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Family Game Show-style Didactic for Teaching Nervous System Disorders during Emergency Medicine Training.

AUDIENCE: Emergency medicine residents and medical students. INTRODUCTION: The field of emergency medicine requires learners to build a vas … nogen activator) contraindications/TPA eligibility, optic neuritis, botulism, giant cell (temporal) arteritis, viral encephalitis, neurocysticercosis, rabies, myasthenia gravis, neurosyphilis, status epilepticus, Bell's palsy, dementia vs. delirium, acute inflammatory demyelinating polyneuropathy (Guillain-Barré); 2) recognize five pattern words associated …

Retrospective serological evidence of exposure to selected equine viruses in horses from Indigenous communities of Costa Rica, 2011.

Horses are essential for transportation and livelihoods in Indigenous communities of Costa Rica. However, information on their exposure to viral pathogens remains scarce. We conducted a retrospective cross-sectional serosurvey using samples collected from horses from four Indigenous communities (Alto Pacuare, Amubre, Paso Marcos, and Vereh) sampled between March and October 2011 (n = 278). Sera were tested in 2014 using commercial immunodiffusion or ELISA assays for antibodies against West Nile virus (WNV), equine herpesviruses 1 and 4 (EHV-1 and EHV-4), influenza A virus, equine arteritis vir…

Systematic establishment of approaches to the detection of equine macrophage polarization and their application in pathogenic infection.

Macrophage phenotypic adaptation critically regulates inflammatory balance during infection; however, progress in equine immunology has been … pathogen-specific marker profiles: Salmonella abortus equi, equine herpesvirus (EHV-1), and equine arteritis virus (EAV) promoted an early M1-like profile, whereas an attenuated equine infectious anemia virus (EIAV) strain drove an M2-like phenotype. Ultimately, this work provides a validated detection system for equine macrophage phenotyping, establishing …

Study on the implementation of the 2015 EULAR/ACR recommendations for polymyalgia rheumatica in clinical practice.

OBJECTIVES: To study the implementation of the 2015 European Alliance of Associations for Rheumatology (EULAR)/American College of Rheumatology (ACR) management recommendations for polymyalgia rheumatica (PMR) among rheumatologists and general practitioners (GPs). METHODS: An online survey (Survey Monkey) comprising 28 questions was distributed among members of the EULAR Study Group on PMR and giant cell arteritis (n=375). Each member was asked to invite at least one GP (snowball principle) with experience in PMR to participate. Statistical analysis included descriptive statistics; difference…

Tocilizumab: From Bench to Bedside - A Comprehensive Review.

INTRODUCTION: Interleukin-6 (IL-6) is a key mediator of inflammation and cancer biology. Tocilizumab, an IL-6 receptor blocker, is used to t … mab continues to demonstrate reliable anti-inflammatory effects in rheumatoid arthritis, giant cell arteritis, and COVID-19, with a consistent safety profile that includes infections, cytopenias, and elevated liver enzymes or lipid levels. In oncology, it is the standard treatment for moderate to severe CRS associated with CAR-T therapy and is increasingly …

Litigation trends within rheumatology: a retrospective analysis of claims data from England for the Getting It Right First Time programme.

OBJECTIVES: To examine rheumatology-related litigation claims over a 5-year period to describe trends and identify learning opportunities. METHODS: Data were extracted from NHS Resolution for all claims within rheumatology or claims referencing 'giant cell arteritis (GCA)' or 'vasculitis' within any specialty over 5 years (2018/19-2022/23). Variables for each claim included cause, injury, costs and claim status. RESULTS: We identified 152 rheumatology claims (total cost £28.2 million). The most frequent injuries were unnecessary pain [n = 70 (46%)], fatality [n = 14 (9%)] and psychiatric/psy…

Ассоциация аутоиммунных заболеваний с раком поджелудочной железы: общенациональное исследование из Швеции.

ЦЕНТРАЛЬНАЯ ИНФОРМАЦИЯ: Во всем мире растет заболеваемость раком поджелудочной железы и аутоиммунными заболеваниями. Хотя некоторые связи между конкретными АД, такими, как панкреатит и ПК, уже давно хорошо подтверждены, ориентированные на население исследования, посвященные изучению более широкого спектра АД и их связи с риском, связанным с ПК, по-прежнему носят ограниченный характер. МЕТОДЫ: Мы провели когортное исследование на основе демографических данных для анализа взаимосвязей между АД и уязвимостью ПК. Диагностическая информация 43 АД была получена в шведском стационарном регистре (Swed

Совпадение в аннотации оригинала
BACKGROUND: The incidence of pancreatic cancer (PC) and autoimmune diseases (ADs) has been increasing worldwide. While certain associations … of PC incidence and mortality, including discoid lupus erythematosus, lupoid hepatitis, giant-cell arteritis, and rheumatic fever. The results of this study back the notion that ADs may have a role in promoting the onset of PC.

Inflammatory/Immune Adverse Events in Chronic Myeloid Leukemia Patients During Treatment With Bosutinib.

BACKGROUND: Bosutinib, a tyrosine kinase inhibitor (TKI), is effective in treating chronic myeloid leukemia (CML) patients resistant or into … ents (55% of the sample), we detected 94 irAEs (2.3% of total adverse events), including giant cell arteritis, psoriasis, erythema nodosum, articular pain, pleural and pericardial effusion, and three cases of recurrent sterile pneumonia. The estimated TAR of the first irAEs was 14.7 (95% CI: 10.4-20.7) events per 100 person-years; considering repeated irAEs …

Concurrent histological lesions and molecular detection of porcine circovirus 3 in pigs with skeletal abnormalities and humpy-back posture.

Porcine circovirus 3 (PCV-3) is associated with various pathological conditions, including systemic disease and reproductive disorders; however, its role in skeletal abnormalities has never been elucidated. This study included 36 cases displaying spinal malformations, rib swelling, head edema, gait abnormalities, and/or increased late-term abortions. Investigated animals consisted of 9 aborted fetuses, 9 piglets, 12 weaners, and 6 finishers. Histologically, PCV-3 associated lesions were identified in 23/36 cases (64%), including (peri-)arteritis and rib fractures with prominent callus formatio…

Exploring Endovascular Photo-Activated Ablation (EPA) for Downstaging Locally Advanced Pancreatic Cancer: A Proof-of-Concept Study in the Normal Porcine Model.

BACKGROUND: Pancreatic cancers can involve large blood vessels early, making complete resection technically challenging or impossible. A min … to 15 mm around the treated vessel, for increasing drug doses. Treated arteries showed necrotising arteritis, without evidence of perforation or obstruction during the observation period, although one animal was euthanised at 1 day, due to technical endovascular device issues and obstruction. The lowest-dose animal euthanised at 7 days showed no lesions on …

Marijuana's Impact On Implant-based Breast Reconstruction: A Retrospective Cohort Study.

BACKGROUND: Studies have shown that chronic marijuana use is associated with increased vascular inflammation, endothelial damage, myocardial infarctions, strokes, arteritis, and cardiomyopathies; however, cannabis's effect on wound healing in immediate direct-to-implant (DTI) breast reconstruction is unknown. With the increasing prevalence of marijuana use, it is imperative to understand its effects on surgical outcomes. METHODS: We performed a retrospective cohort study of consecutive patients in a quaternary-care breast cancer center undergoing immediate DTI reconstruction. Patient demograp…

Increased prevalence of inflammatory arthritis, systemic lupus erythematosus and systemic sclerosis, during 2020-2023 versus 2016-2019 in a Nation-Wide Cohort Study.

Although several studies have explored the geoepidemiology of autoimmune rheumatic diseases (ARD), trends of their frequency overtime are un … stemic Lupus Erythematosus (SLE), Systemic Sclerosis (SSc) and Polymyalgia Rheumatica or Giant Cell Arteritis (PMR/GCA). Two sequential 4-year periods, namely 2016-2019 and 2020-2023 were compared. Prevalence of RA, PsA, AxSpA, SLE and SSc increased significantly during 2020-2023 compared to 2016-2019. This applies to both genders and to all age groups for …

The coincidence of multiple sclerosis and primary vasculitis; from the bench of pathology to the bedside of treatment: a systematic review of case reports.

INTRODUCTION: Multiple sclerosis (MS) is a chronic, disabling neurodegenerative disease, leads to reduced quality of life. The increasing pr … oids, interferon, cyclophosphamide, Glatiramer acetate as MS treatment. The concurrence of Takayasu Arteritis (2 cases), Polyarteritis Nodosa (2 cases), Churg-Strauss Syndrome (1 case), Wegener's Granulomatosis (2 cases), Microscopic Polyangiitis (1 case), Cutaneous leukocytoclastic vasculitis (5 cases), Good pasture's disease (5 cases) were reported with M …

Non-infectious hypertrophic pachymeningitis associated with orbital inflammatory disease: a pooled analysis.

PURPOSE: To describe four cases of non-infectious hypertrophic pachymeningitis (HP)-associated with orbital inflammatory disease (OID). This … erosis (11/37), neurosarcoidosis (1/37), inflammatory myofibroblastic tumour (1/37), and giant cell arteritis (1/37). Orbital pain, headache, visual deterioration, and cranial nerve palsies were common clinical presentations. Both "focal" and "diffuse" HP were observed, with the most common sign of orbital involvement being an inflammatory orbital mass, typ …

Tear inflammatory cytokine profiles in orbital inflammatory disease.

Tear inflammatory cytokines are a novel biomarker studied in a range of ocular surface diseases, periorbital and orbital conditions. This si … , IgG4-related orbital disease (17.6%), orbital granulomatosis with polyangiitis (5.9%), giant cell arteritis (5.9%), herpes zoster ophthalmicus with orbital apex inflammation (5.9%), viral dacryoadenitis (5.9%), bacterial dacryoadenitis (5.9%) and orbital inflammation of uncertain cause (5.9%). Overall, OID patients, and specifically those with dacryoadeni …

Geographic Influence Upon Noninfectious Diseases Accounting for Fever of Unknown Origin: A Systematic Review and Meta-Analysis.

BACKGROUND: Diagnostic outcomes for fever of unknown origin (FUO) remain with notable numbers of undiagnosed cases. A recent systemic review … 8.0%-32.0%). Adult-onset Still's disease (114 [58.5%]), systemic lupus (52 [26.7%]), and giant-cell arteritis (40 [68.9%]) predominated among the noninfectious inflammatory group. Lymphoma (164 [70.1%]) was the most common diagnosis in the cancer group. CONCLUSIONS: In this systematic review and meta-analysis, noninfectious disease diagnostic outcomes vari …