital and through flyers posted in the hospital. See Figure 1 for the CONSORT study flow diagram. Figure 1. Flow diagram of the progress through the study. … Oncologist . 2010 ; 15 : 1083 - 1101 . doi: 10.1634/theoncologist.2010-0206 20930095 PMC3227901 63 Ma Y Yang Y Wang F et al Obesity and risk of colorectal cancer: a systematic review of prospective studies . …

Systematic Review of Intravenous Ascorbate in Cancer Clinical Trials.

BackgroundAscorbate (vitamin C) has been evaluated as a potential treatment for cancer as an independent agent and in combination with standard chemotherapies. This review assesses the evidence for safety and clinical effectiveness of intravenous (IV) ascorbate in treating various types of cancer.MethodsSingle arm and randomized Phase I/II trials were included in this review. The PubMed, MEDLINE, and Cochrane databases were searched. Results were screened by three of the authors (GN, RP, and CJP) to determine if they met inclusion criteria, and then summarized using a narrative approach.Result

The functional imperative in high-grade glioma.

Precision oncology has emerged as a promising strategy for treating high-grade gliomas, yet its clinical impact has been disappointing, with over 300 clinical trials on targeted therapies failing to yield substantial improvements in patient outcomes. Current approaches primarily focus on static, marker-driven tumor features, which capture only a small portion of the complex biology that governs therapeutic responses. Functional precision oncology (FPO) offers a complementary approach, enhancing treatment selection in a personalized manner by dynamically testing patient-derived tumor cells agai

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… Achieving this will require coordinated efforts among multidisciplinary teams, including oncologists, pathologists, bioinformaticians and laboratory scientists, to streamline sample processing, ensure robust data interpretation and deliver individualized treatment strategies. … Oncologist 10.1093/oncolo/oyaf146 (2025). 32. Boongird, A. et al. Glioblastoma with novel EGFR mutations (T790M and exon 20 insertion) yet unresponsive to osimertinib: a case report. Genes Chromosomes Cancer 62 , 423–429 (2023). 33. Makhlin, I. et al. …